SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production

Journal of Cell Biology

Volumn 181, Issue 7, 2008, Pages 1107-1116

  Green, Kim N ^a   Demuro, Angelo ^a   Akbari, Yama ^a   Hitt, Brian D ^a   Smith, Ian F ^a   Parker, Ian ^a   LaFerla, Frank M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CALCIUM; INOSITOL 1,4,5 TRISPHOSPHATE; MEMBRANE PROTEIN; PRESENILIN; PROTEIN PS1; PROTEIN PS2; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2B;

ANIMAL CELL; ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOSOL; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; FIBROBLAST; GENE MUTATION; GENE OVEREXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; STEADY STATE; XENOPUS LAEVIS;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN; ANIMALS; CALCIUM; CHO CELLS; CRICETINAE; CRICETULUS; CYTOSOL; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; FIBROBLASTS; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE; MICE; MICE, KNOCKOUT; MUTATION; PRESENILIN-1; PRESENILIN-2; PROTEIN BINDING; PROTEIN TRANSPORT; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES;

XENOPUS LAEVIS;

EID: 46249123354     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200706171     Document Type: Article

References (28)

1. Aubier, M., and N. Viires. 1998. Calcium ATPase and respiratory muscle function. Eur. Respir. J. 11:758-766.
2. Baba-Aissa, F., L. Raeymaekers, F. Wuytack, L. Dode, and R. Casteels. 1998. Distribution and isoform diversity of the organellar Ca2+ pumps in the brain. Mol. Chem. Neuropathol. 33:199-208.
3. Berridge, M.J., P. Lipp, and M.D. Bootman. 2000. The versatility and universality of calcium signalling. Nat. Rev. Mol. Cell Biol. 1:11-21.
4. Callamaras, N., and I. Parker. 1999. Radial localization of inositol 1,4,5-trisphosphate-sensitive Ca2+ release sites in Xenopus oocytes resolved by axial confocal linescan imaging. J. Gen. Physiol. 113:199-213.
5. Chen, Q., and D. Schubert. 2002. Presenilin-interacting proteins. Expert Rev. Mol. Med. 4:1-18.
6. Demuro, A., E. Mina, R. Kayed, S.C. Milton, I. Parker, and C.G. Glabe. 2005. Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J. Biol. Chem. 280:17294-17300.
7. Duff, K., C. Eckman, C. Zehr, X. Yu, C.M. Prada, J. Perez-tur, M. Hutton, L. Buee, Y. Harigaya, D. Yager, et al. 1996. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature. 383:710-713.
8. Hass, M.R., and B.A. Yankner. 2005. A { gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein. J. Biol. Chem. 280:36895-36904.
9. Herms, J., I. Schneider, I. Dewachter, N. Caluwaerts, H. Kretzschmar, and F. Van Leuven. 2003. Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein. J. Biol. Chem. 278:2484-2489.
10. Herreman, A., D. Hartmann, W. Annaert, P. Saftig, K. Craessaerts, L. Serneels, L. Umans, V. Schrijvers, F. Checler, H. Vanderstichele, et al. 1999. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc. Natl. Acad. Sci. USA. 96:11872-11877.
11. Kasri, N.N., S.L. Kocks, L. Verbert, S.S. Hebert, G. Callewaert, J.B. Parys, L. Missiaen, and H. De Smedt. 2006. Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells. Cell Calcium. 40:41-51.
12. LaFerla, F.M. 2002. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat. Rev. Neurosci. 3:862-872.
13. Leissring, M.A., I. Parker, and F.M. LaFerla. 1999a. Presenilin-2 mutations modulate amplitude and kinetics of inositol 1,4,5-trisphosphate- mediated calcium signals. J. Biol. Chem. 274:32535-32538.
14. Leissring, M.A., B.A. Paul, I. Parker, C.W. Cotman, and F.M. LaFerla. 1999b. Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes. J. Neurochem. 72:1061-1068.
15. Leissring, M.A., Y. Akbari, C.M. Fanger, M.D. Cahalan, M.P. Mattson, and F.M. LaFerla. 2000. Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice. J. Cell Biol. 149:793-798.
16. Leissring, M.A., M.P. Murphy, T.R. Mead, Y. Akbari, M.C. Sugarman, M. Jannatipour, B. Anliker, U. Muller, P. Saftig, B. De Strooper, et al. 2002. A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proc. Natl. Acad. Sci. USA. 99:4697-4702.
17. Lytton, J., M. Westlin, and M.R. Hanley. 1991. Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps. J. Biol. Chem. 266:17067-17071.
18. Pierrot, N., P. Ghisdal, A.S. Caumont, and J.N. Octave. 2004. Intraneuronal amyloid-beta1-42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death. J. Neurochem. 88:1140-1150.
19. Querfurth, H.W., and D.J. Selkoe. 1994. Calcium ionophore increases amyloid beta peptide production by cultured cells. Biochemistry. 33:4550-4561.
20. Querfurth, H.W., J. Jiang, J.D. Geiger, and D.J. Selkoe. 1997. Caffeine stimulates amyloid beta-peptide release from beta-amyloid precursor protein-transfected HEK293 cells. J. Neurochem. 69:1580-1591.
21. Smith, I.F., J.P. Boyle, P.F. Vaughan, H.A. Pearson, R.F. Cowburn, and C.S. Peers. 2002. Ca(2+) stores and capacitative Ca(2+) entry in human neuroblastoma (SH-SY5Y) cells expressing a familial Alzheimer's disease presenilin-1 mutation. Brain Res. 949:105-111.
22. Stutzmann, G.E., A. Caccamo, F.M. LaFerla, and I. Parker. 2004. Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability. J. Neurosci. 24:508-513.
23. Tu, H., O. Nelson, A. Bezprozvanny, Z. Wang, S.F. L ee, Y.H. Hao, L. Serneels, B. De Strooper, G. Yu, and I. Bezprozvanny. 2006. Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell. 126:981-993.
24. Walter, J., A. Capell, J. Grunberg, B. Pesold, A. Schindzielorz, R. Prior, M.B. Podlisny, P. Fraser, P.S. Hyslop, D.J. Selkoe, and C. Haass. 1996. The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Mol. Med. 2:673-691.
25. Yano, K., O.H. Petersen, and A.V. Tepikin. 2004. Dual sensitivity of sarcoplasmic/ endoplasmic Ca2+-ATPase to cytosolic and endoplasmic reticulum Ca2+ as a mechanism of modulating cytosolic Ca2+ oscillations. Biochem. J. 383:353-360.
26. Yoo, A.S., I. Cheng, S. Chung, T.Z. Grenfell, H. Lee, E. Pack-Chung, M. Handler, J. Shen, W. Xia, G. Tesco, et al. 2000. Presenilin-mediated modulation of capacitative calcium entry. Neuron. 27:561-572.
27. Zhang, S.L., A.V. Y eromin, X.H. Zhang, Y. Yu, O. Safrina, A. Penna, J. Roos, K.A. Stauderman, and M.D. Cahalan. 2006. Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Proc. Natl. Acad. Sci. USA. 103:9357-9362.
28. Zhang, Z., P. Nadeau, W. Song, D. Donoviel, M. Yuan, A. Bernstein, and B.A. Yankner. 2000. Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1. Nat. Cell Biol. 2:463-465.