Ex Situ Inhibition of Hepatic Uptake and Efflux Significantly Changes Metabolism: Hepatic Enzyme-Transporter Interplay

Journal of Pharmacology and Experimental Therapeutics

Volumn 308, Issue 3, 2004, Pages 1040-1045

  Lau, Yvonne Y ^a   Wu, Chi Yuan ^a   Okochi, Hideaki ^a   Benet, Leslie Z ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A; DIGOXIGENIN; DIGOXIN; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; ORGANIC ANION TRANSPORTER; QUINIDINE; RIFAMPICIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BOLUS INJECTION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG DISPOSITION; DRUG METABOLISM; DRUG UPTAKE; INTRAHEPATIC BILE DUCT; ISOLATED LIVER; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; LIVER PERFUSION; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BIOLOGICAL TRANSPORT; DIGOXIN; LIVER; MALE; MEMBRANE TRANSPORT PROTEINS; PERFUSION; QUINIDINE; RATS; RATS, SPRAGUE-DAWLEY; RIFAMPIN;

EID: 1342302110     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.061770     Document Type: Article

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