Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mtor cascades which alter therapy response

Oncotarget

Volumn 3, Issue 9, 2012, Pages 954-987

  McCubrey, James A ^a   Steelman, Linda S ^a   Chappell, William H ^a   Abrams, Stephen L ^a   Montalto, Giuseppe ^b   Cervello, Melchiorre ^c   Nicoletti, Ferdinando ^d   Fagone, Paolo ^d   Malaponte, Grazia ^d   Mazzarino, Maria C ^d   Candido, Saverio ^d   Libra, Massimo ^d   Bäsecke, Jörg ^e   Mijatovic, Sanja ^f   Milella, Danijela Maksimovic Ivanic ^f,g   Tafuri, Agostino ^h   Cocco, Lucio ⁱ   Evangelisti, Camilla ^j   Chiarini, Francesca ^j   Martelli, Alberto M ^i,j  

^a EAST CAROLINA UNIVERSITY   (United States)

^b UNIVERSITY OF PALERMO   (Italy)

^c CNR   (Italy)

^d UNIVERSITY OF CATANIA   (Italy)

^e UNIVERSITY OF GÖTTINGEN   (Germany)

^f UNIVERSITY OF BELGRADE   (Serbia)

^g REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^h SAPIENZA UNIVERSITY OF ROME   (Italy)

ⁱ UNIVERSITY OF BOLOGNA   (Italy)

^j RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

more..

Author keywords

Akt; Mtor; Mutations; Pi3k; Raf; Targeted therapy; Therapy resistance

Indexed keywords

GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; RAF PROTEIN; RAS PROTEIN;

AKT GENE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ERK GENE; GENE AMPLIFICATION; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENE MUTATION; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; HUMAN; MEK GENE; MTOR GENE; NF1 DUSP5 GENE; NONHUMAN; ONCOGENE RAS; PHARMACOGENETICS; PI3K GENE; PP2A GENE; PTEN GENE; RAF GENE; REVIEW; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; TSC 1 GENE; TSC 2 GENE; TUMOR SUPPRESSOR GENE;

EID: 84868628069     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.652     Document Type: Review

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