-
1
-
-
0034042711
-
Induction of drug metabolising enzymes: Pharmacokinetic and toxicological consequences in humans
-
Fuhr U 2000 Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans. Clin Pharmacokinet 38:493-504
-
(2000)
Clin Pharmacokinet
, vol.38
, pp. 493-504
-
-
Fuhr, U.1
-
2
-
-
0031682988
-
The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
-
Honkakoski P, Zelko I, Sueyoshi T, Negishi M 1998 The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol Cell Biol 18:5652-5658
-
(1998)
Mol Cell Biol
, vol.18
, pp. 5652-5658
-
-
Honkakoski, P.1
Zelko, I.2
Sueyoshi, T.3
Negishi, M.4
-
3
-
-
0034685779
-
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
-
Moore LB, Parks DJ, Jones SA, Bledsoe RK, Consler TG, Stimmel JB, Goodwin B, Liddle C, Blanchard SG, Willson TM, Collins JL, Kliewer SA 2000 Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J Biol Chem 275:15122-15127
-
(2000)
J Biol Chem
, vol.275
, pp. 15122-15127
-
-
Moore, L.B.1
Parks, D.J.2
Jones, S.A.3
Bledsoe, R.K.4
Consler, T.G.5
Stimmel, J.B.6
Goodwin, B.7
Liddle, C.8
Blanchard, S.G.9
Willson, T.M.10
Collins, J.L.11
Kliewer, S.A.12
-
4
-
-
0033638960
-
Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR
-
Xie W, Barwick JL, Simon CM, Pierce AM, Safe S, Blumberg B, Guzelian PS, Evans RM 2000 Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes Dev 14:3014-3023
-
(2000)
Genes Dev
, vol.14
, pp. 3014-3023
-
-
Xie, W.1
Barwick, J.L.2
Simon, C.M.3
Pierce, A.M.4
Safe, S.5
Blumberg, B.6
Guzelian, P.S.7
Evans, R.M.8
-
5
-
-
0033199499
-
P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR
-
Waxman DJ 1999 P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. Arch Biochem Biophys 369:11-23
-
(1999)
Arch Biochem Biophys
, vol.369
, pp. 11-23
-
-
Waxman, D.J.1
-
6
-
-
0035229502
-
Role reversal: New insights from new ligands for the xenobiotic receptor CAR
-
Tzameli I, Moore DD 2001 Role reversal: new insights from new ligands for the xenobiotic receptor CAR. Trends Endocrinol Metab 12:7-10
-
(2001)
Trends Endocrinol Metab
, vol.12
, pp. 7-10
-
-
Tzameli, I.1
Moore, D.D.2
-
7
-
-
0032766430
-
Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene
-
Kawamoto T, Sueyoshi T, Zelko I, Moore R, Washburn K, Negishi M 1999 Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol Cell Biol 19:6318-6322
-
(1999)
Mol Cell Biol
, vol.19
, pp. 6318-6322
-
-
Kawamoto, T.1
Sueyoshi, T.2
Zelko, I.3
Moore, R.4
Washburn, K.5
Negishi, M.6
-
8
-
-
0032497544
-
Androstane metabolites bind to and deactivate the nuclear receptor CAR-β
-
Forman BM, Tzameli I, Choi HS, Chen J, Simha D, Seol W, Evans RM, Moore DD 1998 Androstane metabolites bind to and deactivate the nuclear receptor CAR-β. Nature 395:612-615
-
(1998)
Nature
, vol.395
, pp. 612-615
-
-
Forman, B.M.1
Tzameli, I.2
Choi, H.S.3
Chen, J.4
Simha, D.5
Seol, W.6
Evans, R.M.7
Moore, D.D.8
-
9
-
-
0033652116
-
Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene
-
Kawamoto T, Kakizaki S, Yoshinari K, Negishi M 2000 Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene. Mol Endocrinol 14:1897-1905
-
(2000)
Mol Endocrinol
, vol.14
, pp. 1897-1905
-
-
Kawamoto, T.1
Kakizaki, S.2
Yoshinari, K.3
Negishi, M.4
-
10
-
-
0035853165
-
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
-
Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, Willson TM, Koller BH, Kliewer SA 2001 The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci USA 98:3369-3374
