Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): One variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region

Drug Metabolism and Disposition

Volumn 32, Issue 1, 2004, Pages 149-154

  Koyano, Satoru ^a,b   Kurose, Kouichi ^a   Saito, Yoshiro ^a   Ozawa, Shogo ^a   Hasegawa, Ryuichi ^a   Komamura, Kazuo ^b   Ueno, Kazuyuki ^b   Kamakura, Shiro ^b   Kitakaze, Masafumi ^b   Nakajima, Toshiharu ^c   Matsumoto, Kenji ^c   Akasawa, Akira ^c   Saito, Hirohisa ^c   Sawada, Jun Ichi ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^c NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CLOTRIMAZOLE; CYTOCHROME P450 3A4; DRUG CARRIER; PACLITAXEL; PREGNANE X RECEPTOR; RIFAMPICIN; XENOBIOTIC AGENT;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG METABOLISM; ENHANCER REGION; GEL MOBILITY SHIFT ASSAY; GENE ACTIVATION; GENE DOSAGE; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REPORTER GENE; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; BIOTRANSFORMATION; BLOTTING, WESTERN; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; CLOTRIMAZOLE; COS CELLS; CYTOCHROME P-450 ENZYME SYSTEM; DNA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENHANCER ELEMENTS (GENETICS); EXONS; GENES, REPORTER; HUMANS; IMMUNOHISTOCHEMISTRY; LUCIFERASES; MOLECULAR SEQUENCE DATA; PACLITAXEL; PLASMIDS; PROMOTER REGIONS (GENETICS); RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RIFAMPIN; TRANS-ACTIVATION (GENETICS);

ANIMALIA;

EID: 1642498313     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.32.1.149     Document Type: Article

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