Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration.

International Review of Cell and Molecular Biology

Volumn 301, Issue , 2013, Pages 215-290

  Bravo, Roberto ^a   Parra, Valentina ^a   Gatica, Damián ^a   Rodriguez, Andrea E ^a   Torrealba, Natalia ^a   Paredes, Felipe ^a   Wang, Zhao V ^c   Zorzano, Antonio ^d   Hill, Joseph A ^c   Jaimovich, Enrique ^a,b   Quest, Andrew F G ^a,b   Lavandero, Sergio ^a,b,c  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

Author keywords

Calcium; Endoplasmic reticulum; ER stress; Metabolism; Organelle dynamics; Pathology; Unfolded protein response

Indexed keywords

17 ALLYAMINO 17 DEMETHOXYGELDANAMYCIN; ACTIVATING TRANSCRIPTION FACTOR 6; ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; ANTINEOPLASTIC AGENT; BORTEZOMIB; CALCIUM; CALPAIN; CARBOPLATIN; CHAPERONE; CISPLATIN; DNA; EEYARESTATIN; FATTY ACID; GLUCOSE; HEAT SHOCK PROTEIN 90 INHIBITOR; IRESTATIN; MELPHALAN; MEMBRANE PROTEIN; PARAQUAT; PROTEIN IRE1; PYRUVATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERSIPELOSTATIN; X BOX BINDING PROTEIN 1;

ADAPTATION; APOPTOSIS; ARTICLE; AUTOPHAGY; CALCIUM HOMEOSTASIS; CANCER CELL; CARDIOTOXICITY; CARDIOVASCULAR DISEASE; CELL DEATH; CELL ENERGY; CELL METABOLISM; CELL NUCLEUS MEMBRANE; CELL ORGANELLE; CELL SURVIVAL; CYTOSOL; CYTOTOXICITY; DIABETES MELLITUS; DNA CROSS LINKING; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENDOPLASMIC RETICULUM STRESS; FATTY ACID OXIDATION; GENE EXPRESSION; GLUCONEOGENESIS; GLYCOSYLATION; HEART HYPERTROPHY; HEART MUSCLE CELL; HUMAN; HYPOXIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; ISCHEMIC HEART DISEASE; LIPID METABOLISM; LIPID RAFT; LIPOGENESIS; LOSS OF FUNCTION MUTATION; METASTASIS; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NEOPLASM; NERVE DEGENERATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STARVATION; UNFOLDED PROTEIN RESPONSE;

EID: 84872375449     PISSN: 19376448     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-407704-1.00005-1     Document Type: Chapter

References (396)

1. Abel E.D., Doenst T. Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy. Cardiovasc. Res. 2011, 90:234-242.
2. Adham I.M., Eck T.J., Mierau K., Müller N., Sallam M.A., Paprotta I., Schubert S., Hoyer-Fender S., Engel W. Reduction of spermatogenesis but not fertility in Creb3l4-deficient mice. Mol. Cell. Biol. 2005, 25:7657-7664.
3. Al-Qusairi L., Laporte J. T-tubule biogenesis and triad formation in skeletal muscle and implication in human diseases. Skelet. Muscle 2011, 1:26.
4. Anderson D.J., Hetzer M.W. Nuclear envelope formation by chromatin-mediated reorganization of the endoplasmic reticulum. Nat. Cell Biol. 2007, 9:1160-1166.
5. Anelli T., Sitia R. Protein quality control in the early secretory pathway. EMBO J. 2008, 27:315-327.
6. Apodaca J., Kim I., Rao H. Cellular tolerance of prion protein PrP in yeast involves proteolysis and the unfolded protein response. Biochem. Biophys. Res. Commun. 2006, 347:319-326.
7. Asada R., Kanemoto S., Kondo S., Saito A., Imaizumi K. The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology. J. Biochem. 2011, 149:507-518.
8. Ashby M.C., Tepikin A.V. ER calcium and the functions of intracellular organelles. Semin. Cell Dev. Biol. 2001, 12:11-17.
9. Aslan J.E., You H., Williamson D.M., Endig J., Youker R.T., Thomas L., Shu H., Du Y., Milewski R.L., Brush M.H., et al. Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis. Mol. Cell 2009, 34:497-509.
10. Audas T.E., Li Y., Liang G., Lu R. A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response. Mol. Cell. Biol. 2008, 28:3952-3966.
11. Avivar-Valderas A., Salas E., Bobrovnikova-Marjon E., Diehl J.A., Nagi C., Debnath J., Aguirre-Ghiso J.A. PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment. Mol. Cell. Biol. 2011, 31:3616-3629.
12. Aydar E., Onganer P., Perrett R., Djamgoz M.B., Palmer C.P. The expression and functional characterization of sigma (sigma) 1 receptors in breast cancer cell lines. Cancer Lett. 2006, 242:245-257.
13. Backer J.M., Krivoshein A.V., Hamby C.V., Pizzonia J., Gilbert K.S., Ray Y.S., Brand H., Paton A.W., Paton J.C., Backer M.V. Chaperone-targeting cytotoxin and endoplasmic reticulum stress-inducing drug synergize to kill cancer cells. Neoplasia 2009, 11:1165-1173.
14. Barlowe C. Atlasin GTPases shape up ER networks. Dev. Cell 2009, 17:157-158.
15. Benyamini P., Webster P., Meyer D.I. Knockdown of p180 eliminates the terminal differentiation of a secretory cell line. Mol. Biol. Cell 2009, 20:732-744.
16. Bernales S., McDonald K.L., Walter P. Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. Plos Biol. 2006, 4:e423.
17. Bernales S., Schuck S., Walter P. ER-phagy: selective autophagy of the endoplasmic reticulum. Autophagy 2007, 3:285-287.
18. Berridge M.J. The endoplasmic reticulum: a multifunctional signaling organelle. Cell Calcium 2002, 32:235-249.
19. Berridge M.J. Remodelling Ca2+ signalling systems and cardiac hypertrophy. Biochem. Soc. Trans. 2006, 34:228-231.
20. Bertolotti A., Zhang Y., Hendershot L.M., Harding H.P., Ron D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol. 2000, 2:326-332.
21. Bi M., Naczki C., Koritzinsky M., Fels D., Blais J., Hu N., Harding H., Novoa I., Varia M., Raleigh J., et al. ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J. 2005, 24:3470-3481.
22. Blais J.D., Addison C.L., Edge R., Falls T., Zhao H., Wary K., Koumenis C., Harding H.P., Ron D., Holcik M., et al. Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress. Mol. Cell. Biol. 2006, 26:9517-9532.
23. Bobrovnikova-Marjon E., Grigoriadou C., Pytel D., Zhang F., Ye J., Koumenis C., Cavener D., Diehl J.A. PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage. Oncogene 2010, 29:3881-3895.
24. Bobrovnikova-Marjon E., Hatzivassiliou G., Grigoriadou C., Romero M., Cavener D.R., Thompson C.B., Diehl J.A. PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:16314-16319.
25. Boden G., Duan X., Homko C., Molina E.J., Song W., Perez O., Cheung P., Merali S. Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Diabetes 2008, 57:2438-2444.
26. Boden G., Song W., Duan X., Cheung P., Kresge K., Barrero C., Merali S. Infusion of glucose and lipids at physiological rates causes acute endoplasmic reticulum stress in rat liver. Obesity (Silver Spring) 2011, 19:1366-1373.
27. Bojarski L., Herms J., Kuznicki J. Calcium dysregulation in Alzheimer's disease. Neurochem. Int. 2008, 52:621-633.
28. Bollo M., Paredes R.M., Holstein D., Zheleznova N., Camacho P., Lechleiter J.D. Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs. PLoS One 2010, 5:e11925.
29. Bommiasamy H., Back S.H., Fagone P., Lee K., Meshinchi S., Vink E., Sriburi R., Frank M., Jackowski S., Kaufman R.J., et al. ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum. J. Cell Sci. 2009, 122:1626-1636.
30. Bordallo J., Plemper R.K., Finger A., Wolf D.H. Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol. Biol. Cell 1998, 9:209-222.
31. Borgese N., Francolini M., Snapp E. Endoplasmic reticulum architecture: structures in flux. Curr. Opin. Cell Biol. 2006, 18:358-364.
32. Boslem E., MacIntosh G., Preston A.M., Bartley C., Busch A.K., Fuller M., Laybutt D.R., Meikle P.J., Biden T.J. A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking. Biochem. J. 2011, 435:267-276.
33. Bravo R., Gutierrez T., Paredes F., Gatica D., Rodriguez A.E., Pedrozo Z., Chiong M., Parra V., Quest A.F.G., Rothermel B.A., et al. Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics. Int. J. Biochem. Cell Biol. 2011, 44:16-20.
34. Bravo R., Vicencio J.M., Parra V., Troncoso R., Munoz J.P., Bui M., Quiroga C., Rodriguez A.E., Verdejo H.E., Ferreira J., et al. Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. J. Cell Sci. 2011, 124:2143-2152.
35. Breckenridge D.G., Germain M., Mathai J.P., Nguyen M., Shore G.C. Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene 2003, 22:8608-8618.
36. Brini M., Carafoli E. Calcium pumps in health and disease. Physiol. Rev. 2009, 89:1341-1378.
37. Browman D.T., Resek M.E., Zajchowski L.D., Robbins S.M. Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER. J. Cell Sci. 2006, 119:3149-3160.
38. Brown A.R., Rebus S., McKimmie C.S., Robertson K., Williams A., Fazakerley J.K. Gene expression profiling of the preclinical scrapie-infected hippocampus. Biochem. Biophys. Res. Commun. 2005, 334:86-95.
39. Brunello L., Zampese E., Florean C., Pozzan T., Pizzo P., Fasolato C. Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake. J. Cell. Mol. Med. 2009, 13:3358-3369.
