Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

Science

Volumn 278, Issue 5338, 1997, Pages 687-689

  Del Peso, Luis ^a   González García, Maribel ^a   Page, Carmen ^a   Herrera, Román ^b   Nuñez, Gabriel ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN SERINE THREONINE KINASE;

ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; KIDNEY CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; BCL-X PROTEIN; CARRIER PROTEINS; CELL LINE; CHROMONES; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INTERLEUKIN-3; MICE; MORPHOLINES; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 1842333237     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.278.5338.687     Document Type: Article

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28. Single-letter abbreviations for the amino acid residues are as follows: A, Ala; E, Glu; F, Phe; G, Gly; H, His; I, Ile; M, Met; N, Asn; P, Pro; R, Arg; S, Ser; T, Thr; V, Val; and Y, Tyr.
29. We thank T. F. Franke, M. Andjelkovich, and P. Tsichlis for reagents and R. Perez-Ballestero, M. Benedict, and N. Inohara for valuable discussions and critical review of the manuscript. Supported in part by NIH grant CA-64556, the University of Michigan/Parke-Davis Fellowship Program (L.d.P.), a Spanish Ministry of Science and Education Postdoctoral Fellowship (M.G.-G.), and an NIH Research Career Development Award (G.N.)