-
1
-
-
33745960190
-
Why women live longer than men, sex differences in longevity
-
Austad SN. Why women live longer than men: sex differences in longevity. Gend Med. 2006, 3: 79-92.
-
(2006)
Gend Med
, vol.3
, pp. 79-92
-
-
Austad, S.N.1
-
2
-
-
0023465080
-
Sex differentials in health and mortality
-
Verbrugge LM, Wingard DL. Sex differentials in health and mortality. Women Health 1987, 12: 103-145.
-
(1987)
Women Health
, vol.12
, pp. 103-145
-
-
Verbrugge, L.M.1
Wingard, D.L.2
-
4
-
-
0030688040
-
Extraordinary lifespans in ants, a test of evolutionary theories of ageing
-
Keller L, Genoud M. Extraordinary lifespans in ants: a test of evolutionary theories of ageing. Nature 1997, 389: 958-960.
-
(1997)
Nature
, vol.389
, pp. 958-960
-
-
Keller, L.1
Genoud, M.2
-
5
-
-
33746314503
-
Extraordinary plasticity in aging in Strongyloides ratti implies a gene-regulatory mechanism of lifespan evolution
-
Gardner MP, Gems D, Viney ME. Extraordinary plasticity in aging in Strongyloides ratti implies a gene-regulatory mechanism of lifespan evolution. Aging Cell 2006, 5: 315-323.
-
(2006)
Aging Cell
, vol.5
, pp. 315-323
-
-
Gardner, M.P.1
Gems, D.2
Viney, M.E.3
-
6
-
-
65949090057
-
RAG GTPases in nutrient-mediated TOR signaling pathway
-
Kim E, Guan KL. RAG GTPases in nutrient-mediated TOR signaling pathway. Cell Cycle 2009, 8: 1014-1018.
-
(2009)
Cell Cycle
, vol.8
, pp. 1014-1018
-
-
Kim, E.1
Guan, K.L.2
-
7
-
-
33747880070
-
Androgens induce prostate cancer cell proliferation through mammalian target of rapamycin activation and post-transcriptional increases in cyclin D proteins
-
Xu Y, Chen SY, Ross KN, Balk SP. Androgens induce prostate cancer cell proliferation through mammalian target of rapamycin activation and post-transcriptional increases in cyclin D proteins. Cancer Res. 2006, 66: 7783-7792.
-
(2006)
Cancer Res
, vol.66
, pp. 7783-7792
-
-
Xu, Y.1
Chen, S.Y.2
Ross, K.N.3
Balk, S.P.4
-
8
-
-
66749130276
-
Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling
-
Glazer HP, Osipov RM, Clements RT, Sellke FW, Bianchi C. Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling. Cell Cycle 2009, 8: 1738-1746.
-
(2009)
Cell Cycle
, vol.8
, pp. 1738-1746
-
-
Glazer, H.P.1
Osipov, R.M.2
Clements, R.T.3
Sellke, F.W.4
Bianchi, C.5
-
9
-
-
77953577017
-
MTOR's role in ageing, protein synthesis or autophagy?
-
Hands SL, Proud CG, Wyttenbach A. mTOR's role in ageing: protein synthesis or autophagy? Aging 2009, 586-597.
-
(2009)
Aging
, pp. 586-597
-
-
Hands, S.L.1
Proud, C.G.2
Wyttenbach, A.3
-
10
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006, 124: 471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
11
-
-
0035736260
-
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
-
Bodine SC, Stitt TN, Gonzalez M, Kline WO, Stover GL, Bauerlein R, Zlotchenko E, Scrimgeour A, Lawrence JC, Glass DJ, Yancopoulos GD. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol. 2001, 3: 1014-1019.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 1014-1019
-
-
Bodine, S.C.1
Stitt, T.N.2
Gonzalez, M.3
Kline, W.O.4
Stover, G.L.5
Bauerlein, R.6
Zlotchenko, E.7
Scrimgeour, A.8
Lawrence, J.C.9
Glass, D.J.10
Yancopoulos, G.D.11
-
12
-
-
0035735902
-
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways
-
Rommel C, Bodine SC, Clarke BA, Rossman R, Nunez L, Stitt TN, Yancopoulos GD, Glass DJ. Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nat Cell Biol. 2001, 3: 1009-1013.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 1009-1013
-
-
Rommel, C.1
Bodine, S.C.2
Clarke, B.A.3
Rossman, R.4
Nunez, L.5
Stitt, T.N.6
Yancopoulos, G.D.7
Glass, D.J.8
-
13
-
-
35348920085
-
Azoospermia in a renal transplant recipient during sirolimus (rapamycin) treatment
-
Skrzypek J, Krause W. Azoospermia in a renal transplant recipient during sirolimus (rapamycin) treatment. Andrologia 2007, 39: 198-199.
-
(2007)
Andrologia
, vol.39
, pp. 198-199
-
-
Skrzypek, J.1
Krause, W.2
-
14
-
-
50549087736
-
Growth stimulation leads to cellular senescence when the cell cycle is blocked
-
Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle 2008, 7: 3355-3361.
-
(2008)
Cell Cycle
, vol.7
, pp. 3355-3361
-
-
Demidenko, Z.N.1
Blagosklonny, M.V.2
-
15
-
-
67649316033
-
Rapamycin decelerates cellular senescence
-
Demidenko ZN, Zubova SG, Bukreeva EI, Pospelov VA, Pospelova TV, Blagosklonny MV. Rapamycin decelerates cellular senescence. Cell Cycle 2009, 8: 1888-1895.
-
(2009)
Cell Cycle
, vol.8
, pp. 1888-1895
-
-
Demidenko, Z.N.1
Zubova, S.G.2
Bukreeva, E.I.3
Pospelov, V.A.4
Pospelova, T.V.5
Blagosklonny, M.V.6
-
16
-
-
67649369064
-
Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence
-
Demidenko ZN, Shtutman M, Blagosklonny MV. Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence. Cell Cycle 2009, 8: 1896-1900.
-
(2009)
Cell Cycle
, vol.8
, pp. 1896-1900
-
-
Demidenko, Z.N.1
Shtutman, M.2
Blagosklonny, M.V.3
-
17
-
-
77953111224
-
Quantifying pharmacologic suppression of cellular senescence, prevention of cellular hypertrophy versus preservation of proliferative potential
-
Demidenko ZN, Blagosklonny MV. Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential. Aging 2009, 1: 1008-1016.
-
(2009)
Aging
, vol.1
, pp. 1008-1016
-
-
Demidenko, Z.N.1
Blagosklonny, M.V.2
-
18
-
-
74849091341
-
Pseudo-DNA damage response in senescent cells
-
Pospelova TV, Demidenk ZN, Bukreeva EI, Pospelov VA, Gudkov AV, Blagosklonny MV. Pseudo-DNA damage response in senescent cells. Cell Cycle 2009, 8: 4112-4118.
-
(2009)
Cell Cycle
, vol.8
, pp. 4112-4118
-
-
Pospelova, T.V.1
Demidenk, Z.N.2
Bukreeva, E.I.3
Pospelov, V.A.4
Gudkov, A.V.5
Blagosklonny, M.V.6
-
19
-
-
0038441503
-
Cell senescence and hypermitogenic arrest
-
Blagosklonny MV. Cell senescence and hypermitogenic arrest. EMBO Rep. 2003, 4: 358-362.
-
(2003)
EMBO Rep
, vol.4
, pp. 358-362
-
-
Blagosklonny, M.V.1
-
20
-
-
33750499504
-
Cell senescence, hypertrophic arrest beyond restriction point
-
Blagosklonny MV. Cell senescence: hypertrophic arrest beyond restriction point. J Cell Physiol. 2006, 209:592-7.
-
(2006)
J Cell Physiol
, vol.209
, pp. 592-597
-
-
Blagosklonny, M.V.1
-
21
-
-
67649347537
-
Growth and aging, a common molecular mechanism
-
Blagosklonny MV, Hall MN. Growth and aging: a common molecular mechanism. Aging 2009, 1: 357-362.
-
(2009)
Aging
, vol.1
, pp. 357-362
-
-
Blagosklonny, M.V.1
Hall, M.N.2
-
22
-
-
33750029285
-
Aging and immortality, quasi-programmed senescence and its pharmacologic inhibition
-
Blagosklonny MV. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle 2006, 5: 2087-2102.
-
(2006)
Cell Cycle
, vol.5
, pp. 2087-2102
-
-
Blagosklonny, M.V.1
-
23
-
-
33847226657
-
An anti-aging drug today, from senescence-promoting genes to anti-aging pill
-
Blagosklonny MV. An anti-aging drug today: from senescence-promoting genes to anti-aging pill. Drug Disc Today 2007, 12: 218-224.
