Potentially reactive cyclic carbamate metabolite of the antiepileptic drug felbamate produced by human liver tissue in vitro

Drug Metabolism and Disposition

Volumn 26, Issue 11, 1998, Pages 1089-1095

  Kapetanovic, Izet M ^b   Torchin, Cynthia D ^b   Thompson, Charles D ^b   Miller, Thomas A ^b   Mcneilly, Patrick J ^b   Macdonald, Timothy L ^b   Kupferberg, Harvey J ^b   Perhach, James L ^b   Sofia, R Duane ^b   Strong, John M ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMIC ACID DERIVATIVE; FELBAMATE;

ARTICLE; DRUG DETERMINATION; DRUG HYDROXYLATION; DRUG INDICATION; DRUG METABOLISM; EPILEPSY; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIVER METABOLISM; MASS SPECTROMETRY; PRIORITY JOURNAL;

ANTICONVULSANTS; BIOTRANSFORMATION; CARBAMATES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HUMANS; LIVER; NAD; NADP; PROPYLENE GLYCOLS; SPECTROMETRY, MASS, SECONDARY ION;

EID: 0031769801     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Adusumalli VE, Choi YM, Romanyshyn LA, Sparadoski RE Jr, Wichmann JK, Wong KK, Kucharczyk N and Sofia RD (1993) Isolation and identification of 3-carbamoyloxy-2-phenylpropionic acid as a major urinary metabolite of felbamate. Drug Metab Dispos 21: 710-716.
2. Anderson LW, Ludeman SM, Colvin OM, Grochow LB and Strong JM (1995) Quantitation of 4-hydroxycyclophosphamide/aldophosphamide in whole blood. J Chromatogr 667:247-257.
3. Glue P, Banfield CR, Perhach JL, Mather GG, Racha JK and Levy RH (1997) Pharmacokinetic interactions with felbamate: in vitro-in vivo correlations. Clin Pharmacokinet 33:214-221.
4. 6-ethenoadenosine. Chem Res Toxicol 4:413-421.
5. Ingelman-Sundberg M, Johansson I, Persson I, Oscarson M, Hu Y, Bertilsson L, Dahl ML and Sjoqvist F (1994) Genetic polymorphism of cytochrome P450: functional consequences and possible relationship to disease and alcohol toxicity. Exper Suppl 71:197-207.
6. Itoga S, Harada S, Nomura F and Nakai T (1998) Genetic polymorphism of human CYP2E1: new alleles detected in exons and exon-intron. Nihon Arukoru Yakubutsu Igakkai Zasshi 33:56-64.
7. Jamis-Dow CA, Klecker RW, Katki AG and Collins JM (1995) Metabolism of taxol by human liver in vitro: a screen for drug interactions and interspecies differences. Cancer Chemother Pharmacol 36:107-114.
8. Lee RP, Parkinson A and Forkert P-G (1998) Isozyme-selective metabolism of ethyl carbamate by cytochrome P450 (CYP2E1) and carboxylesterase (hydrolase A) enzymes in murine liver microsomes. Drug Metab Dispos 26:60-65.
9. Pellock JM and Brodie MJ (1997) Felbamate: 1997 update. Epilepsia 38:1261-1264.
10. Racha JK, Mather GG, Bishop FE, Kunze KL and Levy RH (1996) Involvement of CYP3A4 and CYP2E1 in the metabolism of felbamate in human liver microsomes. ISSX Proc 10:370.
11. Ramasamy R, Oates PJ and Schaefer S (1997) Aldose reductase inhibition protects diabetic and nondiabetic rat hearts from ischemic injury. Diabetes 46:292-300.
12. Romanyshyn LA, Wichmann JK, Kucharczyk N and Sofia RD (1993) Simultaneous determination of felbamate and four metabolites in rat cerebrospinal fluid by high-performance liquid chromatography. J Chromatogr 622:223-228.
13. Seitz HK and Csomos G (1992) [Alcohol and liver: ethanol metabolism and the pathomechanism of alcoholic liver damage]. Orv Hetil 133:3183-3189.
14. Sladek NE, Manthey CL, Maki PA, Zhang Z and Landkamer GJ (1989) Xenobiotic oxidation catalyzed by aldehyde dehydrogenases. Drug Metab Rev 20:697-720.
15. Thompson CD, Gulden PH and Macdonald TL (1997b) Identification of modified atropaldehyde mercapturic acids in rat and human urine after felbamate administration. Chem Res Toxicol 10:457-462.
16. Thompson CD, Kinter MT and Macdonald TL (1996) Synthesis and in vitro reactivity of 3-carbamoyl-2-phenylpropionaldehyde and 2-phenylpropenal: putative reactive metabolites of felbamate. Chem Res Toxicol 9:1225-1229.
17. Yang JT, Morris M, Wong KK, Kucharczyk N and Sofia RD (1992) Felbamate metabolism in pediatric and adult beagle dogs. Drug Metab Dispos 20:84-88.