Calcium pumps in health and disease

Physiological Reviews

Volumn 89, Issue 4, 2009, Pages 1341-1378

  Brini, Marisa ^a   Carafoli, Ernesto ^a,b  

^a VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM CHANNEL L TYPE; CALMODULIN BINDING PROTEIN; CALPAIN; CRE RECOMBINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ISOENZYME; NITRIC OXIDE; PLASMA MEMBRANE CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; REACTIVE OXYGEN METABOLITE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM CALCIUM EXCHANGE PROTEIN;

ALTERNATIVE RNA SPLICING; AUTOREGULATION; BINDING SITE; BREAST CANCER; CALCIUM BINDING; CALCIUM SIGNALING; CELL CYCLE; CELL MEMBRANE POTENTIAL; CELL PROLIFERATION; COLON CANCER; CORRELATION ANALYSIS; DARIER DISEASE; DEPOLYMERIZATION; DYSTONIA; EUKARYOTIC CELL; GENE OVEREXPRESSION; HAILEY HAILEY DISEASE; HEARING LOSS; HEART FAILURE; HOMEOSTASIS; HUMAN; HYPERCALCEMIA; LIVER CANCER; LUNG CANCER; MOLECULAR CLONING; MOLECULAR GENETICS; MOLECULAR INTERACTION; MULTIGENE FAMILY; MYOPATHY; NECK CANCER; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS CANCER; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DEGRADATION; REGULATORY MECHANISM; REVIEW; SQUAMOUS CELL CARCINOMA; THREE DIMENSIONAL IMAGING; TISSUE DISTRIBUTION; TISSUE SPECIFICITY;

ANIMALS; CALCIUM; CALCIUM SIGNALING; CALCIUM-TRANSPORTING ATPASES; DISEASE; HEALTH; HOMEOSTASIS; HUMANS; PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASES; PROTEIN CONFORMATION; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES;

EID: 70349653079     PISSN: 00319333     EISSN: 15221210     Source Type: Journal    
DOI: 10.1152/physrev.00032.2008     Document Type: Review

References (332)

1. 2+-ATPases in muscle and heart. J Biol Chem 272: 23696-23702, 1997.
2. Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal BB. Curcumin and cancer: an "old-age" disease with an "ageold" solution. Cancer Lett 267: 133-164, 2008.
3. Anger M, Samuel JL, Marotte F, Wuytack F, Rappaport L, Lompre AM. The sarco(endo)plasmic reticulum Ca(2+)-ATPase mRNA isoform, SERCA 3, is expressed in endothelial and epithelial cells in various organs. FEBS Lett 334: 45-48, 1993. (Pubitemid 23323035)
4. Antebi A, Fink GR. The yeast Ca(2+)-ATPase homologue, PMR1, is required for normal Golgi function and localizes in a novel Golgi-like distribution. Mol Biol Cell 3: 633-654, 1992. (Pubitemid 23098263)
5. 2+ loads only. Circ Res 92: 881-887, 2003.
6. Aramburu J, Rao A, Klee CB. Calcineurin: from structure to function. Curr Top Cell Regul 36: 237-295, 2000.
7. 2+ pump 4b and the proapoptotic tumor suppressor Ras-associated factor 1 (RASSF1). J Biol Chem 279: 31318-31328, 2004.
8. Arredouani A, Guiot Y, Jonas JC, Liu LH, Nenquin M, Pertusa JA, Rahier J, Rolland JF, Shull GE, Stevens M, Wuytack F, Henquin JC, Gilon P. SERCA3 ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells. Diabetes 51: 3245-3253, 2002. (Pubitemid 35246971)
9. Asahi M, Green NM, Kurzydlowski K, Tada M, MacLennan DH. Phospholamban domain IB forms an interaction site with the loop between transmembrane helices M6 and M7 of sarco(endo)plasmic reticulum Ca2+ ATPases. Proc Natl Acad Sci USA 98: 10061-10066, 2001. (Pubitemid 32802974)
10. Asahi M, Kimura Y, Kurzydlowski K, Tada M, MacLennan DH. Transmembrane helix M6 in sarco(endo)plasmic reticulum Ca(2+)-ATPase forms a functional interaction site with phospholamban. Evidence for physical interactions at other sites. J Biol Chem 274: 32855-32862, 1999. (Pubitemid 129535320)
11. Ashley EA, Sears CE, Bryant SM, Watkins HC, Casadei B. Cardiac nitric oxide synthase 1 regulates basal and beta-adrenergic contractility in murine ventricular myocytes. Circulation 105: 3011-3016, 2002. (Pubitemid 34693835)
12. 2+-ATPase expression during colon cancer cell line differentiation. Biochem Biophys Res Commun 355: 932-936, 2007.
13. 2+ pump and phospholamban in Spodoptera frugiperda (Sf21) cells reveals new insights on ATPase regulation. J Biol Chem 272: 15872-15880, 1997.
14. Axelsen KB, Palmgren MG. Evolution of substrate specificities in the P-type ATPase superfamily. J Mol Evol 46: 84-101, 1998. (Pubitemid 28047242)
15. 2+ exchanger in excitotoxicity. Cell 120: 275-285, 2005.
16. Bayle D, Weeks D, Sachs G. The membrane topology of the rat sarcoplasmic and endoplasmic reticulum calcium ATPases by in vitro translation scanning. J Biol Chem 270: 25678-25684, 1995.
17. 2+ stores. J Invest Dermatol 121: 688-694, 2003.
18. 2+ homeostasis in Brody's disease. A study in skeletal muscle and cultured muscle cells and the effects of dantrolene an verapamil. J Clin Invest 94:741-748, 1994.
19. Berridge MJ, Lipp P, Bootman MD. The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol 1: 11-21, 2000.
20. Bertipaglia I, Carafoli E. Calpains and human disease. Subcell Biochem 45: 29-53, 2007.
21. Bikle DD, Ratnam A, Mauro T, Harris J, Pillai S. Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptor. J Clin Invest 97:1085-1093, 1996. (Pubitemid 26070588)
22. 2+ pumps by curcumin. Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP. Eur J Biochem 268: 6318-6327, 2001.
23. Bobe R, Bredoux R, Corvazier E, Andersen JP, Clausen JD, Dode L, Kovacs T, Enouf J. Identification, expression, function, and localization of a novel (sixth) isoform of the human sarco/endoplasmic reticulum Ca2+ ATPase 3 gene. J Biol Chem 279:24297-24306, 2004. (Pubitemid 38725292)
24. Borge PD Jr, Wolf BA. Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells. J Biol Chem 278: 11359-11368, 2003.
25. Bozulic LD, Malik MT, Powell DW, Nanez A, Link AJ, Ramos KS, Dean WL. Plasma membrane Ca(2+)-ATPase associates with CLP36, alpha-actinin and actin in human platelets. Thromb Haemost 97: 587-597, 2007. (Pubitemid 46592937)
26. Brandl CJ, Green NM, Korczak B, MacLennan DH. Two Ca2+ ATPase genes: homologies and mechanistic implications of deduced amino acid sequences. Cell 44: 597-607, 1986. (Pubitemid 16083698)
27. 2+ pump isoforms in intact cells. J Biol Chem 278: 24500-24508, 2003.
28. 2+ pump. Eur J Biochem 204:939-946, 1992.
29. Brody IA. Muscle contracture induced by exercise. A syndrome attributable to decreased relaxing factor. N Engl J Med 281: 187-192, 1969.
30. Brouland JP, Gelebart P, Kovacs T, Enouf J, Grossmann J, Papp B. The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis. Am J Pathol 167: 233-242, 2005. (Pubitemid 40884784)
31. Brunati AM, Contri A, Muenchbach M, James P, Marin O, Pinna LA. GRP94 (endoplasmin) co-purifies with and is phosphorylated by Golgi apparatus casein kinase. FEBS Lett 471: 151-155, 2000. (Pubitemid 30190055)
32. Buch MH, Pickard A, Rodriguez A, Gillies S, Maass AH, Emerson M, Cartwright EJ, Williams JC, Oceandy D, Redondo JM, Neyses L, Armesilla AL. The sarcolemmal calcium pump inhibits the calcineurin/nuclear factor of activated T-cell pathway via interaction with the calcineurin A catalytic subunit. J Biol Chem 280: 29479-29487, 2005. (Pubitemid 41177021)
33. Burge SM, Wilkinson JD. Darier-White disease: a review of the clinical features in 163 patients. J Am Acad Dermatol 27: 40-50, 1992.
