The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

Genes and Development

Volumn 14, Issue 21, 2000, Pages 2725-2736

  Tirasophon, Witoon ^a   Lee, Kyungho ^a   Callaghan, Brian ^a   Welihinda, Ajith ^a   Kaufman, Randal J ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Endoplasmic reticulum (ER); mRNA degradation; mRNA splicing; Signal transduction; Unfolded protein response (UPR)

Indexed keywords

IRE 1ALPHA PROTEIN; IRE 1BETA PROTEIN; MESSENGER RNA; MUTANT PROTEIN; PROTEIN; PROTEIN IRE1; PROTEIN KINASE; RIBONUCLEASE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHOSPHORYLATION; DIMERIZATION; DOWN REGULATION; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CAENORHABDITIS ELEGANS; CERCOPITHECUS AETHIOPS; COS CELLS; DIMERIZATION; ENDOPLASMIC RETICULUM; ENDORIBONUCLEASES; FUNGAL PROTEINS; GENE EXPRESSION REGULATION; HELMINTH PROTEINS; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN FOLDING; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TRANSFECTION;

MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 0034312290     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.839400     Document Type: Article

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