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3369-3374
-
-
Staudinger, J.L.1
Goodwin, B.2
Jones, S.A.3
Hawkins-Brown, D.4
MacKenzie, K.I.5
LaTour, A.6
Liu, Y.7
Klaassen, C.D.8
Brown, K.K.9
Reinhard, J.10
Willson, T.M.11
Koller, B.H.12
Kliewer, S.A.13
-
11
-
-
0034721159
-
Humanized xenobiotic response in mice expressing nuclear receptor SXR
-
Xie W, Barwick JL, Downes M, Blumberg B, Simon CM, Nelson MC, Neuschwander-Tetri BA, Brunt EM, Guzelian PS, Evans RM 2000 Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature 406:435-439
-
(2000)
Nature
, vol.406
, pp. 435-439
-
-
Xie, W.1
Barwick, J.L.2
Downes, M.3
Blumberg, B.4
Simon, C.M.5
Nelson, M.C.6
Neuschwander-Tetri, B.A.7
Brunt, E.M.8
Guzelian, P.S.9
Evans, R.M.10
-
12
-
-
0034687397
-
The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
-
Wei P, Zhang J, Egan-Hafley M, Liang S, Moore DD 2000 The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature 407:920-923
-
(2000)
Nature
, vol.407
, pp. 920-923
-
-
Wei, P.1
Zhang, J.2
Egan-Hafley, M.3
Liang, S.4
Moore, D.D.5
-
13
-
-
0036142429
-
Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital
-
Ueda A, Hamadeh HK, Webb HK, Yamamoto Y, Sueyoshi T, Afshari CA, Lehmann JM, Negishi M 2002 Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital. Mol Pharmacol 61:1-6
-
(2002)
Mol Pharmacol
, vol.61
, pp. 1-6
-
-
Ueda, A.1
Hamadeh, H.K.2
Webb, H.K.3
Yamamoto, Y.4
Sueyoshi, T.5
Afshari, C.A.6
Lehmann, J.M.7
Negishi, M.8
-
14
-
-
0033591387
-
Bile acids: Natural ligands for an orphan nuclear receptor
-
Parks DJ, Blanchard SG, Bledsoe RK, Chandra G, Consler TG, Kliewer SA, Stimmel JB, Willson TM, Zavacki AM, Moore DD, Lehmann JM 1999 Bile acids: natural ligands for an orphan nuclear receptor. Science 284:1365-1368
-
(1999)
Science
, vol.284
, pp. 1365-1368
-
-
Parks, D.J.1
Blanchard, S.G.2
Bledsoe, R.K.3
Chandra, G.4
Consler, T.G.5
Kliewer, S.A.6
Stimmel, J.B.7
Willson, T.M.8
Zavacki, A.M.9
Moore, D.D.10
Lehmann, J.M.11
-
15
-
-
0033026760
-
Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
-
Wang H, Chen J, Hollister K, Sowers LC, Forman BM 1999 Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 3:543-553
-
(1999)
Mol Cell
, vol.3
, pp. 543-553
-
-
Wang, H.1
Chen, J.2
Hollister, K.3
Sowers, L.C.4
Forman, B.M.5
-
16
-
-
0033591297
-
Identification of a nuclear receptor for bile acids
-
Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, Luk A, Hull MV, Lustig KD, Mangelsdorf DJ, Shan B 1999 Identification of a nuclear receptor for bile acids. Science 284:1362-1365
-
(1999)
Science
, vol.284
, pp. 1362-1365
-
-
Makishima, M.1
Okamoto, A.Y.2
Repa, J.J.3
Tu, H.4
Learned, R.M.5
Luk, A.6
Hull, M.V.7
Lustig, K.D.8
Mangelsdorf, D.J.9
Shan, B.10
-
17
-
-
0035853057
-
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids
-
Xie W, Radominska-Pandya A, Shi Y, Simon CM, Nelson MC, Ong ES, Waxman DJ, Evans RM 2001 An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci USA 98:3375-3380
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3375-3380
-
-
Xie, W.1
Radominska-Pandya, A.2
Shi, Y.3
Simon, C.M.4
Nelson, M.C.5
Ong, E.S.6
Waxman, D.J.7
Evans, R.M.8
-
18
-
-
0037123667
-
Vitamin D receptor as an intestinal bile acid sensor
-
Makishima M, Lu TT, Xie W, Whitfield GK, Domoto H, Evans RM, Haussler MR, Mangelsdorf DJ 2002 Vitamin D receptor as an intestinal bile acid sensor. Science 296:1313-1316
-
(2002)
Science
, vol.296