34. Burk SE, Lytton J, MacLennan DH, Shull GE. cDNA cloning, functional expression, and mRNA tissue distribution of a third organellar Ca2+ pump. J Biol Chem 264: 18561-18568, 1989. (Pubitemid 19277604)
35. Callewaert G, Parys JB, De Smedt H, Raeymaekers L, Wuytack F, Vanoevelen J, Van Baelen K, Simoni A, Rizzuto R, Missiaen L. Similar Ca(2+)-signaling properties in keratinocytes and in COS-1 cells overexpressing the secretory-pathway Ca(2+)-ATPase SPCA1. Cell Calcium 34: 157-162, 2003. (Pubitemid 36798398)
36. Camacho P, Lechleiter JD. Increased frequency of calcium waves in Xenopus laevis oocytes that express a calcium-ATPase. Science 260: 226-229, 1993. (Pubitemid 23140890)
37. Carafoli E. Biogenesis: plasma membrane calcium ATPase: 15 years of work on the purified enzyme. FASEB J 8: 993-1002, 1994. (Pubitemid 24338543)
38. Carafoli E. Calcium-mediated cellular signals: a story of failures. Trends Biochem Sci 29: 371-379, 2004. (Pubitemid 38968754)
39. Carafoli E. The calcium-signalling saga: tap water and protein crystals. Nat Rev Mol Cell Biol 4: 326-332, 2003. (Pubitemid 36383959)
40. Carafoli E. The unusual history and unique properties of the calcium signal. In: Calcium: A Matter of Life and Death, edited by Krebs J, Michalak M. Amsterdam: Elsevier, 2007, vol.41, p. 3-22.
41. Carafoli E, Brini M. Calcium signalling and disease. In: Subcellular Biochemistry, edited by Harris JR. New York: Springer, 2007.
42. Carafoli E, Genazzani A, Guerini D. Calcium controls the transcription of its own transporters and channels in developing neurons. Biochem Biophys Res Commun 266: 624-632, 1999. (Pubitemid 30042486)
43. Carafoli E, Santella L, Branca D, Brini M. Generation, control, and processing of cellular calcium signals. Crit Rev Biochem Mol Biol 36: 107-260, 2001. (Pubitemid 32452513)
44. Caride AJ, Chini EN, Penniston JT, Dousa TP. Selective decrease of mRNAs encoding plasma membrane calcium pump isoforms 2 and 3 in rat kidney. Kidney Int 56: 1818-1825, 1999.
45. 2+-regulated transcriptional repressor. Nature 398: 80-84, 1999.
46. Cartwright EJ, Oceandy D, Neyses L. Physiological implications of the interaction between the plasma membrane calcium pump and nNOS. Pflügers Arch 457: 665-671, 2009.
47. 2+ channels. Annu Rev Cell Dev Biol 16: 521-555, 2000.
48. Chami M, Gozuacik D, Lagorce D, Brini M, Falson P, Peaucellier G, Pinton P, Lecoeur H, Gougeon ML, le Maire M, Rizzuto R, Brechot C, Paterlini-Brechot P. SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis. J Cell Biol 153: 1301-1314, 2001. (Pubitemid 34289267)
49. Chami M, Gozuacik D, Saigo K, Capiod T, Falson P, Lecoeur H, Urashima T, Beckmann J, Gougeon ML, Claret M, le Maire M, Brechot C, Paterlini-Brechot P. Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis. Oncogene 19: 2877-2886, 2000. (Pubitemid 30389077)
50. Chanat E, Huttner WB. Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network. J Cell Biol 115: 1505-1519, 1991. (Pubitemid 21909992)
51. Charlier C, Coppieters W, Rollin F, Desmecht D, Agerholm JS, Cambisano N, Carta E, Dardano S, Dive M, Fasquelle C, Frennet JC, Hanset R, Hubin X, Jorgensen C, Karim L, Kent M, Harvey K, Pearce BR, Simon P, Tama N, Nie H, Vandeputte S, Lien S, Longeri M, Fredholm M, Harvey RJ, Georges M. Highly effective SNP-based association mapping and management of recessive defects in livestock. Nat Genet 40: 449-454, 2008.
52. Chen J, McLean PA, Neel BG, Okunade G, Shull GE, Wortis HH. CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity. Nat Immunol 5: 651-657, 2004. (Pubitemid 38811891)
53. 2+-ATPase isoform 2 alters its membrane targeting. J Biol Chem 278: 18464-18470, 2003.
54. Cho YS, Go MJ, Kim YJ, Heo JY, Oh JH, Ban HJ, Yoon D, Lee MH, Kim DJ, Park M, Cha SH, Kim JW, Han BG, Min H, Ahn Y, Park MS, Han HR, Jang HY, Cho EY, Lee JE, Cho NH, Shin C, Park T, Park JW, Lee JK, Cardon L, Clarke G, McCarthy MI, Lee JY, Lee JK, Oh B, Kim HL. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet 41: 527-1354, 2009.
55. Choi DW. Calcium: still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci 18: 58-60, 1995.
56. 2+ ATPases by lipids of the phosphatidylinositol cycle. Biochem Biophys Res Commun 125: 908-915, 1984.
57. 2+-ATPase. Nature 339: 476-478, 1989.
58. 2+-ATPase of sarcoplasmic reticulum. J Biol Chem 265: 6262-6267, 1990.
59. Costelli P, Tullio RD, Baccino FM, Melloni E. Activation of Ca(2+)-dependent proteolysis in skeletal muscle and heart in cancer cachexia. Br J Cancer 84: 946-950, 2001. (Pubitemid 32385838)
60. 2+-ATPase 2 isoform (SERCA2c). Biochem J 395: 249-258, 2006.
61. 2+-dependent ATPase of the sarcoplasmic reticulum. Annu Rev Biochem 48: 275-292, 1979.
62. Dean WL, Whiteheart SW. Plasma membrane Ca(2+)-ATPase (PMCA) translocates to filopodia during platelet activation. Thromb Haemost 91: 325-333, 2004.
63. + exchanger regulatory factor 2 in apical plasma membranes. J Biol Chem 277: 10506-10511, 2002.
64. 2+-ATPase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins. J Biol Chem 276: 21594-21600, 2001.
65. Denmeade SR, Isaacs JT. The SERCA pump as a therapeutic target: making a "smart bomb" for prostate cancer. Cancer Biol Ther 4: 14-22, 2005.
66. Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, Abbruzzese JL, Ng CS, Badmaev V, Kurzrock R. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 14: 4491-4499, 2008.
67. Dhitavat J, Cobbold C, Leslie N, Burge S, Hovnanian A. Impaired trafficking of the desmoplakins in cultured Darier's disease keratinocytes. J Invest Dermatol 121: 1349-1355, 2003. (Pubitemid 38005484)
68. Dhitavat J, Macfarlane S, Dode L, Leslie N, Sakuntabhai A, MacSween R, Saihan E, Hovnanian A. Acrokeratosis verruciformis of Hopf is caused by mutation in ATP2A2: evidence that it is allelic to Darier's disease. J Invest Dermatol 120: 229-232, 2003. (Pubitemid 36513072)
69. 2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analyses. J Biol Chem 278: 47877-47889, 2003.
70. 2+-ATPase (SERCA) 1 isoforms by steady-state and transient kinetic analyses. J Biol Chem 280: 39124-39134, 2005.
71. 2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses. J Biol Chem 281: 3182-3189, 2006.
72. Domingo S, Gomez-Villafuertes R, Palczewska M, Mellstrošm B, Naranjo JR. DREAM has a neuroprotective action by regulating calcium permeability (Abstract). Meeting on the Molecular Mechanisms of Neurodegeneration 3rd Milan, Italy May 2007, p. 49 (http://users.unimi.it/ triplet/2007/files/AbsBook-MMN-2007).
73. 2+)ATPase in familial benign hypercalcemia. J Clin Endocrinol Metab 68: 893-898, 1989.
74. Dowling P, Doran P, Ohlendieck K. Drastic reduction of sarcalumenin in Dp427 (dystrophin of 427 kDa)-deficient fibres indicates that abnormal calcium handling plays a key role in muscular dystrophy. Biochem J 379: 479-488, 2004. (Pubitemid 38570121)
75. 2+-ATPase (SERCA). Biochem J 383: 361-370, 2004.
