Species comparison in P450 induction: Effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog

Chemico-Biological Interactions

Volumn 134, Issue 3, 2001, Pages 271-281

  Lu, Chuang ^a   Li, Albert P ^a  

^a In Vitro Technologies Inc   (United States)

Author keywords

Cytochromes P450; Dog hepatocytes; Drug drug interactions; Enzyme induction; Human hepatocytes; In vitro metabolism; Minipig hepatocytes; Monkey hepatocytes; Rat hepatocytes; Species differences

Indexed keywords

CYTOCHROME P450 1A; CYTOCHROME P450 3A; CYTOCHROME P450 3A4; CYTOCHROME P450 ISOENZYME; DEXAMETHASONE; ETHOXYRESORUFIN DEETHYLASE; OMEPRAZOLE; RIFAMPICIN; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; HUMAN; HUMAN TISSUE; LIVER CELL CULTURE; MALE; NONHUMAN; RAT; SPECIES DIFFERENCE; SWINE;

ADULT; AGED; ANIMALS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; DOGS; ENZYME INDUCTION; FEMALE; HEPATOCYTES; HUMANS; MALE; MIDDLE AGED; OMEPRAZOLE; RATS; RATS, SPRAGUE-DAWLEY; RIFAMPIN; SPECIES SPECIFICITY; SWINE, MINIATURE;

ANIMALIA; CANIS FAMILIARIS; STAPHYLOCOCCUS PHAGE 3A;

EID: 0035897710     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(01)00162-4     Document Type: Article

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