메뉴 건너뛰기




Volumn 119, Issue 5 SUPPL. 1, 2006, Pages S10-S16

Etiology of insulin resistance

Author keywords

Fat; Insulin resistance; Insulin sensitivity; Obesity; The metabolic syndrome; Type 2 diabetes mellitus

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ACYL COENZYME A; ADIPOCYTOKINE; DIACYLGLYCEROL; GLUCOSE; GLYCOGEN; INTERLEUKIN 6; LEPTIN; PHOSPHATIDYLINOSITOL 3 KINASE; RESISTIN; TYROSINE;

EID: 33645074450     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjmed.2006.01.009     Document Type: Article
Times cited : (660)

References (51)
  • 1
    • 2542418066 scopus 로고    scopus 로고
    • Primary prevention of type 2 diabetes mellitus by lifestyle intervention: Implications for health policy
    • D.F. Williamson, F. Vinicor, B.A. Bowman Primary prevention of type 2 diabetes mellitus by lifestyle intervention implications for health policy Ann Intern Med 40 2004 951 957
    • (2004) Ann Intern Med , vol.40 , pp. 951-957
    • Williamson, D.F.1    Vinicor, F.2    Bowman, B.A.3
  • 4
    • 0043244907 scopus 로고    scopus 로고
    • Economic costs of diabetes in the US in 2002
    • P. Hogan, T. Dall, P. Nikolov Economic costs of diabetes in the US in 2002 Diabetes Care 26 2003 917 932
    • (2003) Diabetes Care , vol.26 , pp. 917-932
    • Hogan, P.1    Dall, T.2    Nikolov, P.3
  • 5
    • 0042358830 scopus 로고    scopus 로고
    • The costs of type 2 diabetes mellitus in Italy: A CODE-2 substudy
    • C. Lucioni, M.P. Garancini, M. Massi-Benedetti The costs of type 2 diabetes mellitus in Italy a CODE-2 substudy Treat Endocrinol 2 2003 121 133
    • (2003) Treat Endocrinol , vol.2 , pp. 121-133
    • Lucioni, C.1    Garancini, M.P.2    Massi-Benedetti, M.3
  • 7
    • 84870816352 scopus 로고    scopus 로고
    • International Diabetes Federation. Diabetes Atlas. Available at: http://www.eatlas.idf.org/. Accessed June 1, 2005.
    • Diabetes Atlas
  • 9
    • 0035787309 scopus 로고    scopus 로고
    • Nuclear magnetic resonance studies of hepatic glucose metabolism in humans
    • M. Roden, K.F. Petersen, G.I. Shulman Nuclear magnetic resonance studies of hepatic glucose metabolism in humans Recent Prog Horm Res 56 2001 219 237
    • (2001) Recent Prog Horm Res , vol.56 , pp. 219-237
    • Roden, M.1    Petersen, K.F.2    Shulman, G.I.3
  • 10
    • 0025376250 scopus 로고
    • Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake: A dose-response euglycemic clamp study in normal and diabetic rats
    • L. Rossetti, A. Giaccari Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake a dose-response euglycemic clamp study in normal and diabetic rats J Clin Invest 85 1990 1785 1792
    • (1990) J Clin Invest , vol.85 , pp. 1785-1792
    • Rossetti, L.1    Giaccari, A.2
  • 12
    • 0026611962 scopus 로고
    • 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus
    • 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus J Clin Invest 89 1992 1069 1075
    • (1992) J Clin Invest , vol.89 , pp. 1069-1075
    • Rothman, D.L.1    Shulman, R.G.2    Shulman, G.I.3
  • 13
    • 0033595120 scopus 로고    scopus 로고
    • Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes
    • G.W. Cline, K.F. Petersen, M. Krssak Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes N Engl J Med 341 1999 240 246
    • (1999) N Engl J Med , vol.341 , pp. 240-246
    • Cline, G.W.1    Petersen, K.F.2    Krssak, M.3
  • 14
    • 0025663581 scopus 로고
    • Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents
    • J.H. Warram, B.C. Martin, A.S. Krolewski Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents Ann Intern Med 113 1990 909 915
    • (1990) Ann Intern Med , vol.113 , pp. 909-915
    • Warram, J.H.1    Martin, B.C.2    Krolewski, A.S.3
  • 15
    • 0026793446 scopus 로고
    • Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a 25-year follow-up study
    • B.C. Martin, J.H. Warram, A.S. Krolewski Role of glucose and insulin resistance in development of type 2 diabetes mellitus results of a 25-year follow-up study Lancet 340 1992 925 929
    • (1992) Lancet , vol.340 , pp. 925-929
    • Martin, B.C.1    Warram, J.H.2    Krolewski, A.S.3
