-
1
-
-
13144260727
-
Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
-
Bertilsson G, Heidrich J, Svensson K, Asman M, Jendeberg L, Sydow-Backman M, Ohlsson R, Postlind H, Blomquist P, and Berkenstam A (1998) Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci USA 95:12208-12213.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 12208-12213
-
-
Bertilsson, G.1
Heidrich, J.2
Svensson, K.3
Asman, M.4
Jendeberg, L.5
Sydow-Backman, M.6
Ohlsson, R.7
Postlind, H.8
Blomquist, P.9
Berkenstam, A.10
-
2
-
-
0032532721
-
Orphan nuclear receptors - New ligands and new possibilities
-
Blumberg B and Evans RM (1998) Orphan nuclear receptors - new ligands and new possibilities. Genes Dev 12:3149-3155.
-
(1998)
Genes Dev
, vol.12
, pp. 3149-3155
-
-
Blumberg, B.1
Evans, R.M.2
-
3
-
-
0032532134
-
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
-
Blumberg B, Sabbagh W, Juguilon H, Bolado J, van Meter CM, Ong ES, and Evans RM (1998) SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev 12:3195-3205.
-
(1998)
Genes Dev
, vol.12
, pp. 3195-3205
-
-
Blumberg, B.1
Sabbagh, W.2
Juguilon, H.3
Bolado, J.4
Van Meter, C.M.5
Ong, E.S.6
Evans, R.M.7
-
5
-
-
0034331073
-
Finding nuclear localization signals
-
Cokol M, Nair R, and Rost B (2000) Finding nuclear localization signals. EMBO Rep 1:411-415.
-
(2000)
EMBO Rep
, vol.1
, pp. 411-415
-
-
Cokol, M.1
Nair, R.2
Rost, B.3
-
6
-
-
0030859287
-
A nuclear localization signal of human aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor 1β is a novel bipartite type recognized by the two components of nuclear pore-targeting complex
-
Eguchi H, Ikuta T, Tachibana T, Yoneda Y, and Kawajiri K (1997) A nuclear localization signal of human aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor 1β is a novel bipartite type recognized by the two components of nuclear pore-targeting complex. J Biol Chem 272:17640-17647.
-
(1997)
J Biol Chem
, vol.272
, pp. 17640-17647
-
-
Eguchi, H.1
Ikuta, T.2
Tachibana, T.3
Yoneda, Y.4
Kawajiri, K.5
-
7
-
-
0032497544
-
Androstane metabolites bind to and deactivate the nuclear receptor CAR-β
-
Forman BM, Tzameli I, Choi HS, Chen J, Simha D, Seo W, Evans RM, and Moore DD (1998) Androstane metabolites bind to and deactivate the nuclear receptor CAR-β. Nature (Lond) 395:612-615.
-
(1998)
Nature (Lond)
, vol.395
, pp. 612-615
-
-
Forman, B.M.1
Tzameli, I.2
Choi, H.S.3
Chen, J.4
Simha, D.5
Seo, W.6
Evans, R.M.7
Moore, D.D.8
-
8
-
-
0035805536
-
Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
-
Geick A, Eichelbaum M, and Burk O (2001) Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem 276:14581-14587.
-
(2001)
J Biol Chem
, vol.276
, pp. 14581-14587
-
-
Geick, A.1
Eichelbaum, M.2
Burk, O.3
-
9
-
-
0032702726
-
The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module
-
Goodwin B, Hodgson E, and Liddle C (1999) The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Mol Pharmacol 56:1329-1339.
-
(1999)
Mol Pharmacol
, vol.56
, pp. 1329-1339
-
-
Goodwin, B.1
Hodgson, E.2
Liddle, C.3
-
10
-
-
0030986236
-
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
-
Heery DM, Kalkhoven S, Hoare S, and Parker MG (1997) A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature (Lond) 387:733-736.
-
(1997)
Nature (Lond)
, vol.387
, pp. 733-736
-
-
Heery, D.M.1
Kalkhoven, S.2
Hoare, S.3
Parker, M.G.4
-
11
-
-
0031682988
-
The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
-
Honkakoski P, Zelko I, Sueyoshi T, and Negishi M (1998) The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol Cell Biol 18:5652-5658.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 5652-5658
-
-
Honkakoski, P.1
Zelko, I.2
Sueyoshi, T.3
Negishi, M.4
-
12
-
-
0032579265
-
Nuclear localization and export signals of the human aryl hydrocarbon receptor
-
Ikuta T, Eguchi H, Tachibana T, Yoneda Y, and Kawajiri K (1998) Nuclear localization and export signals of the human aryl hydrocarbon receptor. J Biol Chem 273:2895-2904.
