CYP3A induction by liver X receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor

Drug Metabolism and Disposition

Volumn 32, Issue 1, 2004, Pages 66-71

  Shenoy, Sarita D ^a   Spencer, Thomas A ^b   Mercer Haines, Nancy A ^a   Alipour, Masumeh ^a   Gargano, Mary D ^a   Runge Morris, Melissa ^a   Kocarek, Thomas A ^a,c  

^a WAYNE STATE UNIVERSITY   (United States)

^b Lamont Doherty Earth Observatory   (United States)

^c Inst of Environ Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

24,25 EPOXYCHOLESTEROL; 25 HYDROXYCHOLESTEROL; BENZENESULFONAMIDE DERIVATIVE; BETA NAPHTHOFLAVONE; CIPROFIBRATE; CYTOCHROME P450 1A1; CYTOCHROME P450 2B; CYTOCHROME P450 3A; CYTOCHROME P450 4A; DEXAMETHASONE; LIGAND; LIVER X RECEPTOR; MESSENGER RNA; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHYL)ETHYL]PHENYL]BENZENESULFONAMIDE; NOVOLIN R; OXYSTEROL; PHENOBARBITAL; PREGNANE X RECEPTOR; RECOMBINANT HUMAN INSULIN; T 090137; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACCUMULATION; ENZYME INDUCTION; GENE INDUCTION; GENETIC TRANSFECTION; IMMUNOREACTIVITY; LIGAND BINDING; LIVER CELL; LIVER CELL CULTURE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; REPORTER GENE;

ANIMALS; ANTICHOLESTEREMIC AGENTS; ARYL HYDROCARBON HYDROXYLASES; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELLS, CULTURED; CYTOCHROME P-450 CYP3A; DNA-BINDING PROTEINS; ENZYME INDUCTION; GENE EXPRESSION REGULATION; GENES, REPORTER; HEPATOCYTES; HYDROXYCHOLESTEROLS; LIGANDS; MALE; MICE; MICE, INBRED C57BL; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; TRANSCRIPTION FACTORS; TRANSFECTION;

ANIMALIA; RODENTIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 1642457373     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.32.1.66     Document Type: Article

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