40. Bui M., Gilady S.Y., Fitzsimmons R.E.B., Benson M.D., Lynes E.M., Gesson K., Alto N.M., Strack S., Scott J.D., Simmen T. Rab32 modulates apoptosis onset and mitochondria-associated membrane (MAM) properties. J. Biol. Chem. 2010, 285:31590-31602.
41. Burelle Y., Wambolt R.B., Grist M., Parsons H.L., Chow J.C.F., Antler C., Bonen A., Keller A., Dunaway G.A., Popov K.M., et al. Regular exercise is associated with a protective metabolic phenotype in the rat heart. Am. J. Physiol. Heart Circ. Physiol. 2004, 287:H1055-H1063.
42. Burkart A., Shi X., Chouinard M., Corvera S. Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response. J. Biol. Chem. 2011, 286:4081-4089.
43. Carafoli E. The fateful encounter of mitochondria with calcium: how did it happen?. Biochim. Biophys. Acta 2010, 1797:595-606.
44. Carvalho P., Goder V., Rapoport T.A. Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell 2006, 126:361-373.
45. Carvalho P., Stanley A.M., Rapoport T.A. Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p. Cell 2010, 143:579-591.
46. Cárdenas C., Miller R.A., Smith I., Bui T., Molgó J., Müller M., Vais H., Cheung K.-H., Yang J., Parker I., et al. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell 2010, 142:270-283.
47. Chan C.-P., Kok K.-H., Jin D.-Y. CREB3 subfamily transcription factors are not created equal: recent insights from global analyses and animal models. Cell Biosci. 2011, 1:6.
48. Chatterjee S., Hirota H., Belfi C.A., Berger S.J., Berger N.A. Hypersensitivity to DNA cross-linking agents associated with up-regulation of glucose-regulated stress protein GRP78. Cancer Res. 1997, 57:5112-5116.
49. Chen K.-H., Guo X., Ma D., Guo Y., Li Q., Yang D., Li P., Qiu X., Wen S., Xiao R.-P., et al. Dysregulation of HSG triggers vascular proliferative disorders. Nat. Cell Biol. 2004, 6:872-883.
50. Cheung K.-H., Mei L., Mak D.-O.D., Hayashi I., Iwatsubo T., Kang D.E., Foskett J.K. Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons. Sci. Signal. 2010, 3:ra22.
51. Cheung K.-H., Shineman D., Müller M., Cárdenas C., Mei L., Yang J., Tomita T., Iwatsubo T., Lee V.M.Y., Foskett J.K. Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Neuron 2008, 58:871-883.
52. Cnop M., Welsh N., Jonas J.-C., Jörns A., Lenzen S., Eizirik D.L. Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 2005, 54(Suppl. 2):S97-S107.
53. Cross B.C., McKibbin C., Callan A.C., Roboti P., Piacenti M., Rabu C., Wilson C.M., Whitehead R. Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum. J. Cell Sci. 2009, 122:4393-4400.
54. Coe H., Michalak M. Calcium binding chaperones of the endoplasmic reticulum. Gen. Physiol. Biophys. 2009, 28:F96-F103. (Spec No Focus).
55. Colgan S.M., Tang D., Werstuck G.H., Austin R.C. Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2. Int. J. Biochem. Cell. Biochem. 2007, 39:1843-1851.
56. Colombo C., Porzio O., Liu M., Massa O., Vasta M., Salardi S., Beccaria L., Monciotti C., Toni S., Pedersen O., et al. Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus. J. Clin. Invest. 2008, 118:2148-2156.
57. Corbett E.F., Oikawa K., Francois P., Tessier D.C., Kay C., Bergeron J.J., Thomas D.Y., Krause K.H., Michalak M. Ca2+ regulation of interactions between endoplasmic reticulum chaperones. J. Biol. Chem. 1999, 274:6203-6211.
58. Corsi A.K., Schekman R. Mechanism of polypeptide translocation into the endoplasmic reticulum. J. Biol. Chem. 1996, 271:30299-30302.
59. Cox J.S., Walter P. A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 1996, 87:391-404.
60. Cox J.S., Shamu C.E., Walter P. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell 1993, 73:1197-1206.
61. Crawshaw S.G., Cross B.C.S., Wilson C.M., High S. The oligomeric state of Derlin-1 is modulated by endoplasmic reticulum stress. Mol. Membr. Biol. 2007, 24:113-120.
62. Cui W., Li J., Ron D., Sha B. The structure of the PERK kinase domain suggests the mechanism for its activation. Acta Crystallogr. D Biol. Crystallogr. 2011, 67:423-428.
63. Cullinan S.B., Zhang D., Hannink M., Arvisais E., Kaufman R.J., Diehl J.A. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol. Cell. Biol. 2003, 23:7198-7209.
64. Cunha D.A., Hekerman P., Ladriere L., Bazarra-Castro A., Ortis F., Wakeham M.C., Moore F., Rasschaert J., Cardozo A.K., Bellomo E., et al. Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. J. Cell Sci. 2008, 121:2308-2318.
65. Cunha D.A., Ladriere L., Ortis F., Igoillo-Esteve M., Gurzov E.N., Lupi R., Marchetti P., Eizirik D.L., Cnop M. Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB. Diabetes 2009, 58:2851-2862.
66. Daneshmand S., Quek M.L., Lin E., Lee C., Cote R.J., Hawes D., Cai J., Groshen S., Lieskovsky G., Skinner D.G., Lee A.S., Pinski J. Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival. Hum. Pathol. 2007, 38:1547-1552.
67. Davenport E.L., Moore H.E., Dunlop A.S., Sharp S.Y., Workman P., Morgan G.J., Davies F.E. Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells. Blood 2007, 110:2641-2649.
68. de Brito O.M., Scorrano L. Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 2008, 456:605-610.
69. Degens H., de Brouwer K.F.J., Gilde A.J., Lindhout M., Willemsen P.H.M., Janssen B.J., van der Vusse G.J., van Bilsen M. Cardiac fatty acid metabolism is preserved in the compensated hypertrophic rat heart. Basic Res. Cardiol. 2006, 101:17-26.
70. Delépine M., Nicolino M., Barrett T., Golamaully M., Lathrop G.M., Julier C. EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome. Nat. Genet. 2000, 25:406-409.
71. Deluca H.F., Engstrom G.W. Calcium uptake by rat kidney mitochondria. Proc. Natl. Acad. Sci. U.S.A. 1961, 47:1744-1750.
72. DenBoer L.M., Hardy-Smith P.W., Hogan M.R., Cockram G.P., Audas T.E., Lu R. Luman is capable of binding and activating transcription from the unfolded protein response element. Biochem. Biophys. Res. Commun. 2005, 331:113-119.
73. Dever T.E. Gene-specific regulation by general translation factors. Cell 2002, 108:545-556.
74. Dickhout J.G., Carlisle R.E., Austin R.C. Interrelationship between cardiac hypertrophy, heart failure, and chronic kidney disease: endoplasmic reticulum stress as a mediator of pathogenesis. Circ. Res. 2011, 108:629-642.
75. Doenst T., Pytel G., Schrepper A., Amorim P., Färber G., Shingu Y., Mohr F.W., Schwarzer M. Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload. Cardiovasc. Res. 2010, 86:461-470.
76. Dong D., Ni M., Li J., Xiong S., Ye W., Virrey J.J., Mao C., Ye R., Wang M., Pen L., Dubeau L., Groshen S., Hofman F.M., Lee A.S. Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development. Cancer Res. 2008, 68:498-505.
77. Dong D., Stapleton C., Luo B., Xiong S., Ye W., Zhang Y., Jhaveri N., Zhu G., Ye R., Liu Z., et al. A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis. Cancer Res. 2011, 71:2848-2857.
78. Donoso P., Sanchez G., Bull R., Hidalgo C. Modulation of cardiac ryanodine receptor activity by ROS and RNS. Front. Biosci. 2011, 16:553-567.
79. Dreier L., Rapoport T.A. In vitro formation of the endoplasmic reticulum occurs independently of microtubules by a controlled fusion reaction. J. Cell Biol. 2000, 148:883-898.
80. Eleveld-Trancikova D., Sanecka A., van Hout-Kuijer M.A., Looman M.W.G., Hendriks I.A.M., Jansen B.J.H., Adema G.J. DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation. Mol. Immunol. 2010, 47:1963-1973.
81. Elouil H., Bensellam M., Guiot Y., Vander Mierde D., Pascal S.M.A., Schuit F.C., Jonas J.C. Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets. Diabetologia 2007, 50:1442-1452.
82. English A.R., Zurek N., Voeltz G.K. Peripheral ER structure and function. Curr. Opin. Cell Biol. 2009, 21:596-602.
83. Fagone P., Jackowski S. Membrane phospholipid synthesis and endoplasmic reticulum function. J. Lipid Res. 2009, 50(Suppl.):S311-S316.
84. Farhan H., Hauri H.-P. Membrane biogenesis: networking at the ER with atlastin. Curr. Biol. 2009, 19:R906-R908.
85. Fawcett T.W., Martindale J.L., Guyton K.Z., Hai T., Holbrook N.J. Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response. Biochem. J. 1999, 339(Pt 1):135-141.
86. Ferrara N., Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr. Rev. 1997, 18:4-25.
87. Friedman J.R., Lackner L.L., West M., DiBenedetto J.R., Nunnari J., Voeltz G.K. ER tubules mark sites of mitochondrial division. Science 2011, 334:358-362.
88. Friedman J.R., Webster B.M., Mastronarde D.N., Verhey K.J., Voeltz G.K. ER sliding dynamics and ER-mitochondrial contacts occur on acetylated microtubules. J. Cell Biol. 2010, 190:363-375.
89. Fu Y., Li J., Lee A.S. GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis. Cancer Res. 2007, 67:3734-3740.
90. Fu Y., Wey S., Wang M., Ye R., Liao C.P., Roy-Burman P., Lee A.S. Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:19444-19449.
91. Fuest M., Willim K., Macnelly S., Fellner N., Resch G.P., Blum H.E., Hasselblatt P. The transcription factor c-Jun protects against sustained hepatic endoplasmic reticulum stress thereby promoting hepatocyte survival. Hepatology 2011, 55:408-418.
92. Fujita E., Kouroku Y., Isoai A., Kumagai H., Misutani A., Matsuda C., Hayashi Y.K., Momoi T. Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II). Hum. Mol. Genet. 2007, 16:618-629.
93. Gao B., Lee S.-M., Chen A., Zhang J., Zhang D.D., Kannan K., Ortmann R.A., Fang D. Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis. EMBO Rep. 2008, 9:480-485.
94. García-Pérez C., Hajnóczky G., Csordás G. Physical coupling supports the local Ca2+ transfer between sarcoplasmic reticulum subdomains and the mitochondria in heart muscle. J. Biol. Chem. 2008, 283:32771-32780.
95. Gault C.R., Obeid L.M., Hannun Y.A. An overview of sphingolipid metabolism: from synthesis to breakdown. Adv. Exp. Med. Biol. 2010, 688:1-23.
96. Ghosh R., Lipson K.L., Sargent K.E., Mercurio A.M., Hunt J.S., Ron D., Urano F. Transcriptional regulation of VEGF-A by the unfolded protein response pathway. PLoS One 2010, 5:e9575.
97. Glembotski C.C. Endoplasmic reticulum stress in the heart. Circ. Res. 2007, 101:975-984.
98. Goedert M., Spillantini M.G. A century of Alzheimer's disease. Science 2006, 314:777-781.
99. Goetz J.G., Nabi I.R. Interaction of the smooth endoplasmic reticulum and mitochondria. Biochem. Soc. Trans. 2006, 34:370-373.
100. Goldfinger M., Shmuel M., Benhamron S., Tirosh B. Protein synthesis in plasma cells is regulated by crosstalk between endoplasmic reticulum stress and mTOR signaling. Eur. J. Immunol. 2011, 41:491-502.
101. Goldstein M.G., Li Z. Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis. J. Hematol. Oncol. 2009, 30(2):5.
102. Gonzales J.C., Gentile C.L., Pfaffenbach K.T., Wei Y., Wang D., Pagliassotti M.J. Chemical induction of the unfolded protein response in the liver increases glucose production and is activated during insulin-induced hypoglycaemia in rats. Diabetologia 2008, 51:1920-1929.
103. Gonzalez T.N., Sidrauski C., Dörfler S., Walter P. Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway. EMBO J. 1999, 18:3119-3132.
104. Green K.N., Demuro A., Akbari Y., Hitt B.D., Smith I.F., Parker I., LaFerla F.M. SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J. Cell Biol. 2008, 181:1107-1116.
105. Grigoriev I., Gouveia S.M., van der Vaart B., Demmers J., Smyth J.T., Honnappa S., Splinter D., Steinmetz M.O., Putney J.W., Hoogenraad C.C., et al. STIM1 is a MT-plus-end-tracking protein involved in remodeling of the ER. Curr. Biol. 2008, 18:177-182.
106. Groenendyk J., Sreenivasaiah P.K., Kim D.H., Agellon L.B., Michalak M. Biology of endoplasmic reticulum stress in the heart. Circ. Res. 2010, 107:1185-1197.
107. Grosskreutz J., Van Den Bosch L., Keller B.U. Calcium dysregulation in amyotrophic lateral sclerosis. Cell Calcium 2010, 47:165-174.
108. Guan D., Wang H., Li V.E., Xu Y., Yang M., Shen Z. N-glycosylation of ATF6beta is essential for its proteolytic cleavage and transcriptional repressor function to ATF6alpha. J. Cell. Biochem. 2009, 108:825-831.
109. Guerrero-Hernandez A., Dagnino-Acosta A., Verkhratsky A. An intelligent sarco-endoplasmic reticulum Ca2+ store: release and leak channels have differential access to a concealed Ca2+ pool. Cell Calcium 2010, 48:143-149.
110. Gupta S., McGrath B., Cavener D.R. PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice. PLoS One 2009, 4:e8008.
111. Hai T.W., Liu F., Coukos W.J., Green M.R. Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev. 1989, 3:2083-2090.
112. Harding H.P., Novoa I., Zhang Y., Zeng H., Wek R., Schapira M., Ron D. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell 2000, 6:1099-1108.
113. Harding H.P., Zhang Y., Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 1999, 397:271-274.
114. Harding H.P., Zhang Y., Zeng H., Novoa I., Lu P.D., Calfon M., Sadri N., Yun C., Popko B., Paules R., et al. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol. Cell 2003, 11:619-633.
115. Hatai T., Matsuzawa A., Inoshita S., Mochida Y., Kuroda T., Sakamaki K., Kuida K., Yonehara S., Ichijo H., Takeda K. Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation. J. Biol. Chem. 2000, 275:26576-26581.
116. Hayashi T., Fujimoto M. Detergent-resistant microdomains determine the localization of sigma-1 receptors to the endoplasmic reticulum-mitochondria junction. Mol. Pharmacol. 2010, 77:517-528.
117. Hayashi T., Su T.-P. Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival. Cell 2007, 131:596-610.
118. Hayashi T., Su T.-P. Cholesterol at the endoplasmic reticulum: roles of the sigma-1 receptor chaperone and implications thereof in human diseases. Subcell. Biochem. 2010, 51:381-398.
119. Hayashi T., Rizzuto R., Hajnóczky G., Su T.-P. MAM: more than just a housekeeper. Trends Cell. Biol. 2009, 19:81-88.
120. Haze K., Okada T., Yoshida H., Yanagi H., Yura T., Negishi M., Mori K. Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. Biochem. J. 2001, 355:19-28.
121. Haze K., Yoshida H., Yanagi H., Yura T., Mori K. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol. Biol. Cell 1999, 10:3787-3799.
122. He C., Klionsky D.J. Regulation mechanisms and signaling pathways of autophagy. Annu. Rev. Genet. 2009, 43:67-93.
123. Hebert D.N., Molinari M. In and out of the ER: protein folding, quality control, degradation, and related human diseases. Physiol. Rev. 2007, 87:1377-1408.
124. Hebert D.N., Garman S.C., Molinari M. The glycan code of the endoplasmic reticulum: asparagine-linked carbohydrates as protein maturation and quality-control tags. Trends Cell. Biol. 2005, 15:364-370.
125. Hetz C., Bernasconi P., Fisher J., Lee A.-H., Bassik M.C., Antonsson B., Brandt G.S., Iwakoshi N.N., Schinzel A., Glimcher L.H., et al. Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science 2006, 312:572-576.
126. Hetz C., Lee A.-H., Gonzalez-Romero D., Thielen P., Castilla J., Soto C., Glimcher L.H. Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:757-762.
127. Hetz C., Russelakis-Carneiro M., Maundrell K., Castilla J., Soto C. Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein. EMBO J. 2003, 22:5435-5445.
128. Hetz C., Russelakis-Carneiro M., Wälchli S., Carboni S., Vial-Knecht E., Maundrell K., Castilla J., Soto C. The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity. J. Neurosci. 2005, 25:2793-2802.
129. Hetzer M.W. The nuclear envelope. Cold Spring Harb. Perspect. Biol. 2010, 2:a000539.
130. Heuson-Stiennon J.A., Wanson J.C., Drochmans P. Isolation and characterization of the sarcoplasmic reticulum of skeletal muscle. J. Cell Biol. 1972, 55:471-488.
131. Hu J., Shibata Y., Zhu P.-P., Voss C., Rismanchi N., Prinz W.A., Rapoport T.A., Blackstone C. A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell 2009, 138:549-561.
132. Høyer-Hansen M., Jäättelä M. Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium. Cell Death Differ. 2007, 14:1576-1582.
133. Høyer-Hansen M., Bastholm L., Szyniarowski P., Campanella M., Szabadkai G., Farkas T., Bianchi K., Fehrenbacher N., Elling F., Rizzuto R., et al. Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. Mol. Cell 2007, 25:193-205.
134. Igoillo-Esteve M., Marselli L., Cunha D.A., Ladrière L., Ortis F., Grieco F.A., Dotta F., Weir G.C., Marchetti P., Eizirik D.L., et al. Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes. Diabetologia 2010, 53:1395-1405.
135. Inoue H., Tanizawa Y., Wasson J., Behn P., Kalidas K., Bernal-Mizrachi E., Mueckler M., Marshall H., Donis-Keller H., Crock P., et al. A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nat. Genet. 1998, 20:143-148.
136. Ishida Y., Nagata K. Autophagy eliminates a specific species of misfolded procollagen and plays a protective role in cell survival against ER stress. Autophagy 2009, 5:1217-1219.
137. Ishida Y., Yamamoto A., Kitamura A., Lamandé S.R., Yoshimori T., Bateman J.F., Kubota H., Nagata K. Autophagic elimination of misfolded procollagen aggregates in the endoplasmic reticulum as a means of cell protection. Mol. Biol. Cell 2009, 20:2744-2754.
138. Ishigaki S., Fonseca S.G., Oslowski C.M., Jurczyk A., Shearstone J.R., Zhu L.J., Permutt M.A., Greiner D.L., Bortell R., Urano F. AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1. Cell Death Differ. 2010, 17:774-786.
139. Ito E., Oka K., Etcheberrigaray R., Nelson T.J., McPhie D.L., Tofel-Grehl B., Gibson G.E., Alkon D.L. Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:534-538.
140. Ito N., Nishibori Y., Ito Y., Takagi H., Akimoto Y., Kudo A., Asanuma K., Sai Y., Miyamoto K.-I., Takenaka H., et al. mTORC1 activation triggers the unfolded protein response in podocytes and leads to nephrotic syndrome. Lab. Invest. 2011, 91:1584-1595.