, pp. 1313-1316
-
-
Makishima, M.1
Lu, T.T.2
Xie, W.3
Whitfield, G.K.4
Domoto, H.5
Evans, R.M.6
Haussler, M.R.7
Mangelsdorf, D.J.8
-
19
-
-
0034874393
-
Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor
-
Goodwin B, Moore LB, Stoltz CM, McKee DD, Kliewer SA 2001 Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor. Mol Pharmacol 60:427-431
-
(2001)
Mol Pharmacol
, vol.60
, pp. 427-431
-
-
Goodwin, B.1
Moore, L.B.2
Stoltz, C.M.3
McKee, D.D.4
Kliewer, S.A.5
-
20
-
-
0025132245
-
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
-
Issemann I, Green S 1990 Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347:645-650
-
(1990)
Nature
, vol.347
, pp. 645-650
-
-
Issemann, I.1
Green, S.2
-
21
-
-
0025604385
-
On the mechanism of induction of microsomal cytochrome P450IVA1 and peroxisome proliferation in rat liver by clofibrate
-
Milton MN, Elcombe CR, Gibson GG 1990 On the mechanism of induction of microsomal cytochrome P450IVA1 and peroxisome proliferation in rat liver by clofibrate. Biochem Pharmacol 40:2727-2732
-
(1990)
Biochem Pharmacol
, vol.40
, pp. 2727-2732
-
-
Milton, M.N.1
Elcombe, C.R.2
Gibson, G.G.3
-
22
-
-
0026705751
-
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
-
Kliewer SA, Umesono K, Noonan DJ, Heyman RA, Evans RM 1992 Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature 358:771-774
-
(1992)
Nature
, vol.358
, pp. 771-774
-
-
Kliewer, S.A.1
Umesono, K.2
Noonan, D.J.3
Heyman, R.A.4
Evans, R.M.5
-
23
-
-
0026730908
-
The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid ω-hydroxylase, by clofibric acid
-
Muerhoff AS, Griffin KJ, Johnson EF 1992 The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid ω-hydroxylase, by clofibric acid. J Biol Chem 267:19051-19053
-
(1992)
J Biol Chem
, vol.267
, pp. 19051-19053
-
-
Muerhoff, A.S.1
Griffin, K.J.2
Johnson, E.F.3
-
24
-
-
0036693059
-
Effect of sex and menstrual cycle phase on cytochrome P450 2C19 activity with omeprazole used as a biomarker
-
Kim MJ, Bertino Jr JS, Gaedigk A, Zhang Y, Sellers EM, Nafziger AN 2002 Effect of sex and menstrual cycle phase on cytochrome P450 2C19 activity with omeprazole used as a biomarker. Clin Pharmacol Ther 72:192-199
-
(2002)
Clin Pharmacol Ther
, vol.72
, pp. 192-199
-
-
Kim, M.J.1
Bertino J.S., Jr.2
Gaedigk, A.3
Zhang, Y.4
Sellers, E.M.5
Nafziger, A.N.6
-
25
-
-
0036784511
-
A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system
-
Raucy J, Warfe L, Yueh MF, Allen SW 2002 A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system. J Pharmacol Exp Ther 303:412-423
-
(2002)
J Pharmacol Exp Ther
, vol.303
, pp. 412-423
-
-
Raucy, J.1
Warfe, L.2
Yueh, M.F.3
Allen, S.W.4
-
26
-
-
0034757015
-
Effect of peroxisome proliferator-activated receptor α activation on leukotriene B4 metabolism in isolated rat hepatocytes
-
Fiedler J, Simon FR, Iwahashi M, Murphy RC 2001 Effect of peroxisome proliferator-activated receptor α activation on leukotriene B4 metabolism in isolated rat hepatocytes. J Pharmacol Exp Ther 299:691-697
-
(2001)
J Pharmacol Exp Ther
, vol.299
, pp. 691-697
-
-
Fiedler, J.1
Simon, F.R.2
Iwahashi, M.3
Murphy, R.C.4
-
27
-
-
0035146291
-
Molecular cloning and regulation of expression of two novel mouse CYP4F genes: Expression in peroxisome proliferator-activated receptor α-deficient mice upon lipopolysaccharide and clofibrate challenges
-
