Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1α. Functional implications in hepatic cholesterol and glucose metabolism

Journal of Biological Chemistry

Volumn 279, Issue 43, 2004, Pages 45139-45147

  Bhalla, Sonali ^a   Ozalp, Cengiz ^a   Fang, Sungsoon ^a   Xiang, Lingjin ^a   Kemper, Jongsook Kim ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDS; ANTIBIOTICS; BIOSYNTHESIS; ENZYME INHIBITION; GENES; GLUCOSE;

HEPATIC BILE ACID; LIGAND AFFINITY (LA); PREGNANE X RECEPTOR (PXR);

CHOLESTEROL;

CHOLESTEROL 7ALPHA MONOOXYGENASE; CYTOCHROME P450 8 B 1; CYTOCHROME P450 ISOENZYME; HEPATOCYTE NUCLEAR FACTOR 4; LIVER ENZYME; LIVER EXTRACT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATING RECEPTOR ALPHA COACTIVATOR 1; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PREGNANE X RECEPTOR; PROTEIN; RIFAMPICIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; BILE ACID SYNTHESIS; CELL NUCLEUS INCLUSION BODY; CHOLESTEROL METABOLISM; DISSOCIATION; DRUG BINDING SITE; DRUG METABOLISM; DRUG PROTEIN BINDING; GENE REPRESSION; GLUCONEOGENESIS; HEP 2 CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALS; BILE ACIDS AND SALTS; BINDING SITES; BLOTTING, WESTERN; CELL LINE; CELL NUCLEUS; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CHROMATIN; COS CELLS; CYTOCHROME P-450 ENZYME SYSTEM; DNA-BINDING PROTEINS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GENES, REPORTER; GENETIC VECTORS; GLUCOSE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; GREEN FLUORESCENT PROTEINS; HEAT-SHOCK PROTEINS; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; IMMUNOPRECIPITATION; LIGANDS; LIVER; MICE; OLIGONUCLEOTIDES; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHOPROTEINS; PLASMIDS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIFAMPIN; RNA, MESSENGER; RNA, SMALL INTERFERING; SEPHAROSE; SIGNAL TRANSDUCTION; STEROID 12-ALPHA-HYDROXYLASE; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 7244243931     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M405423200     Document Type: Article

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