Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16α-carbonitrile Is via interaction with pregnane X receptor

Molecular Pharmacology

Volumn 61, Issue 4, 2002, Pages 832-839

  Guo, Grace L ^a   Staudinger, Jeff ^a   Ogura, Kenichiro ^b   Klaassen, Curtis D ^c  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS   (United States)

^c TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA CYANOPREGNENOLONE; ANION; CARDIAC GLYCOSIDE; CARRIER PROTEIN; COMPLEMENTARY DNA; LUCIFERASE; POLYPEPTIDE; PREGNANE X RECEPTOR; RETINOID X RECEPTOR;

ANIMAL CELL; ARTICLE; BASE PAIRING; DOSE RESPONSE; ELECTROPHORETIC MOBILITY; GENE; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING;

5' UNTRANSLATED REGIONS; ANIMALS; DIMERIZATION; GENE EXPRESSION REGULATION; MOLECULAR WEIGHT; ORGANIC ANION TRANSPORTERS; ORGANIC CATION TRANSPORT PROTEINS; PREGNENOLONE CARBONITRILE; PROMOTER REGIONS (GENETICS); RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; RECEPTORS, STEROID; RETINOID X RECEPTORS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 0036205380     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.4.832     Document Type: Article

References (45)

1. Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2
2. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1
3. Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione
4. Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes
5. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
6. SXR, a novel steroid and xenobiotic-sensing nuclear receptor
7. Cloning of the full-length coding sequence of rat liver-specific organic anion transporter-1 (rlst-1) and a splice variant and partial characterization of the rat 1st-1 gene
8. Effects of microsomal enzyme inducers on carriermediated transport systems in isolated rat hepatocytes
9. Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain
10. Nuclear receptor response elements mediate induction of intestinal mdr1 by rifampin
11. The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module
12. Regulation of the human CYP26B gene by the nuclear pregnane X receptor
13. Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways
14. Nuclear receptor involvement in the regulation of rat cytochrome P450 3A23 expression
15. Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif
16. The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution
17. Immunohistochemical distribution and functional characterization of an organic anion transporting polypeptide 2 (oatp2)
18. Regulation of multidrug resistance-associated protein 2 (MRP2; ABCC2) by the nuclear receptors PXR, FXR, and CAR
19. Effects of phenobarbital on the plasma disappearance and biliary excretion of drugs in rats
20. Plasma disappearance and biliary excretion of sulfobromophthalein and phenol-3,6-dibromphthalein disulfonate after microsomal enzyme induction
21. Effect of microsomal enzyme inducers on the biliary excretion of cardiac glycosides
22. Stimulation of the development of the hepatic excretory mechanism for ouabain in newborn rats with microsomal enzyme inducers
23. Developmental expression of rat organic anion transporting polypeptide 2 (oatp2) and Multidrug resistance protein 2 (Mrp2) in normal and pregnenolone-16α-carbonitrile (PCN) induced rats
24. Hepatic disposition of phenoldibromphthalein disulfonate and sulfobromophthalein
25. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
26. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide
27. Effect of pregnenolone-16alpha-carbonitrile on the rat liver
28. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
29. Nuclear splicing
30. Molecular cloning of the gene for the human prostaglandin transporter hPGT: Gene organization, promoter activity, and chromosomal localization
31. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain
32. Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (1st-1)
33. Genomic organization and tissue-specific expression of splice variants of mouse organic anion transporting polypeptide 2
34. Cyp3A regulation: From pharmacology to nuclear receptors
35. A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids
36. Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anon transporters, OATP1 and OATP2
37. Localization and function of organic aniontransporting polypeptide oatp2 in rat liver
38. Rabbit pregnane X receptor is activated by rifampicin
39. Hormones and resistance
40. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
41. Transport of drugs across the hepatic sinusoidal membrane: Sinusoidal drug influx and efflux in the liver
42. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
43. Induction of UDP-glucuronosyltransferase activities in Gunn, heterozygous, and Wistar rat livers by pregnenolone-16 alphacarbonitrile
44. Rat pregnane X receptor: Molecular cloning, tissue distribution, and xenobiotic regulation