141. Iwawaki T., Hosoda A., Okuda T., Kamigori Y., Nomura-Furuwatari C., Kimata Y., Tsuru A., Kohno K. Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress. Nat. Cell Biol. 2001, 3:158-164.
142. Jeffrey K.D., Alejandro E.U., Luciani D.S., Kalynyak T.B., Hu X., Li H., Lin Y., Townsend R.R., Polonsky K.S., Johnson J.D. Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:8452-8457.
143. Jo Y., Debose-Boyd R.A. Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase. Crit. Rev. Biochem. Mol. Biol. 2010, 45:185-198.
144. Jouaville L.S., Pinton P., Bastianutto C., Rutter G.A., Rizzuto R. Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:13807-13812.
145. Jousse C., Oyadomari S., Novoa I., Lu P., Zhang Y., Harding H.P., Ron D. Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells. J. Cell Biol. 2003, 163:767-775.
146. Jung C.H., Ro S.-H., Cao J., Otto N.M., Kim D.-H. mTOR regulation of autophagy. FEBS Lett. 2010, 584:1287-1295.
147. Kammoun H.L., Chabanon H., Hainault I., Luquet S., Magnan C., Koike T., Ferré P., Foufelle F. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J. Clin. Invest. 2009, 119:1201-1215.
148. Kaneko M., Niinuma Y., Nomura Y. Activation signal of nuclear factor-kappa B in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2. Biol. Pharm. Bull. 2003, 26:931-935.
149. Kaneko M., Takahashi T., Niinuma Y., Nomura Y. Manganese superoxide dismutase is induced by endoplasmic reticulum stress through IRE1-mediated nuclear factor (NF)-kappaB and AP-1 activation. Biol. Pharm. Bull. 2004, 27:1202-1206.
150. Kang R., Zeh H.J., Lotze M.T., Tang D. The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ. 2011, 18:571-580.
151. Kato H., Nakajima S., Saito Y., Takahashi S., Katoh R., Kitamura M. mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway. Cell Death Differ. 2012, 2:310-320.
152. Kawano M., Kumagai K., Nishijima M., Hanada K. Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT. J. Biol. Chem. 2006, 281:30279-30288.
153. Kelley D., He J., Menshikova E. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002, 51:2944-2950.
154. Kharroubi I., Ladriere L., Cardozo A.K., Dogusan Z., Cnop M., Eizirik D.L. Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Endocrinology 2004, 145:5087-5096.
155. Kim R., Emi M., Tanabe K., Murakami S. Role of the unfolded protein response in cell death. Apoptosis 2006, 11:5-13.
156. Kimata Y., Ishiwata-Kimata Y., Ito T., Hirata A., Suzuki T., Oikawa D., Takeuchi M., Kohno K. Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins. J. Cell Biol. 2007, 179:75-86.
157. Klionsky D.J., Cuervo A.M., Seglen P.O. Methods for monitoring autophagy from yeast to human. Autophagy 2007, 3:181-206.
158. Kny M., Standera S., Hartmann-Petersen R., Kloetzel P.-M., Seeger M. Herp regulates Hrd1-mediated ubiquitylation in a ubiquitin-like domain-dependent manner. J. Biol. Chem. 2011, 286:5151-5156.
159. Kokame K., Agarwala K.L., Kato H., Miyata T. Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress. J. Biol. Chem. 2000, 275:32846-32853.
160. Kokame K., Kato H., Miyata T. Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response. J. Biol. Chem. 2001, 276:9199-9205.
161. Kondo S., Murakami T., Tatsumi K., Ogata M., Kanemoto S., Otori K., Iseki K., Wanaka A., Imaizumi K. OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes. Nat. Cell Biol. 2005, 7:186-194.
162. Kondo S., Saito A., Hino S.-I., Murakami T., Ogata M., Kanemoto S., Nara S., Yamashita A., Yoshinaga K., Hara H., et al. BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer. Mol. Cell. Biol. 2007, 27:1716-1729.
163. Kopach O., Kruglikov I., Pivneva T., Voitenko N., Fedirko N. Functional coupling between ryanodine receptors, mitochondria and Ca(2+) ATPases in rat submandibular acinar cells. Cell Calcium 2008, 43:469-481.
164. Kornmann B., Currie E., Collins S.R., Schuldiner M., Nunnari J., Weissman J.S., Walter P. An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science 2009, 325:477-481.
165. Kouroku Y., Fujita E., Tanida I., Ueno T., Isoai A., Kumagai H., Ogawa S., Kaufman R.J., Kominami E., Momoi T. ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ. 2007, 14:230-239.
166. Koves T.R., Li P., An J., Akimoto T., Slentz D., Ilkayeva O., Dohm G.L., Yan Z., Newgard C.B., Muoio D.M. Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J. Biol. Chem. 2005, 280:33588-33598.
167. Kroeger H., Miranda E., MacLeod I., Pérez J., Crowther D.C., Marciniak S.J., Lomas D.A. Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpins. J. Biol. Chem. 2009, 284:22793-22802.
168. Kruse K.B., Brodsky J.L., McCracken A.A. Characterization of an ERAD gene as VPS30/ATG6 reveals two alternative and functionally distinct protein quality control pathways: one for soluble Z variant of human alpha-1 proteinase inhibitor (A1PiZ) and another for aggregates of A1PiZ. Mol. Biol. Cell 2006, 17:203-212.
169. Kruse K.B., Dear A., Kaltenbrun E.R., Crum B.E., George P.M., Brennan S.O., McCracken A.A. Mutant fibrinogen cleared from the endoplasmic reticulum via endoplasmic reticulum-associated protein degradation and autophagy: an explanation for liver disease. Am. J. Pathol. 2006, 168:1299-1308. (quiz 1404-5).
170. Kuznetsov G., Brostrom M.A., Brostrom C.O. Demonstration of a calcium requirement for secretory protein processing and export. Differential effects of calcium and dithiothreitol. J. Biol. Chem. 1992, 267:3932-3939.
171. LaFerla F.M. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat. Rev. Neurosci. 2002, 3:862-872.
172. Lanner J.T., Georgiou D.K., Joshi A.D., Hamilton S.L. Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Cold Spring Harb. Perspect. Biol. 2010, 2. (a003996).
173. Laplante M., Sabatini D.M. An emerging role of mTOR in lipid biosynthesis. Curr. Biol. 2009, 19:R1046-R1052.
174. Le Fourn V., Gaplovska-Kysela K., Guhl B., Santimaria R., Zuber C., Roth J. Basal autophagy is involved in the degradation of the ERAD component EDEM1. CMLS. Cell. Mol. Life Sci. 2009, 66:1434-1445.
175. Lee A.H., Scapa E.F., Cohen D.E., Glimcher L.H. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 2008, 320:1492-1496.
176. Lee E., Nichols P., Spicer D., Groshen S., Yu M.C., Lee A.S. GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer. Cancer Res. 2006, 66:7849-7853.
177. Lee Y.H., White M.F. Insulin receptor substrate proteins and diabetes. Arch. Pharm. Res. 2004, 27:361-370.
178. Leissring M.A., Parker I., LaFerla F.M. Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals. J. Biol. Chem. 1999, 274:32535-32538.
179. Leissring M.A., Paul B.A., Parker I., Cotman C.W., LaFerla F.M. Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes. J. Neurochem. 1999, 72:1061-1068.
180. Li H., Korennykh A.V., Behrman S.L., Walter P. Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:16113-16118.
181. Li X., Zhang K., Li Z. Unfolded protein response in cancer: the physician's perspective. J. Hematol. Oncol. 2011, 23(4):8.
182. Li Z., Okamoto K.-I., Hayashi Y., Sheng M. The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Cell 2004, 119:873-887.
183. Liang G., Audas T.E., Li Y., Cockram G.P., Dean J.D., Martyn A.C., Kokame K., Lu R. Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. Mol. Cell. Biol. 2006, 26:7999-8010.
184. Lim J.H., Lee H.J., Ho Jung M., Song J. Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: a molecular mechanism leading to hepatic insulin resistance. Cell. Signal. 2009, 21:169-177.
185. Lin J.H., Li H., Yasumura D., Cohen H.R., Zhang C., Panning B., Shokat K.M., Lavail M.M., Walter P. IRE1 signaling affects cell fate during the unfolded protein response. Science 2007, 318:944-949.
186. Lin J.H., Li H., Zhang Y., Ron D., Walter P. Divergent effects of PERK and IRE1 signaling on cell viability. PLoS One 2009, 4:e4170.
187. Lipson K.L., Fonseca S.G., Ishigaki S., Nguyen L.X., Foss E., Bortell R., Rossini A.A., Urano F. Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. Cell. Metab. 2006, 4:245-254.
188. Lisbona F., Rojas-Rivera D., Thielen P., Zamorano S., Todd D., Martinon F., Glavic A., Kress C., Lin J.H., Walter P., et al. BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol. Cell 2009, 33:679-691.
189. Liu X.H., Zhang Z.Y., Andersson K.B., Husberg C., Enger U.H., Ræder M.G., Christensen G., Louch W.E. Cardiomyocyte-specific disruption of Serca2 in adult mice causes sarco(endo)plasmic reticulum stress and apoptosis. Cell Calcium 2011, 49:201-207.
190. Lu P.D., Jousse C., Marciniak S.J., Zhang Y., Novoa I., Scheuner D., Kaufman R.J., Ron D., Harding H.P. Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. EMBO J. 2004, 23:169-179.
191. Lu W., Laszlo C.F., Miao Z., Chen H., Wu S. The role of nitric-oxide synthase in the regulation of UVB light-induced phosphorylation of the alpha subunit of eukaryotic initiation factor 2. J. Biol. Chem. 2009, 284:24281-24288.
192. Luo D., He Y., Zhang H., Yu L., Chen H., Xu Z., Tang S., Urano F., Min W. AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response. J. Biol. Chem. 2008, 283:11905-11912.
193. Ma Y., Brewer J.W., Diehl J.A., Hendershot L.M. Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response. J. Mol. Biol. 2002, 318:1351-1365.