-
(2007)
Drug Disc Today
, vol.12
, pp. 218-224
-
-
Blagosklonny, M.V.1
-
24
-
-
74549205329
-
Validation of anti-aging drugs by treating age-related diseases
-
Blagosklonny MV. Validation of anti-aging drugs by treating age-related diseases. Aging 2009, 1: 281-288.
-
(2009)
Aging
, vol.1
, pp. 281-288
-
-
Blagosklonny, M.V.1
-
25
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogenous mice
-
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandezr E, Miller RA. Rapamycin fed late in life extends lifespan in genetically heterogenous mice. Nature 2009, 460: 392-396.
-
(2009)
Nature
, vol.460
, pp. 392-396
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
Nadon, N.L.7
Wilkinson, J.E.8
Frenkel, K.9
Carter, C.S.10
Pahor, M.11
Javors, M.A.12
Fernandezr, E.13
Miller, R.A.14
-
26
-
-
55849132493
-
Insulin and aging
-
Bartke A. Insulin and aging. Cell Cycle 2008, 7: 3338-3343.
-
(2008)
Cell Cycle
, vol.7
, pp. 3338-3343
-
-
Bartke, A.1
-
27
-
-
33846569938
-
Targeting mammalian target of rapamycin (mTOR) for health and diseases
-
Tsang CK, Qi H, Liu LF, Zheng XFS. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Disc Today 2007, 12: 112-124.
-
(2007)
Drug Disc Today
, vol.12
, pp. 112-124
-
-
Tsang, C.K.1
Qi, H.2
Liu, L.F.3
Zheng, X.F.S.4
-
28
-
-
78049499910
-
Why human lifespan is rapidly increasing, solving "longevity riddle" with "revealed-slow-aging" hypothesis
-
Blagosklonny MV. Why human lifespan is rapidly increasing: solving "longevity riddle" with "revealed-slow-aging" hypothesis. Aging 2: 177-182.
-
Aging
, vol.2
, pp. 177-182
-
-
Blagosklonny, M.V.1
-
31
-
-
0034046725
-
Epidemiology of major age-related diseases in women compared to men
-
Giampaoli S. Epidemiology of major age-related diseases in women compared to men. Aging 2000, 12: 93-105.
-
(2000)
Aging
, vol.12
, pp. 93-105
-
-
Giampaoli, S.1
-
33
-
-
77953624143
-
Sex-related differences in length and erosion dynamics of human telomeres favor females
-
Moller P, Mayer S, Mattfeldt T, Muller K, Wiegand P, Bruderlein S. Sex-related differences in length and erosion dynamics of human telomeres favor females. Aging 2009, 1: 733-739.
-
(2009)
Aging
, vol.1
, pp. 733-739
-
-
Moller, P.1
Mayer, S.2
Mattfeldt, T.3
Muller, K.4
Wiegand, P.5
Bruderlein, S.6
-
34
-
-
61849146097
-
The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men
-
Epel ES, Merkin SS, Cawthon R, Blackburn EH, Adler NE, Pletcher MJ, Seeman TE. The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men. Aging 2009, 1: 81-88.
-
(2009)
Aging
, vol.1
, pp. 81-88
-
-
Epel, E.S.1
Merkin, S.S.2
Cawthon, R.3
Blackburn, E.H.4
Adler, N.E.5
Pletcher, M.J.6
Seeman, T.E.7
-
36
-
-
0035112192
-
Evolution of the human menopause
-
Shanley DP, Kirkwood TB. Evolution of the human menopause. Bioessays 2001, 23: 282-287.
-
(2001)
Bioessays
, vol.23
, pp. 282-287
-
-
Shanley, D.P.1
Kirkwood, T.B.2
-
37
-
-
36549011796
-
Testing evolutionary theories of menopause
-
Shanley DP, Sear R, Mace R, Kirkwood TB. Testing evolutionary theories of menopause. Proc Biol Sci. 2007, 274: 2943-2949.
-
(2007)
Proc Biol Sci
, vol.274
, pp. 2943-2949
-
-
Shanley, D.P.1
Sear, R.2
Mace, R.3
Kirkwood, T.B.4
-
38
-
-
38349151564
-
Understanding ageing from an evolutionary perspective
-
Kirkwood TB. Understanding ageing from an evolutionary perspective. J Intern Med. 2008, 263: 117-127.
-
(2008)
J Intern Med
, vol.263
, pp. 117-127
-
-
Kirkwood, T.B.1
-
39
-
-
0032560162
-
Reproductive cessation in female mammals
-
Packer C, Tatar M, Collins A. Reproductive cessation in female mammals. Nature 1998, 392: 807-811.
-
(1998)
Nature
, vol.392
, pp. 807-811
-
-
Packer, C.1
Tatar, M.2
Collins, A.3
-
40
-
-
0020598556
-
Aging and the regulation of luteinizing hormone in C57BL/6J mice, impaired elevations after ovariectomy and spontaneous elevations at advanced ages
-
Gee DM, Flurkey K, Finch CE. Aging and the regulation of luteinizing hormone in C57BL/6J mice: impaired elevations after ovariectomy and spontaneous elevations at advanced ages. Biol Reprod. 1983, 28: 598-607.
-
(1983)
Biol Reprod
, vol.28
, pp. 598-607
-
-
Gee, D.M.1
Flurkey, K.2
Finch, C.E.3
-
41
-
-
0021746332
-
Reproductive senescence in female C57BL/6J mice, ovarian impairments and neuroendocrine impairments that are partially reversible and delayable by ovariectomy
-
Mobbs CV, Gee DM, Finch CE. Reproductive senescence in female C57BL/6J mice: ovarian impairments and neuroendocrine impairments that are partially reversible and delayable by ovariectomy. Endocrinology 1984, 115: 1653-1662.
-
(1984)
Endocrinology
, vol.115
, pp. 1653-1662
-
-
Mobbs, C.V.1
Gee, D.M.2
Finch, C.E.3
-
42
-
-
0031012554
-
Postmenopausal acceleration of age-related mortality increase
-
Horiuchi S. Postmenopausal acceleration of age-related mortality increase. J Gerontol A Biol Sci Med Sci. 1997, 52: B78-92.
-
(1997)
J Gerontol A Biol Sci Med Sci
, vol.52
-
-
Horiuchi, S.1
-
43
-
-
45749113667
-
Unraveling estrogen action in osteoporosis
-
Krum SA, Brown M. Unraveling estrogen action in osteoporosis. Cell Cycle 2008, 7: 1348-1352.
-
(2008)
Cell Cycle
, vol.7
, pp. 1348-1352
-
-
Krum, S.A.1
Brown, M.2
-
44
-
-
36849073113
-
Program-like aging and mitochondria, instead of random damage by free radicals
-
Blagosklonny MV. Program-like aging and mitochondria: instead of random damage by free radicals. J Cell Biochem 2007, 102: 1389-1399.
-
(2007)
J Cell Biochem
, vol.102
, pp. 1389-1399
-
-
Blagosklonny, M.V.1
-
45
-
-
74849115774
-
TOR-driven aging, speeding car without brakes
-
Blagosklonny MV. TOR-driven aging: speeding car without brakes. Cell Cycle 2009, 8: 4055-4059.
-
(2009)
Cell Cycle
, vol.8
, pp. 4055-4059
-
-
Blagosklonny, M.V.1
-
46
-
-
77953645579
-
Rapamycin and quasi-programmed aging, four years later
-
Blagosklonny MV. Rapamycin and quasi-programmed aging: four years later. Cell Cycle 2010, 9
-
(2010)
Cell Cycle
, vol.9
-
-
Blagosklonny, M.V.1
-
47
-
-
6344245674
-
Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development
-
Gangloff YG, Mueller M, Dann SG, Svoboda P, Sticker M, Spetz JF, Um SH, Brown EJ, Cereghini S, Thomas G, Kozma SC. Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol. 2004, 24: 9508-2516.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 9508-2516
-
-
Gangloff, Y.G.1
Mueller, M.2
Dann, S.G.3
Svoboda, P.4
Sticker, M.5
Spetz, J.F.6
Um, S.H.7
Brown, E.J.8
Cereghini, S.9
Thomas, G.10
Kozma, S.C.11
-
48
-
-
3242721268
-
mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
-
Murakami M, Ichisaka T, Maeda M, Oshiro N, Hara K, Edenhofer F, Kiyama H, Yonezawa K, Yamanaka S. mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol. 2004, 24: 6710-6718.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 6710-6718
-
-
Murakami, M.1
Ichisaka, T.2
Maeda, M.3
Oshiro, N.4
Hara, K.5
Edenhofer, F.6
Kiyama, H.7
Yonezawa, K.8
Yamanaka, S.9
-
49
-
-
4544343980
-
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
-
Shah OJ, Wang Z, Hunter T. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol. 2004, 14: 1650-1656.
-
(2004)
Curr Biol
, vol.14
, pp. 1650-1656
-
-
Shah, O.J.1
Wang, Z.2
Hunter, T.3
-
50
-
-
0035851205
-
Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway.A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
-
Tremblay F, Marette A. Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem. 2001, 276: 38052-38060.
-
(2001)
J Biol Chem.
, vol.276
, pp. 38052-38060
-
-
Tremblay, F.1
Marette, A.2
-
51
-
-
1642341446
-
Unlike insulin, amino acids stimulate p70S6K but not GSK-3 or glycogen synthase in human skeletal muscle
-
Liu Z, Wu Y, Nicklas EW, Jahn LA, Price WJ, Barrett EJ. Unlike insulin, amino acids stimulate p70S6K but not GSK-3 or glycogen synthase in human skeletal muscle. Am J Physiol Endocrinol Metab. 2004, 286: E523-528.
-
(2004)
Am J Physiol Endocrinol Metab
, vol.286
-
-
Liu, Z.1
Wu, Y.2
Nicklas, E.W.3
Jahn, L.A.4
Price, W.J.5
Barrett, E.J.6
-
52
-
-
24144446404
-
Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability
-
Tremblay F, Krebs M, Dombrowski L, Brehm A, Bernroider E, Roth E, Nowotny P, Waldhäusl W, Marette A, Roden M. Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes 2005, 54: 2674-2684.
-
(2005)
Diabetes
, vol.54
, pp. 2674-2684
-
-
Tremblay, F.1
Krebs, M.2
Dombrowski, L.3
Brehm, A.4
Bernroider, E.5
Roth, E.6
Nowotny, P.7
Waldhäusl, W.8
Marette, A.9
Roden, M.10
-
53
-
-
34249679233
-
The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man
-
Krebs M, Brunmair B, Brehm A, Artwohl M, Szendroedi J, Nowotny P, Roth E, Fürnsinn C, Promintzer M, Anderwald C, Bischof M, Roden M. The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man. Diabetes 2007, 56: 1600-1607.
-
(2007)
Diabetes
, vol.56
, pp. 1600-1607
-
-
Krebs, M.1
Brunmair, B.2
Brehm, A.3
Artwohl, M.4
Szendroedi, J.5
Nowotny, P.6
Roth, E.7
Fürnsinn, C.8
Promintzer, M.9
Anderwald, C.10
Bischof, M.11
Roden, M.12
-
54
-
-
14244256097
-
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats, possible involvement in obesity-linked insulin resistance
-
Khamzina L, Veilleux A, Bergeron S, Marette A. Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. Endocrinology 2005, 146: 1473-1481.
-
(2005)
Endocrinology
, vol.146
, pp. 1473-1481
-
-
Khamzina, L.1
Veilleux, A.2
Bergeron, S.3
Marette, A.4
-
55
-
-
12544252740
-
Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells
-
Briaud I, Dickson LM, Lingohr MK, McCuaig JF, Lawrence JC, Rhodes CJ. Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells. J Biol Chem. 2005, 280: 2282-2293.
-
(2005)
J Biol Chem
, vol.280
, pp. 2282-2293
-
-
Briaud, I.1
Dickson, L.M.2
Lingohr, M.K.3
McCuaig, J.F.4
Lawrence, J.C.5
Rhodes, C.J.6
-
56
-
-
33845509065
-
Is metformin a primary ovulatory agent in patients with polycystic ovary syndrome?
-
Cheang KI, Sharma ST, Nestler JE. Is metformin a primary ovulatory agent in patients with polycystic ovary syndrome? Gynecol Endocrinol. 2006, 22: 595-604.
-
(2006)
Gynecol Endocrinol
, vol.22
, pp. 595-604
-
-
Cheang, K.I.1
Sharma, S.T.2
Nestler, J.E.3
-
57
-
-
47549107694
-
Hypothalamicpituitary- testicular axis disruptions in older men are differentially linked to age and modifiable risk factors, the European Male Aging Study
-
2008 Jul;93(7):. Epub 2008
-
Wu FC, Tajar A, Pye SR, Silman AJ, Finn JD, O'Neill TW, Bartfai G, Casanueva F, Forti G, Giwercman A, Huhtaniemi IT, Kula K, Punab M, Boonen S, Vanderschueren DEMASG. Hypothalamicpituitary- testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. J Clin Endocrinol Metab. 2008 Jul;93(7):. Epub 2008 2008, 93: 2737-2745.
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 2737-2745
-
-
Wu, F.C.1
Tajar, A.2
Pye, S.R.3
Silman, A.J.4
Finn, J.D.5
O'Neill, T.W.6
Bartfai, G.7
Casanueva, F.8
Forti, G.9
Giwercman, A.10
Huhtaniemi, I.T.11
Kula, K.12
Punab, M.13
Boonen, S.14
Vanderschueren Dema, S.G.15
-
58
-
-
58349087177
-
The aging male hypothalamic-pituitary-gonadal axis: Pulsatility and feedback
-
Veldhuis JD, Keenan DM, Liu PY, Iranmanesh A, Takahashi PY, Nehra AX. The aging male hypothalamic-pituitary-gonadal axis: Pulsatility and feedback. Mol Cell Endocrinol. 2009;299:14-22.
-
(2009)
Mol Cell Endocrinol
, vol.299
, pp. 14-22
-
-
Veldhuis, J.D.1
Keenan, D.M.2
Liu, P.Y.3
Iranmanesh, A.4
Takahashi, P.Y.5
Nehra, A.X.6
-
59
-
-
0015220921
-
Age-associated elevation of hypothalamic, threshold to feedback control, and its role in development, ageine, and disease
-
Dilman VM. Age-associated elevation of hypothalamic, threshold to feedback control, and its role in development, ageine, and disease. Lancet 1971, 1: 1211-1219.
-
(1971)
Lancet
, vol.1
, pp. 1211-1219
-
-
Dilman, V.M.1
-
60
-
-
0018402590
-
Hypothalmic mechanisms of ageing and of specific age pathology--I Sensitivity threshold of hypothalamo-pituitary complex to homeostatic stimuli in the reproductive system
-
Dilman VM, Anisimov VN. Hypothalmic mechanisms of ageing and of specific age pathology--I. Sensitivity threshold of hypothalamo-pituitary complex to homeostatic stimuli in the reproductive system. Exp Gerontol. 1979, 14: 161-174.
-
(1979)
Exp Gerontol
, vol.14
, pp. 161-174
-
-
Dilman, V.M.1
Anisimov, V.N.2
-
61
-
-
10844232033
-
Menopause and hypothalamic-pituitary sensitivity to estrogen
-
Weiss G, Skurnick JH, Goldsmith LT, Santoro NF, Park SJ. Menopause and hypothalamic-pituitary sensitivity to estrogen. JAMA 2004, 292: 2991-2996.
-
(2004)
JAMA
, vol.292
, pp. 2991-2996
-
-
Weiss, G.1
Skurnick, J.H.2
Goldsmith, L.T.3
Santoro, N.F.4
Park, S.J.5
-
62
-
-
0017282517
-
The menopausal transition, analysis of LH, FSH, estradiol, and progesterone concentrations during menstrual cycles of older women
-
Sherman BM, West JH, Korenman SG. The menopausal transition: analysis of LH, FSH, estradiol, and progesterone concentrations during menstrual cycles of older women. J Clin Endocrinol Metab. 1976, 42: 629-636.
-
(1976)
J Clin Endocrinol Metab
, vol.42
, pp. 629-636
-
-
Sherman, B.M.1
West, J.H.2
Korenman, S.G.3
-
63
-
-
33749010586
-
The paradox of declining fertility but increasing twinning rates with advancing maternal age
-
Beemsterboer SN, Homburg R, Gorter NA, Schats R, Hompes PG, Lambalk CB. The paradox of declining fertility but increasing twinning rates with advancing maternal age. Hum Reprod. 2006, 21: 1531-1532.
-
(2006)
Hum Reprod
, vol.21
, pp. 1531-1532
-
-
Beemsterboer, S.N.1
Homburg, R.2
Gorter, N.A.3
Schats, R.4
Hompes, P.G.5
Lambalk, C.B.6
-
64
-
-
24644480086
-
Ovarian aging and the perimenopausal transition, the paradox of endogenous ovarian hyperstimulation
-
Prior JC. Ovarian aging and the perimenopausal transition: the paradox of endogenous ovarian hyperstimulation. Endocrine 2005, 26: 297-300.
