Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 6, 2005, Pages 2063-2068

  Stedman, Catherine A M ^a,b   Liddle, Christopher ^a,b   Coulter, Sally A ^a,b   Sonoda, Junichiro ^c   Alvarez, Jacqueline G A ^c   Moore, David D ^d   Evans, Ronald M ^c   Downes, Michael ^c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b WESTMEAD HOSPITAL   (Australia)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Bile acid; Cholestasis; Cholesterol; High density lipoprotein

Indexed keywords

ANDROSTANE RECEPTOR; BILE ACID; CELL NUCLEUS RECEPTOR; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; MULTIDRUG RESISTANCE PROTEIN 1; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTING POLYPEPTIDE C; PREGNANE X RECEPTOR; SODIUM DEPENDENT ORGANIC ANION TRANSPORTER 2; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; BILE ACID SYNTHESIS; BILE DUCT LIGATION; CHOLESTASIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DETOXIFICATION; GENE EXPRESSION; KNOCKOUT MOUSE; LIPID METABOLISM; LIVER INJURY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; STIMULUS;

ANIMALS; BILE ACIDS AND SALTS; BILE DUCTS; CHOLESTASIS; CHOLESTEROL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; LIPID METABOLISM; LIVER; MALE; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; ORGANIC ANION TRANSPORT POLYPEPTIDE C; ORGANIC CATION TRANSPORT PROTEINS; P-GLYCOPROTEIN; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 13844315320     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0409794102     Document Type: Article

References (31)

1. Chiang, J. Y. (2002) Endocr. Rev. 23, 443-463.
2. Blumberg, B. & Evans, R. M. (1998) Genes Dev. 12, 3149-3155.
3. Kliewer, S. A., Moore, J. T., Wade, L., Staudinger, J. L., Watson, M. A., Jones, S. A., McKee, D. D., Oliver, B. B., Willson, T. M. & Zetterstrom, R. H., (1998) Cell 92, 73-82.
4. Choi, H. S., Chung, M., Tzameli, I., Simha, D., Lee, Y. K., Seol, W. & Moore, D. D. (1997) J. Biol. Chem. 272, 23565-23571.
5. Sonoda, J., Rosenfeld, J. M., Xu, L., Evans, R. M. & Xie, W. (2003) Curr. Drug Metab. 4, 59-72.
6. Goodwin, B., Hodgson, E., D'Costa, D. J., Robertson, G. R. & Liddle, C. (2002) Mol. Pharmacol. 62, 359-365.
7. Xie, W., Radominska-Pandya, A., Shi, Y., Simon, C. M., Nelson, M. C., Ong, E. S., Waxman, D. J. & Evans, R. M. (2001) Proc. Natl. Acad. Sci. USA 98, 3375-3380.
8. Staudinger, J. L., Goodwin, B., Jones, S. A., Hawkins-Brown, D., MacKenzie, K. I., LaTour, A., Liu, Y., Klaassen, C. D., Brown, K. K., Reinhard, J., et al. (2001) Proc. Natl. Acad. Sci. USA 98, 3369-3374.
9. Bachs, L., Pares, A., Elena, M., Piera, C. & Rodes, J. (1992) Gastroenterology 102, 2077-2080.
10. Wietholtz, H., Marschall, H. U., Sjovall, J. & Matern, S. (1996) J. Hepatol. 24, 713-718.
11. Stedman, C., Robertson, G., Coulter, S. & Liddle, C. (2004) J. Biol. Chem. 279, 11336-11343.
12. Guo, G. L., Lambert, G., Negishi, M., Ward, J. M., Brewer, H. B., Jr., Kliewer, S. A., Gonzalez, F. J., Sinal, C. J., Ourlin, J. C., Lasserre, F., et al. (2003) J. Biol. Chem. 278, 45062-45071.
13. Saini, S. P., Sonoda, J., Xu, L., Toma, D., Uppal, H., Mu, Y., Ren, S., Moore, D. D., Evans, R. M. & Xie, W. (2004) Mol. Pharmacol. 65, 292-300.
14. Lew, J. L., Zhao, A., Yu, J., Huang, L., De Pedro, N., Pelaez, F., Wright, S. D. & Cui, J. (2004) J. Biol. Chem. 279, 8856-8861.
15. Xie, W., Barwick, J. L., Downes, M., Blumberg, B., Simon, C. M., Nelson, M. C., Neuschwander-Tetri, B. A., Brunt, E. M., Guzelian, P. S. & Evans, R. M. (2000) Nature 406, 435-439.
16. Wei, P., Zhang, J., Egan-Hafley, M., Liang, S. & Moore, D. D. (2000) Nature 407, 920-923.
17. Wagner, M., Fickert, P., Zollner, G., Fuchsbichler, A., Silbert, D., Tsybrovskyy, O., Zatloukal, K., Guo, G. L., Schuetz, J. D., Gonzalez, F. J., et al. (2003) Gastroenterology 125, 825-838.
18. Trauner, M. & Boyer, J. L. (2003) Physiol. Rev. 83, 633-671.
19. Jung, D. & Kullak-Ublick, G. A. (2003) Hepatology 37, 622-631.
20. Cui, Y., Konig, J., Leier, I., Buchholz, U. & Keppler, D. (2001) J. Biol. Chem. 276, 9626-9630.
21. Zollner, G., Fickert, P., Silbert, D., Fuchsbichler, A., Marschall, H. U., Zatloukal, K., Denk, H. & Trauner, M. (2003) J. Hepatol. 38, 717-727.
22. Kast, H. R., Goodwin, B., Tarr, P. T., Jones, S. A., Anisfeld, A. M., Stoltz, C. M., Tontonoz, P., Kliewer, S., Willson, T. M. & Edwards, P. A. (2002) J. Biol. Chem. 277, 2908-2915.
23. Maglich, J. M., Stoltz, C. M., Goodwin, B., Hawkins-Brown, D., Moore, J. T. & Kliewer, S. A. (2002) Mol. Pharmacol. 62, 638-646.
24. Synold, T. W., Dussault, I. & Forman, B. M. (2001) Nat. Med. 7, 584-590.
25. Longo, M., Crosignani, A., Battezzati, P. M., Squarcia Giussani, C., Invernizzi, P., Zuin, M. & Podda, M. (2002) Gut 51, 265-269.
26. Tabas, I. (2002) J. Clin. Invest. 110, 905-911.
27. Norlin, M. & Chiang, J. Y. (2004) Biochem. Biophys. Res. Commun. 316, 158-164.
28. Zhang, J., Huang, W., Qatanani, M., Evans, R. M. & Moore, D. D. (2004) J. Biol. Chem. 279, 49517-49522.
29. Hofmann, A. F. (1988) in The Liver: Biology and Pathobiology, eds. Arias, I. M., Jacoby, W. B., Popper, H., Schachter, D. & Shafritz, D. A. (Raven, New York), pp. 553-572.
30. Araya, Z. & Wikvall, K. (1999) Biochim. Biophys. Acta 1438, 47-54.
31. Huang, W., Zhang, J., Chua, S. S., Qatanani, M., Han, Y., Granata, R. & Moore, D. D. (2003) Proc. Natl. Acad. Sci. USA 100, 4156-4161.