194. Ma Y., Hendershot L.M. The role of the unfolded protein response in tumour development: friend or foe?. Nat. Rev. Cancer 2004, 4:966-977.
195. Madeo F., Kroemer G. Intricate links between ER stress and apoptosis. Mol. Cell 2009, 33:669-670.
196. Malhotra J.D., Kaufman R.J. Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?. Antioxid. Redox Signal. 2007, 9:2277-2293.
197. Mandic A., Hansson J., Linder S., Shoshan M.C. Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. J. Biol. Chem. 2003, 278:9100-9106.
198. Mao T., Shao M., Qiu Y., Huang J., Zhang Y., Song B., Wang Q., Jiang L., Liu Y., Han J.-D.J., et al. PKA phosphorylation couples hepatic inositol-requiring enzyme 1alpha to glucagon signaling in glucose metabolism. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:15852-15857.
199. Marks A.R. Ryanodine receptors/calcium release channels in heart failure and sudden cardiac death. J. Mol. Cell. Cardiol. 2001, 33:615-624.
200. Martindale J.J., Fernandez R., Thuerauf D., Whittaker R., Gude N., Sussman M.A., Glembotski C.C. Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6. Circ. Res. 2006, 98:1186-1193.
201. Marutani T., Maeda T., Tanabe C., Zou K., Araki W., Kokame K., Michikawa M., Komano H. ER-stress-inducible Herp, facilitates the degradation of immature nicastrin. Biochim. Biophys. Acta 2011, 1810:790-798.
202. Matlack K.E., Mothes W., Rapoport T.A. Protein translocation: tunnel vision. Cell 1998, 92:381-390.
203. Matsuda T., Kido Y., Asahara S.-I., Kaisho T., Tanaka T., Hashimoto N., Shigeyama Y., Takeda A., Inoue T., Shibutani Y., et al. Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice. J. Clin. Invest. 2010, 120:115-126.
204. Mattson M.P. ER calcium and Alzheimer's disease: in a state of flux. Sci. Signal. 2010, 3:pe10.
205. Maxfield F.R., van Meer G. Cholesterol, the central lipid of mammalian cells. Curr. Opin. Cell Biol. 2010, 22:422-429.
206. McCormack J.G., Halestrap A.P., Denton R.M. Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiol. Rev. 1990, 70:391-425.
207. Meares G.P., Hughes K.J., Naatz A., Papa F.R., Urano F., Hansen P.A., Benveniste E.N., Corbett J.A. IRE1-dependent activation of AMPK in response to nitric oxide. Mol. Cell. Biol. 2011, 31:4286-4297.
208. Mehnert M., Sommer T., Jarosch E. ERAD ubiquitin ligases: multifunctional tools for protein quality control and waste disposal in the endoplasmic reticulum. Bioessays 2010, 32:905-913.
209. Mendes C.C.P., Gomes D.A., Thompson M., Souto N.C., Goes T.S., Goes A.M., Rodrigues M.A., Gomez M.V., Nathanson M.H., Leite M.F. The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria. J. Biol. Chem. 2005, 280:40892-40900.
210. Meusser B., Hirsch C., Jarosch E., Sommer T. ERAD: the long road to destruction. Nat. Cell Biol. 2005, 7:766-772.
211. Michalak M., Groenendyk J., Szabo E., Gold L.I., Opas M. Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum. Biochem. J. 2009, 417:651-666.
212. Minamino T., Komuro I., Kitakaze M. Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease. Circ. Res. 2010, 107:1071-1082.
213. Mironov S.L., Symonchuk N. ER vesicles and mitochondria move and communicate at synapses. J. Cell Sci. 2006, 119:4926-4934.
214. Miyazaki Y., Kaikita K., Endo M., Horio E., Miura M., Tsujita K., Hokimoto S., Yamamuro M., Iwawaki T., Gotoh T., et al. C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation. Arterioscler. Thromb. Vasc. Biol. 2011, 31:1124-1132.
215. Molinari M., Calanca V., Galli C., Lucca P., Paganetti P. Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle. Science 2003, 299:1397-1400.
216. Mothes W., Prehn S., Rapoport T.A. Systematic probing of the environment of a translocating secretory protein during translocation through the ER membrane. EMBO J. 1994, 13:3973-3982.
217. Murakami T., Kondo S., Ogata M., Kanemoto S., Saito A., Wanaka A., Imaizumi K. Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress. J. Neurochem. 2006, 96:1090-1100.
218. Murakami T., Saito A., Hino S.-I., Kondo S., Kanemoto S., Chihara K., Sekiya H., Tsumagari K., Ochiai K., Yoshinaga K., et al. Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation. Nat. Cell Biol. 2009, 11:1205-1211.
219. Muriel M.-P., Dauphin A., Namekawa M., Gervais A., Brice A., Ruberg M. Atlastin-1, the dynamin-like GTPase responsible for spastic paraplegia SPG3A, remodels lipid membranes and may form tubules and vesicles in the endoplasmic reticulum. J. Neurochem. 2009, 110:1607-1616.
220. Myhill N., Lynes E.M., Nanji J.A., Blagoveshchenskaya A.D., Fei H., Carmine Simmen K., Cooper T.J., Thomas G., Simmen T. The subcellular distribution of calnexin is mediated by PACS-2. Mol. Biol. Cell 2008, 19:2777-2788.
221. Nakagawa T., Yuan J. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J. Cell Biol. 2000, 150:887-894.
222. Natarajan R., Salloum F.N., Fisher B.J., Smithson L., Almenara J., Fowler A.A. Prolyl hydroxylase inhibition attenuates post-ischemic cardiac injury via induction of endoplasmic reticulum stress genes. Vascul. Pharmacol. 2009, 51:110-118.
223. Nelson O., Tu H., Lei T., Bentahir M., De Strooper B., Bezprozvanny I. Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1. J. Clin. Invest. 2007, 117:1230-1239.
224. Ngoh G.A., Hamid T., Prabhu S.D., Jones S.P. O-GlcNAc signaling attenuates ER stress-induced cardiomyocyte death. Am. J. Physiol. Heart Circ. Physiol. 2009, 297:H1711-H1719.
225. Ni L., Zhou C., Duan Q., Lv J., Fu X., Xia Y., Wang D.W. β-AR blockers suppresses ER stress in cardiac hypertrophy and heart failure. PLoS One 2011, 6:e27294.
226. Ni M., Lee A.S. ER chaperones in mammalian development and human diseases. FEBS Lett. 2007, 581:3641-3651.
227. Nikawa J., Yamashita S. IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae. Mol. Microbiol. 1992, 6:1441-1446.
228. Nikonov A.V., Kreibich G. Organization of translocon complexes in ER membranes. Biochem. Soc. Trans. 2003, 31:1253-1256.
229. Nikonov A.V., Hauri H.-P., Lauring B., Kreibich G. Climp-63-mediated binding of microtubules to the ER affects the lateral mobility of translocon complexes. J. Cell Sci. 2007, 120:2248-2258.
230. Nishitoh H., Matsuzawa A., Tobiume K., Saegusa K., Takeda K., Inoue K., Hori S., Kakizuka A., Ichijo H. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev. 2002, 16:1345-1355.
231. Novoa I., Zeng H., Harding H.P., Ron D. Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha. J. Cell Biol. 2001, 153:1011-1022.
232. Obeng E.A., Carlson L.M., Gutman D.M., Harrington W.J., Lee K.P., Boise L.H. Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood 2006, 107:4907-4916.
233. Ogata M., Hino S.-I., Saito A., Morikawa K., Kondo S., Kanemoto S., Murakami T., Taniguchi M., Tanii I., Yoshinaga K., et al. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol. Cell. Biol. 2006, 26:9220-9231.
234. Oikawa D., Tokuda M., Hosoda A., Iwawaki T. Identification of a consensus element recognized and cleaved by IRE1 alpha. Nucleic Acids Res. 2010, 38:6265-6273.
235. Okada K.-I., Minamino T., Tsukamoto Y., Liao Y., Tsukamoto O., Takashima S., Hirata A., Fujita M., Nagamachi Y., Nakatani T., et al. Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction: possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis. Circulation 2004, 110:705-712.
236. Olivari S., Cali T., Salo K.E.H., Paganetti P., Ruddock L.W., Molinari M. EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation. Biochem. Biophys. Res. Commun. 2006, 349:1278-1284.
237. Orrenius S., Ericsson J.L. Enzyme-membrane relationship in phenobarbital induction of synthesis of drug-metabolizing enzyme system and proliferation of endoplasmic membranes. J. Cell Biol. 1966, 28:181-198.
238. Orsi A., Fioriti L., Chiesa R., Sitia R. Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein. J. Biol. Chem. 2006, 281:30431-30438.
239. Oyadomari S., Harding H.P., Zhang Y., Oyadomari M., Ron D. Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab. 2008, 7:520-532.
240. Ozawa K., Tsukamoto Y., Hori O., Kitao Y., Yanagi H., Stern D.M., Ogawa S. Regulation of tumor angiogenesis by oxygen-regulated protein 150, an inducible endoplasmic reticulum chaperone. Cancer Res. 2001, 61:4206-4213.
241. Ozcan U., Cao Q., Yilmaz E., Lee A.-H., Iwakoshi N.N., Ozdelen E., Tuncman G., Görgün C., Glimcher L.H., Hotamisligil G.S. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004, 306:457-461.
242. Ozcan U., Ozcan L., Yilmaz E., Düvel K., Sahin M., Manning B.D., Hotamisligil G.S. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol. Cell 2008, 29:541-551.
243. Palade G.E. The endoplasmic reticulum. J. Biophys. Biochem. Cytol. 1956, 2:85-98.
244. Pankiv S., Clausen T.H., Lamark T., Brech A., Bruun J.-A., Outzen H., Øvervatn A., Bjørkøy G., Johansen T. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 2007, 282:24131-24145.
245. Park H.R., Tomida A., Sato S., Tsukumo Y., Yun J., Yamori T., Hayakawa Y., Tsuruo T., Shin-ya K. Effect on tumor cells of blocking survival response to glucose deprivation. J. Natl. Cancer Inst. 2004, 96:1300-1310.
246. Park S.W., Zhou Y., Lee J., Lu A., Sun C., Chung J., Ueki K., Ozcan U. The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation. Nat. Med. 2010, 16:429-437.
247. Parker R., Phan T., Baumeister P., Roy B., Cheriyath V., Roy A.L., Lee A.S. Identification of TFII-I as the endoplasmic reticulum stress response element binding factor ERSF: its autoregulation by stress and interaction with ATF6. Mol. Cell. Biol. 2001, 21:3220-3233.
248. Pascoe J.M., Roberts J.J. Interactions between mammalian cell DNA and inorganic platinum compounds. II. Interstrand cross-linking of isolated and cellular DNA by platinum(IV) compounds. Biochem. Pharmacol. 1974, 23:1345-1357.
249. Patterson R.L., Boehning D., Snyder S.H. Inositol 1,4,5-trisphosphate receptors as signal integrators. Annu. Rev. Biochem. 2004, 73:437-465.
250. Peretti D., Dahan N., Shimoni E., Hirschberg K., Lev S. Coordinated lipid transfer between the endoplasmic reticulum and the Golgi complex requires the VAP proteins and is essential for Golgi-mediated transport. Mol. Biol. Cell 2008, 19:3871-3884.
251. Periasamy M., Kalyanasundaram A. SERCA pump isoforms: their role in calcium transport and disease. Muscle Nerve 2007, 35:430-442.
252. Perman J.C., Boström P., Lindbom M., Lidberg U., Ståhlman M., Hägg D., Lindskog H., Scharin Täng M., Omerovic E., Mattsson Hultén L., et al. The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction. J. Clin. Invest. 2011, 121:2625-2640.
253. Petersen K.F., Shulman G.I. Etiology of insulin resistance. Am. J. Med. 2006, 119:S10-S16.
254. Petrovski G., Das S., Juhasz B., Kertesz A., Tosaki A., Das D.K. Cardioprotection by endoplasmic reticulum stress-induced autophagy. Antioxid. Redox Signal. 2011, 14:2191-2200.
255. Pfaffenbach K.T., Nivala A.M., Reese L., Ellis F., Wang D., Wei Y., Pagliassotti M.J. Rapamycin inhibits postprandial-mediated X-box-binding protein-1 splicing in rat liver. J. Nutr. 2010, 140:879-884.
256. Pincus D., Chevalier M.W., Aragón T., van Anken E., Vidal S.E., El-Samad H., Walter P. BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response. PLoS Biol. 2010, 8:e1000415.
257. Plate K.H., Breier G., Weich H.A., Risau W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 1992, 359:845-848.
258. Pomar N., Berlanga J.J., Campuzano S., Hernandez G., Elias M., de Haro C. Functional characterization of Drosophila melanogaster PERK eukaryotic initiation factor 2alpha (eIF2alpha) kinase. Eur. J. Biochem. 2003, 270:293-306.
259. Pozzan T., Rizzuto R., Volpe P., Meldolesi J. Molecular and cellular physiology of intracellular calcium stores. Physiol. Rev. 1994, 74:595-636.
260. Promlek T., Ishiwata-Kimata Y., Shido M., Sakuramoto M., Kohno K., Kimata Y. Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways. Mol. Biol. Cell 2011, 22:3520-3532.
261. Rane N.S., Kang S.-W., Chakrabarti O., Feigenbaum L., Hegde R.S. Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration. Dev. Cell 2008, 15:359-370.
262. Ranganathan A.C., Zhang L., Adam A.P., Aguirre-Ghiso J.A. Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells. Cancer Res. 2006, 66:1702-1711.
263. Rao R.V., Peel A., Logvinova A., del Rio G., Hermel E., Yokota T., Goldsmith P.C., Ellerby L.M., Ellerby H.M., Bredesen D.E. Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. FEBS Lett. 2002, 514:122-128.
264. Reddy R.K., Mao C., Baumeister P., Austin R.C., Kaufman R.J., Lee A.S. Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J. Biol. Chem. 2003, 278:20915-20924.
265. Registre M., Goetz J.G., St Pierre P., Pang H., Lagacé M., Bouvier M., Le P.U., Nabi I.R. The gene product of the gp78/AMFR ubiquitin E3 ligase cDNA is selectively recognized by the 3F3A antibody within a subdomain of the endoplasmic reticulum. Biochem. Biophys. Res. Commun. 2004, 320:1316-1322.
266. Rizzuto R., Pinton P., Carrington W., Fay F.S., Fogarty K.E., Lifshitz L.M., Tuft R.A., Pozzan T. Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses. Science 1998, 280:1763-1766.
267. Robertson R.P. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes. J. Biol. Chem. 2004, 279:42351-42354.
268. Robertson R.P., Harmon J., Tran P.O.T., Poitout V. Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 2004, 53(Suppl. 1):S119-S124.
269. Romero-Ramirez L., Cao H., Nelson D., Hammond E., Lee A.H., Yoshida H., Mori K., Glimcher L.H., Denko N.C., Giaccia A.J., et al. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res. 2004, 64:5943-5947.
270. Romero-Ramirez L., Cao H., Regalado M.P., Kambham N., Siemann D., Kim J.J., Le Q.T., Koong A.C. X box-binding protein 1 regulates angiogenesis in human pancreatic adenocarcinomas. Transl. Oncol. 2009, 2:31-38.
271. Rouschop K.M.A., van den Beucken T., Dubois L., Niessen H., Bussink J., Savelkouls K., Keulers T., Mujcic H., Landuyt W., Voncken J.W., et al. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. J. Clin. Invest. 2010, 120:127-141.
272. Roybal C.N., Yang S., Sun C.W., Hurtado D., Vander Jagt D.L., Townes T.M., Abcouwer S.F. Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4. J. Biol. Chem. 2004, 279:14844-14852.
273. Rubio C., Pincus D., Korennykh A., Schuck S., El-Samad H., Walter P. Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity. J. Cell Biol. 2011, 193:171-184.
274. Rutkowski D.T., Wu J., Back S.H., Callaghan M.U., Ferris S.P., Iqbal J., Clark R., Miao H., Hassler J.R., Fornek J., et al. UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev. Cell 2008, 15:829-840.
275. Rzymski T., Milani M., Pike L., Buffa F., Mellor H.R., Winchester L., Pires I., Hammond E., Ragoussis I., Harris A.L. Regulation of autophagy by ATF4 in response to severe hypoxia. Oncogene 2010, 29:4424-4435.
276. Safdar A., Little J.P., Stokl A.J., Hettinga B.P., Akhtar M., Tarnopolsky M.A. Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis. J. Biol. Chem. 2011, 286:10605-10617.
277. Saito A., Hino S.-I., Murakami T., Kanemoto S., Kondo S., Saitoh M., Nishimura R., Yoneda T., Furuichi T., Ikegawa S., et al. Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis. Nat. Cell Biol. 2009, 11:1197-1204.
278. Santos C.X.C., Tanaka L.Y., Wosniak J., Laurindo F.R.M. Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase. Antioxid. Redox Signal. 2009, 11:2409-2427.
279. Sari F.R., Widyantoro B., Thandavarayan R.A., Harima M., Lakshmanan A.P., Zhang S., Muslin A.J., Suzuki K., Kodama M., Watanabe K. Attenuation of CHOP-mediated myocardial apoptosis in pressure-overloaded dominant negative p38α mitogen-activated protein kinase mice. Cell. Physiol. Biochem. 2011, 27:487-496.
280. Schäfer A., Wolf D.H. Sec61p is part of the endoplasmic reticulum-associated degradation machinery. EMBO J. 2009, 28:2874-2884.
281. Schewe D.M., Aguirre-Ghiso J.A. ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:10519-10524.
282. Schon E.A., Area-Gomez E. Is Alzheimer's disease a disorder of mitochondria-associated membranes?. J. Alzheimers Dis. 2010, 20(Suppl. 2):S281-S292.
283. Schröder M. Endoplasmic reticulum stress responses. Cell. Mol. Life Sci. 2008, 65:862-894.
284. Schröder M., Kaufman R.J. ER stress and the unfolded protein response. Mutat. Res. 2005, 569:29-63.
285. Schulz T.J., Westermann D., Isken F., Voigt A., Laube B., Thierbach R., Kuhlow D., Zarse K., Schomburg L., Pfeiffer A.F.H., et al. Activation of mitochondrial energy metabolism protects against cardiac failure. Aging (Albany NY) 2010, 2:843-853.
286. Sequeira S.J., Ranganathan A.C., Adam A.P., Iglesias B.V., Farias E.F., Aguirre-Ghiso J.A. Inhibition of proliferation by PERK regulates mammary acinar morphogenesis and tumor formation. PLoS One 2007, 2:e615.
287. Severino A., Campioni M., Straino S., Salloum F.N., Schmidt N., Herbrand U., Frede S., Toietta G., Di Rocco G., Bussani R., et al. Identification of protein disulfide isomerase as a cardiomyocyte survival factor in ischemic cardiomyopathy. J. Am. Coll. Cardiol. 2007, 50:1029-1037.
288. Sha H., He Y., Chen H., Wang C., Zenno A., Shi H., Yang X., Zhang X., Qi L. The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis. Cell. Metab. 2009, 9:556-564.
289. Shamu C.E., Walter P. Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J. 1996, 15:3028-3039.
290. Shen J., Prywes R. Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6. J. Biol. Chem. 2004, 279:43046-43051.
291. Shen J., Chen X., Hendershot L., Prywes R. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev. Cell. 2002, 3:99-111.
292. Shen J., Snapp E.L., Lippincott-Schwartz J., Prywes R. Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response. Mol. Cell. Biol. 2005, 25:921-932.
