Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

Neuron

Volumn 58, Issue 6, 2008, Pages 871-883

  Cheung, King Ho ^a   Shineman, Diana ^a,b   Müller, Marioly ^a   Cárdenas, César ^a   Mei, Lijuan ^a   Yang, Jun ^a   Tomita, Taisuke ^c   Iwatsubo, Takeshi ^c   Lee, Virginia M Y ^a,b   Foskett, J Kevin ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

HUMDISEASE; MOLNEURO

Indexed keywords

AMYLOID BETA PROTEIN[25-35]; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; PRESENILIN; RYANODINE RECEPTOR; AMYLOID BETA PROTEIN; CALCIUM;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CHANNEL GATING; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; ANIMAL; ARMYWORM; CELL CULTURE; COMPARATIVE STUDY; DRUG ANTAGONISM; GENETICS; HUMAN; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CALCIUM; CALCIUM SIGNALING; CELLS, CULTURED; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; ION CHANNEL GATING; PRESENILINS; SPODOPTERA;

EID: 45249117227     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2008.04.015     Document Type: Article

References (67)

1. Balaban R.S. Cardiac energy metabolism homeostasis: role of cytosolic calcium. J. Mol. Cell. Cardiol. 34 (2002) 1259-1271
2. Barrow P.A., Empson R.M., Gladwell S.J., Anderson C.M., Killick R., Yu X., Jefferys J.G., and Duff K. Functional phenotype in transgenic mice expressing mutant human presenilin-1. Neurobiol. Dis. 7 (2000) 119-126
3. Berridge M.J., Lipp P., and Bootman M.D. The versatility and universality of calcium signalling. Nat. Rev. Mol. Cell Biol. 1 (2000) 11-21
4. Blennow K., de Leon M.J., and Zetterberg H. Alzheimer's disease. Lancet 368 (2006) 387-403
5. Buckner R.L., Snyder A.Z., Shannon B.J., LaRossa G., Sachs R., Fotenos A.F., Sheline Y.I., Klunk W.E., Mathis C.A., Morris J.C., and Mintun M.A. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J. Neurosci. 25 (2005) 7709-7717
6. Buxbaum J.D., Ruefli A.A., Parker C.A., Cypess A.M., and Greengard P. Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner. Proc. Natl. Acad. Sci. USA 91 (1994) 4489-4493
7. Cai W., Hisatsune C., Nakamura K., Nakamura T., Inoue T., and Mikoshiba K. Activity-dependent expression of inositol 1,4,5-trisphosphate receptor type 1 in hippocampal neurons. J. Biol. Chem. 279 (2004) 23691-23698
8. Cedazo-Minguez A., Popescu B.O., Ankarcrona M., Nishimura T., and Cowburn R.F. The presenilin 1 deltaE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations. J. Biol. Chem. 277 (2002) 36646-36655
9. Chan S.L., Mayne M., Holden C.P., Geiger J.D., and Mattson M.P. Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons. J. Biol. Chem. 275 (2000) 18195-18200
10. Cirrito J.R., Yamada K.A., Finn M.B., Sloviter R.S., Bales K.R., May P.C., Schoepp D.D., Paul S.M., Mennerick S., and Holtzman D.M. Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron 48 (2005) 913-922
11. Citron M., Westaway D., Xia W., Carlson G., Diehl T., Levesque G., Johnson-Wood K., Lee M., Seubert P., Davis A., et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat. Med. 3 (1997) 67-72
12. De Strooper B. Loss-of-function presenilin mutations in Alzheimer disease. Talking point on the role of presenilin mutations in Alzheimer disease. EMBO Rep. 8 (2007) 141-146
13. Edbauer D., Winkler E., Regula J.T., Pesold B., Steiner H., and Haass C. Reconstitution of gamma-secretase activity. Nat. Cell Biol. 5 (2003) 486-488
14. Etcheberrigaray R., Hirashima N., Nee L., Prince J., Govoni S., Racchi M., Tanzi R.E., and Alkon D.L. Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families. Neurobiol. Dis. 5 (1998) 37-45
