Axonopathy and transport deficits early in the pathogenesis of Alzheimer's diseases

Science

Volumn 307, Issue 5713, 2005, Pages 1282-1288

  Stokin, Gorazd B ^a   Lillo, Concepción ^b   Falzone, Tomás L ^a   Brusch, Richard G ^a   Rockenstein, Edward ^c   Mount, Stephanie L ^a   Raman, Rema ^e   Davies, Peter ^f   Masliah, Eliezer ^c,d   Williams, David S ^b,c   Goldstein, Lawrence S B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b San Diego   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMEDICAL ENGINEERING; HUMAN ENGINEERING; LIVING SYSTEMS STUDIES; PATHOLOGY; PROTEINS; REDUCTION;

AXONAL DEFECTS; PATHOGENESIS; SENILE PLAQUES;

DISEASES;

AMYLOID PRECURSOR PROTEIN; KINESIN;

MEDICINE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ORGANELLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; MEMBRANE VESICLE; MICROTUBULE; MOUSE; NERVE FIBER TRANSPORT; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NEUROPATHY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; SENILE PLAQUE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; AXONAL TRANSPORT; AXONS; BASAL NUCLEUS OF MEYNERT; BRAIN; CELLS, CULTURED; CYTOPLASMIC VESICLES; FEMALE; HIPPOCAMPUS; HUMANS; KINESIN; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICROTUBULE-ASSOCIATED PROTEINS; NEURONS; ORGANELLES; SENILE PLAQUES; TIME FACTORS;

EID: 20044385920     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1105681     Document Type: Article

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38. We thank D. W. Cleveland, F. H. Gage, P. R. Mouton, and R. D. Terry for helpful discussions; M. Yasuda for help with primary hippocampal cultures; M. P. Sundsmo and the UCSD Alzheimer's Disease Research Center (ADRC) for human samples; and the UCSD Cancer Center Digital Imaging Shared Resource for help with imaging. Supported by an Ellison Medical Foundation Senior Scholar Award in Aging Research (L.S.B.G.); NIH grant nos. EY13408, EY12598 (D.S.W.), and PSO AG05131 (A.D.R.C.); a Pew Foundation fellowship (T.L.F.); and a Boehringer-Ingelheim Fonds fellowship (G.B.S.). L.S.B.G. is an Investigator of the Howard Hughes Medical Institute.