A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matα2 repressor degradation

Genes and Development

Volumn 15, Issue 20, 2001, Pages 2660-2674

  Swanson, R ^a   Locher, M ^a   Hochstrasser, M ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

ERAD; Proteasome; Protein degradation; Ubiquitin; UPR

Indexed keywords

LIGASE; PROTEASOME; UBIQUITIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CAT CRY SYNDROME; CELL NUCLEUS MEMBRANE; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENETIC COMPLEMENTATION; GENETIC CONSERVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN LOCALIZATION; SARCOPLASMIC RETICULUM;

AMINO ACID SEQUENCE; CYSTEINE ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; FLUORESCENT ANTIBODY TECHNIQUE; FUNGAL PROTEINS; GENETIC VECTORS; HOMEODOMAIN PROTEINS; IMMUNOBLOTTING; LIGASES; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; NUCLEAR ENVELOPE; PROTEIN CONFORMATION; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

ANIMALIA; FELIS CATUS;

EID: 0035887277     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.933301     Document Type: Article

References (45)

1. The recognition component of the N-end rule pathway
2. A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae
3. Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation
4. Impairment of the ubiquitin-proteasome system by protein aggregation
5. Role of Cuelp in ubiquitination and degradation at the ER surface
6. Rsp5 WW domains interact directly with the carboxyl-terminal domain of RNA polymerase II
7. Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MATα2 repressor
8. A regulatory link between ER-associated protein degradation and the unfolded-protein response
9. New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites
10. Degradation signals for ubiquitin system proteolysis in Saccharomyces cerevisiae
11. Degradation of unassembled Vph1p reveals novel aspects of the yeast ER quality control system
12. ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway
13. Ubiquitin-dependent protein degradation
14. The Saccharomyces cerevisiae ubiquitin-proteasome system
15. An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of parkin
16. Degradation signal masking by heterodimerization of MATα2 and MATα1 blocks their mutual destruction by the ubiquitin-proteasome pathway
17. Characterizing class IWW domains defines key specificity determinants and generates mutant domains with novel specificities
18. UBE3A/E6-AP mutations cause Angelman syndrome
19. Substrate targeting in the ubiquitin system
20. The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein
21. Regulation of p53 localization
22. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
23. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
24. Predicting coiled coils from protein sequences
25. Clinical and molecular characterisation of 80 patients with 5p deletion: Genotype-phenotype correlation
26. Inactivation of SSM4, a new Saccharomyces cerevisiae gene, suppresses mRNA instability due to rna14 mutations
27. Rpn4p acts as a transcription factor by binding to PACE, a nonamer box found upstream of 26S proteasomal and other genes in yeast
28. Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds
29. A single 13-kilobase divergent locus in the Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genome contains nine open reading frames that are homologous to or related to cellular proteins
30. Mechanisms underlying ubiquitination
31. Retrograde protein translocation: ERADication of secretory proteins in health and disease
32. Binding sites of ubiquitin-protein ligase: Binding of ubiquitin-protein conjugates and of ubiquitin-carrier protein
33. A role for actin, Cdc1p, and Myo2p in the inheritance of late Golgi elements in Saccharomyces cerevisiae
34. Rna14p, a component of the yeast nuclear cleavage/polyadenylation factor I, is also localised in mitochondria
35. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
36. The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast
37. A viable ubiquitin-activating enzyme mutant for evaluating ubiquitin system function in Saccharomyces cerevisiae
38. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation
39. The ubiquitin system
40. Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p
41. Themes and variations on ubiquitylation
42. HRD gene dependence of endoplasmic reticulum-associated degradation
43. The inner nuclear membrane
44. Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases