Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress

Nature Cell Biology

Volumn 3, Issue 2, 2001, Pages 158-164

  Iwawaki, Takao ^a   Hosoda, Akira ^a   Okuda, Tetsuo ^a   Kamigori, Yusuke ^a   Nomura Furuwatari, Chizumi ^a   Kimata, Yukio ^a,b   Tsuru, Akio ^a,b   Kohno, Kenji ^a,b  

^a NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; RIBONUCLEASE;

ARTICLE; ENDOPLASMIC RETICULUM; GENE ACTIVATION; GLYCOSYLATION; HUMAN; HUMAN CELL; OLIGOMERIZATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ASSEMBLY; PROTEIN FOLDING; PROTEIN SYNTHESIS REGULATION; RNA CLEAVAGE; TRANSCRIPTION REGULATION; TRANSLATION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; APOPTOSIS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELLS, CULTURED; DOXYCYCLINE; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ENDORIBONUCLEASES; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RNA, RIBOSOMAL, 28S; SEQUENCE ALIGNMENT; TRANSFECTION; TUNICAMYCIN;

MAMMALIA;

EID: 0035147411     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35055065     Document Type: Article

References (36)

1. Protein folding in the cell
2. Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls
3. The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins
4. Calcium-dependent regulation of protein synthesis in intact mammalian cells
5. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase
6. +/CDC28-related kinase activity is required for signaling from the ER to the nucleus
7. A hybrid protein kinase-RNase in an interferon-induced pathway?
8. Intracellular signaling from the endoplasmic reticulum to the nucleus
9. Signaling from endoplasmic reticulum to nucleus: Transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway
10. The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum
11. A 22 b p cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins
12. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase / endoribonuclease (Ire1p) in mammalian cells
13. Cloning of mammalian Ire1 reveals diversity in the ER stress response
14. 3 pituitary cells by perturbants of early protein processing that induce GRP78
15. Regulation of eukaryotic protein synthesis by protein kinases that phosphorylate initiation factor eIF-2
16. Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase
17. Purification and properties of the double-stranded RNA-activated eukaryotic initiation factor 2 kinase from rabbit reticulocytes
18. Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha subunit kinase, PEK, involved in translational control
19. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
20. Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2α kinase
21. A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2α
22. Activation of the double-stranded RNA-regulated protein kinase by depletion of endoplasmic reticular calcium stores
23. Calcium depletion from the endoplasmic reticulum activates the double-stranded RNA-dependent protein kinase (PKR) to inhibit protein synthesis
24. Inhibition of biosynthesis of polyisoprenol sugars in chick embryo microsomes by tunicamycin
25. Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus
26. The unfolded protein response pathway in Saccharomyces cerevisiae
27. The structure of ribosomal RNA: A three-dimensional jigsaw puzzle
28. Correlation of the expansion segments in mammalian rRNA with the fine structure of the 80S ribosome
29. 2-terminal kinase by double-stranded RNA and encephalomyocarditis virus: Involvement of RNase L, protein kinase R, and alternative pathways
30. Perk is essential for translational regulation and cell survival during the unfolded protein response
31. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
32. Evading the interferon response: Hepatitis C virus and the interferon-induced protein kinase, PKR
33. nA) in interferon-treated cells
34. nA system in HeLa cells
35. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
36. Efficient selection for high-expression transfectants with a novel eukaryotic vector