The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 98, Issue 6, 2001, Pages 3369-3374

  Staudinger, Jeff L ^a,c   Goodwin, Bryan ^a   Jones, Stacey A ^a   Hawkins Brown, Diane ^a   MacKenzie, Kathleen I ^a   LaTour, Anne ^b   Liu, Yaping ^c   Klaassen, Curtis D ^c   Brown, Kathleen K ^a   Reinhard, John ^a   Willson, Timothy M ^a   Koller, Beverly H ^b   Kliewer, Steven A ^a  

^a GLAXOSMITHKLINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA CYANOPREGNENOLONE; BILE ACID; CELL NUCLEUS RECEPTOR; CYTOCHROME P450 3A; LITHOCHOLIC ACID; LIVER PROTECTIVE AGENT; PROTEIN PXR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE ACID METABOLISM; CONTROLLED STUDY; GENE EXPRESSION; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CHOLESTASIS, INTRAHEPATIC; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LITHOCHOLIC ACID; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OXIDOREDUCTASES, N-DEMETHYLATING; PREGNENOLONE CARBONITRILE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID;

ANIMALIA; EUKARYOTA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0035853165     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.051551698     Document Type: Article

References (41)