Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR

Science

Volumn 298, Issue 5592, 2002, Pages 422-424

  Zhang, Jun ^a   Huang, Wendong ^a   Chua, Steven S ^a   Wei, Ping ^a   Moore, David D ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DOSAGE; ENZYME INHIBITION; TOXICITY;

HEPATOTOXICITY;

ENZYMES;

ANDROSTANE DERIVATIVE; ANDROSTANOL 1; CONSTITUTIVE ANDROSTANE RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR AGONIST; LIVER PROTECTIVE AGENT; PARACETAMOL; STEROID RECEPTOR; UNCLASSIFIED DRUG;

ENZYME; METABOLISM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG METABOLISM; DRUG RESPONSE; LIVER PROTECTION; LIVER TOXICITY; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR INTRINSIC ACTIVITY;

ACETAMINOPHEN; ACETYLCYSTEINE; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANDROSTANOLS; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BENZOQUINONES; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; GLUTATHIONE; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HUMANS; IMINES; ISOENZYMES; LIVER; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; OXIDOREDUCTASES, N-DEMETHYLATING; PHENOBARBITAL; PYRIDINES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0037064177     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1073502     Document Type: Article

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32. We thank S. Karpen for advice and S. Safe for TCPOBOP. Supported by NIH grant R01 DK46546.