Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2

EMBO Journal

Volumn 23, Issue 1, 2004, Pages 169-179

  Lu, Phoebe D ^a   Jousse, Céline ^a   Marciniak, Stefan J ^a   Zhang, Yuhong ^a   Novoa, Isabel ^a   Scheuner, Donalyn ^b   Kaufman, Randal J ^b   Ron, David ^a   Harding, Heather P ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Preconditioning; Protein kinases; Reactive oxygen species; Signal transduction; Translation

Indexed keywords

INITIATION FACTOR; PANCREATIC ENDOPLASMIC RETICULUM KINASE; PEROXYNITRITE; PHOSPHOTRANSFERASE; PROTEIN SUBUNIT; TRANSLATION INITIATION FACTOR 2; UNCLASSIFIED DRUG;

ARTICLE; CELL PROTECTION; DIMERIZATION; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; GENE EXPRESSION; GENE REPRESSION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RNA TRANSLATION; SIGNAL TRANSDUCTION;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; CELL LINE, TRANSFORMED; CELL SURVIVAL; CELL TRANSFORMATION, VIRAL; CYTOPROTECTION; DIMERIZATION; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME INHIBITORS; EUKARYOTIC INITIATION FACTOR-2; GENE EXPRESSION REGULATION; GLUTAMATES; MICE; OXIDATIVE STRESS; PANCREAS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN STRUCTURE, TERTIARY; REACTIVE OXYGEN SPECIES; RECOMBINANT FUSION PROTEINS; RETROVIRIDAE; SIGNAL TRANSDUCTION; TACROLIMUS; THAPSIGARGIN; TRANS-ACTIVATORS; TUNICAMYCIN;

EID: 0842285401     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600030     Document Type: Article

References (42)

