The glucocorticoid receptor is essential for induction of cytochrome P- 4502B by steroids but not for drug or steroid induction of CYP3A or P-450 reductase in mouse liver

Drug Metabolism and Disposition

Volumn 28, Issue 3, 2000, Pages 268-278

  Schuetz, Erin G ^a   Schmid, Wolfgang ^b   Schutz, Gunther ^b   Brimer, Cynthia ^a   Yasuda, Kazuto ^a   Kamataki, Tetsuya ^c   Bornheim, Lester ^d   Myles, Kathy ^e   Cole, Timothy J ^e  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c HOKKAIDO UNIVERSITY   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA CYANOPREGNENOLONE; CIS ACTING ELEMENT; CYTOCHROME P450 3A; CYTOCHROME P450 REDUCTASE; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID ANTAGONIST; GLUCOCORTICOID RECEPTOR; MIFEPRISTONE; PENTOXYRESORUFIN DEALKYLASE; PHENOBARBITAL; RIFAMPICIN; TYROSINE AMINOTRANSFERASE;

ANIMAL EXPERIMENT; ARTICLE; BINDING COMPETITION; CONTROLLED STUDY; DRUG ACTIVATION; DRUG METABOLISM; ENZYME ACTIVATION; FEMALE; GENE INDUCTION; GENOTYPE; IMMUNOBLOTTING; LIGAND BINDING; LIVER; LIVER MICROSOME; MALE; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION;

ALDOSTERONE; ANIMALS; BINDING, COMPETITIVE; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; ENZYME INDUCTION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; ISOENZYMES; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, MUTANT STRAINS; MICROSOMES, LIVER; NADPH-FERRIHEMOPROTEIN REDUCTASE; PREGNENOLONE CARBONITRILE; RABBITS; RECEPTORS, GLUCOCORTICOID; RIFAMPIN; RNA, MESSENGER; STEROIDS; TRITIUM;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0034012654     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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