Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle

Science

Volumn 299, Issue 5611, 2003, Pages 1397-1400

  Molinari, Maurizio ^a   Calanca, Verena ^a   Galli, Carmela ^a   Lucca, Paola ^a   Paganetti, Paolo ^b  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMEDICAL ENGINEERING;

ENDOPLASMIC RETICULUM;

PROTEINS;

ALPHA MANNOSIDASE; ALPHA MANNOSIDASE 1 LIKE PROTEIN; CALNEXIN; GLYCOPROTEIN; MEMBRANE PROTEIN; PROTEIN EDEM; PROTEIN ERAD; UNCLASSIFIED DRUG;

BIOCHEMISTRY; PROTEIN;

ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN STRUCTURE; PROTEIN TARGETING; REGULATORY MECHANISM; STRESS; STRUCTURE ANALYSIS;

ASPARTIC ENDOPEPTIDASES; CALNEXIN; CELL LINE; DOWN-REGULATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPLASMIC RETICULUM; GLYCOPROTEINS; GLYCOSYLATION; HUMANS; KINETICS; MEMBRANE PROTEINS; MOLECULAR WEIGHT; POLYSACCHARIDES; PROTEIN CONFORMATION; PROTEIN FOLDING; RNA INTERFERENCE; TRANSFECTION; UP-REGULATION;

EID: 0037470410     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1079474     Document Type: Article

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18. We thank L. Ellgaard, F. Grassi, A. Helenius, and R. Mancini for helpful comments on the manuscript; we are greatly indebted to K. Nagata and N. Hosokawa for the HA-EDEM expression plasmid and to R. Agami for pSUPER. M.M. is supported by grants from the Max Cloetta Foundation, Foundation for Research on Neurodegenerative Diseases, A+D-fond of the Swiss Academy of Medical Sciences, Swiss National Center of Competence in Research on Neural Plasticity and Repair, and Swiss National Science Foundation.