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Volumn 53, Issue SUPPL. 1, 2004, Pages

β-Cell Glucose Toxicity, Lipotoxicity, and Chronic Oxidative Stress in Type 2 Diabetes

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; ANTIOXIDANT ENZYME; BEZAFIBRATE; ENZYME; GLUCOSE; LIPID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

EID: 0842284799     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.2007.s119     Document Type: Conference Paper
Times cited : (753)

References (56)
  • 1
    • 0026443163 scopus 로고
    • Salicylate hydroxylation as an early marker of in vivo oxidative stress in diabetic patients
    • Ghiselli A, Laurenti O, De Mattia G, Maiani G, Ferro-Luzzi A: Salicylate hydroxylation as an early marker of in vivo oxidative stress in diabetic patients. Free Radic Biol Med 13:621-626, 1992
    • (1992) Free Radic Biol Med , vol.13 , pp. 621-626
    • Ghiselli, A.1    Laurenti, O.2    De Mattia, G.3    Maiani, G.4    Ferro-Luzzi, A.5
  • 2
  • 6
    • 0036163156 scopus 로고    scopus 로고
    • Reduced β-cell mass and expression of oxidative stress related DNA damage in the islet of Japanese type II diabetic patients
    • Sakuaba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S: Reduced β-cell mass and expression of oxidative stress related DNA damage in the islet of Japanese type II diabetic patients. Diabetologia 45:85-96, 2002
    • (2002) Diabetologia , vol.45 , pp. 85-96
    • Sakuaba, H.1    Mizukami, H.2    Yagihashi, N.3    Wada, R.4    Hanyu, C.5    Yagihashi, S.6
  • 7
    • 0024311551 scopus 로고
    • Impairment of glutathione metabolism in erythrocytes from patients with diabetes mellitus
    • Murakami K, Kondo T, Ohtsuka Y, Fujiwara Y, Shimada M, Kawakami Y: Impairment of glutathione metabolism in erythrocytes from patients with diabetes mellitus. Metabolism 38:753-758, 1989
    • (1989) Metabolism , vol.38 , pp. 753-758
    • Murakami, K.1    Kondo, T.2    Ohtsuka, Y.3    Fujiwara, Y.4    Shimada, M.5    Kawakami, Y.6
  • 8
    • 0033974277 scopus 로고    scopus 로고
    • Evaluation of oxidative stress before and after control of glycemia and after vitamin E supplementation in diabetic patients
    • Sharma A, Kharb S, Chugh SN, Kakkar R, Singh GP: Evaluation of oxidative stress before and after control of glycemia and after vitamin E supplementation in diabetic patients. Metabolism 49:160-162, 2000
    • (2000) Metabolism , vol.49 , pp. 160-162
    • Sharma, A.1    Kharb, S.2    Chugh, S.N.3    Kakkar, R.4    Singh, G.P.5
  • 9
    • 0028797103 scopus 로고
    • Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: Regulation of glutathione synthesis and efflux
    • Yoshida K, Hirokawa J, Tagami S, Kawakami Y, Urata Y, Kondo T: Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: regulation of glutathione synthesis and efflux. Diabetologia 38:201-210, 1995
    • (1995) Diabetologia , vol.38 , pp. 201-210
    • Yoshida, K.1    Hirokawa, J.2    Tagami, S.3    Kawakami, Y.4    Urata, Y.5    Kondo, T.6
  • 12
    • 0032863183 scopus 로고    scopus 로고
    • Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants
    • Tanaka Y, Gleason CE, Tran PO, Harmon JS, Robertson RP: Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. Proc Natl Acad Sci U S A 96:10857-10862, 1999
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 10857-10862
    • Tanaka, Y.1    Gleason, C.E.2    Tran, P.O.3    Harmon, J.S.4    Robertson, R.P.5
  • 13
    • 0023259759 scopus 로고
    • Glucose autoxidation and protein modification: The potential role of 'autoxidative glycosylation' in diabetes
    • Wolff SP, Dean RT: Glucose autoxidation and protein modification: the potential role of 'autoxidative glycosylation' in diabetes. Biochem J 245:243-250, 1987
    • (1987) Biochem J , vol.245 , pp. 243-250
    • Wolff, S.P.1    Dean, R.T.2
  • 14
    • 0023708392 scopus 로고
    • Hydroxyl radical production and autoxidative glycosylation: Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing
    • Hunt JV, Dean RT, Wolff SP: Hydroxyl radical production and autoxidative glycosylation: glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing. Biochem J 256:205-212, 1988
    • (1988) Biochem J , vol.256 , pp. 205-212
    • Hunt, J.V.1    Dean, R.T.2    Wolff, S.P.3
  • 15
    • 0037119417 scopus 로고    scopus 로고
    • Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression
    • Kaneto H, Xu G, Fujii N, Kim S, Bonner-Weir S, Weir GC: Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J Biol Chem 277:30010-30018, 2002
    • (2002) J Biol Chem , vol.277 , pp. 30010-30018
    • Kaneto, H.1    Xu, G.2    Fujii, N.3    Kim, S.4    Bonner-Weir, S.5    Weir, G.C.6
  • 17
    • 0025732948 scopus 로고
    • Role of oxidative stress in development of complications in diabetes
    • Baynes JW: Role of oxidative stress in development of complications in diabetes. Diabetes 40:405-412, 1991
    • (1991) Diabetes , vol.40 , pp. 405-412
    • Baynes, J.W.1
  • 18
    • 0037125997 scopus 로고    scopus 로고
    • A role for glutathione peroxidase in protecting pancreatic β-cells against oxidative stress in a model of glucose toxicity
    • Tanaka Y, Tran PO, Harmon J, Robertson RP: A role for glutathione peroxidase in protecting pancreatic β-cells against oxidative stress in a model of glucose toxicity. Proc Natl Acad Sci U S A 99:12363-12368, 2002
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 12363-12368
    • Tanaka, Y.1    Tran, P.O.2    Harmon, J.3    Robertson, R.P.4
  • 19
    • 0019852821 scopus 로고
    • CuZn-superoxide dismutase, Mnsuperoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse
    • Grankvist K, Marklund SL, Taljedal IB: CuZn-superoxide dismutase, Mnsuperoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse. Biochem J 199:393-398, 1981
    • (1981) Biochem J , vol.199 , pp. 393-398
    • Grankvist, K.1    Marklund, S.L.2    Taljedal, I.B.3
  • 20
    • 0031669435 scopus 로고    scopus 로고
    • Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing R1Nm5F cells against the toxicity of reactive oxygen species
    • Tiedge M, Lortz S, Munday R, Lenzen S: Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing R1Nm5F cells against the toxicity of reactive oxygen species. Diabetes 47:1578-1585, 1998
    • (1998) Diabetes , vol.47 , pp. 1578-1585
    • Tiedge, M.1    Lortz, S.2    Munday, R.3    Lenzen, S.4
  • 21
    • 0024514128 scopus 로고
    • Oxygen free-radical scavengers and immune destruction of murine islets in allograft rejection and multiple low-dose streptozocin-induced insulitis
    • Mendola J, Wright JR Jr, Lacy PE: Oxygen free-radical scavengers and immune destruction of murine islets in allograft rejection and multiple low-dose streptozocin-induced insulitis. Diabetes 38:379-385, 1989
    • (1989) Diabetes , vol.38 , pp. 379-385
    • Mendola Jr., J.1    Wright Jr., J.R.2    Lacy, P.E.3
  • 22
    • 0024381221 scopus 로고
    • Involvement of O2 radicals in 'autoimmune' diabetes
    • Nomikos IN, Wang Y, Lafferty KJ: Involvement of O2 radicals in 'autoimmune' diabetes. Immunol Cell Biol 67:85-87, 1989