  • 16
    • 0037418309 scopus 로고    scopus 로고
    • Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease
    • A.B. Goldfine, C. Bouche, R.A. Parker Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease Proc Natl Acad Sci U S A 100 2003 2724 2729
    • (2003) Proc Natl Acad Sci U S a , vol.100 , pp. 2724-2729
    • Goldfine, A.B.1    Bouche, C.2    Parker, R.A.3
  • 17
    • 0032980306 scopus 로고    scopus 로고
    • Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus
    • Finland-United States Investigation of NIDDM Genetics (FUSION) Study investigators E.R.
    • R.M. Watanabe, T. Valle, E.R. Hauser Finland-United States Investigation of NIDDM Genetics (FUSION) Study investigators Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus Hum Hered 49 1999 159 168
    • (1999) Hum Hered , vol.49 , pp. 159-168
    • Watanabe, R.M.1    Valle, T.2    Hauser3
  • 18
    • 0030941820 scopus 로고    scopus 로고
    • Metabolic defects in lean nondiabetic offspring of NIDDM parents: A cross-sectional study
    • G. Perseghin, S. Ghosh, K. Gerow, G.I. Shulman Metabolic defects in lean nondiabetic offspring of NIDDM parents a cross-sectional study Diabetes 46 1997 1001 1009
    • (1997) Diabetes , vol.46 , pp. 1001-1009
    • Perseghin, G.1    Ghosh, S.2    Gerow, K.3    Shulman, G.I.4
  • 19
    • 0029787329 scopus 로고    scopus 로고
    • Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects
    • D.I. Phillips, S. Caddy, V. Ilic Intramuscular triglyceride and muscle insulin sensitivity evidence for a relationship in nondiabetic subjects Metabolism 45 1996 947 950
    • (1996) Metabolism , vol.45 , pp. 947-950
    • Phillips, D.I.1    Caddy, S.2    Ilic, V.3
  • 22
    • 0032764784 scopus 로고    scopus 로고
    • 13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents
    • 13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents Diabetes 48 1999 1600 1606
    • (1999) Diabetes , vol.48 , pp. 1600-1606
    • Perseghin, G.1    Scifo, P.2    De Cobelli, F.3
  • 23
    • 0024244339 scopus 로고
    • Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM
    • G.M. Reaven, C. Hollenbeck, C.Y. Jeng Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM Diabetes 37 1988 1020 1024
    • (1988) Diabetes , vol.37 , pp. 1020-1024
    • Reaven, G.M.1    Hollenbeck, C.2    Jeng, C.Y.3
  • 24
    • 0013844340 scopus 로고
    • The glucose fatty acid cycle in obesity and maturity-onset diabetes mellitus
    • P.J. Randle, P.B. Garland, E.A. Newsholme, C.N. Hales The glucose fatty acid cycle in obesity and maturity-onset diabetes mellitus Ann N Y Acad Sci 131 1965 324 333
    • (1965) Ann N Y Acad Sci , vol.131 , pp. 324-333
    • Randle, P.J.1    Garland, P.B.2    Newsholme, E.A.3    Hales, C.N.4
  • 25
    • 0028342686 scopus 로고
    • Mechanisms of fatty acid-induced inhibition of glucose uptake
    • G. Boden, X. Chen, J. Ruiz Mechanisms of fatty acid-induced inhibition of glucose uptake J Clin Invest 93 1994 2438 2446
    • (1994) J Clin Invest , vol.93 , pp. 2438-2446
    • Boden, G.1    Chen, X.2    Ruiz, J.3
  • 26
    • 0029948212 scopus 로고    scopus 로고
    • Mechanism of free fatty acid-induced insulin resistance in humans
    • M. Roden, T.B. Price, G. Perseghin Mechanism of free fatty acid-induced insulin resistance in humans J Clin Invest 97 1996 2859 2865
    • (1996) J Clin Invest , vol.97 , pp. 2859-2865
    • Roden, M.1    Price, T.B.2    Perseghin, G.3
  • 27
    • 0032954778 scopus 로고    scopus 로고
    • Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
    • A. Dresner, D. Laurent, M. Marcucci Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity J Clin Invest 103 1999 253 259
    • (1999) J Clin Invest , vol.103 , pp. 253-259
    • Dresner, A.1    Laurent, D.2    Marcucci, M.3
  • 28
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • G.I. Shulman Cellular mechanisms of insulin resistance J Clin Invest 106 2000 171 176
    • (2000) J Clin Invest , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 29
    • 0028124189 scopus 로고
    • Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin
    • T. Okada, Y. Kawano, T. Sakakibara Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin J Biol Chem 269 1994 3568 3573
    • (1994) J Biol Chem , vol.269 , pp. 3568-3573
    • Okada, T.1    Kawano, Y.2    Sakakibara, T.3
  • 30
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
    • M.E. Griffin, M.J. Marcucci, G.W. Cline Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade Diabetes 48 1999 1270 1274
    • (1999) Diabetes , vol.48 , pp. 1270-1274
    • Griffin, M.E.1    Marcucci, M.J.2    Cline, G.W.3
  • 31
    • 8544244084 scopus 로고    scopus 로고
    • PKC-theta knockout mice are protected from fat-induced insulin resistance
    • J.K. Kim, J.J. Fillmore, M.J. Sunshine PKC-theta knockout mice are protected from fat-induced insulin resistance J Clin Invest 114 2004 823 827
    • (2004) J Clin Invest , vol.114 , pp. 823-827
    • Kim, J.K.1    Fillmore, J.J.2    Sunshine, M.J.3
  • 32
    • 0034671645 scopus 로고    scopus 로고
    • Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo
    • S.F. Previs, D.J. Withers, J.M. Ren Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo J Biol Chem 275 2000 38990 38994
    • (2000) J Biol Chem , vol.275 , pp. 38990-38994
    • Previs, S.F.1    Withers, D.J.2    Ren, J.M.3
  • 33
    • 3543029821 scopus 로고    scopus 로고
    • Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
    • V.T. Samuel, Z.X. Liu, X. Qu Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease J Biol Chem 279 2004 32345 32353
    • (2004) J Biol Chem , vol.279 , pp. 32345-32353
    • Samuel, V.T.1    Liu, Z.X.2    Qu, X.3
  • 34
    • 27244440736 scopus 로고    scopus 로고
    • Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice
    • S. Neschen, K. Morino, L.E. Hammond Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice Cell Metab 2 2005 55 65
    • (2005) Cell Metab , vol.2 , pp. 55-65
    • Neschen, S.1    Morino, K.2    Hammond, L.E.3
  • 35
    • 0033964872 scopus 로고    scopus 로고
    • Lipodystrophies
    • A. Garg Lipodystrophies Am J Med 108 2000 143 152
    • (2000) Am J Med , vol.108 , pp. 143-152
    • Garg, A.1
  • 36
    • 0032532753 scopus 로고    scopus 로고
    • Life without white fat: A transgenic mouse
    • J. Moitra, M.M. Mason, M. Olive Life without white fat a transgenic mouse Genes Dev 12 1998 3168 3181
    • (1998) Genes Dev , vol.12 , pp. 3168-3181
    • Moitra, J.1    Mason, M.M.2    Olive, M.3
  • 37
    • 0034708580 scopus 로고    scopus 로고
    • Mechanism of insulin resistance in A-ZIP/F-1 fatless mice
    • J.K. Kim, O. Gavrilova, Y. Chen Mechanism of insulin resistance in A-ZIP/F-1 fatless mice J Biol Chem 275 2000 8456 8460
    • (2000) J Biol Chem , vol.275 , pp. 8456-8460
    • Kim, J.K.1    Gavrilova, O.2    Chen, Y.3
  • 38
    • 0033517284 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
    • I. Shimomura, R.E. Hammer, S. Ikemoto Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy Nature 401 1999 73 76
    • (1999) Nature , vol.401 , pp. 73-76
    • Shimomura, I.1    Hammer, R.E.2    Ikemoto, S.3
  • 39
    • 0036114844 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
    • K.F. Petersen, E.A. Oral, S. Dufour Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy J Clin Invest 109 2002 1345 1350
    • (2002) J Clin Invest , vol.109 , pp. 1345-1350
    • Petersen, K.F.1    Oral, E.A.2    Dufour, S.3
  • 40
    • 0034033388 scopus 로고    scopus 로고
    • Mechanism of troglitazone action in type 2 diabetes
    • K.F. Petersen, M. Krssak, S. Inzucchi Mechanism of troglitazone action in type 2 diabetes Diabetes 49 2000 827 831
    • (2000) Diabetes , vol.49 , pp. 827-831
    • Petersen, K.F.1    Krssak, M.2    Inzucchi, S.3
  • 41
    • 0032005178 scopus 로고    scopus 로고
    • Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial
    • D.G. Maggs, T.A. Buchanan, C.F. Burant Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus a randomized, double-blind, placebo-controlled trial Ann Intern Med 128 1998 176 185
    • (1998) Ann Intern Med , vol.128 , pp. 176-185
    • Maggs, D.G.1    Buchanan, T.A.2    Burant, C.F.3
  • 42
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