15. 2+ release channels. Physiol. Rev. 87 (2007) 593-658
16. Gandy S., Doeven M.K., and Poolman B. Alzheimer disease: presenilin springs a leak. Nat. Med. 12 (2006) 1121-1123
17. Genazzani A.A., Carafoli E., and Guerini D. Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons. Proc. Natl. Acad. Sci. USA 96 (1999) 5797-5801
18. 2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia. Neurobiol. Dis. 18 (2005) 638-648
19. Guo Q., Furukawa K., Sopher B.L., Pham D.G., Xie J., Robinson N., Martin G.M., and Mattson M.P. Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide. Neuroreport 8 (1996) 379-383
20. Haass C., and Selkoe D.J. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat. Rev. Mol. Cell Biol. 8 (2007) 101-112
21. Hardy J. A hundred years of Alzheimer's disease research. Neuron 52 (2006) 3-13
22. Hardy J., and Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297 (2002) 353-356
23. Hebert S.S., Serneels L., Dejaegere T., Horre K., Dabrowski M., Baert V., Annaert W., Hartmann D., and De Strooper B. Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity. Neurobiol. Dis. 17 (2004) 260-272
24. Hirashima N., Etcheberrigaray R., Bergamaschi S., Racchi M., Battaini F., Binetti G., Govoni S., and Alkon D.L. Calcium responses in human fibroblasts: a diagnostic molecular profile for Alzheimer's disease. Neurobiol. Aging 17 (1996) 549-555
25. Hutton M., and Hardy J. The presenilins and Alzheimer's disease. Hum. Mol. Genet. 6 (1997) 1639-1646
26. 2+ release. J. Physiol. 573 (2006) 645-662
27. 2+ mobilization is altered in fibroblasts from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA 91 (1994) 534-538
28. Johnston J.M., Burnett P., Thomas A.P., and Tezapsidis N. Calcium oscillations in type-1 astrocytes, the effect of a presenilin 1 (PS1) mutation. Neurosci. Lett. 395 (2006) 159-164
29. Jolly-Tornetta C., Gao Z.Y., Lee V.M., and Wolf B.A. Regulation of amyloid precursor protein secretion by glutamate receptors in human Ntera 2 neurons. J. Biol. Chem. 273 (1998) 14015-14021
30. Kamenetz F., Tomita T., Hsieh H., Seabrook G., Borchelt D., Iwatsubo T., Sisodia S., and Malinow R. APP processing and synaptic function. Neuron 37 (2003) 925-937
31. 2+ content in presenilin double knock-out cells. Cell Calcium 40 (2006) 41-51
32. LaFerla F.M. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat. Rev. Neurosci. 3 (2002) 862-872
33. 3 receptors. Cell Calcium 38 (2005) 45-51
34. Leissring M.A., Parker I., and LaFerla F.M. Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals. J. Biol. Chem. 274 (1999) 32535-32538
35. Leissring M.A., Paul B.A., Parker I., Cotman C.W., and LaFerla F.M. Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes. J. Neurochem. 72 (1999) 1061-1068
36. Leissring M.A., Akbari Y., Fanger C.M., Cahalan M.D., Mattson M.P., and LaFerla F.M. Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice. J. Cell Biol. 149 (2000) 793-798
37. Leissring M.A., LaFerla F.M., Callamaras N., and Parker I. Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling. Neurobiol. Dis. 8 (2001) 469-478
38. 2+ entry into HEK293 cells. Cell. Signal. 17 (2005) 437-445
39. 2+ inhibition. Proc. Natl. Acad. Sci. USA 95 (1998) 15821-15825
40. Mattson M.P. Pathways towards and away from Alzheimer's disease. Nature 430 (2004) 631-639
41. Mattson M.P., and Guo Q. Cell and molecular neurobiology of presenilins: a role for the endoplasmic reticulum in the pathogenesis of Alzheimer's disease?. J. Neurosci. Res. 50 (1997) 505-513