    • (1989) Immunol Cell Biol , vol.67 , pp. 85-87
    • Nomikos, I.N.1    Wang, Y.2    Lafferty, K.J.3
  • 23
    • 0029911348 scopus 로고    scopus 로고
    • Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone
    • Sreenan S, Sturis J, Pugh W, Burant CF, Polonsky KS: Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone. Am J Physiol 271:E742-E747, 1996
    • (1996) Am J Physiol , vol.271
    • Sreenan, S.1    Sturis, J.2    Pugh, W.3    Burant, C.F.4    Polonsky, K.S.5
  • 24
    • 0032852505 scopus 로고    scopus 로고
    • In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression
    • Harmon JS, Gleason CE, Tanaka Y, Oseid EA, Hunter-Berger KK, Robertson RP: In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression. Diabetes 48:1995-2000, 1999
    • (1999) Diabetes , vol.48 , pp. 1995-2000
    • Harmon, J.S.1    Gleason, C.E.2    Tanaka, Y.3    Oseid, E.A.4    Hunter-Berger, K.K.5    Robertson, R.P.6
  • 25
    • 0034646746 scopus 로고    scopus 로고
    • Dietary troglitazone decreases oxidative stress in early stage type II diabetic rats
    • Fukui T, Noma T, Mizushige K, Aki Y, Kimura S, Abe Y: Dietary troglitazone decreases oxidative stress in early stage type II diabetic rats. Life Sci 66:2043-2049, 2000
    • (2000) Life Sci , vol.66 , pp. 2043-2049
    • Fukui, T.1    Noma, T.2    Mizushige, K.3    Aki, Y.4    Kimura, S.5    Abe, Y.6
  • 26
    • 0031739607 scopus 로고    scopus 로고
    • Oxidative stress measurement by in vivo electron spin resonance spectroscopy in rats with streptozotocin-induced diabetes
    • Sano T, Umeda F, Hashimoto T, Nawata H, Utsumi H: Oxidative stress measurement by in vivo electron spin resonance spectroscopy in rats with streptozotocin-induced diabetes. Diabetologia 41:1355-1360, 1998
    • (1998) Diabetologia , vol.41 , pp. 1355-1360
    • Sano, T.1    Umeda, F.2    Hashimoto, T.3    Nawata, H.4    Utsumi, H.5
  • 27
    • 0032844258 scopus 로고    scopus 로고
    • Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice
    • Ho E, Chen G, Bray TM: Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice. FASEB J 13:1845-1854, 1999
    • (1999) FASEB J , vol.13 , pp. 1845-1854
    • Ho, E.1    Chen, G.2    Bray, T.M.3
  • 29
    • 0032980829 scopus 로고    scopus 로고
    • Interactions between vitamin E and glucose on B-cell functions in the rat: An in vivo and in vitro study
    • Tajiri Y, Grill VE: Interactions between vitamin E and glucose on B-cell functions in the rat: an in vivo and in vitro study. Pancreas 18:274-281, 1999
    • (1999) Pancreas , vol.18 , pp. 274-281
    • Tajiri, Y.1    Grill, V.E.2
  • 32
    • 0030798658 scopus 로고    scopus 로고
    • Targeted overexpression of Cu/Zn superoxide dismutase protects pancreatic β-cells against oxidative stress
    • Kubisch HM, Wang J, Bray TM, Phillips JP: Targeted overexpression of Cu/Zn superoxide dismutase protects pancreatic β-cells against oxidative stress. Diabetes 46:1563-1566, 1997
    • (1997) Diabetes , vol.46 , pp. 1563-1566
    • Kubisch, H.M.1    Wang, J.2    Bray, T.M.3    Phillips, J.P.4
  • 34
    • 0032847555 scopus 로고    scopus 로고
    • Overexpression of catalase provides partial protection to transgenic mouse β-cells
    • Xu B, Moritz JT, Epstein PN: Overexpression of catalase provides partial protection to transgenic mouse β-cells. Free Radic Biol Med 27:830-837, 1999
    • (1999) Free Radic Biol Med , vol.27 , pp. 830-837
    • Xu, B.1    Moritz, J.T.2    Epstein, P.N.3
  • 35
    • 0032898667 scopus 로고    scopus 로고
    • Fatty acids, lipotoxicity and insulin secretion
    • McGarry JD, Dobbins RL: Fatty acids, lipotoxicity and insulin secretion. Diabetologia 42:128-138, 1999
    • (1999) Diabetologia , vol.42 , pp. 128-138
    • McGarry, J.D.1    Dobbins, R.L.2
  • 36
    • 0024995157 scopus 로고
    • A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation
    • Sako Y, Grill VE: A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation. Endocrinology 127:1580-1589, 1990
    • (1990) Endocrinology , vol.127 , pp. 1580-1589
    • Sako, Y.1    Grill, V.E.2
  • 37
    • 0027303165 scopus 로고
    • Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release
    • Elks ML: Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release. Endocrinology 133:208-214, 1993
    • (1993) Endocrinology , vol.133 , pp. 208-214
    • Elks, M.L.1
  • 38
    • 0028268936 scopus 로고
    • Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
    • Zhou YP, Grill VE: Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 93:870-876, 1994
    • (1994) J Clin Invest , vol.93 , pp. 870-876
    • Zhou, Y.P.1    Grill, V.E.2
  • 39
    • 0029036835 scopus 로고
    • Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans
    • Zhou YP, Grill V: Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans. J Clin Endocrinol Metab 80:1584-1590, 1995
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 1584-1590
    • Zhou, Y.P.1    Grill, V.2
  • 41
    • 0033042342 scopus 로고    scopus 로고
    • Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats
    • Mason TM, Goh T, Tchipashvili V, Sandhu H, Gupta N, Lewis GF, Giacca A: Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats. Diabetes 48:524-530, 1999
    • (1999) Diabetes , vol.48 , pp. 524-530
    • Mason, T.M.1    Goh, T.2    Tchipashvili, V.3    Sandhu, H.4    Gupta, N.5    Lewis, G.F.6    Giacca, A.7
  • 42
    • 0030731946 scopus 로고    scopus 로고
    • Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels
    • Gremlich S, Bonny C, Waeber G, Thorens B: Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels. J Biol Chem 272:30261-30269, 1997
    • (1997) J Biol Chem , vol.272 , pp. 30261-30269
    • Gremlich, S.1    Bonny, C.2    Waeber, G.3    Thorens, B.4
  • 44
    • 0034033180 scopus 로고    scopus 로고
    • Inhibition of insulin gene expression by long-term exposure of pancreatic β-cells to palmitate is dependent on the presence of a stimulatory glucose concentration
    • Jacqueminet S, Briaud I, Rouault C, Reach G, Poitout V: Inhibition of insulin gene expression by long-term exposure of pancreatic β-cells to palmitate is dependent on the presence of a stimulatory glucose concentration. Metabolism 49:532-536, 2000
    • (2000) Metabolism , vol.49 , pp. 532-536
    • Jacqueminet, S.1    Briaud, I.2    Rouault, C.3    Reach, G.4    Poitout, V.5
  • 45
    • 0035145780 scopus 로고    scopus 로고
    • Lipotoxicity of the pancreatic β-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids
    • Briaud I, Harmon JS, Kelpe CL, Segu VB, Poitout V: Lipotoxicity of the pancreatic β-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids. Diabetes 50:315-321, 2001
    • (2001) Diabetes , vol.50 , pp. 315-321
    • Briaud, I.1    Harmon, J.S.2    Kelpe, C.L.3    Segu, V.B.4    Poitout, V.5
  • 47
    • 0032478314 scopus 로고    scopus 로고
    • Fatty acid-induced β-cell apoptosis: A link between obesity and diabetes
    • Shimabukuro M, Zhou YT, Levi M, Unger RH: Fatty acid-induced β-cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U S A 95:2498-2502, 1998
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 2498-2502