-
(1998)
J Biol Chem
, vol.273
, pp. 2895-2904
-
-
Ikuta, T.1
Eguchi, H.2
Tachibana, T.3
Yoneda, Y.4
Kawajiri, K.5
-
13
-
-
0036170211
-
Characterization of the LxxLL motif in the aryl hydrocarbon receptor: Effects on subcellular localization and transcriptional activity
-
Ikuta T, Watanabe J, and Kawajiri K (2002) Characterization of the LxxLL motif in the aryl hydrocarbon receptor: effects on subcellular localization and transcriptional activity. J Biochem 131:79-85.
-
(2002)
J Biochem
, vol.131
, pp. 79-85
-
-
Ikuta, T.1
Watanabe, J.2
Kawajiri, K.3
-
14
-
-
0033279823
-
Regulation of nuclear localization: A key to a door
-
Kaffman A and O'Shea EK (1999) Regulation of nuclear localization: a key to a door. Annu Rev Cell Dev Biol 15:291-339.
-
(1999)
Annu Rev Cell Dev Biol
, vol.15
, pp. 291-339
-
-
Kaffman, A.1
O'Shea, E.K.2
-
15
-
-
0037169551
-
Regulation of multidrug receptors pregnane X receptor, farnesoid X-activated receptor and constitutive androstane redeptor
-
Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonnoz P, Kliwer S, Wilson TM, and Edwards PA (2002) Regulation of multidrug receptors pregnane X receptor, farnesoid X-activated receptor and constitutive androstane redeptor. J Biol Chem 277:2908-2915.
-
(2002)
J Biol Chem
, vol.277
, pp. 2908-2915
-
-
Kast, H.R.1
Goodwin, B.2
Tarr, P.T.3
Jones, S.A.4
Anisfeld, A.M.5
Stoltz, C.M.6
Tontonnoz, P.7
Kliwer, S.8
Wilson, T.M.9
Edwards, P.A.10
-
16
-
-
0032766430
-
Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene
-
Kawamoto T, Sueyoshi T, Zelko I, Moore R, Washburn K, and Negishi M (1999) Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol Cell Biol 19:6318-6322.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 6318-6322
-
-
Kawamoto, T.1
Sueyoshi, T.2
Zelko, I.3
Moore, R.4
Washburn, K.5
Negishi, M.6
-
17
-
-
0031838805
-
cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)
-
Kikuchi Y, Suzuki H, Hirohashi T, Tyson CA, and Sugiyama Y (1998) cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). FEBS Lett 433:149-152.
-
(1998)
FEBS Lett
, vol.433
, pp. 149-152
-
-
Kikuchi, Y.1
Suzuki, H.2
Hirohashi, T.3
Tyson, C.A.4
Sugiyama, Y.5
-
18
-
-
0032498303
-
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
-
Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterstrom RH, et al. (1998) An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92:73-82.
-
(1998)
Cell
, vol.92
, pp. 73-82
-
-
Kliewer, S.A.1
Moore, J.T.2
Wade, L.3
Staudinger, J.L.4
Watson, M.A.5
Jones, S.A.6
McKee, D.D.7
Oliver, B.B.8
Willson, T.M.9
Zetterstrom, R.H.10
-
19
-
-
0029029232
-
Nuclear localization signals overlap DNA- or RNA-binding domains in nucleic acid-binding proteins
-
La Casse EC and Lefebvre YA (1995) Nuclear localization signals overlap DNA- or RNA-binding domains in nucleic acid-binding proteins. Nucleic Acids Res 23:1647-1656.
-
(1995)
Nucleic Acids Res
, vol.23
, pp. 1647-1656
-
-
La Casse, E.C.1
Lefebvre, Y.A.2
-
20
-
-
0032169485
-
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
-
Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT and Kliewer SA (1998) The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Investig 102:1016-1023.
-
(1998)
J Clin Investig
, vol.102
, pp. 1016-1023
-
-
Lehmann, J.M.1
McKee, D.D.2
Watson, M.A.3
Willson, T.M.4
Moore, J.T.5
Kliewer, S.A.6
-
21
-
-
0034463909
-
Endocrine disrupting chemicals, phthalic acid and nonylphenol, activate pregnane X receptor-mediated transcription
-
Masuyama H, Hiramatsu Y, Kunitomi M, Kudo T, and MacDonald PN (2000) Endocrine disrupting chemicals, phthalic acid and nonylphenol, activate pregnane X receptor-mediated transcription. Mol Endocrinol 14:421-428.