1. Anderson ME 1985 Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol 113: 548-555
2. Bertolotti A, Zhang Y, Hendershot L, Harding H, Ron D 2000 Dynamic interaction of BiP and the ER stress transducers in the unfolded protein response. Nat Cell Biol 2: 326-332
3. Brostrom CO, Brostrom MA 1998 Regulation of translational initiation during cellular responses to stress. Prog Nucleic Acid Res Mol Biol 58: 79-125
4. Chen J 2000 Heme-regulated eIF2α kinase. In Translational Control of Gene Expression, Sonenberg N, Hershey JWB, and Mathews MB (eds) pp 529-546. Cold Spring Harbor: CSHL Press
5. Davis JB, Maher P 1994 Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell line. Brain Res 652:169-173
6. DeGracia DJ, Kumar R, Owen CR, Krause GS, White BC 2002 Molecular pathways of protein synthesis inhibition during brain reperfusion: implications for neuronal survival or death. J Cereb Blood Flow Metab 22: 127-141
7. Dever TE 2002 Gene-specific regulation by general translation factors. Cell 108: 545-556
8. Frerichs KU, Hallenbeck JM 1998 Hibernation in ground squirrels induces state and species-specific tolerance to hypoxia and aglycemia: an in vitro study in hippocampal slices. J Cereb Blood Flow Metab 18: 168-175
9. Frerichs KU, Kennedy C, Sokoloff L, Hallenbeck JM 1994 Local cerebral blood flow during hibernation, a model of natural tolerance to 'cerebral ischemia'. J Cereb Blood Flow Metab 14: 193-205
10. Frerichs KU, Smith CB, Brenner M, DeGracia DJ, Krause GS, Marrone L, Dever TE, Hallenbeck JM 1998 Suppression of protein synthesis in brain during hibernation involves inhibition of protein initiation and elongation. Proc Natl Acad Sci USA 95: 14511-14516
11. Griffith OW 1980 Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 106: 207-212
12. Harding H, Novoa I, Zhang Y, Zeng H, Wek RC, Schapira M, Ron D 2000a Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 6: 1099-1108
13. Harding H, Zeng H, Zhang Y, Jungreis R, Chung P, Plesken H, Sabatini D, Ron D 2001 Diabetes mellitus and exocrine pancreatic dysfunction in Perk-/- mice reveals a role for translational control in survival of secretory cells. Mol Cell 7: 1153-1163
14. Harding H, Zhang Y, Bertolotti A, Zeng H, Ron D 2000b Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell 5: 897-904
15. Harding H, Zhang Y, Zeng H, Novoa I, Lu P, Calfon M, Sadri N, Yun C, Popko B, Paules R, Stojdl D, Bell J, Hettmann T, Leiden J, Ron D 2003 An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 11: 619-633
16. Harding HP, Calfon M, Urano F, Novoa I, Ron D 2002 Transcriptional and translational control in the mammalian unfolded protein response. Annu Rev Cell Dev Biol 18: 575-599
17. Hinnebusch AG 2000 Mechanism and regulation of initiator methionyl-tRNA binding to ribosomes. In Translational Control of Gene Expression, Sonenberg N, Hershey JWB, Mathews MB (eds) pp 185-243. Cold Spring Harbor: CSHL Press
18. Kaufman RJ 2000 The double-stranded RNA-activated protein kinase PKR. In Translational Control of Gene Expression, Sonenberg N, Hershey JWB, Mathews MB (eds) pp 503-527. Cold Spring Harbor: CSHL Press
19. Kaufman RJ 2002 Orchestrating the unfolded protein response in health and disease. J Clin Invest 110: 1389-1398
20. Kumar R, Azam S, Sullivan J, Owen C, Cavener D, Zhang P, Ron D, Harding H, Chen J, Han A, White B, Krause G, DeGracia D 2001 Brain ischemia and reperfusion activates the eukaryotic initiation factor 2α kinase, PERK. J Neurochem 77: 1418-1421
21. Landau N, Littman D 1992 Packaging system for rapid production of murine leukemia virus vectors with variable tropism. J Virol 66: 5110-5113
22. Liu CY, Schroder M, Kaufman RJ 2000 Ligand-independent dimerization activates the stress-response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum. J Biol Chem 275: 24881-24885
23. Lockhart DJ, Dong H, Byrne MC, Follettie MT, Gallo MV, Chee MS, Mittmann M, Wang C, Kobayashi M, Horton H, Brown EL 1996 Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat Biotechnol 14: 1675-1680
24. Maher P, Davis JB 1996 The role of monoamine metabolism in oxidative glutamate toxicity. J Neurosci 16: 6394-6401
25. McCullough KD, Martindale JL, Klotz LO, Aw TY, Holbrook NJ 2001 Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 21: 1249-1259
26. Miyamoto M, Murphy TH, Schnaar RL, Coyle JT 1989 Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line. J Pharmacol Exp Ther 250: 1132-1140
27. Morgenstern JP, Land H 1990 Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res 18: 3587-3596
28. Morimoto BH, Koshland Jr DE 1990 Induction and expression of long- and short-term neurosecretory potentiation in a neural cell line. Neurone 5: 875-880
29. Murphy TH, Miyamoto M, Sastre A, Schnaar RL, Coyle JT 1989 Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neurone 2: 1547-1558
30. Novoa I, Zeng H, Harding H, Ron D 2001 Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2α. J Cell Biol 153: 1011-1022
31. Novoa I, Zhang Y, Zeng H, Jungreis R, Harding HP, Ron D 2003 Stress-induced gene expression requires programmed recovery from translational repression. EMBO J 22: 1180-1187
32. Ron D, Harding H 2000 PERK and translational control by stress in the endoplasmic reticulum. In Translational Control, Hershey J, Mathews M, Sonenberg N (eds) pp 547-560. Cold Spring Harbor: CSHL Press
33. Scheuner D, Song B, McEwen E, Gillespie P, Saunders T, Bonner-Weir S, Kaufman RJ 2001 Translational control is required for the unfolded protein response and in-vivo glucose homeostasis. Mol Cell 7: 1165-1176
34. Schubert D, Piasecki D 2001 Oxidative glutamate toxicity can be a component of the excitotoxicity cascade. J Neurosci 21: 7455-7462
35. Spencer DM, Wandless TJ, Schreiber SL, Crabtree GR 1993 Controlling signal transduction with synthetic ligands. Science 262: 1019-1024
36. Srivastava SP, Kumar KU, Kaufman RJ 1998 Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase. J Biol Chem 273: 2416-2423
37. Tan S, Sagara Y, Liu Y, Maher P, Schubert D 1998a The regulation of reactive oxygen species production during programmed cell death. J Cell Biol 141: 1423-1432
38. Tan S, Somia N, Maher P, Schubert D 2001 Regulation of antioxidant metabolism by translation initiation factor 2alpha. J Cell Biol 152: 997-1006
39. Tan S, Wood M, Maher P 1998b Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells. J Neurochem 71: 95-105
40. Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J, Gannon M, Ma K, McNaughton K, Cavener DR 2002a The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol 22: 3864-3874
41. Zhang P, McGrath BC, Reinert J, Olsen DS, Lei L, Gill S, Wek SA, Vattem KM, Wek RC, Kimball SR, Jefferson LS, Cavener DR 2002b The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol 22: 6681-6688
42. Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, Remotti H, Stevens JL, Ron D 1998 CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev 12: 982-995