    • Shimabukuro, M.1    Zhou, Y.T.2    Levi, M.3    Unger, R.H.4
  • 48
    • 0035156817 scopus 로고    scopus 로고
    • Distinct effects of saturated and monounsaturated fatty acids on β-cell turnover and function
    • Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY: Distinct effects of saturated and monounsaturated fatty acids on β-cell turnover and function. Diabetes 50:69-76, 2001
    • (2001) Diabetes , vol.50 , pp. 69-76
    • Maedler, K.1    Spinas, G.A.2    Dyntar, D.3    Moritz, W.4    Kaiser, N.5    Donath, M.Y.6
  • 49
    • 0035430782 scopus 로고    scopus 로고
    • Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation
    • Cnop M, Hannaert JC, Hoorens A, Eizirik DL, Pipeleers DG: Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. Diabetes 50:1771-1777, 2001
    • (2001) Diabetes , vol.50 , pp. 1771-1777
    • Cnop, M.1    Hannaert, J.C.2    Hoorens, A.3    Eizirik, D.L.4    Pipeleers, D.G.5
  • 51
    • 50549202600 scopus 로고
    • The glucose fatty acid cycle, its role in insulin sensitivity and the metabolic disturbances in diabetes mellitus
    • Randle PJ, Garland PB, Hales CN, Newsholme EA: The glucose fatty acid cycle, its role in insulin sensitivity and the metabolic disturbances in diabetes mellitus. Lancet 1:785-789, 1963
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3    Newsholme, E.A.4
  • 52
    • 0036307357 scopus 로고    scopus 로고
    • Lipid partitioning in the pancreatic β-cell: Physiologic and pathophysiologic implications
    • Poitout V: Lipid partitioning in the pancreatic β-cell: physiologic and pathophysiologic implications. Curr Opin Endocrinol Diabetes 9:152-159, 2002
    • (2002) Curr Opin Endocrinol Diabetes , vol.9 , pp. 152-159
    • Poitout, V.1
  • 53
    • 0030029605 scopus 로고    scopus 로고
    • Are the β-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?
    • Prentki M, Corkey BE: Are the β-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45:273-283, 1996
    • (1996) Diabetes , vol.45 , pp. 273-283
    • Prentki, M.1    Corkey, B.E.2
  • 54
    • 0036720490 scopus 로고    scopus 로고
    • Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of Langerhans: A study using adenoviral expression of diacylglycerol acyltransferase
    • Kelpe CL, Johnson LM, Poitout V: Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of Langerhans: a study using adenoviral expression of diacylglycerol acyltransferase. Endocrinology 143:3326-3332, 2002
    • (2002) Endocrinology , vol.143 , pp. 3326-3332
    • Kelpe, C.L.1    Johnson, L.M.2    Poitout, V.3
  • 55
    • 0035514684 scopus 로고    scopus 로고
    • Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats
    • Harmon JS, Gleason CE, Tanaka Y, Poitout V, Robertson RP: Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats. Diabetes 50:2481-2486, 2001
    • (2001) Diabetes , vol.50 , pp. 2481-2486
    • Harmon, J.S.1    Gleason, C.E.2    Tanaka, Y.3    Poitout, V.4    Robertson, R.P.5
  • 56
    • 0036318123 scopus 로고    scopus 로고
    • Differential effects of hyperlipidemia on insulin secretion in islets of Langerhans from hyperglycemic versus normoglycemic rats
    • Briaud I, Kelpe CL, Johnson LM, Tran PO, Poitout V: Differential effects of hyperlipidemia on insulin secretion in islets of Langerhans from hyperglycemic versus normoglycemic rats. Diabetes 51:662-668, 2002
    • (2002) Diabetes , vol.51 , pp. 662-668
    • Briaud, I.1    Kelpe, C.L.2    Johnson, L.M.3    Tran, P.O.4    Poitout, V.5


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