The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity

Journal of Biological Chemistry

Volumn 279, Issue 47, 2004, Pages 49517-49522

  Zhang, Jun ^a,c   Huang, Wendong ^a   Qatanani, Mohammed ^a   Evans, Ronald M ^b   Moore, David D ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANE RECEPTORS; BILE ACID; LITHOCHOLIC ACID (LCA);

BODY FLUIDS; HYDROPHOBICITY; LIVING SYSTEMS STUDIES; METABOLISM; TOXICITY;

PROTEINS;

BILE ACID; CLOTRIMAZOLE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 3A1; DIELDRIN; LITHOCHOLIC ACID; MULTIDRUG RESISTANCE PROTEIN 3; ORGANIC ANION TRANSPORTER; PARACETAMOL; PREGNANE X RECEPTOR; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; CONTROLLED STUDY; ENZYME INDUCTION; LIVER TOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; XENOBIOTIC METABOLISM;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BILE ACIDS AND SALTS; BILIRUBIN; BLOTTING, NORTHERN; CLOTRIMAZOLE; CYTOCHROME P-450 CYP3A; DETERGENTS; DIELDRIN; GROWTH INHIBITORS; LITHOCHOLIC ACID; LIVER; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; OXIDOREDUCTASES, N-DEMETHYLATING; PHENOTYPE; PROTEIN BINDING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RNA; SODIUM; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 10344224570     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M409041200     Document Type: Article

References (42)

