Endocrine disrupting chemicals, phthalic acid and nonylphenol, activate Pregnane X receptor-mediated transcription

Molecular Endocrinology

Volumn 14, Issue 3, 2000, Pages 421-428

  Masuyama, Hisashi ^a   Hiramatsu, Yuji ^a   Kunitomi, Mamoru ^a   Kudo, Takafumi ^a   MacDonald, Paul N ^b  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ALCOHOL; CELL NUCLEUS RECEPTOR; CYTOCHROME P450 3A1; CYTOCHROME P450 ISOENZYME; ESTRADIOL; NONYLPHENOL; PHTHALIC ACID; PREGNANE DERIVATIVE; PREGNANE X RECEPTOR; RECEPTOR INTERACTING PROTEIN 140; STEROID RECEPTOR COACTIVATOR 1; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSACTIVATION;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0034463909     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.14.3.0424     Document Type: Article

References (36)

1. The steroid and thyroid hormone receptor superfamily
2. Molecular mechanisms of action of steroid/thyroid receptor superfamily members
3. The RXR heterodimers and orphan receptors
4. Nuclear receptor coactivators and corepressors
5. The N-terminal domain of transcription factor lib is required for direct interaction with vitamin D receptor and participates in vitamin D-mediated transcription
6. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
7. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
8. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
9. Rat pregnane X receptor: Molecular cloning, tissue distribution, and xenobiotic regulation
10. SXR, a novel steroid and xenobiotic-sensing nuclear receptor
11. Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene
12. Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element
13. P450 genes; structure, evolution and regulation
14. Substrate specificities and functions of the P450 cytochromes
15. Endocrine disrupters and reproductive development: A weight-of-evidence overview
16. Modulation of rat hepatic CYP3A by nonylphenol
17. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
18. Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor
19. Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1
20. Identification of the gal4 suppressor Sug1 as a subunit of the yeast 26 S proteasome
21. Research needs for the risk assessment of health and environmental effects of endocrine disruptors. A report of the US EPA-sponsored workshop
22. Plasma levels of estradiol, estrone, estrone sulfate and sex hormone binding globulin in patients receiving rifampicin
23. Effects of rifabutin and rifampicin on the pharmacokinetics of ethinylestradiol and norethindrone
24. Regulation of CYP3A9 gene expression by estrogen and catalytic studies using cytochrome P450 3A9 expressed in Escherichia coli
25. Estrogen receptor-associated proteins: Possible mediators of hormone-induced transcription
26. Evidence for ligand-dependent intramolecular folding of the AF-2 domain in vitamin D receptor-activated transcription and coactivator interaction
27. Inhibitors of the proteasome block degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
28. Molecular biology of proteasomes
29. Structure and functions of the 20S and 26S proteasome
30. Proteasome-mediated degradation of the vitamin D receptor (VDR) and a putative role for SUG1 interaction with the AF-2 domain of VDR
31. Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif
32. A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids
33. The retinoblastoma protein associates with the protein phosphatase type I catalytic subunit
34. The vitamin D receptor interacts with general transcription factor IIB
35. Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein
36. Analysis of rat cytochrome P450 Isoenzyme expression using semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR)