-
1
-
-
0035966320
-
The unfolding tale of the unfolded protein response
-
Ma Y, Hendershot LM (2001) The unfolding tale of the unfolded protein response. Cell 107:827-830.
-
(2001)
Cell
, vol.107
, pp. 827-830
-
-
Ma, Y.1
Hendershot, L.M.2
-
2
-
-
22244446505
-
The mammalian unfolded protein response
-
Schroder M, Kaufman RJ (2005) The mammalian unfolded protein response. Annu Rev Biochem 74:739-789.
-
(2005)
Annu Rev Biochem
, vol.74
, pp. 739-789
-
-
Schroder, M.1
Kaufman, R.J.2
-
3
-
-
0034282912
-
Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response
-
Wang Y, et al. (2000) Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response. J Biol Chem 275:27013-27020.
-
(2000)
J Biol Chem
, vol.275
, pp. 27013-27020
-
-
Wang, Y.1
-
4
-
-
34548189283
-
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress
-
Wu J, et al. (2007) ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress. Dev Cell 13:351-364.
-
(2007)
Dev Cell
, vol.13
, pp. 351-364
-
-
Wu, J.1
-
5
-
-
0033590451
-
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
-
Harding HP, Zhang Y, Ron D (1999) Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397:271-274.
-
(1999)
Nature
, vol.397
, pp. 271-274
-
-
Harding, H.P.1
Zhang, Y.2
Ron, D.3
-
6
-
-
0034968330
-
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival
-
Harding HP, et al. (2001) Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell 7:1153-1163.
-
(2001)
Mol Cell
, vol.7
, pp. 1153-1163
-
-
Harding, H.P.1
-
7
-
-
0036091476
-
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas
-
Zhang P, et al. (2002) The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol 22:3864-3874.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 3864-3874
-
-
Zhang, P.1
-
8
-
-
33751430251
-
PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis
-
Zhang W, et al. (2006) PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. Cell Metab 4:491-497.
-
(2006)
Cell Metab
, vol.4
, pp. 491-497
-
-
Zhang, W.1
-
9
-
-
36048996065
-
PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice
-
Iida K, Li Y, McGrath BC, Frank A, Cavener DR (2007) PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice. BMC Cell Biol 8:38.
-
(2007)
BMC Cell Biol
, vol.8
, pp. 38
-
-
Iida, K.1
Li, Y.2
McGrath, B.C.3
Frank, A.4
Cavener, D.R.5
-
10
-
-
54049133335
-
PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation
-
August 6, 10.1002/JCP.21543
-
Wei J, Sheng X, Feng D, McGrath B Cavener DR (August 6, 2008) PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation. J Cell Physiol, 10.1002/JCP.21543.
-
(2008)
J Cell Physiol
-
-
Wei, J.1
Sheng, X.2
Feng, D.3
McGrath, B.4
Cavener, D.R.5
-
12
-
-
34248226985
-
Key stages in mammary gland development. Secretory activation in the mammary gland: It's not just about milk protein synthesis!
-
Anderson SM, Rudolph MC, McManaman JL, Neville MC (2007) Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis! Breast Cancer Res 9:204.
-
(2007)
Breast Cancer Res
, vol.9
, pp. 204
-
-
Anderson, S.M.1
Rudolph, M.C.2
McManaman, J.L.3
Neville, M.C.4
-
13
-
-
39849102805
-
Regulation of sterol synthesis in eukaryotes
-
Espenshade PJ, Hughes AL (2007) Regulation of sterol synthesis in eukaryotes. Annu Rev Genet 41:401-427.
-
(2007)
Annu Rev Genet
, vol.41
, pp. 401-427
-
-
Espenshade, P.J.1
Hughes, A.L.2
-
14
-
-
33645863768
-
Transcriptional regulation of metabolism
-
Desvergne B, Michalik L, Wahli W (2006) Transcriptional regulation of metabolism. Physiol Rev 86:465-514.
-
(2006)
Physiol Rev
, vol.86
, pp. 465-514
-
-
Desvergne, B.1
Michalik, L.2
Wahli, W.3
-
15
-
-
0037162719
-
Crucial step in cholesterol homeostasis: Sterols promote binding of SCAP to INSIG-1, amembrane protein that facilitates retention of SREBPs in ER
-
Yang T, et al. (2002) Crucial step in cholesterol homeostasis: Sterols promote binding of SCAP to INSIG-1, amembrane protein that facilitates retention of SREBPs in ER. Cell 110:489-500.
