Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways

Journal of Pharmacology and Experimental Therapeutics

Volumn 300, Issue 1, 2002, Pages 206-212

  Guo, Grace L ^a   Choudhuri, Supratim ^a   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA CYANOPREGNENOLONE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3 INDOLEMETHANOL; ALLYL SULFIDE; AROMATIC HYDROCARBON RECEPTOR; BETA NAPHTHOFLAVONE; BUTYLATED HYDROXYANISOLE; CARDIAC GLYCOSIDE; CARRIER PROTEIN; CLOFIBRIC ACID; CONSTITUTIVE ANDROSTANE RECEPTOR; DEXAMETHASONE; DRUG METABOLIZING ENZYME; ENZYME INDUCING AGENT; ETHOXYQUIN; LIGAND; MESSENGER RNA; OLTIPRAZ; ORGANIC ANION TRANSPORTER 2; PERFLUORODECANOIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHENOBARBITAL; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; POLYCHLORINATED BIPHENYL; PREGNANE X RECEPTOR; RECEPTOR; SPIRONOLACTONE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DRUG METABOLISM; GENE EXPRESSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; RNA TRANSLATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, NORTHERN; DNA PROBES; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIGANDS; LIVER; MALE; MEMBRANES; ORGANIC ANION TRANSPORT POLYPEPTIDE C; PHARMACEUTICAL PREPARATIONS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0036138199     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.300.1.206     Document Type: Article

References (53)

1. Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2
2. Induction of phase I and phase II drug-metabolizing enzyme mRNA, protein, and activity by BHA, ethoxyquin, and oltipraz
3. Fibrates induce mdr2 gene expression and biliary phospholipid secretion in the mouse
4. Central role of PPARalpha in the mechanism of action of hepatocarcinogenic peroxisome proliferators
5. Up-regulation of multidrug resistance-associated protein 2 (MRP2) expression in rat hepatocytes by dexamethasone
6. Effects of microsomal enzyme inducers on carrier-mediated transport systems in isolated rat hepatocytes
7. Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells
8. Quantitative RT-PCR on CYP1A1 heterogeneous nuclear RNA: A surrogate for the in vitro transcription run-on assay
9. Induction of drug metabolising enzymes: Pharmacokinetic and toxicological consequences in humans
10. Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain
11. Nuclear receptor response elements mediate induction of intestinal mdr1 by rifampin
12. Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology
13. The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance
14. The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
15. Processing of gonadotropin-releasing hormone gene transcripts in the rat brain
16. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta
17. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha
18. The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution
19. Immunohistochemical distribution and functional characterization of an organic anion transporting polypeptide 2 (oatp2)
20. Induction of cMrp/cMoat gene expression by cisplatin, 2-acetylaminofluorene, or cycloheximide in rat hepatocytes
21. Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene
22. Studies on the mechanism of phenobarbital-enhanced sulfobromophthalein disappearance
23. Effects of phenobarbital on the plasma disappearance and biliary excretion of drugs in rats
24. Plasma disappearance and biliary excretion of sulfobromophthalein and phenol-3,6-dibromphthalein disulfonate after microsomal enzyme induction
25. Effect of microsomal enzyme inducers on the billary excretion of cardiac glycosides
26. Stimulation of the development of the hepatic excretory mechanism for ouabain in newborn rats with microsomal enzyme inducers
27. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
28. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
29. Identification of a nuclear receptor for bile acids
30. Is peroxisome proliferation an obligatory precursor step in the carcinogenicity of di(2-ethylhexyl)phthalate (DEHP)?
31. Overexpression of mdr2 gene by peroxisome proliferators in the mouse liver
32. Aryl hydrocarbon receptor-inducible or constitutive expression of human UDP glucuronosyltransferase UGT1A6
33. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain
34. Characterization of inducible nature of MRP3 in rat liver
35. Bile acids: Natural ligands for an orphan nuclear receptor
36. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha
37. Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anon transporters, OATP1 and OATP2
38. Localization and function of organic anion-transporting polypeptide oatp2 in rat liver
39. Cellular and molecular biology of aryl hydrocarbon (Ah) receptor-mediated gene expression
40. Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers
41. Rabbit pregnane X receptor is activated by rifampicin
42. Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells
43. Split genes and RNA splicing
44. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
45. The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
46. Phenobarbital response elements of cytochrome p450 genes and nuclear receptors
47. Chemoprotection against cancer by phase 2 enzyme induction
48. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
49. P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR
50. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
51. The human estrogen receptor structural gene contains a DNA sequence that binds activated mouse and human Ah receptors: A possible mechanism of estrogen receptor regulation by 2,3,7,8-tetrachlorodibenzop-dioxin
52. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR
53. Rat pregnane X receptor: Molecular cloning, tissue distribution, and xenobiotic regulation