-
(2000)
Mol Endocrinol
, vol.14
, pp. 421-428
-
-
Masuyama, H.1
Hiramatsu, Y.2
Kunitomi, M.3
Kudo, T.4
MacDonald, P.N.5
-
22
-
-
0031707505
-
Nucleocytoplasmic transport: The soluble phase
-
Mattaj IW and Engelmeier L (1998) Nucleocytoplasmic transport: the soluble phase. Annu Rev Biochem 67:265-306.
-
(1998)
Annu Rev Biochem
, vol.67
, pp. 265-306
-
-
Mattaj, I.W.1
Engelmeier, L.2
-
23
-
-
0034691064
-
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
-
Moore LB, Goodwin B, Jones SA, Wisely BG, Serabjit-Singh C, Willson TM, Collins JL, and Kliwer SA (2000a) St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. Proc Natl Acad Sci USA 97:7500-7502.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 7500-7502
-
-
Moore, L.B.1
Goodwin, B.2
Jones, S.A.3
Wisely, B.G.4
Serabjit-Singh, C.5
Willson, T.M.6
Collins, J.L.7
Kliwer, S.A.8
-
24
-
-
0034685779
-
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
-
Moore LB, Parks DJ, Jones SA, Bledsoe RK, Consler TG, Stimmel JB, Goodwin B, Liddle C, Blanchard SG, Willson TM, et al. (2000b) Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J Biol Chem 275:15122-15127.
-
(2000)
J Biol Chem
, vol.275
, pp. 15122-15127
-
-
Moore, L.B.1
Parks, D.J.2
Jones, S.A.3
Bledsoe, R.K.4
Consler, T.G.5
Stimmel, J.B.6
Goodwin, B.7
Liddle, C.8
Blanchard, S.G.9
Willson, T.M.10
-
25
-
-
0030964105
-
Nucleocytoplasmic transport: Signals mechanisms and regulation
-
Nigg EA (1997) Nucleocytoplasmic transport: signals mechanisms and regulation. Nature (Lond) 386:779-787.
-
(1997)
Nature (Lond)
, vol.386
, pp. 779-787
-
-
Nigg, E.A.1
-
26
-
-
0033574663
-
A unified nomenclature system for the nuclear receptor superfamily
-
Nuclear Receptors Nomenclature Committee (1999) A unified nomenclature system for the nuclear receptor superfamily (Letter). Cell 97:161-163.
-
(1999)
Cell
, vol.97
, pp. 161-163
-
-
-
27
-
-
0033516469
-
Hormone-dependent translocation of vitamin D receptor is linked to transactivation
-
Racz A and Barsony J (1999) Hormone-dependent translocation of vitamin D receptor is linked to transactivation. J Biol Chem 274:19352-19360.
-
(1999)
J Biol Chem
, vol.274
, pp. 19352-19360
-
-
Racz, A.1
Barsony, J.2
-
28
-
-
0023375195
-
The neighbor-joining method: A new method for reconstructing phylogenetic trees
-
Saitou N and Nei M (1987) The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 4:406-425.
-
(1987)
Mol Biol Evol
, vol.4
, pp. 406-425
-
-
Saitou, N.1
Nei, M.2
-
29
-
-
0030059953
-
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells
-
Schuetz EG, Beck WT, and Schuetz JD (1996a) Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol 49:311-318.
-
(1996)
Mol Pharmacol
, vol.49
, pp. 311-318
-
-
Schuetz, E.G.1
Beck, W.T.2
Schuetz, J.D.3
-
30
-
-
0029916534
-
P-glycoprotein: A major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans
-
Schuetz EG, Schinkel AH, Relling MV, and Schuetz JD (1996b) P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans. Proc Natl Acad Sci USA 93:4001-4005.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 4001-4005
-
-
Schuetz, E.G.1
Schinkel, A.H.2
Relling, M.V.3
Schuetz, J.D.4
-
31
-
-
0035038386
-
Promiscuous regulator of xenobiotic removal
-
Schuetz E and Strom S (2001) Promiscuous regulator of xenobiotic removal. Nat Med 7:536-537.