-
(2002)
Cell
, vol.110
, pp. 489-500
-
-
Yang, T.1
-
16
-
-
0032489460
-
Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies
-
Sakai J, Nohturfft A, Goldstein JL, Brown MS (1998) Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies. J Biol Chem 273:5785-5793.
-
(1998)
J Biol Chem
, vol.273
, pp. 5785-5793
-
-
Sakai, J.1
Nohturfft, A.2
Goldstein, J.L.3
Brown, M.S.4
-
17
-
-
0031301274
-
Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs
-
Rawson RB, et al. (1997) Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs. Mol Cell 1:47-57.
-
(1997)
Mol Cell
, vol.1
, pp. 47-57
-
-
Rawson, R.B.1
-
18
-
-
0034637605
-
Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum
-
Liu CY, Schroder M, Kaufman RJ (2000) Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum. J Biol Chem 275:24881-24885.
-
(2000)
J Biol Chem
, vol.275
, pp. 24881-24885
-
-
Liu, C.Y.1
Schroder, M.2
Kaufman, R.J.3
-
19
-
-
0037166237
-
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress
-
Ma K, Vattem KM, Wek RC (2002) Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress. J Biol Chem 277:18728-18735.
-
(2002)
J Biol Chem
, vol.277
, pp. 18728-18735
-
-
Ma, K.1
Vattem, K.M.2
Wek, R.C.3
-
20
-
-
0023270025
-
Use of nile red for the rapid in situ quantitation of lipids on thin-layer chromatograms
-
Fowler SD, Brown WJ, Warfel J, Greenspan P (1987) Use of nile red for the rapid in situ quantitation of lipids on thin-layer chromatograms. J Lipid Res 28:1225-1232.
-
(1987)
J Lipid Res
, vol.28
, pp. 1225-1232
-
-
Fowler, S.D.1
Brown, W.J.2
Warfel, J.3
Greenspan, P.4
-
21
-
-
34247199449
-
Metabolic regulation in the lactatingmammarygland: A lipid synthesizing machine
-
Rudolph MC, et al. (2007) Metabolic regulation in the lactatingmammarygland: A lipid synthesizing machine. Physiol Genomics 28:323-336.
-
(2007)
Physiol Genomics
, vol.28
, pp. 323-336
-
-
Rudolph, M.C.1
-
22
-
-
7244221504
-
Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1
-
Lee JN, Ye J (2004) Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1. J Biol Chem 279:45257-45265.
-
(2004)
J Biol Chem
, vol.279
, pp. 45257-45265
-
-
Lee, J.N.1
Ye, J.2
-
23
-
-
34548220998
-
Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2
-
Colgan SM, Tang D, Werstuck GH, Austin RC (2007) Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2. Int J Biochem Cell Biol 39:1843-1851.
-
(2007)
Int J Biochem Cell Biol
, vol.39
, pp. 1843-1851
-
-
Colgan, S.M.1
Tang, D.2
Werstuck, G.H.3
Austin, R.C.4
-
24
-
-
0031568872
-
Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2)
-
Miserez AR, Cao G, Probst LC, Hobbs HH (1997) Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2). Genomics 40:31-40.
-
(1997)
Genomics
, vol.40
, pp. 31-40
-
-
Miserez, A.R.1
Cao, G.2
Probst, L.C.3
Hobbs, H.H.4
-
25
-
-
23844530704
-
Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7)
-
Sundqvist A, et al. (2005) Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). Cell Metab 1:379-391.
-
(2005)
Cell Metab
, vol.1
, pp. 379-391
-
-
Sundqvist, A.1
-
26
-
-
17144389838
-
Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition
-
Jiang HY, Wek RC (2005) Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition. J Biol Chem 280:14189-14202.
-
(2005)
J Biol Chem
, vol.280
, pp. 14189-14202
-
-
Jiang, H.Y.1
Wek, R.C.2
-
27
-
-
0034973982
-
Translational control is required for the unfolded protein response and in vivo glucose homeostasis
-
Scheuner D, et al. (2001) Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell 7:1165-1176.
-
(2001)
Mol Cell
, vol.7
, pp. 1165-1176
-
-
Scheuner, D.1
-
28
-
-
0033739622
-
PERK mediates cell-cycle exit during the mammalian unfolded protein response
-
Brewer JW, Diehl JA (2000) PERK mediates cell-cycle exit during the mammalian unfolded protein response. Proc Natl Acad Sci USA 97:12625-12630.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 12625-12630
-
-
Brewer, J.W.1
Diehl, J.A.2
-
29
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-789.
