Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor

Journal of Pharmacology and Experimental Therapeutics

Volumn 306, Issue 3, 2003, Pages 1027-1034

  Sahi, Jasminder ^a   Milad, Mark A ^a   Zheng, Xianxian ^a   Rose, Kelly A ^a   Wang, Hongbing ^b   Stilgenbauer, Linda ^a   Gilbert, Darryl ^b   Jolley, Summer ^b   Stern, Ralph H ^a   Lecluyse, Edward L ^b  

^a PFIZER INC   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AVASIMIBE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; CYTOCHROME P450 3A4; DIGOXIN; FELODIPINE; GLYCOPROTEIN P; MESSENGER RNA; MIDAZOLAM; MULTIDRUG RESISTANCE PROTEIN 1; PHENOBARBITAL; PREGNANE X RECEPTOR; RIFAMPICIN; TESTOSTERONE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; DOSE RESPONSE; DRUG CLEARANCE; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; ENZYME SUBSTRATE; FEMALE; GENE EXPRESSION; GENE INDUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; MALE; NORMAL HUMAN; PRIORITY JOURNAL;

ACETATES; CYTOCHROME P-450 ENZYME SYSTEM; DIGOXIN; DRUG INTERACTIONS; ENZYME INDUCTION; ENZYME INHIBITORS; GENE EXPRESSION; HEPATOCYTES; HUMANS; MICROSOMES, LIVER; MIDAZOLAM; P-GLYCOPROTEIN; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RNA, MESSENGER; SULFONIC ACIDS;

EID: 0042934069     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.050526     Document Type: Article

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