76. Drogemuller C, Drogemuller M, Leeb T, Mascarello F, Testoni S, Rossi M, Gentile A, Damiani E, Sacchetto R. Identification of a missense mutation in the bovine ATP2A1 gene in congenital pseudomyotonia of Chianina cattle: an animal model of human Brody disease. Genomics 92: 474-477, 2008.
77. 2+-ATPase isoform 2a is the PMCA of hair bundles. J Neurosci 21: 5066-5078, 2001.
78. Dyer JL, Khan SZ, Bilmen JG, Hawtin SR, Wheatley M, Javed MU, Michelangeli F. Curcumin: a new cell-permeant inhibitor of the inositol 1,4,5-trisphosphate receptor. Cell Calcium 31: 45-52, 2002. (Pubitemid 34189556)
79. Ebashi F, Ebashi S. Removal of calcium and relaxation in actomyosin systems. Nature 194: 378-379, 1962.
80. Ebashi S, Kodama A, Ebashi F. Troponin I: preparation and physiological function. J Biochem 64: 465-477, 1968.
81. Eckstein-Ludwig U, Webb RJ, Van Goethem ID, East JM, Lee AG, Kimura M, O'Neill PM, Bray PG, Ward SA, Krishna S. Artemisinins target the SERCA of Plasmodium falciparum. Nature 424: 957-961, 2003. (Pubitemid 37051688)
82. El-Yazbi AF, Cho WJ, Schulz R, Daniel EE. Calcium extrusion by plasma membrane calcium pump is impaired in caveolin-1 knockout mouse small intestine. Eur J Pharmacol 591: 80-87, 2008.
83. Elias PM, Ahn SK, Denda M, Brown BE, Crumrine D, Kimutai LK, Komuves L, Lee SH, Feingold KR. Modulations in epidermal calcium regulate the expression of differentiation-specific markers. J Invest Dermatol 119: 1128-1136, 2002. (Pubitemid 35430490)
84. Elshorst B, Hennig M, Forsterling H, Diener A, Maurer M, Schulte P, Schwalbe H, Griesinger C, Krebs J, Schmid H, Vorherr T, Carafoli E. NMR solution structure of a complex of calmodulin with a binding peptide of the Ca2+ pump. Biochemistry 38: 12320-12332, 1999. (Pubitemid 129516201)
85. 2+. J Biol Chem 272: 17981-17986, 1997.
86. Faddy HM, Smart CE, Xu R, Lee GY, Kenny PA, Feng M, Rao R, Brown MA, Bissell MJ, Roberts-Thomson SJ, Monteith GR. Localization of plasma membrane and secretory calcium pumps in the mammary gland. Biochem Biophys Res Commun 369: 977-981, 2008.
87. 2+-ATPase (hSPCA1). J Biol Chem 278: 24721-24730, 2003.
88. Fairclough RJ, Lonie L, Van Baelen K, Haftek M, Munro CS, Burge SM, Hovnanian A. Hailey-Hailey disease: identification of novel mutations in ATP2C1 and effect of missense mutation A528P on protein expression levels. J Invest Dermatol 123: 67-71, 2004. (Pubitemid 38833465)
89. 2+ pump contains a site that interacts with its calmodulin-binding domain. J Biol Chem 266: 2930-2936, 1991.
90. 2+ pump interacts with the transduction domain of the enzyme. Protein Sci 1: 1613-1621, 1992.
91. Farber JL. The role of calcium in cell death. Life Sci 29: 1289-1295, 1981.
92. Ficarella R, Di Leva F, Bortolozzi M, Ortolano S, Donaudy F, Petrillo M, Melchionda S, Lelli A, Domi T, Fedrizzi L, Lim D, Shull GE, Gasparini P, Brini M, Mammano F, Carafoli E. A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness. Proc Natl Acad Sci USA 104: 1516-1521, 2007. (Pubitemid 46214622)
93. Fleckenstein A, Janke J, Doring HJ, Leder O. Myocardial fiber necrosis due to intracellular Ca overload - a new principle in cardiac pathophysiology. Recent Adv Stud Cardiac Struct Metab 4: 563-580, 1974.
94. 2+ response and cell viability in Darier disease. J Cell Sci 119: 671-679, 2006.
95. Franz WM, Muller OJ, Katus HA. Cardiomyopathies: from genetics to the prospect of treatment. Lancet 358: 1627-1637, 2001.
96. Frederick JR, Neumar RW. Histochemical analysis of plasma membrane calcium-ATPase activity in hippocampal CA1 pyramidal neurons following transient forebrain ischemia. Acad Emerg Med 8: 511, 2001.
97. Fujimoto T. Calcium pump of the plasma membrane is localized in caveolae. J Cell Biol 120: 1147-1157, 1993. (Pubitemid 23988695)
98. Garcia ML, Murray KD, Garcia VB, Strehler EE, Isackson PJ. Seizure-induced alterations of plasma membrane calcium ATPase isoforms 1, 2 and 3 mRNA and protein in rat hippocampus. Brain Res 45: 230-238, 1997.
99. Gatto C, Hale CC, Xu W, Milanick MA. Eosin, a potent inhibitor of the plasma membrane Ca pump, does not inhibit the cardiac Na-Ca exchanger. Biochemistry 34: 965-972, 1995.
100. Gelebart P, Kovacs T, Brouland JP, van Gorp R, Grossmann J, Rivard N, Panis Y, Martin V, Bredoux R, Enouf J, Papp B. Expression of endomembrane calcium pumps in colon and gastric cancer cells. Induction of SERCA3 expression during differentiation. J Biol Chem 277: 26310-26320, 2002. (Pubitemid 34967122)
101. Gelebart P, Martin V, Enouf J, Papp B. Identification of a new SERCA2 splice variant regulated during monocytic differentiation. Biochem Biophys Res Commun 303: 676-684, 2003. (Pubitemid 36349223)
102. Getsios S, Huen AC, Green KJ. Working out the strength and flexibility of desmosomes. Nat Rev Mol Cell Biol 5: 271-281, 2004. (Pubitemid 38480608)
103. 2+-ATPase b-splice variants. Ann NY Acad Sci 986: 461-471, 2003.
104. 2+ homeostasis and viability in cerebellar neurons. J Neurosci 25: 10822-10830, 2005.
105. 2+-ATPase activity after glycosylation of erythrocyte membranes in vivo and in vitro. Diabetes 39: 707-711, 1990.
106. Gonzalez Flecha FL, Castello PR, Caride AJ, Gagliardino JJ, Rossi JP. The erythrocyte calcium pump is inhibited by nonenzymic glycation: studies in situ and with the purified enzyme. Biochem J 293: 369-375, 1993.
107. 2+)ATPase. Biochem Biophys Res Commun 77: 1203-1209, 1977.
108. Grati M, Aggarwal N, Strehler EE, Wenthold RJ. Molecular determinants for differential membrane trafficking of PMCA1 and PMCA2 in mammalian hair cells. J Cell Sci 119: 2995-3007, 2006. (Pubitemid 44177878)
109. Green KJ, Gaudry CA. Are desmosomes more than tethers for intermediate filaments? Nat Rev Mol Cell Biol 1: 208-216, 2000.
110. Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, Parker I, LaFerla FM. SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J Cell Biol 181: 1107-1116, 2008. (Pubitemid 351915486)
111. Greenough M, Pase L, Voskoboinik I, Petris MJ, O'Brien AW, Camakaris J. Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cells. Am J Physiol Cell Physiol 287: C1463-C1471, 2004. (Pubitemid 39382908)
112. Gros R, Afroze T, You XM, Kabir G, Van Wert R, Kalair W, Hoque AE, Mungrue IN, Husain M. Plasma membrane calcium ATPase overexpression in arterial smooth muscle increases vasomotor responsiveness and blood pressure. Circ Res 93: 614-621, 2003. (Pubitemid 37222157)
113. Guerini D, Carafoli E. The calcium pumps. In: Calcium as a Cellular Regulators, edited by Carafoli E, Klee C. New York: Oxford Univ. Press, 1999, vol.10, p. 249-278.
114. 2+-ATPase by tryptic fragments of calmodulin. J Biol Chem 259: 15172-15177, 1984.