293. Shi Y., Vattem K.M., Sood R., An J., Liang J., Stramm L., Wek R.C. Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Mol. Cell. Biol. 1998, 18:7499-7509.
294. Shibata Y., Voeltz G.K., Rapoport T.A. Rough sheets and smooth tubules. Cell 2006, 126:435-439.
295. Shibata Y., Voss C., Rist J.M., Hu J., Rapoport T.A., Prinz W.A., Voeltz G.K. The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum. J. Biol. Chem. 2008, 283:18892-18904.
296. Shinkai Y., Yamamoto C., Kaji T. Lead induces the expression of endoplasmic reticulum chaperones GRP78 and GRP94 in vascular endothelial cells via the JNK-AP-1 pathway. Toxicol. Sci. 2010, 114:378-386.
297. Shuda M., Kondoh N., Imazeki N., Tanaka K., Okada T., Mori K., Hada A., Arai M., Wakatsuki T., Matsubara O., et al. Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis. J. Hepatol. 2003, 38:605-614.
298. Shweiki D., Itin A., Soffer D., Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992, 359:843-845.
299. Sidrauski C., Walter P. The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 1997, 90:1031-1039.
300. Silva J.M., Wong A., Carelli V., Cortopassi G.A. Inhibition of mitochondrial function induces an integrated stress response in oligodendroglia. Neurobiol. Dis. 2009, 34:357-365.
301. Simmen T., Aslan J.E., Blagoveshchenskaya A.D., Thomas L., Wan L., Xiang Y., Feliciangeli S.F., Hung C.H., Crump C.M., Thomas G. PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. EMBO J. 2005, 24:717-729.
302. Small D.H. Dysregulation of calcium homeostasis in Alzheimer's disease. Neurochem. Res. 2009, 34:1824-1829.
303. Smith I.F., Green K.N., LaFerla F.M. Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals. Cell Calcium 2005, 38:427-437.
304. Song X.J., Yang C.Y., Liu B., Wei Q., Korkor M.T., Liu J.Y., Yang P. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int. J. Med. Sci. 2011, 8:564-572.
305. Spiotto M.T., Banh A., Papandreou I., Cao H., Galvez M.G., Gurtner G.C., Denko N.C., Le Q.T., Koong A.C. Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth. Cancer Res. 2010, 70:78-88.
306. Spruce B.A., Campbell L.A., McTavish N., Cooper M.A., Appleyard M.V., O'Neill M., Howie J., Samson J., Watt S., Murray K., et al. Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo. Cancer Res. 2004, 64:4875-4886.
307. Sriburi R., Bommiasamy H., Buldak G.L., Robbins G.R., Frank M., Jackowski S., Brewer J.W. Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis. J. Biol. Chem. 2007, 282:7024-7034.
308. Sriburi R., Jackowski S., Mori K., Brewer J.W. XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. J. Cell Biol. 2004, 167:35-41.
309. Steele A.D., Hetz C., Yi C.H., Jackson W.S., Borkowski A.W., Yuan J., Wollmann R.H., Lindquist S. Prion pathogenesis is independent of caspase-12. Prion 2007, 1:243-247.
310. Stefan C.J., Manford A.G., Baird D., Yamada-Hanff J., Mao Y., Emr S.D. Osh proteins regulate phosphoinositide metabolism at ER-plasma membrane contact sites. Cell. 2011, 144:389-401.
311. Sterz J., von Metzler I., Hahne J.C., Lamottke B., Rademacher J., Heider U., Terpos E., Sezer O. The potential of proteasome inhibitors in cancer therapy. Expert Opin. Investig. Drugs 2008, 17:879-895.
312. Stokin G.B., Lillo C., Falzone T.L., Brusch R.G., Rockenstein E., Mount S.L., Raman R., Davies P., Masliah E., Williams D.S., et al. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science 2005, 307:1282-1288.
313. Strehler E.E., Treiman M. Calcium pumps of plasma membrane and cell interior. Curr. Mol. Med. 2004, 4:323-335.
314. Strøm C.C., Aplin M., Ploug T., Christoffersen T.E.H., Langfort J., Viese M., Galbo H., Haunsø S., Sheikh S.P. Expression profiling reveals differences in metabolic gene expression between exercise-induced cardiac effects and maladaptive cardiac hypertrophy. FEBS J. 2005, 272:2684-2695.
315. Støy J., Edghill E.L., Flanagan S.E., Ye H., Paz V.P., Pluzhnikov A., Below J.E., Hayes M.G., Cox N.J., Lipkind G.M., et al. Insulin gene mutations as a cause of permanent neonatal diabetes. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:15040-15044.
316. Sun J., Yamaguchi N., Xu L., Eu J.P., Stamler J.S., Meissner G. Regulation of the cardiac muscle ryanodine receptor by O(2) tension and S-nitrosoglutathione. Biochemistry 2008, 47:13985-13990.
317. Sutendra G., Dromparis P., Wright P., Bonnet S., Haromy A., Hao Z., McMurtry M.S., Michalak M., Vance J.E., Sessa W.C., et al. The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension. Sci. Transl. Med. 2011, 3. (88ra55).
318. Swanson R., Locher M., Hochstrasser M. A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation. Genes Dev. 2001, 15:2660-2674.
319. Szabadkai G., Bianchi K., Várnai P., De Stefani D., Wieckowski M.R., Cavagna D., Nagy A.I., Balla T., Rizzuto R. Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels. J. Cell Biol. 2006, 175:901-911.
320. Tabas I., Ron D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat. Cell Biol. 2011, 13:184-190.
321. Tao J., Zhu W., Li Y., Xin P., Li J., Liu M., Li J., Redington A.N., Wei M. Apelin-13 protects the heart against ischemia-reperfusion injury through inhibition of ER-dependent apoptotic pathways in a time-dependent fashion. Am. J. Physiol. Heart Circ. Physiol. 2011, 301:H1471-H1486.
322. Taylor C.W., Tovey S.C. IP(3) receptors: toward understanding their activation. Cold Spring Harb. Perspect. Biol. 2010, 2. (a004010).
323. Taylor C.W., da Fonseca P.C.A., Morris E.P. IP(3) receptors: the search for structure. Trends Biochem. Sci. 2004, 29:210-219.
324. Teckman J.H., Perlmutter D.H. Retention of mutant alpha(1)-antitrypsin Z in endoplasmic reticulum is associated with an autophagic response. Am. J. Physiol. Gastrointest. Liver Physiol. 2000, 279:G961-G974.
325. Terasaki M., Chen L.B., Fujiwara K. Microtubules and the endoplasmic reticulum are highly interdependent structures. J. Cell Biol. 1986, 103:1557-1568.
326. Teske B.F., Wek S.A., Bunpo P., Cundiff J.K., McClintick J.N., Anthony T.G., Wek R.C. The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress. Mol. Biol. Cell 2011, 22:4390-4405.
327. Thinakaran G., Sisodia S.S. Presenilins and Alzheimer disease: the calcium conspiracy. Nat. Neurosci. 2006, 9:1354-1355.
328. Thuerauf D.J., Hoover H., Meller J., Hernandez J., Su L., Andrews C., Dillmann W.H., McDonough P.M., Glembotski C.C. Sarco/endoplasmic reticulum calcium ATPase-2 expression is regulated by ATF6 during the endoplasmic reticulum stress response: intracellular signaling of calcium stress in a cardiac myocyte model system. J. Biol. Chem. 2001, 276:48309-48317.
329. Thuerauf D.J., Marcinko M., Belmont P.J., Glembotski C.C. Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viability. J. Biol. Chem. 2007, 282:22865-22878.
330. Thuerauf D.J., Marcinko M., Gude N., Rubio M., Sussman M.A., Glembotski C.C. Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes. Circ. Res. 2006, 99:275-282.
331. Thuerauf D.J., Morrison L., Glembotski C.C. Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction. J. Biol. Chem. 2004, 279:21078-21084.
332. Thuerauf D.J., Morrison L.E., Hoover H., Glembotski C.C. Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16. J. Biol. Chem. 2002, 277:20734-20739.
333. Tirasophon W., Lee K., Callaghan B., Welihinda A., Kaufman R.J. The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response. Genes Dev. 2000, 14:2725-2736.
334. Tirasophon W., Welihinda A.A., Kaufman R.J. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev. 1998, 12:1812-1824.
335. Toko H., Takahashi H., Kayama Y., Okada S., Minamino T., Terasaki F., Kitaura Y., Komuro I. ATF6 is important under both pathological and physiological states in the heart. J. Mol. Cell. Cardiol. 2010, 49:113-120.
336. Torres M., Castillo K., Armisén R., Stutzin A., Soto C., Hetz C. Prion protein misfolding affects calcium homeostasis and sensitizes cells to endoplasmic reticulum stress. PLoS One 2010, 5:e15658.
337. Toulmay A., Prinz W.A. Lipid transfer and signaling at organelle contact sites: the tip of the iceberg. Curr. Opin. Cell. Biol. 2011, 23:458-463.
338. Troncoso R., Vicencio J.M., Parra V., Nemchenko A., Kawashima Y., del Campo A., Toro B., Battiprolu P.K., Aranguiz P., Chiong M., et al. Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy. Cardiovasc. Res. 2011, 93:320-329.
339. Tu H., Nelson O., Bezprozvanny A., Wang Z., Lee S.-F., Hao Y.-H., Serneels L., De Strooper B., Yu G., Bezprozvanny I. Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell 2006, 126:981-993.
340. Urano F., Wang X., Bertolotti A., Zhang Y., Chung P., Harding H.P., Ron D. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000, 287:664-666.
341. van Bilsen M., van Nieuwenhoven F.A., van der Vusse G.J. Metabolic remodelling of the failing heart: beneficial or detrimental?. Cardiovasc. Res. 2009, 81:420-428.