-
(2005)
Endocrine
, vol.26
, pp. 297-300
-
-
Prior, J.C.1
-
65
-
-
77953648175
-
Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment
-
Niikura Y, Niikura T, Tilly JL. Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment. Aging 2009, 1: 971-978.
-
(2009)
Aging
, vol.1
, pp. 971-978
-
-
Niikura, Y.1
Niikura, T.2
Tilly, J.L.3
-
66
-
-
67649151060
-
Young adult donor bone marrow infusions into female mice postpone age-related reproductive failure and improve offspring survival
-
Selesniemi K, Lee HJ, Niikura T, Tilly JL. Young adult donor bone marrow infusions into female mice postpone age-related reproductive failure and improve offspring survival. Aging 2009, 1: 49-57.
-
(2009)
Aging
, vol.1
, pp. 49-57
-
-
Selesniemi, K.1
Lee, H.J.2
Niikura, T.3
Tilly, J.L.4
-
67
-
-
70350266820
-
The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system
-
Roa J, Garcia-Galiano D, Varela L, Sanchez-Garrido MA, Pineda R, Castellano JM, Ruiz-Pino F, Romero M, Aguilar E, Lopez M, Gaytan F, Dieguez C, Pinilla L, Tena-Sempere M. The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system. Endocrinology 2009, 150: 5016-5026.
-
(2009)
Endocrinology
, vol.150
, pp. 5016-5026
-
-
Roa, J.1
Garcia-Galiano, D.2
Varela, L.3
Sanchez-Garrido, M.A.4
Pineda, R.5
Castellano, J.M.6
Ruiz-Pino, F.7
Romero, M.8
Aguilar, E.9
Lopez, M.10
Gaytan, F.11
Dieguez, C.12
Pinilla, L.13
Tena-Sempere, M.14
-
68
-
-
34547124065
-
Follicle-stimulating hormone increases tuberin phosphorylation and mammalian target of rapamycin signaling through an extracellular signal-regulated kinase-dependent pathway in rat granulosa cells
-
Kayampilly PP, Menon KM. Follicle-stimulating hormone increases tuberin phosphorylation and mammalian target of rapamycin signaling through an extracellular signal-regulated kinase-dependent pathway in rat granulosa cells. Endocrinology 2007, 148: 3950-3957.
-
(2007)
Endocrinology
, vol.148
, pp. 3950-3957
-
-
Kayampilly, P.P.1
Menon, K.M.2
-
69
-
-
33750302398
-
Estrogen-induced activation of mammalian target of rapamycin is mediated via tuberin and the small GTPase Ras homologue enriched in brain
-
Yu J, Henske EP. Estrogen-induced activation of mammalian target of rapamycin is mediated via tuberin and the small GTPase Ras homologue enriched in brain. Cancer Res. 2006, 66: 9461-9466.
-
(2006)
Cancer Res
, vol.66
, pp. 9461-9466
-
-
Yu, J.1
Henske, E.P.2
-
70
-
-
38849108820
-
Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool
-
Reddy P, Liu L, Adhikari D, Jagarlamudi K, Rajareddy S, Shen Y, Du C, Tang W, Hämäläinen T, Peng SL, Lan ZJ, Cooney AJ, Huhtaniemi I, Liu K. Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool. Science 2008, 319: 611-613.
-
(2008)
Science
, vol.319
, pp. 611-613
-
-
Reddy, P.1
Liu, L.2
Adhikari, D.3
Jagarlamudi, K.4
Rajareddy, S.5
Shen, Y.6
Du, C.7
Tang, W.8
Hämäläinen, T.9
Peng, S.L.10
Lan, Z.J.11
Cooney, A.J.12
Huhtaniemi, I.13
Liu, K.14
-
71
-
-
74049132482
-
Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles
-
Adhikari D, Flohr G, Gorre N, Shen Y, Yang H, Lundin E, Lan Z, Gambello MJ, Liu K. Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles. Mol Hum Reprod 2009, 15: 765-770.
-
(2009)
Mol Hum Reprod
, vol.15
, pp. 765-770
-
-
Adhikari, D.1
Flohr, G.2
Gorre, N.3
Shen, Y.4
Yang, H.5
Lundin, E.6
Lan, Z.7
Gambello, M.J.8
Liu, K.9
-
72
-
-
77949898034
-
Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles
-
Adhikari D, Zheng W, Shen Y, Gorre N, Hamalainen T, Cooney AJ, Huhtaniemi I, Lan ZJ, Liu K. Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles. Hum Mol Genet 19: 397-410.