115. 2+ pump: focus on calpain sensitivity. J Biol Chem 278: 38141-38148, 2003.
116. 2+ pump of endo(sarco)plasmic reticulum. J Biol Chem 275: 31361-31368, 2000.
117. Gunteski-Hamblin AM, Clarke DM, Shull GE. Molecular cloning and tissue distribution of alternatively spliced mRNAs encoding possible mammalian homologues of the yeast secretory pathway calcium pump. Biochemistry 31: 7600-7608, 1992.
118. Hailey H, Hailey H. Familial benign chronic pemphigus. Report of 13 cases in 4 generations of a family and report of 9 additional cases in 4 generations of a family. Arch Dermatol Syphilol 39: 679-685, 1939.
119. Hammes A, Oberdorf-Maass S, Rother T, Nething K, Gollnick F, Linz KW, Meyer R, Hu K, Han H, Gaudron P, Ertl G, Hoffmann S, Ganten U, Vetter R, Schuh K, Benkwitz C, Zimmer HG, Neyses L. Overexpression of the sarcolemmal calcium pump in the myocardium of transgenic rats. Circ Res 83: 877-888, 1998. (Pubitemid 28503076)
120. + countertransport and electrogenicity in proteoliposomes containing erythrocyte plasma membrane Ca-ATPase and exogenous lipids. J Biol Chem 269:14268-14275, 1994.
121. Harada M, Hashimoto K, Fujiwara K. Immunohistochemical distribution of CD44 and desmoplakin I & II in Hailey-Hailey's disease and Darier's disease. J Dermatol 21: 389-393, 1994. (Pubitemid 24231359)
122. Hare JM, Stamler JS. NO/redox disequilibrium in the failing heart and cardiovascular system. J Clin Invest 115: 509-517, 2005. (Pubitemid 40322220)
123. Hashimoto K, Fujiwara K, Harada M, Setoyama M, Eto H. Junctional proteins of keratinocytes in Grover's disease, Hailey-Hailey's disease and Darier's disease. J Dermatol 22: 159-170, 1995. (Pubitemid 26014914)
124. Hasselbach W, Makinose M. The calcium pump of the "relaxing granules" of muscle and its dependence on ATP-splitting. Biochem Z 333: 518-528, 1961.
125. 2+/ calmodulin-dependent protein kinase. Characterization of optimal conditions for calcium pump phosphorylation. J Biol Chem 269: 31198-31206, 1994.
126. Heilker R, Manning-Krieg U, Zuber JF, Spiess M. In vitro binding of clathrin adaptors to sorting signals correlates with endocytosis and basolateral sorting. EMBO J 15: 2893-2899, 1996. (Pubitemid 26176267)
127. 2+ ATPase. Functional properties of the enzyme and its splicing products. J Biol Chem 269: 26178-26183, 1994.
128. 2+)-ATPase in the plasma membrane of a glucose-responsive insulinoma. Biochim Biophys Acta 1022: 333-338, 1990.
129. 2+ binding sites. J Biol Chem 268: 10252-10259, 1993.
130. 2+-pump inhibitor caloxin. Cell Calcium 33: 241-245, 2003.
131. Hu Z, Bonifas JM, Beech J, Bench G, Shigihara T, Ogawa H, Ikeda S, Mauro T, Epstein EH Jr. Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease. Nat Genet 24: 61-65, 2000. (Pubitemid 30041422)
132. Hua S, Ma H, Lewis D, Inesi G, Toyoshima C. Functional role of "N" (nucleotide) and "P" (phosphorylation) domain interactions in the sarcoplasmic reticulum (SERCA) ATPase. Biochemistry 41: 2264-2272, 2002. (Pubitemid 34160887)
133. Huang B, Wang S, Qin D, Boutjdir M, El-Sherif N. Diminished basal phosphorylation level of phospholamban in the postinfarction remodeled rat ventricle: role of beta-adrenergic pathway, G(i) protein, phosphodiesterase, and phosphatases. Circ Res 85: 848-855, 1999. (Pubitemid 29504160)
134. Huke S, Liu LH, Biniakiewicz D, Abraham WT, Periasamy M. Altered force-frequency response in non-failing hearts with decreased SERCA pump-level. Cardiovasc Res 59: 668-677, 2003. (Pubitemid 38368683)
135. Huster D, Lutsenko S. The distinct roles of the N-terminal copper-binding sites in regulation of catalytic activity of the Wilson's disease protein. J Biol Chem 278: 32212-32218, 2003. (Pubitemid 37048413)
136. Hutter MC, Krebs J, Meiler J, Griesinger C, Carafoli E, Helms V. A structural model of the complex formed by phospholamban and the calcium pump of sarcoplasmic reticulum obtained by molecular mechanics. Chem Biochem 3: 1200-1208, 2002. (Pubitemid 36005312)
137. Ikeda S, Shigihara T, Mayuzumi N, Yu X, Ogawa H. Mutations of ATP2C1 in Japanese patients with Hailey-Hailey disease: intrafamilial and interfamilial phenotype variations and lack of correlation with mutation patterns. J Invest Dermatol 117: 1654-1656, 2001. (Pubitemid 34032801)
138. 2+ pump of sarcoplasmic reticulum. Nature 342: 90-92, 1989.
139. 2+ pump of human erythrocytes. J Biol Chem 263: 2905-2910, 1988.
140. 2+-ATPase by selective calpain cleavage of the calmodulin-binding domain. J Biol Chem 264: 8289-8296, 1989.
141. 2+-ATPase activator from human erythrocytes: its similarity to the activator of 3′:5′-cyclic nucleotide phosphodiesterase. Biochem Biophys Res Commun 77: 1210-1216, 1977.
142. 2+-stimulated
143. 2+ homeostasis and cardiomyocyte function. J Biol Chem 275: 38073-38080, 2000.
144. John LM, Lechleiter JD, Camacho P. Differential modulation of SERCA2 isoforms by calreticulin. J Cell Biol 142: 963-973, 1998. (Pubitemid 28402052)
145. 2+ pump revealed by intermolecular thiol cross-linking. J Biol Chem 277: 28319-28329, 2002.
146. Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, Walter K, Nikolskaya T, Nikolsky Y, Hartigan J, Smith DR, Hidalgo M, Leach SD, Klein AP, Jaffee EM, Goggins M, Maitra A, Iacobuzio-Donahue C, Eshleman JR, Kern SE, Hruban RH, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321: 1801-1806, 2008.
147. Kadambi VJ, Ponniah S, Harrer JM, Hoit BD, Dorn GW, 2nd Walsh RA, Kranias EG. Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice. J Clin Invest 97: 533-539, 1996. (Pubitemid 26039421)
148. Kamagate A, Herchuelz A, Bollen A, Van Eylen F. Expression of multiple plasma membrane Ca(2+)-ATPases in rat pancreatic islet cells. Cell Calcium 27: 231-246, 2000. (Pubitemid 30312463)
149. 2+-adenosine triphosphatase in sarcoplasmic reticulum (Brody's disease). Ann Neurol 20: 38-49, 1986.
150. Katz AM. Discovery of phospholamban. A personal history. Ann NY Acad Sci 853: 9-19, 1998.
151. Kaufman RJ, Swaroop M, Murtha-Riel P. Depletion of manganese within the secretory pathway inhibits O-linked glycosylation in mammalian cells. Biochemistry 33: 9813-9819, 1994. (Pubitemid 24286053)
152. Kawada H, Nishiyama C, Takagi A, Tokura T, Nakano N, Maeda K, Mayuzumi N, Ikeda S, Okumura K, Ogawa H. Transcriptional regulation of ATP2C1 gene by Sp1 and YY1 and reduced function of its promoter in Hailey-Hailey disease keratinocytes. J Invest Dermatol 124: 1206-1214, 2005. (Pubitemid 40847408)
153. 2+-ATPase isoforms 1, 2, 3, and 4. J Biol Chem 268: 2740-2748, 1993.
154. Kellermayer R. Hailey-Hailey disease as an orthodisease of PMR1 deficiency in Saccharomyces cerevisiae. FEBS Lett 579: 2021-2025, 2005. (Pubitemid 40469664)
155. 2+ cycling. Curr Opin Drug Discov Dev 6: 658-666, 2003.