342. van Huizen R., Martindale J.L., Gorospe M., Holbrook N.J. P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling. J. Biol. Chem. 2003, 278:15558-15564.
343. Vasington F.D., Murphy J.V. Ca ion uptake by rat kidney mitochondria and its dependence on respiration and phosphorylation. J. Biol. Chem. 1962, 237:2670-2677.
344. Vembar S.S., Brodsky J.L. One step at a time: endoplasmic reticulum-associated degradation. Nat. Rev. Mol. Cell Biol. 2008, 9:944-957.
345. Voeltz G.K., Prinz W.A., Shibata Y., Rist J.M., Rapoport T.A. A class of membrane proteins shaping the tubular endoplasmic reticulum. Cell 2006, 124:573-586.
346. Walter P., Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science 2011, 334:1081-1086.
347. Wang H., Kouri G., Wollheim C.B. ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity. J. Cell Sci. 2005, 118:3905-3915.
348. Wang H.G., Pathan N., Ethell I.M., Krajewski S., Yamaguchi Y., Shibasaki F., McKeon F., Bobo T., Franke T.F., Reed J.C. Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science 1999, 284:339-343.
349. Wang H.J., Guay G., Pogan L., Sauvé R., Nabi I.R. Calcium regulates the association between mitochondria and a smooth subdomain of the endoplasmic reticulum. J. Cell Biol. 2000, 150:1489-1498.
350. Wang Q., Li L., Ye Y. Inhibition of p97-dependent protein degradation by Eeyarestatin I. J. Biol. Chem. 2008, 283:7445-7454.
351. Wang X., Su B., Fujioka H., Zhu X. Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients. Am. J. Pathol. 2008, 173:470-482.
352. Wang X., Su B., Lee H.-G., Li X., Perry G., Smith M.A., Zhu X. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J. Neurosci. 2009, 29:9090-9103.
353. Wang X., Su B., Zheng L., Perry G., Smith M.A., Zhu X. The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. J. Neurochem. 2009, 109(Suppl. 1):153-159.
354. Wang Y., Inoue H., Ravnskjaer K., Viste K., Miller N., Liu Y., Hedrick S., Vera L., Montminy M. Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:3087-3092.
355. Wang Y., Vera L., Fischer W.H., Montminy M. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 2009, 460:534-537.
356. Waterman-Storer C.M., Salmon E.D. Endoplasmic reticulum membrane tubules are distributed by microtubules in living cells using three distinct mechanisms. Curr. Biol. 1998, 8:798-806.
357. Watson M.L. The nuclear envelope; its structure and relation to cytoplasmic membranes. J. Biophys. Biochem. Cytol. 1955, 1:257-270.
358. Webb G.C., Akbar M.S., Zhao C., Steiner D.F. Expression profiling of pancreatic beta cells: glucose regulation of secretory and metabolic pathway genes. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:5773-5778.
359. Wiertz E.J., Tortorella D., Bogyo M., Yu J., Mothes W., Jones T.R., Rapoport T.A., Ploegh H.L. Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. Nature 1996, 384:432-438.
360. Wilkinson B.M., Regnacq M., Stirling C.J. Protein translocation across the membrane of the endoplasmic reticulum. J. Membr. Biol. 1997, 155:189-197.
361. Wu J., Kaufman R.J. From acute ER stress to physiological roles of the Unfolded Protein Response. Cell Death Differ. 2006, 13:374-384.
362. Wu J., Ruas J.L., Estall J.L., Rasbach K.A., Choi J.H., Ye L., Boström P., Tyra H.M., Crawford R.W., Campbell K.P., et al. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metab. 2011, 13:160-169.
363. Wu J., Rutkowski D.T., Dubois M., Swathirajan J., Saunders T., Wang J., Song B., Yau G.D.-Y., Kaufman R.J. ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress. Dev. Cell 2007, 13:351-364.
364. Xu W., Liu L., Charles I.G., Moncada S. Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response. Nat. Cell Biol. 2004, 6:1129-1134.
365. Yamada M., Tomida A., Yun J., Cai B., Yoshikawa H., Taketani Y., Tsuruo T. Cellular sensitization to cisplatin and carboplatin with decreased removal of platinum-DNA adduct by glucose-regulated stress. Cancer Chemother. Pharmacol. 1999, 44:59-64.
366. Yamaguchi Y., Larkin D., Lara-Lemus R., Ramos-Castañeda J., Liu M., Arvan P. Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERK. J. Biol. Chem. 2008, 283:17020-17029.
367. Yamamoto K., Sato T., Matsui T., Sato M., Okada T., Yoshida H., Harada A., Mori K. Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1. Dev. Cell 2007, 13:365-376.
368. Yamamoto K., Yoshida H., Kokame K., Kaufman R.J., Mori K. Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. J. Biochem. 2004, 136:343-350.
369. Yan W., Frank C.L., Korth M.J., Sopher B.L., Novoa I., Ron D., Katze M.G. Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:15920-15925.
370. Yang W., Tiffany-Castiglioni E., Koh H.C., Son I.H. Paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y cells. Toxicol. Lett. 2009, 191:203-210.
371. Yanagitani K., Imagawa Y., Iwawaki T., Hosoda A., Saito M., Kimata Y., Kohno K. Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA. Mol. Cell 2009, 34:191-200.
372. Ye J., Kumanova M., Hart L.S., Sloane K., Zhang H., De Panis D.N., Bobrovnikova-Marjon E., Diehl J.A., Ron D., Koumenis C. The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J. 2010, 29:2082-2096.
373. Ye J., Rawson R.B., Komuro R., Chen X., Davé U.P., Prywes R., Brown M.S., Goldstein J.L. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol. Cell 2000, 6:1355-1364.
374. Ye Y., Meyer H.H., Rapoport T.A. The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol. Nature 2001, 414:652-656.
375. Ye Y., Shibata Y., Yun C., Ron D., Rapoport T.A. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature 2004, 429:841-847.
376. Yeh C.-H., Chen T.-P., Wang Y.-C., Lin Y.-M., Fang S.-W. AMP-activated protein kinase activation during cardioplegia-induced hypoxia/reoxygenation injury attenuates cardiomyocytic apoptosis via reduction of endoplasmic reticulum stress. Mediators Inflamm. 2010, 2010:130636.
377. Yoo B.C., Krapfenbauer K., Cairns N., Belay G., Bajo M., Lubec G. Overexpressed protein disulfide isomerase in brains of patients with sporadic Creutzfeldt-Jakob disease. Neurosci. Lett. 2002, 334:196-200.
378. Yorimitsu T., Klionsky D.J. Endoplasmic reticulum stress: a new pathway to induce autophagy. Autophagy 2007, 3:160-162.
379. Yorimitsu T., Nair U., Yang Z., Klionsky D.J. Endoplasmic reticulum stress triggers autophagy. J. Biol. Chem. 2006, 281:30299-30304.
380. Yoshida H., Haze K., Yanagi H., Yura T., Mori K. Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors. J. Biol. Chem. 1998, 273:33741-33749.
381. Yoshida H., Matsui T., Yamamoto A., Okada T., Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 2001, 107:881-891.
382. Yoshida H., Oku M., Suzuki M., Mori K. pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response. J. Cell Biol. 2006, 172:565-575.
383. Yoshida H., Uemura A., Mori K. pXBP1(U), a negative regulator of the unfolded protein response activator pXBP1(S), targets ATF6 but not ATF4 in proteasome-mediated degradation. Cell Struct. Funct. 2009, 34:1-10.
384. Yu J.-T., Chang R.C.-C., Tan L. Calcium dysregulation in Alzheimer's disease: from mechanisms to therapeutic opportunities. Prog. Neurobiol. 2009, 89:240-255.
385. Zalk R., Lehnart S.E., Marks A.R. Modulation of the ryanodine receptor and intracellular calcium. Annu. Rev. Biochem. 2007, 76:367-385.
386. Zampese E., Fasolato C., Kipanyula M.J., Bortolozzi M., Pozzan T., Pizzo P. Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:2777-2782.
387. Zenisek D., Matthews G. The role of mitochondria in presynaptic calcium handling at a ribbon synapse. Neuron 2000, 25:229-237.
388. Zhang K., Wang S., Malhotra J., Hassler J.R., Back S.H., Wang G., Chang L., Xu W., Miao H., Leonardi R., et al. The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis. EMBO J. 2011, 30:1357-1375.
389. Zhang W., Patil S., Chauhan B., Guo S., Powell D.R., Le J., Klotsas A., Matika R., Xiao X., Franks R., et al. FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J. Biol. Chem. 2006, 281:10105-10117.
390. Zhao P., Xiao X., Kim A.S., Leite M.F., Xu J., Zhu X., Ren J., Li J. c-Jun inhibits thapsigargin-induced ER stress through up-regulation of DSCR1/Adapt78. Exp. Biol. Med. (Maywood) 2008, 233:1289-1300.
391. Zheng H.C., Takahashi H., Li X.H., Hara T., Masuda S., Guan Y.F., Takano Y. Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas. Hum. Pathol. 2008, 39:1042-1049.
392. Zhou Y., Lee J., Reno C.M., Sun C., Park S.W., Chung J., Lee J., Fisher S.J., White M.F., Biddinger S.B., et al. Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat. Med. 2011, 17:356-365.
393. Zhu C., Johansen F.E., Prywes R. Interaction of ATF6 and serum response factor. Mol. Cell. Biol. 1997, 17:4957-4966.
394. Zhuang L., Scolyer R.A., Lee C.S., McCarthy S.W., Cooper W.A., Zhang X.D., Thompson J.F., Hersey P. Expression of glucose-regulated stress protein GRP78 is related to progression of melanoma. Histopathology 2009, 54:462-470.
395. Zimmet P., Alberti K.G., Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001, 414:782-787.
396. Zinszner H., Kuroda M., Wang X., Batchvarova N., Lightfoot R.T., Remotti H., Stevens J.L., Ron D. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev. 1998, 12:982-995.