Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2

International Journal of Biochemistry and Cell Biology

Volumn 39, Issue 10, 2007, Pages 1843-1851

  Colgan, Stephen M ^a   Tang, Damu ^b   Werstuck, Geoff H ^a   Austin, Richard C ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b ST JOSEPH S HOSPITAL   (Canada)

Author keywords

Caspases; Cholesterol; ER stress; SREBP; UPR

Indexed keywords

3BETA (2 DIETHYLAMINOETHOXY)ANDROST 5 EN 17 ONE; FILIPIN; HOMOCYSTEINE; PROTEINASE INHIBITOR; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; THAPSIGARGIN; TUNICAMYCIN;

ARTICLE; CELL STRAIN MCF 7; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; LIPID METABOLISM; PROTEIN DEGRADATION;

CASPASE 3; CHOLESTEROL; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; GENE EXPRESSION; HELA CELLS; HUMANS; PROTEIN PROCESSING, POST-TRANSLATIONAL; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; SULFONES; THAPSIGARGIN; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 34548220998     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2007.05.002     Document Type: Article

References (33)

1. DeBose-Boyd R.A., Brown M.S., Li W.P., Nohturfft A., Goldstein J.L., and Espenshade P.J. Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. Cell 99 (1999) 703-712
2. Feng B., Yao P.M., Li Y., Devlin C.M., Zhang D., Harding H.P., et al. The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat Cell Biol 5 (2003) 781-792
3. Goldstein J.L., DeBose-Boyd R.A., and Brown M.S. Protein sensors for membrane sterols. Cell 124 (2006) 35-46
4. Gong Y., Lee J.N., Lee P.C., Goldstein J.L., Brown M.S., and Ye J. Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. Cell Metab 3 (2006) 15-24
5. Harding H.P., Zhang Y., Khersonsky S., Marciniak S., Scheuner D., Kaufman R.J., et al. Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression. Cell Metab 2 (2005) 361-371
6. Higgins M.E., and Ioannou Y.A. Apoptosis-induced release of mature sterol regulatory element-binding proteins activates sterol-responsive genes. J Lipid Res 42 (2001) 1939-1946
7. Horton J.D., Goldstein J.L., and Brown M.S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109 (2002) 1125-1131
8. Hossain G.S., van Thienen J.V., Werstuck G.H., Zhou J., Sood S.K., Dickhout J.G., et al. TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia. J Biol Chem 278 (2003) 30317-30327
9. Hua X., Nohturfft A., Goldstein J.L., and Brown M.S. Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein. Cell 87 (1996) 415-426
10. Janicke R.U., Sprengart M.L., Wati M.R., and Porter A.G. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 273 (1998) 9357-9360
11. Ji C., and Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 124 (2003) 1488-1499
12. Kaufman R.J. Orchestrating the unfolded protein response in health and disease. J Clin Invest 110 (2002) 1389-1398
13. Lawrence de Koning A.B., Werstuck G.H., Zhou J., and Austin R.C. Hyperhomocysteinemia and its role in the development of atherosclerosis. Clin Biochem 36 (2003) 431-441
14. Lee A.S. The glucose-regulated proteins: stress induction and clinical applications. Trends Biochem Sci 26 (2001) 504-510
15. Lee J.N., and Ye J. Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1. J Biol Chem 279 (2004) 45257-45265
16. Lee T.H., and Linstedt A.D. Osmotically induced cell volume changes alter anterograde and retrograde transport, Golgi structure, and COPI dissociation. Mol Biol Cell 10 (1999) 1445-1462
17. Morishima N., Nakanishi K., Takenouchi H., Shibata T., and Yasuhiko Y. An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem 277 (2002) 34287-34294
18. Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B.A., et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403 (2000) 98-103
19. Okada T., Haze K., Nadanaka S., Yoshida H., Seidah N.G., Hirano Y., et al. A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. J Biol Chem 278 (2003) 31024-31032
20. Outinen P.A., Sood S.K., Liaw P.C., Sarge K.D., Maeda N., Hirsh J., et al. Characterization of the stress-inducing effects of homocysteine. Biochem J 332 Pt 1 (1998) 213-221
21. Outinen P.A., Sood S.K., Pfeifer S.I., Pamidi S., Podor T.J., Li J., et al. Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells. Blood 94 (1999) 959-967
22. Pai J.T., Brown M.S., and Goldstein J.L. Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins. Proc Natl Acad Sci USA 93 (1996) 5437-5442
23. Rawson R.B., DeBose-Boyd R., Goldstein J.L., and Brown M.S. Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein. J Biol Chem 274 (1999) 28549-28556
24. Ron D. Translational control in the endoplasmic reticulum stress response. J Clin Invest 110 (2002) 1383-1388
25. Rutkowski D.T., and Kaufman R.J. A trip to the ER: coping with stress. Trends Cell Biol 14 (2004) 20-28
26. Shimomura I., Shimano H., Horton J.D., Goldstein J.L., and Brown M.S. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J Clin Invest 99 (1997) 838-845
27. Sun L.P., Li L., Goldstein J.L., and Brown M.S. Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro. J Biol Chem 280 (2005) 26483-26490
28. Wang H., Kouri G., and Wollheim C.B. ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity. J Cell Sci 118 (2005) 3905-3915
29. Wang X., Pai J.T., Wiedenfeld E.A., Medina J.C., Slaughter C.A., Goldstein J.L., et al. Purification of an interleukin-1 beta converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains. J Biol Chem 270 (1995) 18044-18050
30. Wang X., Zelenski N.G., Yang J., Sakai J., Brown M.S., and Goldstein J.L. Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. Embo J 15 (1996) 1012-1020
31. Werstuck G.H., Lentz S.R., Dayal S., Hossain G.S., Sood S.K., Shi Y.Y., et al. Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways. J Clin Invest 107 (2001) 1263-1273
32. Yabe D., Brown M.S., and Goldstein J.L. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci USA 99 (2002) 12753-12758
33. Yang T., Espenshade P.J., Wright M.E., Yabe D., Gong Y., Aebersold R., et al. Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell 110 (2002) 489-500