156. 2+-ATPase2a and phospholamban in the human heart. Biochem Biophys Res Commun 306: 550-557, 2003.
157. Kimura Y, Kurzydlowski K, Tada M, MacLennan DH. Phospholamban inhibitory function is activated by depolymerization. J Biol Chem 272: 15061-15064, 1997. (Pubitemid 27255517)
158. Kirichok Y, Krapivinsky G, Clapham DE. The mitochondrial calcium uniporter is a highly selective ion channel. Nature 427: 360-364, 2004. (Pubitemid 38133664)
159. 2+-ATPase 2 gene transcription through modification of Sp1 binding. Biochem Biophys Res Commun 328: 116-124, 2005.
160. Korosec B, Glavac D, Rott T, Ravnik-Glavac M. Alterations in the ATP2A2 gene in correlation with colon and lung cancer. Cancer Genet Cytogenet 171: 105-111, 2006. (Pubitemid 44751179)
161. Korosec B, Glavac D, Volavsek M, Ravnik-Glavac M. Alterations in genes encoding sarcoplasmic-endoplasmic reticulum Ca(2+) pumps in association with head and neck squamous cell carcinoma. Cancer Genet Cytogenet 181: 112-118, 2008. (Pubitemid 351273425)
162. Kowalczyk AP, Bornslaeger EA, Norvell SM, Palka HL, Green KJ. Desmosomes: intercellular adhesive junctions specialized for attachment of intermediate filaments. Int Rev Cytol 185: 237-302, 1999.
163. 2+-ATPase isoform 2. J Biol Chem 273: 18693-18696, 1998.
164. Kranias EG, Bers DM. Calcium and cardiomyopathies. Subcell Biochem 45: 523-537, 2007.
165. Kuhn A, Goldstein DR, Hodges A, Strand AD, Sengstag T, Kooperberg C, Becanovic K, Pouladi MA, Sathasivam K, Cha JH, Hannan AJ, Hayden MR, Leavitt BR, Dunnett SB, Ferrante RJ, Albin R, Shelbourne P, Delorenzi M, Augood SJ, Faull RL, Olson JM, Bates GP, Jones L, Luthi-Carter R. Mutant Huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage. Hum Mol Genet 16: 1845-1861, 2007.
166. Kulkarni RN, Roper MG, Dahlgren G, Shih DQ, Kauri LM, Peters JL, Stoffel M, Kennedy RT. Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3. Diabetes 53: 1517-1525, 2004. (Pubitemid 38697664)
167. Kuo TH, Kim HR, Zhu L, Yu Y, Lin HM, Tsang W. Modulation of endoplasmic reticulum calcium pump by Bcl-2. Oncogene 17: 1903-1910, 1998.
168. Kurnellas MP, Li H, Deng L, Ehrlich DJ, Elkabes S. Molecular alterations in the cerebellum of the plasma membrane calcium ATPase 2 (PMCA2)-null mouse indicate abnormalities in Purkinje neurons. Mol Cell Neurosci 34: 178-188, 2007. (Pubitemid 46157105)
169. Kurnellas MP, Shull GE, Elkabes S. Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury. FASEB J 19: 298-300, 2005. (Pubitemid 40189288)
170. Lamberth S, Schmid H, Muenchbach M, Vorherr T, Krebs J, Carafoli E, Griesinger C. NMR solution structure of phospholamban. Helv Chim Acta 83: 2141-2152, 2000. (Pubitemid 30784636)
171. Lapinskas PJ, Cunningham KW, Liu XF, Fink GR, Culotta VC. Mutations in PMR1 suppress oxidative damage in yeast cells lacking superoxide dismutase. Mol Cell Biol 15: 1382-1388, 1995.
172. Lasa M, Marin O, Pinna LA. Rat liver Golgi apparatus contains a protein kinase similar to the casein kinase of lactating mammary gland. Eur J Biochem 243: 719-725, 1997. (Pubitemid 27073440)
173. Lecker SH, Goldberg AL, Mitch WE. Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. J Am Soc Nephrol 17: 1807-1819, 2006.
174. Lee WJ, Roberts-Thomson SJ, Monteith GR. Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines. Biochem Biophys Res Commun 337: 779-783, 2005. (Pubitemid 41446982)
175. Lee WJ, Robinson JA, Holman NA, McCall MN, Roberts-Thomson SJ, Monteith GR. Antisense-mediated inhibition of the plasma membrane calcium-ATPase suppresses proliferation of MCF-7 cells. J Biol Chem 280: 27076-27084, 2005.
176. 2+-induced differentiation of human keratinocytes. J Biol Chem 282: 22582-22591, 2007.
177. 2+ pumps (PMCAs) in pathologies of mammalian cells. Front Biosci 7: d53-84, 2002.
178. 2+ pump (PMCA) isoforms in the gerbil brain: effect of ischemia-reperfusion injury. Neurochem Int 35: 221-227, 1999.
179. 2+ pump and calretiulin in gerbil forebrain. In: Neurochemistry. Cellular, Molecular and Clinical Aspects, edited by Teelken A, Kor, J. New York: Plenum, 1997.
180. Leinonen PT, Myllyla RM, Hagg PM, Tuukkanen J, Koivunen J, Peltonen S, Oikarinen A, Korkiamaki T, Peltonen J. Keratinocytes cultured from patients with Hailey-Hailey disease and Darier disease display distinct patterns of calcium regulation. Br J Dermatol 153: 113-117, 2005. (Pubitemid 41044536)
181. 2+)-ATPase in the obesity syndrome. Lessons from animal models. Int J Obes Relat Metab Disord 19: 97-102, 1995.
182. 2+-adenosine triphosphatase in pancreatic islets isolated from a normal and a non-insulin-dependent diabetes mellitus rat model. Metabolism 47: 185-189, 1998.
183. 2+-dependent redox modulation of SERCA 2b by ERp57. J Cell Biol 164: 35-46, 2004.
184. 2+ exchanger. J Biol Chem 266: 1014-1020, 1991.
185. Lin P, Le-Niculescu H, Hofmeister R, McCaffery JM, Jin M, Hennemann H, McQuistan T, De Vries L, Farquhar MG. The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident protein. J Cell Biol 141: 1515-1527, 1998. (Pubitemid 28309167)
186. Linde CI, Di Leva F, Domi T, Tosatto SC, Brini M, Carafoli E. Inhibitory interaction of the 14-3-3 proteins with ubiquitous (PMCA1) and tissue-specific (PMCA3) isoforms of the plasma membrane Ca2+ pump. Cell Calcium 43: 550-561, 2008. (Pubitemid 351663985)
187. 2+ homeostasis of bladder smooth muscle: evidence from PMCA gene-ablated mice. Am J Physiol Cell Physiol 292: C423-C431, 2007.
188. 2+ pump. J Biol Chem 276: 26737-26740, 2001.
189. 2+-ATPase isoform 3. J Biol Chem 272: 30538-30545, 1997.
190. Luo W, Grupp IL, Harrer J, Ponniah S, Grupp G, Duffy JJ, Doetschman T, Kranias EG. Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation. Circ Res 75: 401-409, 1994. (Pubitemid 24979945)
191. Lytton J, Westlin M, Burk SE, Shull GE, MacLennan DH. Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps. J Biol Chem 267: 14483-14489, 1992.
192. Lytton J, Westlin M, Hanley MR. Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps. J Biol Chem 266: 17067-17071, 1991. (Pubitemid 21907906)
193. Lytton J, Zarain-Herzberg A, Periasamy M, MacLennan DH. Molecular cloning of the mammalian smooth muscle sarco(endo)plasmic reticulum Ca2+-ATPase. J Biol Chem 264: 7059-7065, 1989. (Pubitemid 19114826)
194. MacLennan DH. Purification and properties of an adenosine triphosphatase from sarcoplasmic reticulum. J Biol Chem 245: 4508-4518, 1970.
195. 2+-dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence. Nature 316: 696-700, 1985.
196. MacLennan DH, Kranias EG. Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol 4: 566-577, 2003.
197. Mandal D, Woolf TB, Rao R. Manganese selectivity of pmr1, the yeast secretory pathway ion pump, is defined by residue gln783 in transmembrane segment 6. Residue Asp778 is essential for cation transport. J Biol Chem 275: 23933-23938, 2000. (Pubitemid 30624682)
198. Mandal DM, Wilson AF, Elston RC, Weissbecker K, Keats BJ, Bailey-Wilson JE. Effects of misspecification of allele frequencies on the type I error rate of model-free linkage analysis. Hum Hered 50: 126-132, 2000.
