The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

Nature

Volumn 407, Issue 6806, 2000, Pages 920-923

  Wei, Ping ^a   Zhang, Jun ^a   Egan Hafley, Margarete ^a   Liang, Shuguang ^a   Moore, David D ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BIS(3,5 DICHLORO 2 PYRIDYLOXY)BENZENE; CAR RECEPTOR; CELL NUCLEUS RECEPTOR; COCAINE; CYTOCHROME P450; PHENOBARBITAL; UNCLASSIFIED DRUG; ZOXAZOLAMINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; GENE EXPRESSION; HEPATOMEGALY; KNOCKOUT MOUSE; LIVER TOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; XENOBIOTIC METABOLISM;

ALANINE TRANSAMINASE; ANIMAL; CELL LINE; COCAINE; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE TARGETING; HUMAN; LIVER; MALE; MICE; PHARMACEUTICAL PREPARATIONS; PHENOBARBITAL; PYRIDINES; RECEPTORS, VIRUS; SUPPORT, U.S. GOV'T, P.H.S.; XENOBIOTICS; ZOXAZOLAMINE;

EID: 0034687397     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35038112     Document Type: Article

References (22)

1. P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR
2. 1, 4-Bis[2-(3, 5-dichloropyridyloxy)] benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity
3. The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
4. The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
5. The xenobiotic compound 1, 4-bis[2-(3, 5-dichloropyridyloxy)] benzene is an agonist ligand for the nuclear receptor CAR
6. The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution
7. Orphan nuclear receptors, constitutive androstane receptor and pregnane X receptor share xenobiotic and steriod ligands
8. A new orphan member of the nuclear receptor superfamily that interacts with a subset of retinoic acid response elements
9. Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR
10. Differences between induction effects of 1, 4-bis[2-(3, 5-dichloropyridyloxy)] benzene and phenobarbitone
11. The quantitative distinction of hyperplasia from hypertrophy in hepatomegaly induced in the rat liver by phenobarbital
12. Role of increased DNA replication in the carcinogenic risk of nonmutagenic chemical carcinogens
13. Genetic expression of aryl hydrocarbon hydroxylase induction. Presence or absence of association wiht zoxazolamine, diphenylhydantoin, and hexobarbital metabolism
14. Effect of cytochrome P450 inducers on cocaine-mediated hepatotoxicity
15. An orphan nuclear receptor activated by pregnanes defines a novel steriod signaling pathway
16. SXR, a novel steriod and xenobiotic-sensing nuclear receptor
17. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
18. Humanized xenobiotic response in mice expressing nuclear receptor SXR
19. Interindividual variations in human liver cytochrome P-450 enzymes in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
20. Human cytochrome P4502B6: Interindividual hepatic expressions, substrate specificity, and role in procarcinogen activation
21. Hepatotoxicity of psychotropic drugs
22. Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism