The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology

Journal of Biochemistry

Volumn 149, Issue 5, 2011, Pages 507-518

  Asada, Rie ^a   Kanemoto, Soshi ^a   Kondo, Shinichi ^a   Saito, Atsushi ^a   Imaizumi, Kazunori ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

bZIP transcription factor; endoplasmic reticulum stress; OASIS family; regulated intramembrane proteolysis; unfolded protein response

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; BOX B BINDING FACTOR 2; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN H; ENDOPLASMIC RETICULUM KINASE; HUMAN HOMOLOG ON CHROMOSOME 7; INOSITOL REQUIRING ENZYME 1; MEMBRANE PROTEIN; OLD ASTROCYTE SPECIFICALLY INDUCED SUBSTANCE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR LUMAN; UNCLASSIFIED DRUG;

CELL FUNCTION; CELL NUCLEUS; CYTOSOL; ENDOPLASMIC RETICULUM; HUMAN; MEMBRANE BINDING; NONHUMAN; PROTEIN BINDING; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; UNFOLDED PROTEIN RESPONSE;

ANIMALS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL PHYSIOLOGICAL PHENOMENA; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ENDOPLASMIC RETICULUM; HUMANS; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

EUKARYOTA;

EID: 79955424672     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvr041     Document Type: Review

References (78)

1. Schroder, M. and Kaufman, R.J. (2005) ER stress and the unfolded protein response. Mut. Res. 569, 29-63 (Pubitemid 39643256)
2. Ron, D. (2002) Translational control in the endoplasmic reticulum stress response. J. Clin. Invest. 110, 1383-1388 (Pubitemid 35396906)
3. Kaufman, R.J. (2002) Orchestrating the unfolded protein response in health and disease. J. Clin. Invest. 101, 1389-1398 (Pubitemid 35396907)
4. Harding, H.P., Zhang, Y., and Ron, D. (1999) Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397, 271-274 (Pubitemid 29051178)
5. Urano, F., Wang, X., Bertolotti, A., Zhang, Y., Chung, P., Harding, H.P., and Ron, D. (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287, 664-666 (Pubitemid 30070916)
6. Tirasophon, W., Lee, K., Callaghan, B., Welihinda, A., and Kaufman, R.J. (2000) The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response. Genes Dev. 14, 2725-2736 (Pubitemid 32531199)
7. Li, M., Baumeister, P., Roy, B., Phan, T., Foti, D., Luo, S., and Lee, A.S. (2000) ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1. Mol. Cell. Biol. 20, 5096-5106 (Pubitemid 30431563)
8. Yoshida, H., Haze, K., Yanagi, H., Yura, T., and Mori, K. (1998) Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors. J. Biol. Chem. 273, 33741-33749
9. Harding, H.P., Novoa, I., Zhang, Y., Zeng, H., Wek, R., Schapira, M., and Ron, D. (2000) Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell 6, 1099-1108
10. DenBoer, L.M., Hardy-Smith, P.W., Hogan, M.R., Cockram, G.P., Audas, T.E., and Lu, R. (2005) Luman is capable of binding and activating transcription from the unfolded protein response element. Biochem. Biophys. Res. Commun. 331, 113-119 (Pubitemid 40545149)
11. Liang, G., Audas, T.E., Li, Y., Cockram, G.P., Dean, J.D., Martyn, A.C., Kokame, K., and Lu, R. (2006) Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. Mol. Cell. Biol. 26, 7999-8010 (Pubitemid 44630999)
12. Kondo, S., Murakami, T., Tatsumi, K., Ogata, M., Kanemoto, S., Otori, K., Iseki, K., Wanaka, A., and Imaizumi, K. (2005) OASIS, a CREB/ATF-family member, modulates UPR signaling in astrocytes. Nat. Cell Biol. 7, 186-194 (Pubitemid 40268134)
13. Kondo, S., Saito, A., Hino, S., Murakami, T., Ogata, M., Kanemoto, S., Nara, S., Yamashita, A., Yoshinaga, K., Hara, H., and Imaizumi, K. (2007) BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer. Mol. Cell. Biol. 27, 1716-1729
14. Zhang, K., Shen, X., Wu, J., Sakaki, K., Saunders, T., Rutkowski, D.T., Back, S.H., and Kaufman, R.J. (2006) Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 124, 587-599 (Pubitemid 43199443)
15. Nagamori, I., Yabuta, N., Fujii, T., Tanaka, H., Yomogida, K., Nishimune, Y., and Nojima, H. (2005) Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway. Genes Cells 10, 575-594 (Pubitemid 40867489)
16. Stirling, J. and O'Hare, P. (2006) CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P. Mol. Biol. Cell 17, 413-426 (Pubitemid 43049493)
17. Newman, J.R. and Keating, A.E. (2003) Comprehensive identification of human bZIP interactions with coiled-coil arrays. Science 300, 2097-2101 (Pubitemid 36760137)
18. Bailey, D. and O'Hare, P. (2007) Transmembrane bZIP transcription factors in ER stress signaling and the unfolded protein response. Antioxid. Redox Signal. 9, 2305-2321 (Pubitemid 350059018)
19. Shen, J., Chen, X., Hendershot, L., and Prywes, R. (2002) ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev. Cell 3, 99-111 (Pubitemid 34778399)
20. Murakami, T., Saito, A., Hino, S., Kondo, S., Kanemoto, S., Chihara, K., Sekiya, H., Tsumagari, K., Ochiai, K., Yoshinaga, K., Saitoh, M., Nishimura, R., Yoneda, T., Kou, I., Furuichi, T., Ikegawa, S., Ikawa, M., Okabe, M., Wanaka, A., and Imaizumi, K. (2009) Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation. Nat. Cell Biol. 11, 1205-1211
21. Saito, A., Hino, S., Murakami, T., Kanemoto, S., Kondo, S., Saitoh, M., Nishimura, R., Yoneda, T., Furuichi, T., Ikegawa, S., Ikawa, M., Okabe, M., and Imaizumi, K. (2009) Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis. Nat. Cell Biol. 11, 1197-1204
22. Omori, Y., Imai, J., Watanabe, M., Komatsu, T., Suzuki, Y., Kataoka, K., Watanabe, S., Tanigami, A., and Sugano, S. (2001) CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression. Nucleic Acids Res. 29, 2154-2162 (Pubitemid 32472086)
23. Stelzer, G. and Don, J. (2002) Atce1: a novel mouse cyclic adenosine 3′,5′-monophosphate-responsive element-binding protein-like gene exclusively expressed in postmeiotic spermatids. Endocrinology 143, 1578-1588 (Pubitemid 34415871)
24. Cao, G., Ni, X., Jiang, M., Ma, Y., Cheng, H., Guo, L., Ji, C., Gu, S., Xie, Y., and Mao, Y. (2002) Molecular cloning and characterization of a novel human cAMP response element-binding (CREB) gene (CREB4). J. Hum. Genet. 47, 373-376 (Pubitemid 34733517)
25. Shen, X., Ellis, R.E., Sakaki, K., and Kaufman, R.J. (2005) Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. PLoS Genet. 1, 355-368
26. Fox, R.M., Hanlon, C.D., and Andrew, D.J. (2010) The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. J. Cell Biol. 191, 479-492
27. Kristie, T.M. and Sharp, P.A. (1993) Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16). J. Biol. Chem. 268, 6525-6534 (Pubitemid 23099352)
28. Wilson, A.C., LaMarco, K., Peterson, M.G., and Herr, W. (1993) The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein. Cell 74, 115-125 (Pubitemid 23219883)
29. Lu, R., Yang, P., O'Hare, P., and Misra, V. (1997) Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor. Mol. Cell. Biol. 17, 5117-5126 (Pubitemid 27357610)
30. Ko, J., Jang, S.W., Kim, Y.S., Kim, I.S., Sung, H.J., Kim, H.H., Park, J.Y., Lee, Y.H., Kim, J., and Na, D.S. (2004) Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines. FASEB J. 18, 890-892
31. Lu, R. and Misra, V. (2000) Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency. J. Virol. 74, 934-943 (Pubitemid 30036230)
32. Eleveld-Trancikova, D., Sanecka, A., van Hout-Kuijer, M.A., Looman, M.W.G., Hendriks, I.A.M., Jansen, B.J.H., and Adema, G.J. (2010) DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation. Mol. Immunol. 47, 1963-1973
33. Raggo, C., Rapin, N., Stirling, J., Gobeil, P., Smith- Windsor, E., O'Hare, P., and Misra, V. (2002) Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis. Mol. Cell. Biol. 22, 5639-5649 (Pubitemid 34815814)
34. DenBoer, L.M., Hardy-Smith, P.W., Hogan, M.R., Cockram, G.P., Audas, T.E., and Lu, R. (2005) Luman is capable of binding and activating transcription from the unfolded protein response element. Biochem. Biophys. Res. Commun. 331, 113-119 (Pubitemid 40545149)
35. Liang, G., Audas, T.E., Li, Y., Cockram, G.P., Dean, J.D., Martyn, A.C., Kokame, K., and Lu, R. (2006) Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. Mol. Cell. Biol. 26, 7999-8010 (Pubitemid 44630999)
36. Molinari, M., Calanca, V., Galli, C., Lucca, P., and Paganetti, P. (2003) Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle. Science 299, 1397-1400 (Pubitemid 36254653)
37. Schulze, A., Standera, S., Buerger, E., Kikkert, M., van Voorden, S., Wiertz, E., Koning, F., Kloetzel, P.M., and Seeger, M. (2005) The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway. J. Mol. Biol. 354, 1021-1027 (Pubitemid 41698912)
38. + homeostasis and mitochondrial function during endoplasmic reticulum stress. J. Biol. Chem. 279, 28733-28743 (Pubitemid 38900158)
39. Hori, O., Ichinoda, F., Yamaguchi, A., Tamatani, T., Taniguchi, M., Koyama, Y., Katayama, T., Tohyama, M., Stern, D.M., Ozawa, K., Kitao, Y., and Ogawa, S. (2004) Role of Herp in the endoplasmic reticulum stress response. Genes Cells 9, 457-469 (Pubitemid 38771935)
40. Audas, T.E., Li, Y., Liang, G., and Lu, R. (2008) A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response. Mol. Cell. Biol. 28, 3952-3966 (Pubitemid 351812982)
41. Hartgers, F.C., Vissers, J.L., Looman, M.W., van Zoelen, C., Huffine, C., Figdor, C.G., and Adema, G.J. (2000) DC-STAMP, a novel multimembrane-spanning molecule preferentially expressed by dendritic cells. Eur. J. Immunol. 30, 3585-3590 (Pubitemid 32005231)
42. Eleveld-Trancikova, D., Triantis, V., Moulin, V., Looman, M.W., Wijers, M., Fransen, J.A., Lemckert, A.A., Havenga, M.J., Figdor, C.G., Janssen, R.A., and Adema, G.J. (2005) The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum. J. Leukoc. Biol. 77, 337-343 (Pubitemid 40289563)
43. Sawatani, Y., Miyamoto, T., Nagai, S., Maruya, M., Imai, J., Miyamoto, K., Fujita, N., Ninomiya, K., Suzuki, T., Iwasaki, R., Toyama, Y., Shinohara, M., Koyasu, S., and Suda, T. (2008) The role of DC-STAMP in maintenance of immune tolerance through regulation of dendritic cell function. Int. Immunol. 20, 1259-1268
44. Jansen, B.J., Eleveld-Trancikova, D., Sanecka, A., van Hout-Kuijer, M., Hendriks, I.A., Looman, M.G., Leusen, J.H., and Adema, G.J. (2009) OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation. Mol. Immunol. 46, 505-515
45. Horton, J.D., Goldstein, J.L., and Brown, M.S. (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109, 1125-1131 (Pubitemid 34496588)
46. Honma, Y., Kanazawa, K., Mori, T., Tanno, Y., Tojo, M., Kiyosawa, H., Takeda, J., Nikaido, T., Tsukamoto, T., Yokoya, S., and Wanaka, A. (1999) Identification of a novel gene, OASIS, which encodes for a putative CREB/ATF family transcription factor in the long-term cultured astrocytes and gliotic tissue. Brain Res. Mol. Brain Res. 69, 93-103 (Pubitemid 29238190)
47. Murakami, T., Kondo, S., Ogata, M., Kanemoto, S., Saito, A., Wanaka, A., and Imaizumi, K. (2006) Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress. J. Neurochem. 96, 1090-1100
48. Chen, X., Shen, J., and Prywes, R. (2002) The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi. J. Biol. Chem. 277, 045-052
49. Chihara, K., Saito, A., Murakami, T., Hino, S., Aoki, Y., Sekiya, H., Aikawa, Y., Wanaka, A., and Imaizumi, K. (2009) Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice. J. Neurochem. 110, 956-965
50. Omori, Y., Imai, J., Suzuki, Y., Watanabe, S., Tanigami, A., and Sugano, S. (2002) OASIS is a transcriptional activator of CREB/ATF family with a transmembrane domain. Biochem. Biophys. Res. Commun. 293, 470-477 (Pubitemid 34694232)
51. Murakami, T., Hino, S., Nishimura, R., Yoneda, T., Wanaka, A., and Imaizumi, K. (2011) Distinct mechanisms are responsible for osteopenia and growth retardation in OASIS-deficient mice. Bone 48, 514-523
52. Eddleston, M. and Mucke, L. (1993) Molecular profile of reactive astrocytes - implications for their role in neurologic disease. Neuroscience 54, 15-36 (Pubitemid 23147085)
53. Storlazzi, C.T., Mertens, F., Nascimento, A., Isaksson, M., Wejde, J., Brosjo, O., Mandahl, N., and Panagopoulos, I. (2003) Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma. Hum. Mol. Genet. 12, 2349-2358 (Pubitemid 37160879)
54. Paccaud, J.P., Reith, W., Carpentier, J.L., Ravazzola, M., Amherdt, M., Schekman, R., and Orci, L. (1996) Cloning and functional characterization of mammalian homologues of the COPII component Sec23. Mol. Biol. Cell 7, 1535-1546 (Pubitemid 26339727)
55. Fromme, J.C., Orci, L., and Schekman, R. (2008) Coordination of COPII vesicle trafficking by Sec23. Trends Cell Biol. 98, 330-336
56. Boyadjiev, S.A., Fromme, J.C., Ben, J., Chong, S.S., Nauta, C., Hur, D.J., Zhang, G., Hamamoto, S., Schekman, R., Ravazzola, M., Orci, L., and Eyaid, W. (2006) Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking. Nat. Genet. 38, 1192-1197 (Pubitemid 44470366)
57. Omori, Y., Imai, J., Watanabe, M., Komatsu, T., Suzuki, Y., Kataoka, K., Watanabe, S., Tanigami, A., and Sugano, S. (2001) CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression. Nucleic Acids Res. 29, 2154-2162 (Pubitemid 32472086)
58. Luebke-Wheeler, J., Zhang, K., Battle, M., Si-Tayeb, K., Garrison, W., Chhinder, S., Li, J., Kaufman, R.J., and Duncan, S.A. (2008) Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Hepatology 48, 1242-1250
59. Li, J., Ning, G., and Duncan, S.A. (2000) Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha. Genes Dev. 14, 464-474 (Pubitemid 30131891)
60. Hayhurst, G.P., Lee, Y.H., Lambert, G., Ward, J.M., and Gonzalez, F.J. (2001) Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol. Cell. Biol. 21, 1393-1403 (Pubitemid 32114986)