199. 2+-ATPase (SERCA) 3 isoforms. Expression, regulation, and function of the membranes of the SERCA3 family. J Biol Chem 277: 24442-24452, 2002.
200. + gradients in murine epidermis: quantitative measurement using PIXE. J Invest Dermatol 111: 1198-1201, 1998.
201. Mayuzumi N, Ikeda S, Kawada H, Ogawa H. Effects of drugs and anticytokine antibodies on expression of ATP2A2 and ATP2C1 in cultured normal human keratinocytes. Br J Dermatol 152: 920-924, 2005. (Pubitemid 40704931)
202. Metze D, Hamm H, Schorat A, Luger T. Involvement of the adherens junction-actin filament system in acantholytic dyskeratosis of Hailey-Hailey disease. A histological, ultrastructural, and histochemical study of lesional and non-lesional skin. J Cutan Pathol 23: 211-222, 1996. (Pubitemid 126443447)
203. 2+-ATPase activity and ionized calcium in Type 2 diabetic patients with neuropathy. Diabetes Res Clin Pract 49: 113-118, 2000.
204. Missiaen L, Robberecht W, van den Bosch L, Callewaert G, Parys JB, Wuytack F, Raeymaekers L, Nilius B, Eggermont J, De Smedt H. Abnormal intracellular Ca(2+) homeostasis and disease. Cell Calcium 28: 1-21, 2000.
205. 2+ store in A7r5 and 16HBE14o- cells. J Biol Chem 277: 6898-6902, 2002.
206. Moncoq K, Trieber CA, Young HS. The molecular basis for cyclopiazonic acid inhibition of the sarcoplasmic reticulum calcium pump. J Biol Chem 282: 9748-9757, 2007.
207. 2+ transport. Nat Rev Cancer 7: 519-530, 2007.
208. Most P, Pleger ST, Volkers M, Heidt B, Boerries M, Weichenhan D, Loffler E, Janssen PM, Eckhart AD, Martini J, Williams ML, Katus HA, Remppis A, Koch WJ. Cardiac adenoviral S100A1 gene delivery rescues failing myocardium. J Clin Invest 114: 1550-1563, 2004. (Pubitemid 40385546)
209. Nakayama S, Kawasaki H, Kretsinger R. Evolution of EF-hand proteins. In: Calcium Homeostasis, edited by Carafoli E. Berlin: Springer, 2000, p. 29-58.
210. 2+-dependent ATPase following phosphorylation by cAMP-dependent protein kinase. Biochem J 351: 195-205, 2000.
211. Neumar RW, Meng FH, Mills AM, Siman R. Brain ischemia causes proteolytic modificatioin of plasma membrane calcium ATPase. Soc for Neurosci 812: 841, 1999.
212. Nicholson C, Bruggencate GT, Steinberg R, Stockle H. Calcium modulation in brain extracellular microenvironment demonstrated with ion-selective micropipette. Proc Natl Acad Sci USA 74: 1287-1290, 1977. (Pubitemid 8065652)
213. Niggli V, Adunyah ES, Carafoli E. Acidic phospholipids, unsaturated fatty acids, and limited proteolysis mimic the effect of calmodulin on the purified erythrocyte Ca2+-ATPase. J Biol Chem 256: 8588-8592, 1981. (Pubitemid 12254807)
214. 2+)-ATPase of the erythrocyte membrane. Reconstitution and effect of calmodulin and phospholipids. J Biol Chem 256: 395-401, 1981.
215. 2+)-ATPase from human erythrocyte membranes using a calmodulin affinity column. J Biol Chem 254: 9955-9958, 1979.
216. + exchange in reconstituted liposomal systems. J Biol Chem 257: 2350-2356, 1982.
217. Oancea E, Meyer T. Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals. Cell 95: 307-318, 1998. (Pubitemid 28507320)
218. Oceandy D, Cartwright EJ, Emerson M, Prehar S, Baudoin FM, Zi M, Alatwi N, Venetucci L, Schuh K, Williams JC, Armesilla AL, Neyses L. Neuronal nitric oxide synthase signaling in the heart is regulated by the sarcolemmal calcium pump 4b. Circulation 115: 483-492, 2007. (Pubitemid 46184200)
219. 2+-ATPase (PMCA) in the heart. Biochem Soc Trans 35: 927-930, 2007.
220. 2+-dependent Golgi endoproteases. J Biol Chem 267: 17465-17471, 1992.
221. 2+ ATPase (SERCA1) and is associated with Brody disease. Hum Genet 106: 482-491, 2000.
222. Odermatt A, Becker S, Khanna VK, Kurzydlowski K, Leisner E, Pette D, MacLennan DH. Sarcolipin regulates the activity of SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+-ATPase. J Biol Chem 273: 12360-12369, 1998. (Pubitemid 28240605)
223. 2+/calmodulin-dependent phosphorylation or by interaction with phospholamban. J Biol Chem 271: 14206-14213, 1996.
224. 2+ ATPase, are associated with Brody disease. Nat Genet 14: 191-194, 1996.
225. Odermatt A, Taschner PE, Scherer SW, Beatty B, Khanna VK, Cornblath DR, Chaudhry V, Yee WC, Schrank B, Karpati G, Breuning MH, Knoers N, MacLennan DH. Characterization of the gene encoding human sarcolipin (SLN), a proteolipid associated with SERCA1: absence of structural mutations in five patients with Brody disease. Genomics 45: 541-553, 1997. (Pubitemid 27506129)
226. 2+-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes. J Biol Chem 282: 26517-26527, 2007.
227. 2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4. J Biol Chem 279: 33742-33750, 2004.
228. 2+ stores. FEBS Lett 274: 214-216, 1990.
229. 2+)ATPase activity in rats. Int J Neurosci 103: 33-40, 2000.
230. Orrenius S, Nicotera P. The calcium ion and cell death. J Neural Transm Suppl 43: 1-11, 1994.
231. Ortega C, Ortolano S, Carafoli E. The plasma membrane calcium pump. In: Calcium: A Matter of Life or Death, edited by Krebs J, Michalak M. New York: Springer, 2007, vol.41, p. 179-197.
232. 2+ ATPase isoform 1 (SERCA1) impairs diaphragm function and is lethal in neonatal mice. J Biol Chem 278: 13367-13375, 2003.
233. Pande J, Szewczyk MM, Kuszczak I, Grover S, Escher E, Grover AK. Functional effects of caloxin 1c2, a novel engineered selective inhibitor of plasma membrane Ca(2+)-pump isoform 4, on coronary artery. J Cell Mol Med 12: 1049-1060, 2008. (Pubitemid 351718081)
234. Pantano S, Carafoli E. The role of phosphorylation on the structure and dynamics of phospholamban: a model from molecular simulations. Proteins 66: 930-940, 2007. (Pubitemid 46273077)
235. Parekh AB, Putney JW Jr. Store-operated calcium channels. Physiol Rev 85: 757-810, 2005.
236. Pedersen P, Carafoli E. Ion motive ATPases. I. Ubiquity, properties, and significance to cell function. Trends Biochem Sci 12: 146-150, 1987.
237. Perez-Moreno M, Jamora C, Fuchs E. Sticky business: orchestrating cellular signals at adherens junctions. Cell 112: 535-548, 2003. (Pubitemid 36263085)
238. 2+-ATPase isoform 2 (SERCA2) gene. J Biol Chem 274: 2556-2562, 1999.
239. Petersen OH, Tepikin AV. Polarized calcium signaling in exocrine gland cells. Annu Rev Physiol 70: 273-299, 2008.
240. Popescu LM, Gherghiceanu M, Mandache E, Cretoiu D. Caveolae in smooth muscles: nanocontacts. J Cell Mol Med 10: 960-990, 2006.
