Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 1, 2003, Pages 223-228

  Goodwin, Bryan ^b   Gauthier, Karine C ^b   Umetani, Michihisa ^b   Watson, Michael A ^b   Lochansky, Matthew I ^b   Collins, Jon L ^b   Leitersdorf, Eran ^a   Mangelsdorf, David J ^b   Kliewer, Steven A ^b   Repa, Joyce J ^b  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

5BETA CHOLESTAN 3ALPHA,7ALPHA,12ALPHA TRIOL; 7ALPHA HYDROXYCHOLEST 4 EN 3 ONE; BILE ACID; CELL NUCLEUS RECEPTOR; CHENODEOXYCHOLIC ACID; CHOLEST 4 EN 3 ONE; CHOLIC ACID; CYTOCHROME P450 3A; LIGAND; PREGNANE X RECEPTOR; STEROL 27 HYDROXYLASE; STEROL DERIVATIVE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE ACID SYNTHESIS; BILE FLOW; CEREBROTENDINOUS XANTHOMATOSIS; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; HYDROXYLATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRECURSOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; XENOBIOTIC METABOLISM;

ANIMALS; BILE ACIDS AND SALTS; CELL NUCLEUS; CHOLESTEROL; CHOLESTEROL, DIETARY; CLONING, MOLECULAR; CYTOCHROME P-450 CYP27A1; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; ESCHERICHIA COLI; LIGANDS; MICE; MICE, KNOCKOUT; PLANT PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; STEROID HYDROXYLASES; XENOBIOTICS;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0037422578     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0237082100     Document Type: Article

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