Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

Genes and Development

Volumn 14, Issue 23, 2000, Pages 3014-3023

  Xie, Wen ^a   Barwick, Joyce L ^c   Simon, Cynthia M ^a   Pierce, Alexis M ^a   Safe, Stephen ^d   Blumberg, Bruce ^e   Guzelian, Philip S ^c   Evans, Ronald M ^a,b  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d TEXAS A AND M UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CAR, metabolic safety; CYP gene; Nuclear receptor; SXR PXR

Indexed keywords

CELL NUCLEUS RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 2B; CYTOCHROME P450 3A; GENE PRODUCT; PREGNENOLONE X RECEPTOR; STEROID AND XENOBIOTIC RECEPTOR; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; RAT; STEROID METABOLISM; TRANSGENIC MOUSE; XENOBIOTIC METABOLISM;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CELLS, CULTURED; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; MICE; MICE, TRANSGENIC; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RESPONSE ELEMENTS; STEROID HYDROXYLASES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; XENOBIOTICS;

ANIMALIA; MUS MUSCULUS; STAPHYLOCOCCUS PHAGE 3A;

EID: 0033638960     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.846800     Document Type: Article

References (42)

1. Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes
2. A new orphan member of the nuclear receptor superfamily that interacts with a subset of retinoic acid response elements
3. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
4. SXR, a novel steroid and xenobiotic-sensing nuclear receptor
5. Orphan nuclear receptors new ligands and new possibilities
6. Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR
7. Xenoblotic-inducible transcription of cyctochrome P450 genes
8. The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue
9. Identification of a nuclear receptor that is identified by farnesol metabolites
10. Androstane metabolites bind to and deactivate the nuclear receptor CAR-β
11. Herb-drug interactions
12. Human cytochromes P450: Problems and prospects
13. The aryl hydrocarbon receptor complex
14. Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene
15. Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes
16. Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene
17. The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
18. Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene
19. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
20. A pleiotropic response to phenobarbital-type enzyme inducers in the F344/NCr rat: Effects of chemicals of varied structure
21. St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
22. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
23. Induction of cytochrome P-450 in the Norway rat, Rattus norvegicus, following exposure to potential environmental contaminants
24. Rip locus Regulation of female-specific isozyme (I-P-450(16α) of testosterone 16α-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA
25. Phenobarbital induction mediated by a distal CYP2B2 sequence in rat liver transiently transfected in situ
26. Indinavir concentrations and St John's wort
27. Phenobarbital induction and tissue-specific expression of the rat CYP2B2 gene in transgenic mice
28. Acute heart transplant rejection due to Saint John's wort
29. Molecular mechanisms of cytochrome P-450 induction by xenobiotics an expanded role for nuclear hormone receptors
30. Regulation of gene expression in adult rathepatocytes cultured on extracellular matrix
31. Use of human hepatocytes to study P450 gene induction
32. The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
33. Localization of a phenobarbital-responsive element (PBRE) in the 5'-flanking region of the rat CYP2B2 gene
34. The xenobiotic compound 1,4-Bis[2-(3,5-Dichloropyridyloxy)]Benzene is an agonist ligand for the nuclear receptor CAR
35. Phenobarbital induction of cytochrome P-450 gene expression
36. P450 gene induction by structurally diverse xenochemicals central role of nuclear receptors CAR, PXR, and PPAR
37. Induction of cytochrome P4501A1: A model for analyzing mammalian gene transcription
38. LXR, a nuclear receptor that defines a distinct retinoid response pathway
39. Conditional expression of erbB2 oncogene in transgenic mice elicits striking hyperplasia in stratified epithelia, and up-regulation of TGFα expression
40. Humanized xenobiotic response in mice expressing nuclear receptor SXR
41. Induction of polymorphic 4'-hydroxylation of S-mephenytoin by rifampicin