241. Porgpermdee S, Yu X, Takagi A, Mayuzumi N, Ogawa H, Ikeda S. Expression of SPCA1 (Hailey-Hailey disease gene product) in acantholytic dermatoses. J Dermatol Sci 40: 137-140, 2005. (Pubitemid 41446211)
242. Prasad V, Okunade GW, Miller ML, Shull GE. Phenotypes of SERCA and PMCA knockout mice. Biochem Biophys Res Commun 322: 1192-1203, 2004. (Pubitemid 39164649)
243. Preiano BS, Guerini D, Carafoli E. Expression and functional characterization of isoforms 4 of the plasma membrane calcium pump. Biochemistry 35: 7946-7953, 1996. (Pubitemid 26202535)
244. Ràcz E, Csikòs M, Kornsée Z, Horvàth A, Karpati S. Identification of mutations in the ATP2A2 gene in patients with Darier's disease from Hungary. Exp Dermatol 13: 396-399, 2004. (Pubitemid 38868213)
245. 2+ permeability. Biochem Biophys Res Commun 235: 451-454, 1997.
246. Ramos-Castaneda J, Park YN, Liu M, Hauser K, Rudolph H, Shull GE, Jonkman MF, Mori K, Ikeda S, Ogawa H, Arvan P. Deficiency of ATP2C1, a Golgi ion pump, induces secretory pathway defects in endoplasmic reticulum (ER)-associated degradation and sensitivity to ER stress. J Biol Chem 280: 9467-9473, 2005. (Pubitemid 40409641)
247. 2+-ATPase protein expression in mammary tissue. Am J Physiol Cell Physiol 279: C1595-C1602, 2000.
248. 2+-ATPase. Am J Physiol Cell Physiol 286: C164-C169, 2004.
249. 2+-ATPase isoform 2 impairs calcium transport into milk. J Biol Chem 279: 42369-42373, 2004.
250. 2+ currents in compensated hypertrophy and heart failure. Cardiovasc Res 37: 300-311, 1998.
251. 2+-ATPase pump. J Biol Chem 280: 37195-37203, 2005.
252. 2+: molecular determinants and functional consequences. Physiol Rev 86: 369-408, 2006.
253. Rizzuto R, Pozzan T. When calcium goes wrong: genetic alterations of a ubiquitous signaling route. Nat Genet 34: 135-141, 2003. (Pubitemid 36666920)
254. 2+ oscillations via an interaction with SERCA2b. J Cell Biol 149: 1235-1248, 2000.
255. 2+ ATPase family. Cell 58: 133-145, 1989.
256. Sacchetto R, Testoni S, Gentile A, Damiani E, Rossi M, Liguori R, Drogemuller C, Mascarello F. A defective SERCA1 protein is responsible for congenital pseudomyotonia in Chianina cattle. Am J Pathol 174: 565-573, 2009.
257. 2+ transport ATPases by thapsigargin. J Biol Chem 267: 12606-12613, 1992.
258. 2+ transport ATPase by thapsigargin at subnanomolar concentrations. J Biol Chem 266: 13503-13506, 1991.
259. Salamino F, Sparatore B, Melloni E, Michetti M, Viotti PL, Pontremoli S, Carafoli E. The plasma membrane calcium pump is the preferred calpain substrate within the erythrocyte. Cell Calcium 15: 28-35, 1994. (Pubitemid 24038873)
260. Santella L, Carafoli E. Calcium signaling in the cell nucleus. FASEB J 11: 1091-1109, 1997.
261. 2+-extrusion from human red cells. Experientia 22: 364-365, 1966.
262. 2+)-binding protein localized to the Golgi lumen. J Cell Biol 133: 257-268, 1996.
263. Schmidt AG, Haghighi K, Frank B, Pater L, Dorn GW, Walsh RA, Kranias EG. Polymorphic SERCA2a variants do not account for inter-individual differences in phospholamban-SERCA2a interactions in human heart failure. J Mol Cell Cardiol 35: 867-870, 2003. (Pubitemid 36773599)
264. Schmitt JP, Kamisago M, Asahi M, Li GH, Ahmad F, Mende U, Kranias EG, MacLennan DH, Seidman JG, Seidman CE. Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science 299: 1410-1413, 2003. (Pubitemid 36254657)
265. 2+ ATPase 4 is required for sperm motility and male fertility. J Biol Chem 279: 28220-28226, 2004.
266. Schuh K, Quaschning T, Knauer S, Hu K, Kocak S, Roethlein N, Neyses L. Regulation of vascular tone in animals overexpressing the sarcolemmal calcium pump. J Biol Chem 278: 41246-41252, 2003. (Pubitemid 37280952)
267. 2+/ calmodulin-dependent membrane-associated kinase CASK. J Biol Chem 278: 9778-9783, 2003.
268. Schuh K, Uldrijan S, Telkamp M, Rothlein N, Neyses L. The plasma membrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I. J Cell Biol 155: 201-205, 2001. (Pubitemid 34289295)
269. Schultz Jel J, Glascock BJ, Witt SA, Nieman ML, Nattamai KJ, Liu LH, Lorenz JN, Shull GE, Kimball TR, Periasamy M. Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity. Am J Physiol Heart Circ Physiol 286: H1146-H1153, 2004. (Pubitemid 38248632)
270. Schultz JM, Yang Y, Caride AJ, Filoteo AG, Penheiter AR, Lagziel A, Morell RJ, Mohiddin SA, Fananapazir L, Madeo AC, Penniston JT, Griffith AJ. Modification of human hearing loss by plasma-membrane calcium pump PMCA2. N Engl J Med 352: 1557-1564, 2005. (Pubitemid 40517096)
271. Schwinger RH, Munch G, Bolck B, Karczewski P, Krause EG, Erdmann E. Reduced Ca2+-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylation. J Mol Cell Cardiol 31: 479-491, 1999. (Pubitemid 29121635)
272. Sears CE, Bryant SM, Ashley EA, Lygate CA, Rakovic S, Wallis HL, Neubauer S, Terrar DA, Casadei B. Cardiac neuronal nitric oxide synthase isoform regulates myocardial contraction and calcium handling. Circ Res 92: e52-59, 2003.
273. 2+-ATPase of sarcoplasmic reticulum. J Biol Chem 264: 17816-17823, 1989.
274. 2+-ATPase isoform 4 is localized in lipid rafts of cerebellum synaptic plasma membranes. J Biol Chem 281: 447-453, 2006.
275. Sgambato-Faure VXY, Berke JD, Hyman SE, Strehler EE. The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump. Biochem Biophys Res Commun 343: 630-637, 2006.
276. Shimizu H, Tan Kinoshita MT, Suzuki H. Darier's disease with esophageal carcinoma. Eur J Dermatol 10: 470-472, 2000.
277. +- and other cation transport ATPases. J Biol Chem 263: 8646-8657, 1988.
278. Soszynski M, Bartosz G. Effect of peroxynitrite on erythrocytes. Biochim Biophys Acta 1291: 107-114, 1996.
279. Spiden SL, Bortolozzi M, Di Leva F, de Angelis MH, Fuchs H, Lim D, Ortolano S, Ingham NJ, Brini M, Carafoli E, Mammano F, Steel KP. The novel mouse mutation Oblivion inactivates the PMCA2 pump and causes progressive hearing loss. PLoS Genet 4: e1000238, 2008.
280. 2+-ATPase gene cause deafness in deafwaddler mice. Nat Genet 19: 390-394, 1998.
281. Strehler EE, Zacharias DA. Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. Physiol Rev 81: 21-50, 2001.
282. Striggow F, Ehrlich BE. Ligand-gated calcium channels inside and out. Curr Opin Cell Biol 8: 490-495, 1996. (Pubitemid 26254044)
283. Stuart RO, Sun A, Bush KT, Nigam SK. Dependence of epithelial intercellular junction biogenesis on thapsigargin-sensitive intracellular calcium stores. J Biol Chem 271: 13636-13641, 1996. (Pubitemid 26185412)
284. Sudbrak R, Brown J, Dobson-Stone C, Carter S, Ramser J, White J, Healy E, Dissanayake M, Larregue M, Perrussel M, Lehrach H, Munro CS, Strachan T, Burge S, Hovnanian A, Monaco AP. Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca2+ pump. Hum Mol Genet 9: 1131-1140, 2000. (Pubitemid 30216019)
285. Szasz I, Sarkadi B, Schubert A, Gardos G. Effects of lanthanum on calcium-dependent phenomena in human red cells. Biochim Biophys Acta 512: 331-340, 1978. (Pubitemid 9033853)
286. 2+ pump inhibitors obtained using biotechnology. Pflügers Arch 456: 255-266, 2008.