    • O. Braissant, F. Foufelle, C. Scotto Differential expression of peroxisome proliferator-activated receptors (PPARs) tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat Endocrinology 137 1996 354 366
    • (1996) Endocrinology , vol.137 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3
  • 43
    • 0036310037 scopus 로고    scopus 로고
    • The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes
    • A.B. Mayerson, R.S. Hundal, S. Dufour The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes Diabetes 51 2002 797 802
    • (2002) Diabetes , vol.51 , pp. 797-802
    • Mayerson, A.B.1    Hundal, R.S.2    Dufour, S.3
  • 44
    • 14644435731 scopus 로고    scopus 로고
    • Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes
    • K.F. Petersen, S. Dufour, D. Befroy Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes Diabetes 54 2005 603 608
    • (2005) Diabetes , vol.54 , pp. 603-608
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3
  • 45
    • 0038025371 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in the elderly: Possible role in insulin resistance
    • K.F. Petersen, D. Befroy, S. Dufour Mitochondrial dysfunction in the elderly possible role in insulin resistance Science 300 2003 1140 1142
    • (2003) Science , vol.300 , pp. 1140-1142
    • Petersen, K.F.1    Befroy, D.2    Dufour, S.3
  • 46
    • 1642377274 scopus 로고    scopus 로고
    • Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    • K.F. Petersen, S. Dufour, D. Befroy Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes N Engl J Med 350 2004 664 671
    • (2004) N Engl J Med , vol.350 , pp. 664-671
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3
  • 47
    • 31044433308 scopus 로고    scopus 로고
    • Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents
    • K. Morino, K. Petersen, S. Dufour Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents J Clin Invest 115 2005 3587 3593
    • (2005) J Clin Invest , vol.115 , pp. 3587-3593
    • Morino, K.1    Petersen, K.2    Dufour, S.3
  • 48
    • 0033542032 scopus 로고    scopus 로고
    • Body weight patterns from 20 to 49 years of age and subsequent risk for diabetes mellitus: The Johns Hopkins Precursors Study
    • F.L. Brancati, N.Y. Wang, L.A. Mead Body weight patterns from 20 to 49 years of age and subsequent risk for diabetes mellitus the Johns Hopkins Precursors Study Arch Intern Med 159 1999 957 963
    • (1999) Arch Intern Med , vol.159 , pp. 957-963
    • Brancati, F.L.1    Wang, N.Y.2    Mead, L.A.3
  • 49
    • 0029920426 scopus 로고    scopus 로고
    • Perilipin: Possible roles in structure and metabolism of intracellular neutral lipids in adipocytes and steroidogenic cells
    • C. Londos, J. Gruia-Gray, D.L. Brasaemle Perilipin possible roles in structure and metabolism of intracellular neutral lipids in adipocytes and steroidogenic cells Int J Obes Relat Metab Disord 20 suppl 3 1996 S97 S101
    • (1996) Int J Obes Relat Metab Disord , vol.20 , Issue.3 SUPPL.
    • Londos, C.1    Gruia-Gray, J.2    Brasaemle, D.L.3
  • 50
    • 14344268795 scopus 로고    scopus 로고
    • Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity
    • J.T. Tansey, C. Sztalryd, J. Gruia-Gray Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity Proc Natl Acad Sci U S A 98 2001 6494 6499
    • (2001) Proc Natl Acad Sci U S a , vol.98 , pp. 6494-6499
    • Tansey, J.T.1    Sztalryd, C.2    Gruia-Gray, J.3
  • 51
    • 4143094816 scopus 로고    scopus 로고
    • Metabolic adaptations in the absence of perilipin: Increased beta-oxidation and decreased hepatic glucose production associated with peripheral insulin resistance but normal glucose tolerance in perilipin-null mice
    • P.K. Saha, H. Kojima, J. Martinez-Botas Metabolic adaptations in the absence of perilipin increased beta-oxidation and decreased hepatic glucose production associated with peripheral insulin resistance but normal glucose tolerance in perilipin-null mice J Biol Chem 279 2004 35150 35158
    • (2004) J Biol Chem , vol.279 , pp. 35150-35158
    • Saha, P.K.1    Kojima, H.2    Martinez-Botas, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.