AKT Activity Determines Sensitivity to Mammalian Target of Rapamycin (mTOR) Inhibitors by Regulating Cyclin D1 and c-myc Expression

Journal of Biological Chemistry

Volumn 279, Issue 4, 2004, Pages 2737-2746

  Gera, Joseph F ^a   Mellinghoff, Ingo K ^a   Shi, Yijiang ^a   Rettig, Matthew B ^a   Tran, Chris ^a   Hsu, Jung Hsin ^a   Sawyers, Charles L ^b   Lichtenstein, Alan K ^a  

^a UCLA MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CELLS; GENES; PROTEINS;

POLYSOMES;

BIOCHEMISTRY;

CYCLIN D1; PROTEIN KINASE B; RAPAMYCIN;

ANIMAL CELL; ARTICLE; CELL CYCLE G1 PHASE; DNA MICROARRAY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; MOLECULAR CLONING; NONHUMAN; ONCOGENE C MYC; POLYSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; RNA TRANSLATION; TARGET CELL; TUMOR XENOGRAFT;

CELL LINE; CYCLIN D1; G1 PHASE; GENE EXPRESSION REGULATION; GENES, MYC; HUMANS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MYC; SIGNAL TRANSDUCTION; SIROLIMUS;

ANIMALIA; MAMMALIA;

EID: 1642535431     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M309999200     Document Type: Article

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