Cui X, Kawashima H, Barclay TB, Peters JM, Gonzalez FJ, Morgan ET, Strobel HW 2001 Molecular cloning and regulation of expression of two novel mouse CYP4F genes: expression in peroxisome proliferator-activated receptor α-deficient mice upon lipopolysaccharide and clofibrate challenges. J Pharmacol Exp Ther 296:542-550
-
(2001)
J Pharmacol Exp Ther
, vol.296
, pp. 542-550
-
-
Cui, X.1
Kawashima, H.2
Barclay, T.B.3
Peters, J.M.4
Gonzalez, F.J.5
Morgan, E.T.6
Strobel, H.W.7
-
28
-
-
0035861625
-
Antagonism of the actions of peroxisome proliferator-activated receptor-α by bile acids
-
Sinal CJ, Yoon M, Gonzalez FJ 2001 Antagonism of the actions of peroxisome proliferator-activated receptor-α by bile acids. J Biol Chem 276:47154-47162
-
(2001)
J Biol Chem
, vol.276
, pp. 47154-47162
-
-
Sinal, C.J.1
Yoon, M.2
Gonzalez, F.J.3
-
29
-
-
0035914467
-
Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450
-
Schuetz EG, Strom S, Yasuda K, Lecureur V, Assem M, Brimer C, Lamba J, Kim RB, Ramachandran V, Komoroski BJ, Venkataramanan R, Cai H, Sinal CJ, Gonzalez FJ, Schuetz JD 2001 Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. J Biol Chem 276:39411-39418
-
(2001)
J Biol Chem
, vol.276
, pp. 39411-39418
-
-
Schuetz, E.G.1
Strom, S.2
Yasuda, K.3
Lecureur, V.4
Assem, M.5
Brimer, C.6
Lamba, J.7
Kim, R.B.8
Ramachandran, V.9
Komoroski, B.J.10
Venkataramanan, R.11
Cai, H.12
Sinal, C.J.13
Gonzalez, F.J.14
Schuetz, J.D.15
-
31
-
-
0030014851
-
Androgen regulation of molecular forms of β-D-glucuronidase in the mouse epididymis: Comparison with liver and kidney
-
Abou-Haila A, Tulsiani DR, Skudlarek MD, Orgebin-Crist MC 1996 Androgen regulation of molecular forms of β-D-glucuronidase in the mouse epididymis: comparison with liver and kidney. J Androl 17:194-207
-
(1996)
J Androl
, vol.17
, pp. 194-207
-
-
Abou-Haila, A.1
Tulsiani, D.R.2
Skudlarek, M.D.3
Orgebin-Crist, M.C.4
-
32
-
-
0027164575
-
Cloning and nucleotide sequence of a novel, male-predominant carboxylesterase in mouse liver
-
Aida K, Moore R, Negishi M 1993 Cloning and nucleotide sequence of a novel, male-predominant carboxylesterase in mouse liver. Biochim Biophys Acta 1174:72-74
-
(1993)
Biochim Biophys Acta
, vol.1174
, pp. 72-74
-
-
Aida, K.1
Moore, R.2
Negishi, M.3
-
33
-
-
0024333259
-
Phenobarbital-inducible aldehyde dehydrogenase in the rat. cDNA sequence and regulation of the mRNA by phenobarbital in responsive rats
-
Dunn TJ 1989 Phenobarbital-inducible aldehyde dehydrogenase in the rat. cDNA sequence and regulation of the mRNA by phenobarbital in responsive rats. J Biol Chem 264:13057-13065
-
(1989)
J Biol Chem
, vol.264
, pp. 13057-13065
-
-
Dunn, T.J.1
-
34
-
-
0028813823
-
A novel isoenzyme of aldehyde dehydrogenase specifically involved in the biosynthesis of 9-cis and all-trans retinoic acid
-
Labrecque J, Dumas F, Lacroix A, Bhat PV 1995 A novel isoenzyme of aldehyde dehydrogenase specifically involved in the biosynthesis of 9-cis and all-trans retinoic acid. Biochem J 305(Pt 2):681-684
-
(1995)
Biochem J
, vol.305
, Issue.PART 2
, pp. 681-684
-
-
Labrecque, J.1
Dumas, F.2
Lacroix, A.3
Bhat, P.V.4
-
35
-
-
0029920350
-
Mouse microsomal class 3 aldehyde dehydrogenase: AHD3 cDNA sequence, inducibility by dioxin and clofibrate, and genetic mapping
-
Vasiliou V, Kozak CA, Lindahl R, Nebert DW 1996 Mouse microsomal class 3 aldehyde dehydrogenase: AHD3 cDNA sequence, inducibility by dioxin and clofibrate, and genetic mapping. DNA Cell Biol 15:235-245
-
(1996)
DNA Cell Biol
, vol.15
