The impact of in vitro binding on in vitro - In vivo extrapolations, projections of metabolic clearance and clinical drug-drug interactions

Current Drug Metabolism

Volumn 7, Issue 3, 2006, Pages 251-264

  Grime, Ken ^a   Riley, R J ^a  

^a Department of Physical and Metabolic Sciences ^*  (United Kingdom)

Author keywords

Clearance; Cytochrome P450 (CYP); Drug drug interaction (DDI); Hepatocytes; In vitro in vivo extrapolation (IVIVE); Relative activity factor (RAF)

Indexed keywords

BOSENTAN; BUFURALOL; CIMETIDINE; CYCLOSPORIN; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DESIPRAMINE; FLUCONAZOLE; FLUOXETINE; FLUVOXAMINE; ITRACONAZOLE; KETOCONAZOLE; MIDAZOLAM; NORFLUOXETINE; PYRROLE DERIVATIVE; QUINIDINE; TACROLIMUS; TOLTERODINE;

ACCURACY; ALGORITHM; AREA UNDER THE CURVE; CLINICAL LABORATORY; CORRELATION ANALYSIS; DATA ANALYSIS; DATA BASE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG METABOLISM; DRUG PROTEIN BINDING; ENZYME INHIBITION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIVER CLEARANCE; LIVER METABOLISM; MEDICAL LITERATURE; MOLECULAR MODEL; NONHUMAN; PREDICTION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REVIEW;

ANIMALS; AREA UNDER CURVE; DRUG INTERACTIONS; HUMANS; KINETICS; LIVER; PHARMACEUTICAL PREPARATIONS; RECEPTORS, DRUG; SPECIES SPECIFICITY;

EID: 33645961595     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920006776359266     Document Type: Review

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