Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5- trisphosphate-mediated calcium signaling in Xenopus oocytes

Journal of Neurochemistry

Volumn 72, Issue 3, 1999, Pages 1061-1068

  Leissring, Malcolm A ^a   Paul, Brooke A ^a   Parker, Ian ^a   Cotman, Carl W ^a   Laferla, Frank M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; Calcium signaling; Inositol 1,4,5 trisphosphate; Presenilin

Indexed keywords

INOSITOL 1,4,5 TRISPHOSPHATE; PRESENILIN 1;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CHLORIDE CURRENT; ELECTROPHYSIOLOGY; FAMILIAL DISEASE; GENE MUTATION; NERVE DEGENERATION; NONHUMAN; OOCYTE; PHOTOLYSIS; PRIORITY JOURNAL; SECOND MESSENGER; SIGNAL TRANSDUCTION; XENOPUS;

ALZHEIMER DISEASE; ANIMALS; BLOTTING, WESTERN; CALCIUM SIGNALING; CHLORIDE CHANNELS; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; FLUORESCENT DYES; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE; LYSOPHOSPHOLIPIDS; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; MUTATION, MISSENSE; OOCYTES; PHOTOLYSIS; PRESENILIN-1; SIGNAL TRANSDUCTION; XENOPUS LAEVIS;

ANIMALIA;

EID: 0032972683     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0721061.x     Document Type: Article

References (39)

1. Baumann K., Paganetti P. A., Sturchler-Pierrat C., Wong C., Hartmann H., Cescato R., Frey P., Yankner B. A., Sommer B., and Staufenbiel M. (1997) Distinct processing of endogenous and overexpressed recombinant presenilin 1. Neurobiol. Aging 18, 181-189.
2. Baumeister R., Leimer U., Zweckbronner I., Jakubek C., Grunberg J., and Haass C. (1997) Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing. Genes Funct. 1, 149-159.
3. Berridge M. J. (1998) Neuronal calcium signaling. Neuron 21, 13-26.
4. Borchelt D. R., Thinakaran G., Eckman C. B., Lee M. K., Davenport F., Ratovitsky T., Prada C. M., Kim G., Seekins S., Yager D., Slunt H. H., Wang R., Seeger M., Levey A. I., Gandy S. E., Copeland N. G., Jenkins N. A., Price D. L., Younkin S. G., and Sisodia S. S. (1996) Familial Alzheimer's disease-linked presenilin 1 variants elevate Abetal-42/1-40 ratio in vitro and in vivo. Neuron 17, 1005-1013.
5. 2+. Cell Calcium 15, 66-78.
6. 2+ from intracellular stores. Methods Enzymol. 291, 380-403.
7. Citron M., Westaway D., Xia W., Carlson G., Diehl T., Levesque G., Johnson-Wood K., Lee M., Seuhert P., Davis A., Kholodenko D., Motter R., Sherrington R., Perry B., Yao H., Strome R., Lieberburg I., Rommens J., Kim S., Schenk D., Fraser P., St. George-Hyslop P. H., and Selkoe D. J. (1997) Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nat. Med. 3, 67-72.
8. Clark R. F., Hutton M., Fuldne R. A., Froelich S., Karran E.. Talbot C., Crook R., Lendon C., Prihar G., He C., Korenblat K., Martinez A., Wragg M., Busfield F., Behrens M. I., Myers A., Norton J., Morris J., Mehta N., Pearson C., Lincoln S., Baker M., Duff K., Zehr C., Perez-Tur J., Houlden H., Ruiz A., Ossa J., Lopera F., Arcos M., Madrigal L., Collinge J., Humphreys C., Ashworth A., Sarner S., Fox N., Harvey R., Kennedy A., Roques P., Cline R. T., Philips C. A., Venter J. C., Forsell L., Axelman K., Lilius L., Johnston J., Cowburn R., Viitanen M., Winblad B., Kosik K., Haltia M., Poyhonen M., Dickson D., Mann D., Neary D., Snowden J., Lantos P., Lannfelt L., Rossor M., Roberts G. W., Adams M. D., Hardy J., and Goate A. (1995) The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families. Alzheimer's Disease Collaborative Group. Nat. Genet. 11, 219-222.
9. Cribbs D. H., Chen L.-S., Bende S. M., and LaFerla F. M. (1996) Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brain. Am. J. Pathol. 148, 1797-1806.
10. Doan A., Thinakaran G., Borchelt D. R., Slunt H. H., Ratovitsky T., Podlisny M., Selkoe D. J., Seeger M., Gandy S. E., Price D. L., and Sisodia S. S. (1996) Protein topology of presenilin 1. Neuron 17, 1023-1030.
11. Duff K., Eckman C., Zehr C., Yu X., Prada C.-M., Perez-tur J., Hutton M., Buee L., Harigaya Y., Yager D., Morgan D., Gordon M. N., Holcomb L., Refolo L., Zenk B., Hardy J., and Younkin S. (1996) Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710-713.
12. Guo Q., Furukawa K., Sopher B. L., Pham D. G., Martin G. M., and Mattson M. P. (1996) Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide. Neuroreport 8, 379-383.
13. Guo Q., Sopher B. L., Furukawa K., Pham D. G., Robinson N., Martin G. M., and Mattson M. P. (1997) Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid β-peptide: involvement of calcium and oxyradicals. J. Neurosci. 17, 4212-4222.
14. 2+ mobilization is altered in fibroblasts from patients with Alzheimer's disease. Proc. Natl. Acad. Sci. USA 91, 534-538.
15. Khachaturian Z. S. (1994) Calcium hypothesis of Alzheimer's disease and brain aging. Ann. NY Acad. Sci. 747, 1-11.
16. Kovacs D. M., Fausett H. J., Page K. J., Kim T. W., Moir R. D., Merriam D. E., Hollister R. D., Hallmark O. G., Mancini R., Felsenstein K. M., Hyman B. T., Tanzi R. E., and Wasco W. (1996) Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat. Med. 2, 224-229.
17. Lehmann S., Cheisa R., and Harris D. A. (1997) Evidence for a six-transmembrane domain structure of presenilin 1. J. Biol. Chem. 272, 12047-12051.
18. Levitan D. and Greenwald I. (1995) Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377, 351-354.
19. Levitan D., Doyle T. G., Brousseau D., Lee M. K., Thinakaran G., Slunt H. H., Sisodia S. S., and Greenwald I. (1996) Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 93, 14940-14944.
20. Li X. and Greenwald I. (1996) Membrane topology of the C. elegans sel-12 presenilin. Neuron 17, 1015-1021.
21. Liguri G., Cecchi C., Latorraca S., Pieri A., Sorbi S., Degl'Innocenti D., and Ramponi G. (1996) Alteration of acylphosphatase levels in familial Alzheimer's disease fibroblasts with presenilin gene mutations. Neurosci. Lett. 210, 153-156.
22. Machaca K. and Hartzell H. C. (1998) Asymmetrical distribution of Ca-activated Cl channels in Xenopus oocytes. Biophys. J. 74, 1286-1295 [erratum in Biophys. J. (1998) 74, 3313].
23. + channel currents in mammalian cells. Neurobiol. Dis. 4, 398-409.
24. Mattson M. P., Guo Q., Furukawa K., and Pedersen W. A. (1998) Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease. J. Neurochem. 70, 1-14.
25. McCoy K. R., Mullins R. D., Newcomb T. G., Ng G. M., Pavlinkova G., Polinsky R. J., Nee L. E., and Sisken J. E. (1993) Serum-and bradykinin-induced calcium transients in familial Alzheimer's fibroblasts. Neurobiol. Aging 14, 447-455.
26. Miledi R. and Parker I. (1984) Chloride current induced by injection of calcium into Xenopus oocytes. J. Physiol. (Lond.) 357, 173-183.
27. Parker I., Callamaras N., and Wier W. G. (1997) A high-resolution, confocal laser-scanning microscope and flash photolysis system for physiological studies. Cell Calcium 21, 441-452.
28. Querfurth H. W. and Selkoe D. J. (1994) Calcium ionophore increases amyloid β-peptide production by cultured cells. Biochemistry 33, 4550-4561.
29. Querfurth H. W., Wijsman E. M., St. George-Hyslop P. H., and Selkoe D. J. (1995) Beta APP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family. Brain Res. Mol. Brain Res. 28, 319-337.
30. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T. D., Hardy J., Hutton M., Kukull W., Larson E., Levy-Lahad E., Viitanen M., Peskind E., Poorkaj P., Schellenberg G., Tanzi R., Wasco W., Lannfelt L., Selkoe D., and Younkin S. (1996) Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2, 864-870.
31. Sherrington R., Rogaev E. I., Liang Y., Rogaeva E. A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., Tsuda T., Mar L., Foncin J.-F., Bruni A. C., Montesi M. P., Sorbi S., Rainero I., Pinessi L., Nee L., Chumakov I., Pollen D., Brookes A., Sanseau P., Polinsky R. J., Wasco W., DaSilva H. A. R., Haines J. L., Pericak-Vance M. A., Tanzi R. E., Roses A. D., Fraser P. E., Rommens J. M., and St. George-Hyslop P. H. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.
32. Sumikawa K. and Miledi R. (1989) Change in desensitization of cat muscle acetylcholine receptor caused by coexpression of Torpedo actylcholine receptor subunits in Xenopus oocytes. Proc. Natl. Acad. Sci. USA 86, 367-371.
33. Thinakaran G., Borchelt D. R., Lee M. K., Slunt H. H., Spitzer L., Kim G., Ratovitsky T., Davenport F., Nordstedt C., Seeger M., Hardy J., Levey A. I., Gandy S. E., Jenkins N. A., Copeland N. G., Price D. L., and Sisodia S. S. (1996) Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17, 181-190.
34. Thinakaran G., Regard J. B., Bouton C. M. L., Harris C. L., Price D. L., Borchelt D. R., and Sisodia S. S. (1998) Stable association of presenilin derivatives and absence of presenilin interactions with APP. Neurobiol. Dis. 4, 438-453.
35. Tigyi G., Dyer D., Matute C., and Miledi R. (1990) A serum factor that activates the phosphatidylinositol phosphate signaling system in Xenopus oocytes. Proc. Natl. Acad Sci. USA 87, 1521-1525.
36. Van Broeckhoven C. (1995) Presenilins and Alzheimer disease. Nat. Genet. 11, 230-232.
37. Weber L., Leissring M. A., Yang A. T., Glabe C. J., Cribbs D. H., and LaFerla F. M. (1996) Presenilin-1 immunoreactivity is localized intracellulary in Alzheimer's disease brain, but not detected in amyloid plaques. Exp. Neurol. 143, 37-44.
38. 2+ evoked by inositol trisphosphate in Xenopus oocytes. J. Physiol. (Lond.) 482, 533-553.
39. Zhang J., Kang D. E., Xia W., Okochi M., Mori H., Selkoe D. J., and Koo E. H. (1998) Subcellular distribution and turnover of presenilins in transfected cells. J. Biol. Chem. 273, 12436-12442.