61. Parviz, F., Matullo, C., Garrison, W.D., Savatski, L., Adamson, J.W., Ning, G., Kaestner, K.H., Rossi, J.M., Zaret, K.S., and Duncan, S.A. (2003) Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. Nat. Genet. 34, 292-296 (Pubitemid 36792861)
62. Chan, C.P., Mak, T.Y., Chin, K.T., Ng, I.O., and Jin, D.Y. (2010) N-linked glycosylation is required for optimal proteolytic activation of membrane-bound transcription factor CREB-H. J. Cell Sci. 123, 1438-1448
63. Chin, K.T., Zhou, H.J., Wong, C.M., Lee, J.M., Chan, C.P., Qiang, B.Q., Yuan, J.G., Ng, I.O., and Jin, D.Y. (2005) The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma. Nucleic Acids Res. 33, 1859-1873 (Pubitemid 41748332)
64. Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., and Loréal, O. (2001) A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem. 276, 7811-7819
65. Nemeth, E., Valore, E.V., Territo, M., Schiller, G., Lichtenstein, A., and Ganz, T. (2003) Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 101, 2461-2463 (Pubitemid 36857598)
66. Ganz, T. (2006) Hepcidin-a peptide hormone at the interface of innate immunity and iron metabolism. Curr. Top Microbiol. Immunol. 306, 183-198 (Pubitemid 47400322)
67. Vecchi, C., Montosi, G., Zhang, K., Lamberti, I., Duncan, S.A., Kaufman, R.J., and Pietrangelo, A. (2009) ER stress controls iron metabolism through induction of hepcidin. Science 325, 877-880
68. Cao, G., Ni, X., Jiang, M., Ma, Y., Cheng, H., Guo, L., Ji, C., Gu, S., Xie, Y., and Mao, Y. (2002) Molecular cloning and characterization of a novel human cAMP response element-binding (CREB) gene (CREB4). J. Hum. Genet. 47, 373-376 (Pubitemid 34733517)
69. Qi, H., Fillion, C., Labrie, Y., Grenier, J., Fournier, A., Berger, L., El-Alfy, M., and Labrie, C. (2002) AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up-regulated by androgens in LNCaP human prostate cancer cells. Cancer Res. 62, 721-733 (Pubitemid 34126947)
70. Fujii, T., Tamura, K., Masai, K., Tanaka, H., Nishimune, Y., and Nojima, H. (2002) Use of stepwise subtraction to comprehensively isolate mouse genes whose transcription is up-regulated during spermiogenesis. EMBO Rep. 3, 367-372 (Pubitemid 34467608)
71. Nagamori, I., Yomogida, K., Ikawa, M., Okabe, M., Yabuta, N., and Nojima, H. (2006) The testes-specific bZip type transcription factor Tisp40 plays a role in ER stress responses and chromatin packaging during spermiogenesis. Genes Cells 11, 1161-1171 (Pubitemid 44426206)
72. Yamaguchi, A., Hori, O., Stern, D.M., Hartmann, E., Ogawa, S., and Tohyama, M. (1999) Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosomeassociated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation. J. Cell Biol. 147, 1195-1204 (Pubitemid 30012806)
73. Adham, I.M., Eck, T.J., Mierau, K., Müller, N., Sallam, M.A., Paprotta, I., Schubert, S., Hoyer-Fender, S., and Engel, W. (2005) Reduction of spermatogenesis but not fertility in Creb3l4-deficient mice. Mol. Cell. Biol. 25, 7657-7664 (Pubitemid 41170127)
74. Gregorieff, A., Stange, D.E., Kujala, P., Begthel, H., van den Born, M., Korving, J., Peters, P.J., and Clevers, H. (2009) The ets-domain transcription factor Spdef promotes maturation of goblet and Paneth cells in the intestinal epithelium. Gastroenterology 137, 1333-1345
75. Shroyer, N.F., Helmrath, M.A., Wang, V.Y., Antalffy, B., Henning, S.J., and Zoghbi, H.Y. (2007) Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis. Gastroenterology 132, 2478-2488 (Pubitemid 46890862)
76. Yang, Q., Bermingham, N.A., Finegold, M.J., and Zoghbi, H.Y. (2001) Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science 294, 2155-2158 (Pubitemid 33150670)
77. Noah, T.K., Kazanjian, A., Whitsett, J., and Shroyer, N.F. (2010) SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells. Exp. Cell Res. 316, 452-465
78. Oettgen, P., Finger, E., Sun, Z., Akbarali, Y., Thamrongsak, U., Boltax, J., Grall, F., Dube, A., Weiss, A., Brown, L., Quinn, G., Kas, K., Endress, G., Kunsch, C., and Libermann, T.A. (2000) PDEF, a novel prostate epithelium-specific ETS transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression. J. Biol. Chem. 275, 1216-1225 (Pubitemid 30051174)