1. Xie, W., Radominska-Pandya, A., Shi, Y., Simon, C. M., Nelson, M. C., Ong, E. S., Waxman, D. J., and Evans, R. M. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 3375-3380
2. Staudinger, J., Liu, Y., Madan, A., Habeebu, S., and Klaassen, C. D. (2001) Drug Metab. Dispos. 29, 1467-1472
3. Willson, T. M., and Kliewer, S. A. (2002) Nat. Rev. Drug Discov. 1, 259-266
4. Honkakoski, P., Sueyoshi, T., and Negishi, M. (2003) Ann. Med. 35, 172-182
5. Sonoda, J., Rosenfeld, J. M., Xu, L., Evans, R. M., and Xie, W. (2003) Curr. Drug Metab. 4, 59-72
6. Xie, W., Barwick, J. L., Downes, M., Blumberg, B., Simon, C. M., Nelson, M. C., Neuschwander-Tetri, B. A., Brunt, E. M., Guzelian, P. S., and Evans, R. M. (2000) Nature 406, 435-439
7. Wei, P., Zhang, J., Egan-Hafley, M., Liang, S., and Moore, D. D. (2000) Nature 407, 920-923
8. Xie, W., Barwick, J. L., Simon, C. M., Pierce, A. M., Safe, S., Blumberg, B., Guzelian, P. S., and Evans, R. M. (2000) Genes Dev. 14, 3014-3023
9. Moore, L. B., Parks, D. J., Jones, S. A., Bledsoe, R. K., Consler, T. G., Stimmel, J. B., Goodwin, B., Liddle, C., Blanehard, S. G., Willson, T. M., Collins, J. L., and Kliewer, S. A. (2000) J. Biol. Chem. 273, 15122-15127
10. Wei, P., Zhang, J., Dohan, D., Han, Y., and Moore, D. D. (2002) Pharmacogenomics J. 2, 117-126
11. Maglich, J. M., Stoltz, C. M., Goodwin, B., Hawkins-Brown, D., Moore, J. T., and Kliewer, S. A. (2002) Mol. Pharmacol. 62, 638-646
12. Huang, W., Zhang, J., Chua, S. S., Qatanani, M., Han, Y., Granata, R., and Moore, D. D. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 4156-4161
13. Xie, W., Yeuh, M. F., Radominska-Pandya, A., Saini, S. P., Negishi, Y., Bottroff, B. S., Cabrera, G. Y., Tukey, R. H., and Evans, R. M. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 4150-4155
14. Chiang, J. Y. L. (1998) Front Biosci. 3, D176-D193
15. Radominska, A., Treat, S., and Little, J. (1993) Semin. Liver Dis. 13, 219-234
16. Araya, Z., and Wikvall, K. (1999) Biochim. Biophys. Acta 1438, 47-54
17. Chen, L. J., and Segel, I. H. (1985) Arch. Biochem. Biophys. 241, 371-379
18. Hofmann, A. F. (1990) Hepatology 12, 17S-25S
19. Parks, D. J., Blanehard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D., and Lehmann, J. M. (1999) Science 284, 1365-1368
20. Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., and Shan, B. (1999) Science 284, 1362-1365
21. Wang, H., Chen, J., Hollister, K., Sowers, L. C., and Forman, B. M. (1999) Mol. Cell 3, 543-553
22. Urizar, N. L., Dowhan, D. H., and Moore, D. D. (2000) J. Biol. Chem. 275, 39313-39317
23. Sinai, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., and Gonzalez, F. J. (2000) Cell 102, 731-744
24. Kast, H. R., Goodwin, B., Tarr, P. T., Jones, S. A., Anisfeld, A. M., Stoltz, C. M., Tontonoz, P., Kliewer, S., Willson, T. M., and Edwards, P. A. (2002) J. Biol. Chem. 277, 2908-2915
25. del Castillo-Olivares, A., and Gu, G. (2001) Nucleic Acids Res. 29, 4035-4042
26. Chiang, J. Y. (2002) Endocr. Rev. 23, 443-463
27. Kitada, H., Miyata, M., Nakamura, T., Tozawa, A., Honma, W., Shimada, M., Nagata, K., Sinai, C. J., Guo, G. L., Gonzalez, F. J., and Yamazoe, Y. (2003) J. Biol. Chem. 278, 17838-17844
28. Sonoda, J., Xie, W., Rosenfeld, J. M., Barwick, J. L., Guzelian, P. S., and Evans, R. M. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 13801-13806
29. Guo, G. L., Lambert, G., Negishi, M., Ward, J. M., Brewer, H. B., Jr., Kliewer, S. A., Gonzalez, F. J., and Sinal, C. J. (2003) J. Biol. Chem. 278, 45062-45071
30. Saini, S. P., Sonoda, J., Xu, L., Toma, D., Uppal, H., Mu, Y., Ren, S., Moore, D. D., Evans, R. M., and Xie, W. (2004) Mol. Pharmacol. 65, 292-300
31. Zhang, J., Huang, W., Chua, S. S., Wei, P., and Moore, D. D. (2002) Science 298, 422-424
32. Xiong, H., Yoshinari, K., Brouwer, K. L., and Negishi, M. (2002) Drug Metab. Dispos. 30, 918-923
33. Staudinger, J. L., Goodwin, B., Jones, S. A., Hawkins-Brown, D., MacKenzie, K. I., LaTour, A., Liu, Y., Klaassen, C. D., Brown, K. K., Reinhard, J., Willson, T. M., Koller, B. H., and Kliewer, S. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 3369-3374
34. Moore, L. B., Maglich, J. M., McKee, D. D., Wisely, B., Willson, T. M., Kliewer, S.A., Lambert, M. H., and Moore, J. T. (2002) Mol. Endocrinol. 16, 977-986
35. Kawamoto, T., Sueyoshi, T., Zelko, I., Moore, R., Washburn, K., and Negishi, M. (1999) Mol. Cell. Biol. 19, 6318-6322
36. Zelko, I., Sueyoshi, T., Kawamoto, T., Moore, R., and Negishi, M. (2001) Mol. Cell. Biol. 21, 2838-2846
37. Makishima, M., Lu, T. T., Xie, W., Whitfield, G. K., Domoto, H., Evans, R. M., Haussler, M. R., and Mangelsdorf, D. J. (2002) Science 296, 1313-1316
38. Maruyama, T., Miyamoto, Y., Nakamura, T., Tamai, Y., Okada, H., Sugiyama, E., Itadani, H., and Tanaka, K. (2002) Biochem. Biophys. Res. Commun. 298, 714-719
39. Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., Hinuma, S., Fujisawa, Y., and Fujino, M. (2003) J. Biol. Chem. 278, 9435-9440
40. Holt, J. A., Luo, G., Billin, A. N., Bisi, J., McNeill, Y. Y., Kozarsky, K. F., Donahee, M., Wang, D. Y., Mansfield, T. A., Kliewer, S. A., Goodwin, B., and Jones, S. A. (2003) Genes Dev. 17, 1581-1591
41. Gupta, S., Natarajan, R., Payne, S. G., Studer, E. J., Spiegel, S., Dent, P., and Hylemon, P. B. (2004) J. Biol. Chem. 279, 5821-5828
42. Jenkins, J. K., and Boothby, L. A. (2002) Ann. Pharmacother. 36, 1462-1465