The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR)

Journal of Biological Chemistry

Volumn 279, Issue 37, 2004, Pages 38379-38385

  Burk, Oliver ^a   Koch, Ina ^b   Raucy, Judy ^c   Hustert, Elisabeth ^b   Eichelbaum, Michel ^a   Brockmöller, Jürgen ^d   Zanger, Ulrich M ^a   Wojnowski, Leszek ^d,e  

^a DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^b Epidauros Biotechnologie AG   (Germany)

^c California Toxicol Res Institute   (United States)

^d UNIVERSITY OF GÖTTINGEN   (Germany)

^e JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BIOLOGICAL ORGANS; BIOPSY; DRUG INTERACTIONS; METABOLISM;

CYTOCHROME; XENOBIOTICS;

RNA;

CELL NUCLEUS RECEPTOR; CLOTRIMAZOLE; CONSTITUTIVELY ACTIVATED RECEPTOR; CYTOCHROME P450 3A5; MIFEPRISTONE; OMEPRAZOLE; PHENOBARBITAL; PREGNANE X RECEPTOR; RIFAMPICIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG EXPOSURE; DRUG INTERACTION; ENZYME INDUCTION; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; INTESTINE BIOPSY; INTESTINE CELL; LIVER CELL; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSACTIVATION; TRANSCRIPTION INITIATION SITE; XENOBIOTIC METABOLISM;

ALLELES; AMINO ACID MOTIFS; BIOPSY; CYTOCHROME P-450 ENZYME SYSTEM; GENES, DOMINANT; GENES, REPORTER; GENOTYPE; HEPATOCYTES; HETEROZYGOTE; HUMANS; INTESTINES; LIVER; PLASMIDS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RIFAMPIN; RNA; RNA, MESSENGER; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION; XENOBIOTICS;

EUKARYOTA; STAPHYLOCOCCUS PHAGE 3A;

EID: 4644231469     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M404949200     Document Type: Article

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