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
30
-
-
33744732467
-
Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: A link between a key cell proliferative pathway and membrane synthesis
-
Du X, Kristiana I, Wong J, Brown AJ (2006) Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: A link between a key cell proliferative pathway and membrane synthesis. Mol Biol Cell 17:2735-2745.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 2735-2745
-
-
Du, X.1
Kristiana, I.2
Wong, J.3
Brown, A.J.4
-
31
-
-
0041923552
-
Insig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytes
-
Li J, Takaishi K, Cook W, McCorkle SK, Unger RH (2003) Insig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytes. Proc Natl Acad Sci USA 100:9476-9481.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 9476-9481
-
-
Li, J.1
Takaishi, K.2
Cook, W.3
McCorkle, S.K.4
Unger, R.H.5
-
32
-
-
33644876816
-
Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression
-
Harding HP, et al. (2005) Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression. Cell Metab 2:361-371.
-
(2005)
Cell Metab
, vol.2
, pp. 361-371
-
-
Harding, H.P.1
-
33
-
-
0842285401
-
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2
-
Lu PD, et al. (2004) Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. EMBO J 23:169-179.
-
(2004)
EMBO J
, vol.23
, pp. 169-179
-
-
Lu, P.D.1
-
34
-
-
33846602706
-
The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid
-
Guo F, Cavener DR (2007) The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. Cell Metab 5:103-114.
-
(2007)
Cell Metab
, vol.5
, pp. 103-114
-
-
Guo, F.1
Cavener, D.R.2
-
35
-
-
44349163999
-
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice
-
Oyadomari S, Harding HP, Zhang Y, Oyadomari M, Ron D (2008) Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab 7:520-532.
-
(2008)
Cell Metab
, vol.7
, pp. 520-532
-
-
Oyadomari, S.1
Harding, H.P.2
Zhang, Y.3
Oyadomari, M.4
Ron, D.5
-
36
-
-
45849137877
-
Regulation of hepatic lipogenesis by the transcription factor XBP1
-
Lee AH, Scapa EF, Cohen DE, Glimcher LH (2008) Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320:1492-1496.
-
(2008)
Science
, vol.320
, pp. 1492-1496
-
-
Lee, A.H.1
Scapa, E.F.2
Cohen, D.E.3
Glimcher, L.H.4
-
37
-
-
34147172715
-
Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis
-
Sriburi R, et al. (2007) Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis. J Biol Chem 282:7024-7034.
-
(2007)
J Biol Chem
, vol.282
, pp. 7024-7034
-
-
Sriburi, R.1
-
38
-
-
0035543866
-
Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice
-
Wagner KU, et al. (2001) Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice. Transgenic Res 10:545-553.
-
(2001)
Transgenic Res
, vol.10
, pp. 545-553
-
-
Wagner, K.U.1
-
39
-
-
33845261493
-
A rapid method of total lipid extraction and purification
-
Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911-917.
-
(1959)
Can J Biochem Physiol
, vol.37
, pp. 911-917
-
-
Bligh, E.G.1
Dyer, W.J.2
-
40
-
-
0030728468
-
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
-
Kamijo T, et al. (1997) Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91:649-659.
-
(1997)
Cell
, vol.91
, pp. 649-659
-
-
Kamijo, T.1
-
41
-
-
33749564033
-
Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest
-
Zhang F, et al. (2006) Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest. J Biol Chem 281:30036-30045.
-
(2006)
J Biol Chem
, vol.281
, pp. 30036-30045
-
-
Zhang, F.1
-
42
-
-
36849095955
-
Inactivation of VEGF in mammary gland epithelium severely compromises mammary gland development and function
-
Rossiter H, et al. (2007) Inactivation of VEGF in mammary gland epithelium severely compromises mammary gland development and function. FASEB J 21:3994-4004.
-
(2007)
FASEB J
, vol.21
, pp. 3994-4004
-
-
Rossiter, H.1
-
43
-
-
2342483040
-
SREBPs suppress IRS-2-mediated insulin signalling in the liver
-
Ide T, et al. (2004) SREBPs suppress IRS-2-mediated insulin signalling in the liver. Nat Cell Biol 6:351-357.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 351-357
-
-
Ide, T.1
-
44
-
-
30544433533
-
ATP citrate lyase is an important component of cell growth and transformation
-
Bauer DE, Hatzivassiliou G, Zhao F, Andreadis C, Thompson CB (2005) ATP citrate lyase is an important component of cell growth and transformation. Oncogene 24:6314-6322.
-
(2005)
Oncogene
, vol.24
, pp. 6314-6322
-
-
Bauer, D.E.1
Hatzivassiliou, G.2
Zhao, F.3
Andreadis, C.4
Thompson, C.B.5
|