Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene

Toxicology in Vitro

Volumn 20, Issue 4, 2006, Pages 426-438

  Harrigan, Jeanine A ^a,c   McGarrigle, Barbara P ^a   Sutter, Thomas R ^b   Olson, James R ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY OF MEMPHIS   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Benzo(a)pyrene; CYP1A1; CYP1B1; Liver slice; Lung slice

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; BENZO[A]PYRENE; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; DNA; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DNA ADDUCT; IN VITRO STUDY; IN VIVO STUDY; LIVER METABOLISM; LIVER SLICE; LUNG EMBOLISM; LUNG SLICE; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BENZO(A)PYRENE; BIOTRANSFORMATION; CARCINOGENS; CYTOCHROME P-450 CYP1A1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; GENE EXPRESSION; INJECTIONS, INTRAPERITONEAL; LIVER; LUNG; MALE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN;

ANIMALIA;

EID: 33645240574     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2005.08.015     Document Type: Article

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