The role of nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension

Science Translational Medicine

Volumn 3, Issue 88, 2011, Pages

  Sutendra, Gopinath ^a   Dromparis, Peter ^a   Wright, Paulette ^b   Bonnet, Sébastien ^a,c   Haromy, Alois ^a   Hao, Zhengrong ^b   McMurtry, M Sean ^a   Michalak, Marek ^a   Vance, Jean E ^a   Sessa, William C ^b   Michelakis, Evangelos D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CALCIUM; GREEN FLUORESCENT PROTEIN; HYPOXIA INDUCIBLE FACTOR; INTRAMITOCHONDRIAL CALCIUM; MITOCHONDRIAL ENZYME; PHOSPHOLIPID; PROTEIN NOGO; PROTEIN NOGO A; PROTEIN NOGO B; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL; ACTIVATING TRANSCRIPTION FACTOR 6; HYPOXIA INDUCIBLE FACTOR 1; MYELIN PROTEIN; POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL STRUCTURE; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENDOPLASMIC RETICULUM STRESS; GENE DOSAGE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NONHUMAN; PATHOGENESIS; PHOSPHOLIPID TRANSFER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PULMONARY ARTERY; PULMONARY HYPERTENSION; SMOOTH MUSCLE FIBER; VIRAL GENE DELIVERY SYSTEM; ANIMAL; ANOXIA; CYTOLOGY; ENDOPLASMIC RETICULUM; GENETICS; METABOLISM; MOUSE MUTANT; PATCH CLAMP; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ACTIVATING TRANSCRIPTION FACTOR 6; ANIMALS; ANOXIA; ENDOPLASMIC RETICULUM; HUMANS; HYPERTENSION, PULMONARY; HYPOXIA-INDUCIBLE FACTOR 1; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MYELIN PROTEINS; MYOCYTES, SMOOTH MUSCLE; NFATC TRANSCRIPTION FACTORS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; PULMONARY ARTERY; SIGNAL TRANSDUCTION;

EID: 79959464127     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3002194     Document Type: Article

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52. Funding: This study was funded by the Canadian Institutes of Health Research, the Canada Research Chair Program (E.D.M.), and the Alberta Heritage Foundation for Medical Research (E.D.M. and P.D.). Author contributions: G.S. performed the experiments, analyzed the data, and wrote the first and co-wrote the final version of the manuscript. P.D. performed the experiments, analyzed the data, and edited the manuscript. P.W., A.H., S.B., and Z.H. performed the experiments. M.S.M., M.M., J.E.V., and W.C.S. contributed materials and co-edited the manuscript. E.D.M. generated the hypothesis; designed, directed, and funded the study; and co-wrote the final version of the manuscript. Competing interests: The authors declare that they have no competing interests.