PXR and CAR: Nuclear receptors which play a pivotal role in drug disposition and chemical toxicity

Drug Metabolism Reviews

Volumn 38, Issue 3, 2006, Pages 515-597

  Stanley, Lesley ^a   Horsburgh, Brian ^b   Ross, Jillian ^c   Scheer, Nico ^d   Roland Wolf, C ^c,e  

^a Department of Investigative Toxicology ^*  (United Kingdom)

^b ITI Life Sciences   (United Kingdom)

^c CXR Biosciences Ltd   (United Kingdom)

^d Artemis Pharmaceuticals GmbH   (Germany)

^e UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Constitutive androstane receptor; CYP2B; CYP3A; Cytochrome P450; Humanised mice; Null mice; Pregnane X receptor; Transcription factors

Indexed keywords

16ALPHA CYANOPREGNENOLONE; ANTINEOPLASTIC AGENT; ATORVASTATIN; CELL NUCLEUS RECEPTOR; CERIVASTATIN; CISPLATIN; CLOTRIMAZOLE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYPROTERONE ACETATE; CYTOCHROME P450 2B; CYTOCHROME P450 3A; DEXAMETHASONE; DOCETAXEL; DRUG METABOLIZING ENZYME; ENZYME INDUCING AGENT; FLUINDOSTATIN; GW 3333; IXABEPILONE; MEVINOLIN; MIFEPRISTONE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; NIFEDIPINE; PACLITAXEL; PREGNANE X RECEPTOR; PREGNENOLONE; RIFAMPICIN; SIMVASTATIN; SPIRONOLACTONE; SR 12813; TAXANE DERIVATIVE; TRABECTEDIN; XENOBIOTIC AGENT;

ACUTE TOXICITY; BILE ACID METABOLISM; BILIRUBIN BLOOD LEVEL; CANCER CELL CULTURE; CELL STRAIN HEK293; CELL STRAIN HEPG2; DOSE RESPONSE; DRUG DETOXIFICATION; DRUG DISPOSITION; DRUG ELIMINATION; DRUG INACTIVATION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG TRANSPORT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; GENE CONTROL; GENE EXPRESSION; HUMAN; IN VITRO SELECTION; IN VITRO STUDY; INFECTION; INFLAMMATION; LIVER CANCER; LIVER CARCINOGENESIS; LIVER DISEASE; LIVER INJURY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; RNA SPLICING; TRANSCRIPTION INITIATION; XENOBIOTIC METABOLISM;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG TOXICITY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; TRANSCRIPTION FACTORS; XENOBIOTICS;

EID: 33746706762     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.1080/03602530600786232     Document Type: Review

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