-
Hum Mol Genet
, vol.19
, pp. 397-410
-
-
Adhikari, D.1
Zheng, W.2
Shen, Y.3
Gorre, N.4
Hamalainen, T.5
Cooney, A.J.6
Huhtaniemi, I.7
Lan, Z.J.8
Liu, K.9
-
73
-
-
22144499238
-
Caloric restriction reduces cell loss and maintains estrogen receptor-alpha immunoreactivity in the pre-optic hypothalamus of female B6D2F1 mice
-
Yaghmaie F, Saeed O, Garan SA, Freitag W, Timiras PS, Sternberg H. Caloric restriction reduces cell loss and maintains estrogen receptor-alpha immunoreactivity in the pre-optic hypothalamus of female B6D2F1 mice. Neuro Endocrinol Lett. 2005, 26: 197-203.
-
(2005)
Neuro Endocrinol Lett
, vol.26
, pp. 197-203
-
-
Yaghmaie, F.1
Saeed, O.2
Garan, S.A.3
Freitag, W.4
Timiras, P.S.5
Sternberg, H.6
-
74
-
-
77953149043
-
Calorie restriction, decelerating mTORdriven aging from cells to organisms (including humans)
-
Blagosklonny MV. Calorie restriction: decelerating mTORdriven aging from cells to organisms (including humans). Cell Cycle 9: 683-688.
-
Cell Cycle
, vol.9
, pp. 683-688
-
-
Blagosklonny, M.V.1
-
75
-
-
0001047561
-
The effect of retardation of growth upon the breeding period and duration of life of rats
-
Osborne TB, Mendel LB, Ferry EL. The effect of retardation of growth upon the breeding period and duration of life of rats. Science 1917, 45: 294-295.
-
(1917)
Science
, vol.45
, pp. 294-295
-
-
Osborne, T.B.1
Mendel, L.B.2
Ferry, E.L.3
-
76
-
-
52449090721
-
Moderate caloric restriction initiated in rodents during adulthood sustains function of the female reproductive axis into advanced chronological age
-
Selesniemi K, Lee H-J, Tilly J. Moderate caloric restriction initiated in rodents during adulthood sustains function of the female reproductive axis into advanced chronological age. Aging Cell 2008, 7:622-9.
-
(2008)
Aging Cell
, vol.7
, pp. 622-629
-
-
Selesniemi, K.1
Lee, H.-J.2
Tilly, J.3
-
77
-
-
28844433635
-
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
-
Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 2005, 310: 1642-1646.
-
(2005)
Science
, vol.310
, pp. 1642-1646
-
-
Shaw, R.J.1
Lamia, K.A.2
Vasquez, D.3
Koo, S.H.4
Bardeesy, N.5
Depinho, R.A.6
Montminy, M.7
Cantley, L.C.8
-
78
-
-
34548784576
-
Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome
-
Palomba S, Orio FJ, Falbo A, Russo T, Tolino A, Zullo F. Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome. J Clin Endocrinol Metab. 2007, 92: 3498-3503.
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 3498-3503
-
-
Palomba, S.1
Orio, F.J.2
Falbo, A.3
Russo, T.4
Tolino, A.5
Zullo, F.6
-
79
-
-
50849113473
-
Metformin slows down aging and extends life span of female SHR mice
-
Anisimov VN, Berstein LM, Egormin PA, Piskunova TS, Popovich IG, Zabezhinski MA, Tyndyk ML, Yurova MV, Kovalenko IG, Poroshina TE, Semenchenko AV. Metformin slows down aging and extends life span of female SHR mice. Cell Cycle 2008, 7: 2769-2773.
-
(2008)
Cell Cycle
, vol.7
, pp. 2769-2773
-
-
Anisimov, V.N.1
Berstein, L.M.2
Egormin, P.A.3
Piskunova, T.S.4
Popovich, I.G.5
Zabezhinski, M.A.6
Tyndyk, M.L.7
Yurova, M.V.8
Kovalenko, I.G.9
Poroshina, T.E.10
Semenchenko, A.V.11
-
80
-
-
0017049855
-
Why do women live longer than men
-
Waldron I, Johnston S. Why do women live longer than men? J Human Stress 1976, 2: 19-30.
-
(1976)
J Human Stress
, vol.2
, pp. 19-30
-
-
Waldron, I.1
Johnston, S.2
|