287. 2+ transport activity in skeletal muscle of diabetic rats. Am J Physiol Endocrinol Metab 260: E626-E632, 1991.
288. 2+-ATPase gene causes deafness in Wriggle Mouse Sagami. Biochem Biophys Res Commun 261: 773-778, 1999.
289. Tavadia S, Tait RC, McDonagh TA, Munro CS. Platelet and cardiac function in Darier's disease. Clin Exp Dermatol 26: 696-699, 2001. (Pubitemid 33070430)
290. Taylor RS, Jones SM, Dahl RH, Nordeen MH, Howell KE. Characterization of the Golgi complex cleared of proteins in transit and examination of calcium uptake activities. Mol Biol Cell 8: 1911-1931, 1997.
291. 2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase. Proc Natl Acad Sci USA 87: 2466-2470, 1990.
292. Thomas RC. The plasma membrane calcium ATPase (PMCA) of neurones is electroneutral and exchanges 2 H(+) for each Ca(2+) or Ba(2+) ion extruded. J Physiol 587: 315-327, 2009.
293. Toyofuku T, Kurzydlowski K, Tada M, MacLennan DH. Amino acids Lys-Asp-Asp-Lys-Pro-Val402 in the Ca(2+)-ATPase of cardiac sarcoplasmic reticulum are critical for functional association with phospholamban. J Biol Chem 269: 22929-22932, 1994. (Pubitemid 2134885)
294. Toyofuku T, Kurzydlowski K, Tada M, MacLennan DH. Identification of regions in the Ca(2+)-ATPase of sarcoplasmic reticulum that affect functional association with phospholamban. J Biol Chem 268: 2809-2815, 1993. (Pubitemid 23057913)
295. 2+-ATPase of sarcoplasmic reticulum. Arch Biochem Biophys 476: 3-11, 2008.
296. 2+ ATPase. Proc Natl Acad Sci USA 100: 467-472, 2003.
297. Toyoshima C, Nakasako M, Nomura H, Ogawa H. Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution. Nature 405: 647-655, 2000. (Pubitemid 30428644)
298. Toyoshima C, Nomura H. Structural changes in the calcium pump accompanying the dissociation of calcium. Nature 418: 605-611, 2002. (Pubitemid 34886857)
299. Tu CL, Oda Y, Komuves L, Bikle DD. The role of the calcium-sensing receptor in epidermal differentiation. Cell Calcium 35: 265-273, 2004. (Pubitemid 38292370)
300. Uhlemann AC, Cameron A, Eckstein-Ludwig U, Fischbarg J, Iserovich P, Zuniga FA, East M, Lee A, Brady L, Haynes RK, Krishna S. A single amino acid residue can determine the sensitivity of SERCAs to artemisinins. Nat Struct Mol Biol 12: 628-629, 2005. (Pubitemid 40980816)
301. 2+ pumps in the Golgi apparatus. Biochim Biophys Acta 1742: 103-112, 2004.
302. 2+ accumulation in the Golgi apparatus of HeLa cells assessed via RNA-mediated interference. Biochem Biophys Res Commun 306: 430-436, 2003.
303. Van Baelen K, Vanoevelen J, Missiaen L, Raeymaekers L, Wuytack F. The Golgi PMR1 P-type ATPase of Caenorhabditis elegans. Identification of the gene and demonstration of calcium and manganese transport. J Biol Chem 276: 10683-10691, 2001. (Pubitemid 38089239)
304. 2+ homeostasis and store-operated channels in prostate cancer cells. Cancer Cell 1: 169-179, 2002.
305. 2+ ions. J Biol Chem 280: 22800-22808, 2005.
306. 2+ homeostasis and apoptotic resistance of neuroendocrine-differentiated prostate cancer cells. Cell Death Differ 11: 321-330, 2004.
307. Varadi A, Lebel L, Hashim Y, Mehta Z, Ashcroft SJ, Turner R. Sequence variants of the sarco(endo)plasmic reticulum Ca(2+)-transport ATPase 3 gene (SERCA3) in Caucasian type II diabetic patients (UK Prospective Diabetes Study 48). Diabetologia 42: 1240-1243, 1999. (Pubitemid 29459822)
308. 2+-ATPase isoforms is expressed in islets of Langerhans and pancreatic beta-cell lines. Biochem J 314: 663-669, 1996.
309. Varki A. Factors controlling the glycosylation potential of the Golgi apparatus. Trends Cell Biol 8: 34-40, 1998. (Pubitemid 28040845)
310. Venkatachalam K, Montell C. TRP channels. Annu Rev Biochem 76: 387-417, 2007.
311. 2+-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart. Circ Res 89: 838-846, 2001.
312. 2+ pumps and their modulation by phospholamban. Biochem J 286: 591-595, 1992.
313. 2+-transport ATPase (SERCA2a/b). Biochem J 303: 979-984, 1994.
314. 2+ pump. J Biol Chem 263: 14152-14159, 1988.
315. Vorum H, Hager H, Christensen BM, Nielsen S, Honore B. Human calumenin localizes to the secretory pathway and is secreted to the medium. Exp Cell Res 248: 473-481, 1999. (Pubitemid 29394806)
316. Wang P, Wang X, Pei D. Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV. J Biol Chem 279: 20461-20470, 2004. (Pubitemid 38623493)
317. 2+-ATPase, reveals residues critical for ion selectivity and transport. J Biol Chem 275: 23927-23932, 2000.
318. Wei Y, Marchi V, Wang R, Rao R. An N-terminal EF hand-like motif modulates ion transport by Pmr1, the yeast Golgi Ca(2+)/Mn(2+)-ATPase. Biochemistry 38: 14534-14541, 1999. (Pubitemid 129517592)
319. West DW, Clegg RA. Casein kinase activity in rat mammary gland Golgi vesicles. Demonstration of latency and requirement for a transmembrane ATP carrier. Biochem J 219: 181-187, 1984.
320. Wheelock MJ, Johnson KR. Cadherins as modulators of cellular phenotype. Annu Rev Cell Dev Biol 19: 207-235, 2003.
321. Williams JC, Armesilla AL, Mohamed TM, Hagarty CL, McIntyre FH, Schomburg S, Zaki AO, Oceandy D, Cartwright EJ, Buch MH, Emerson M, Neyses L. The sarcolemmal calcium pump, alpha-1 syntrophin, neuronal nitric-oxide synthase are parts of a macromolecular protein complex. J Biol Chem 281: 23341-23348, 2006. (Pubitemid 44274108)
322. Wood JD, Muchinsky SJ, Filoteo AG, Penniston JT, Tempel BL. Low endolymph calcium concentrations in deafwaddler2J mice suggest that PMCA2 contributes to endolymph calcium maintenance. J Assoc Res Otolaryngol 5: 99-110, 2004.
323. 2+ pumps. Biosci Rep 15: 299-306, 1995.
324. 2+-ATPase, hSPCA2, has unusual properties and is expressed in the brain. J Biol Chem 280: 11608-11614, 2005.
325. 2+/calmodulin-dependent protein kinase. J Biol Chem 268:8394-8397, 1993.
326. Xu GG, Gao ZY, Borge PD Jr, Jegier PA, Young RA, Wolf BA. Insulin regulation of beta-cell function involves a feedback loop on SERCA gene expression, Ca(2+) homeostasis, insulin expression and secretion. Biochemistry 39: 14912-14919, 2000.
327. Yoshida M, Yamasaki K, Daiho T, Iizuka H, Suzuki H. ATP2C1 is specifically localized in the basal layer of normal epidermis and its depletion triggers keratinocyte differentiation. J Dermatol Sci 43: 21-33, 2006. (Pubitemid 43817497)
328. 2+ transport ATPase mediate resistance to thapsigargin in thapsigargin-resistant hamster cells. J Biol Chem 273: 3542-3546, 1998.
329. 2+ pump in reconstituted proteoliposomes. Biophys J 64: 1232-1242, 1993.
330. 2+-ATPase. Cell Calcium 19: 453-458, 1996.
331. 2+ pump using trypsin proteolysis. Biochemistry 29: 8070-8076, 1990.
332. Zylinska L, Soszynski M, Sobolewska B, Gulczynska E. Characterization of erythrocyte compounds in asphyxiated newborns. Mol Cell Biol Res Commun 2: 185-189, 1999. (Pubitemid 129533216)