, pp. 235-245
-
-
Vasiliou, V.1
Kozak, C.A.2
Lindahl, R.3
Nebert, D.W.4
-
36
-
-
0031022338
-
The multiple murine 3 β-hydroxysteroid dehydrogenase isoforms: Structure, function, and tissue- and developmentally specific expression
-
Payne AH, Abbaszade IG, Clarke TR, Bain PA, Park CH 1997 The multiple murine 3 β-hydroxysteroid dehydrogenase isoforms: structure, function, and tissue- and developmentally specific expression. Steroids 62:169-175
-
(1997)
Steroids
, vol.62
, pp. 169-175
-
-
Payne, A.H.1
Abbaszade, I.G.2
Clarke, T.R.3
Bain, P.A.4
Park, C.H.5
-
37
-
-
0031030593
-
The regulation of 3 β-hydroxysteroid dehydrogenase expression
-
Mason JI, Keeney DS, Bird IM, Rainey WE, Morohashi K, Leers-Sucheta S, Melner MH 1997 The regulation of 3 β-hydroxysteroid dehydrogenase expression. Steroids 62:164-168
-
(1997)
Steroids
, vol.62
, pp. 164-168
-
-
Mason, J.I.1
Keeney, D.S.2
Bird, I.M.3
Rainey, W.E.4
Morohashi, K.5
Leers-Sucheta, S.6
Melner, M.H.7
-
38
-
-
0037108916
-
Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR)
-
Sonoda J, Xie W, Rosenfeld JM, Barwick JL, Guzelian PS, Evans RM 2002 Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR). Proc Natl Acad Sci USA 99:13801-13806
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 13801-13806
-
-
Sonoda, J.1
Xie, W.2
Rosenfeld, J.M.3
Barwick, J.L.4
Guzelian, P.S.5
Evans, R.M.6
-
39
-
-
0036765785
-
Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification
-
Maglich JM, Stoltz CM, Goodwin B, Hawkins-Brown D, Moore JT, Kliewer SA 2002 Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol Pharmacol 62:638-646
-
(2002)
Mol Pharmacol
, vol.62
, pp. 638-646
-
-
Maglich, J.M.1
Stoltz, C.M.2
Goodwin, B.3
Hawkins-Brown, D.4
Moore, J.T.5
Kliewer, S.A.6
-
40
-
-
0034725705
-
Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes
-
Zhang F, Zhang W, Liu L, Fisher CL, Hui D, Childs S, Dorovini-Zis K, Ling V 2000 Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes. J Biol Chem 275:23287-23294
-
(2000)
J Biol Chem
, vol.275
, pp. 23287-23294
-
-
Zhang, F.1
Zhang, W.2
Liu, L.3
Fisher, C.L.4
Hui, D.5
Childs, S.6
Dorovini-Zis, K.7
Ling, V.8
-
41
-
-
0035805536
-
Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
-
Geick A, Eichelbaum M, Burk O 2001 Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem 276:14581-14587
-
(2001)
J Biol Chem
, vol.276
, pp. 14581-14587
-
-
Geick, A.1
Eichelbaum, M.2
Burk, O.3
-
42
-
-
0035038919
-
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
-
Synold TW, Dussault I, Forman BM 2001 The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 7:584-590
-
(2001)
Nat Med
, vol.7
, pp. 584-590
-
-
Synold, T.W.1
Dussault, I.2
Forman, B.M.3
-
43
-
-
0037169551
-
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
-
Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA 2002 Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem 277:2908-2915
-
(2002)
J Biol Chem
, vol.277
, pp. 2908-2915
-
-
Kast, H.R.1
Goodwin, B.2
Tarr, P.T.3
Jones, S.A.4
Anisfeld, A.M.5
Stoltz, C.M.6
Tontonoz, P.7
Kliewer, S.8
Willson, T.M.9
Edwards, P.A.10
-
44
-
-
0036137072
-
Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats
-
Cherrington NJ, Hartley DP, Li N, Johnson DR, Klaassen CD 2002 Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats. J Pharmacol Exp Ther 300:97-104
-
(2002)
J Pharmacol Exp Ther
, vol.300
, pp. 97-104
-
-
Cherrington, N.J.1
Hartley, D.P.2
Li, N.3
Johnson, D.R.4