-
(2001)
Nat Med
, vol.7
, pp. 536-537
-
-
Schuetz, E.1
Strom, S.2
-
32
-
-
0035914467
-
Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters and cytochrome P450
-
Schuetz EG, Strom S, Yasuda K, Lecureur V, Assem M, Brimer C, Lamba J, Kim RB, Ramachandran V, Komoroski BJ, et al. (2001) Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters and cytochrome P450. J Biol Chem 276:39411-39418.
-
(2001)
J Biol Chem
, vol.276
, pp. 39411-39418
-
-
Schuetz, E.G.1
Strom, S.2
Yasuda, K.3
Lecureur, V.4
Assem, M.5
Brimer, C.6
Lamba, J.7
Kim, R.B.8
Ramachandran, V.9
Komoroski, B.J.10
-
33
-
-
0035853165
-
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
-
Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, et al. (2001) The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci USA 98:3369-3374.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3369-3374
-
-
Staudinger, J.L.1
Goodwin, B.2
Jones, S.A.3
Hawkins-Brown, D.4
MacKenzie, K.I.5
LaTour, A.6
Liu, Y.7
Klaassen, C.D.8
Brown, K.K.9
Reinhard, J.10
-
34
-
-
0035038919
-
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
-
Synold TW, Dussault I, and Forman BM (2001) The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 7:584-590.
-
(2001)
Nat Med
, vol.7
, pp. 584-590
-
-
Synold, T.W.1
Dussault, I.2
Forman, B.M.3
-
35
-
-
0030780220
-
Identification of novel homologues of mouse importin α, the α subunit of the nuclear pore targeting-complex and their tissue-specific expression
-
Tsuji L, Takumi T, Imamoto N, and Yoneda Y (1997) Identification of novel homologues of mouse importin α, the α subunit of the nuclear pore targeting-complex and their tissue-specific expression. FEBS Lett 416:30-34.
-
(1997)
FEBS Lett
, vol.416
, pp. 30-34
-
-
Tsuji, L.1
Takumi, T.2
Imamoto, N.3
Yoneda, Y.4
-
36
-
-
0033199499
-
P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR and PPAR
-
Waxman DJ (1999) P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR and PPAR. Arch Biochem Biophys 369:11-23.
-
(1999)
Arch Biochem Biophys
, vol.369
, pp. 11-23
-
-
Waxman, D.J.1
-
37
-
-
0034721159
-
Humanized xenobiotic response in mice expressing nuclear receptor SXR
-
Xie W, Barwick JL, Downes M, Blumberg B, Simon CM, Nelson MC, Neuschwander-Tetri BA, Blunt EM, Guzelian PS, and Evans RM (2000a) Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature (Lond) 406:435-439.
-
(2000)
Nature (Lond)
, vol.406
, pp. 435-439
-
-
Xie, W.1
Barwick, J.L.2
Downes, M.3
Blumberg, B.4
Simon, C.M.5
Nelson, M.C.6
Neuschwander-Tetri, B.A.7
Blunt, E.M.8
Guzelian, P.S.9
Evans, R.M.10
-
38
-
-
0033638960
-
Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR
-
Xie W, Barwick JL, Simon CM, Pierce AM, Safe S, Blumberg B, Guzelian PS, and Evans RM (2000b) Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes Dev 14:3014-3023.
-
(2000)
Genes Dev
, vol.14
, pp. 3014-3023
-
-
Xie, W.1
Barwick, J.L.2
Simon, C.M.3
Pierce, A.M.4
Safe, S.5
Blumberg, B.6
Guzelian, P.S.7
Evans, R.M.8
-
39
-
-
0035853057
-
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids
-
Xie W, Radominska-Pandya A, Shi Y, Simon CM, Nelson MC, Ong ES, Waxman DJ, and Evans RM (2001) An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Pro Natl Acad Sci USA 98:3375-3380.
-
(2001)
Pro Natl Acad Sci USA
, vol.98
, pp. 3375-3380
-
-
Xie, W.1
Radominska-Pandya, A.2
Shi, Y.3
Simon, C.M.4
Nelson, M.C.5
Ong, E.S.6
Waxman, D.J.7
Evans, R.M.8
-
40
-
-
0035076197
-
The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver
-
Zelko I, Sueyoshi T, Kawamoto T, Moore R, and Negishi M (2001) The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver. Mol Cell Biol 21:2838-2846.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 2838-2846
-
-
Zelko, I.1
Sueyoshi, T.2
Kawamoto, T.3
Moore, R.4
Negishi, M.5
|