42. Mattson M.P., and Chan S.L. Neuronal and glial calcium signaling in Alzheimer's disease. Cell Calcium 34 (2003) 385-397
43. Mattson M.P., Zhu H., Yu J., and Kindy M.S. Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis. J. Neurosci. 20 (2000) 1358-1364
44. McCormack J.G., Halestrap A.P., and Denton R.M. Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiol. Rev. 70 (1990) 391-425
45. Meberg P.J., and Miller M.W. Culturing hippocampal and cortical neurons. Methods Cell Biol. 71 (2003) 111-127
46. 2+ leak function of presenilin 1. J. Clin. Invest. 117 (2007) 1230-1239
47. Oh Y.S., and Turner R.J. Effect of gamma-secretase inhibitors on muscarinic receptor-mediated calcium signaling in human salivary epithelial cells. Am. J. Physiol. Cell Physiol. 291 (2006) C76-C82
48. Querfurth H.W., and Selkoe D.J. Calcium ionophore increases amyloid beta peptide production by cultured cells. Biochemistry 33 (1994) 4550-4561
49. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T.D., Hardy J., Hutton M., Kukull W., et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2 (1996) 864-870
50. Schneider I., Reverse D., Dewachter I., Ris L., Caluwaerts N., Kuiperi C., Gilis M., Geerts H., Kretzschmar H., Godaux E., et al. Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation. J. Biol. Chem. 276 (2001) 11539-11544
51. Shen J., and Kelleher III R.J. The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proc. Natl. Acad. Sci. USA 104 (2007) 403-409
52. 2+ entry in human neuroblastoma (SH-SY5Y) cells expressing a familial Alzheimer's disease presenilin-1 mutation. Brain Res. 949 (2002) 105-111
53. Smith I.F., Green K.N., and LaFerla F.M. Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals. Cell Calcium 38 (2005) 427-437
54. 2+ release in the 3xTg-AD mouse model of Alzheimer's disease. J. Neurochem. 94 (2005) 1711-1718
55. 3 signaling, and Alzheimer's disease. Neuroscientist 11 (2005) 110-115
56. 2+ signals and altered membrane excitability. J. Neurosci. 24 (2004) 508-513
57. 2+ disruptions in young, adult, and aged Alzheimer's disease mice. J. Neurosci. 26 (2006) 5180-5189
58. Sugawara H., Kurosaki M., Takata M., and Kurosaki T. Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor. EMBO J. 16 (1997) 3078-3088
59. Supnet C., Grant J., Kong H., Westaway D., and Mayne M. Amyloid-beta-(1-42) increases ryanodine receptor-3 expression and function in neurons of TgCRND8 mice. J. Biol. Chem. 281 (2006) 38440-38447
60. Suzuki N., Cheung T.T., Cai X.D., Odaka A., Otvos Jr. L., Eckman C., Golde T.E., and Younkin S.G. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science 264 (1994) 1336-1340
61. 2+ signaling. FASEB J. 19 (2005) 2069-2071
62. 2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell 126 (2006) 981-993
63. Verkhratsky A. Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons. Physiol. Rev. 85 (2005) 201-279
64. 3R. Nat. Cell Biol. 7 (2005) 1021-1028
65. Yoo A.S., Cheng I., Chung S., Grenfell T.Z., Lee H., Pack-Chung E., Handler M., Shen J., Xia W., Tesco G., et al. Presenilin-mediated modulation of capacitative calcium entry. Neuron 27 (2000) 561-572
66. 2+ release from intracellular stores. Neurobiol. Dis. 15 (2004) 269-278
67. Zatti G., Burgo A., Giacomello M., Barbiero L., Ghidoni R., Sinigaglia G., Florean C., Bagnoli S., Binetti G., Sorbi S., et al. Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels. Cell Calcium 39 (2006) 539-550