Klaassen, C.D.5
-
45
-
-
0036479102
-
The S100 family heterodimer, MRP-8/14, binds with high affinity to heparin and heparan sulfate glycosaminoglycans on endothelial cells
-
Robinson MJ 2002 The S100 family heterodimer, MRP-8/14, binds with high affinity to heparin and heparan sulfate glycosaminoglycans on endothelial cells. J Biol Chem 277:3658-3665
-
(2002)
J Biol Chem
, vol.277
, pp. 3658-3665
-
-
Robinson, M.J.1
-
46
-
-
0036792050
-
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
-
Yabe D, Brown MS, Goldstein JL 2002 Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci USA 99:12753-12758
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12753-12758
-
-
Yabe, D.1
Brown, M.S.2
Goldstein, J.L.3
-
47
-
-
0035896581
-
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
-
Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loreal O 2001 A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 276:7811-7819
-
(2001)
J Biol Chem
, vol.276
, pp. 7811-7819
-
-
Pigeon, C.1
Ilyin, G.2
Courselaud, B.3
Leroyer, P.4
Turlin, B.5
Brissot, P.6
Loreal, O.7
-
48
-
-
0037174609
-
C/EBPα regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism
-
Courselaud B, Pigeon C, Inoue Y, Inoue J, Gonzalez FJ, Leroyer P, Gilot D, Boudjema K, Guguen-Guillouzo C, Brissot P, Loreal O, Ilyin G 2002 C/EBPα regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. J Biol Chem 277:41163-41170
-
(2002)
J Biol Chem
, vol.277
, pp. 41163-41170
-
-
Courselaud, B.1
Pigeon, C.2
Inoue, Y.3
Inoue, J.4
Gonzalez, F.J.5
Leroyer, P.6
Gilot, D.7
Boudjema, K.8
Guguen-Guillouzo, C.9
Brissot, P.10
Loreal, O.11
Ilyin, G.12
-
49
-
-
0025720431
-
Serum urate as an antioxidant for ascorbic acid
-
Sevanian A, Davies KJ, Hochstein P 1991 Serum urate as an antioxidant for ascorbic acid. Am J Clin Nutr 54(Suppl 6):1129S-1134S
-
(1991)
Am J Clin Nutr
, vol.54
, Issue.SUPPL. 6
-
-
Sevanian, A.1
Davies, K.J.2
Hochstein, P.3
-
50
-
-
0033973712
-
The heme synthesis and degradation pathways: Role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties
-
Ryter SW, Tyrrell RM 2000 The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties. Free Radic Biol Med 28:289-309
-
(2000)
Free Radic Biol Med
, vol.28
, pp. 289-309
-
-
Ryter, S.W.1
Tyrrell, R.M.2
-
51
-
-
0035201366
-
Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: Studies with cDNA and oligonucleotide expression arrays
-
Rae JM, Johnson MD, Lippman ME, Flockhart DA 2001 Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: studies with cDNA and oligonucleotide expression arrays. J Pharmacol Exp Ther 299:849-857
-
(2001)
J Pharmacol Exp Ther
, vol.299
, pp. 849-857
-
-
Rae, J.M.1
Johnson, M.D.2
Lippman, M.E.3
Flockhart, D.A.4
-
52
-
-
0037064177
-
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
-
Zhang J, Huang W, Chua SS, Wei P, Moore DD 2002 Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science 298:422-424
-
(2002)
Science
, vol.298
, pp. 422-424
-
-
Zhang, J.1
Huang, W.2
Chua, S.S.3
Wei, P.4
Moore, D.D.5
-
53
-
-
0036042919
-
Software and methods for oligonucleotide and cDNA array data analysis
-
software0001.1-0001.9
-
Zapala MA, Lockhart DJ, Pankratz DG, Garcia AJ, Barlow C, Lockhart DJ 2002 Software and methods for oligonucleotide and cDNA array data analysis. Genome Biol 3:software0001.1-0001.9
-
(2002)
Genome Biol
, vol.3
-
-
Zapala, M.A.1
Lockhart, D.J.2
Pankratz, D.G.3
Garcia, A.J.4
Barlow, C.5
Lockhart, D.J.6
|