메뉴 건너뛰기




Volumn 9, Issue 20, 2010, Pages 4098-4105

Novel insights into the molecular origins and treatment of lung cancer

Author keywords

Adenocarcinoma; Cancer stem cells; Chemotherapy; Customized therapy; EGFR; Genomic profiling; Hypoxia inducible factor; Kras; Lung cancer; Synthetic lethal

Indexed keywords

6 ACETYL 8 CYCLOPENTYL 5 METHYL 2 [5 (1 PIPERAZINYL) 2 PYRIDINYLAMINO] 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; K RAS PROTEIN; VASCULOTROPIN RECEPTOR;

EID: 77958457957     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.20.13588     Document Type: Review
Times cited : (18)

References (95)
  • 1
    • 0027173231 scopus 로고
    • Estimates of the worldwide incidence of eighteen major cancers in 1985
    • Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer 1993; 54:594-606.
    • (1993) Int J Cancer , vol.54 , pp. 594-606
    • Parkin, D.M.1    Pisani, P.2    Ferlay, J.3
  • 4
    • 34648815009 scopus 로고    scopus 로고
    • Lung cancer in never smokers - A different disease
    • Sun S, Schiller JH, Gazdar AF. Lung cancer in never smokers - a different disease. Nat Rev Cancer 2007; 7:778-90.
    • (2007) Nat Rev Cancer , vol.7 , pp. 778-790
    • Sun, S.1    Schiller, J.H.2    Gazdar, A.F.3
  • 7
    • 0142228320 scopus 로고    scopus 로고
    • Tobacco carcinogens, their biomarkers and tobacco-induced cancer
    • Hecht SS. Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nat Rev Cancer 2003; 3:733-44.
    • (2003) Nat Rev Cancer , vol.3 , pp. 733-744
    • Hecht, S.S.1
  • 8
    • 20144369093 scopus 로고    scopus 로고
    • Tobacco smoke and involuntary smoking
    • Tobacco smoke and involuntary smoking. IARC Monogr Eval Carcinog Risks Hum 2004; 83:1-1438.
    • (2004) IARC Monogr Eval Carcinog Risks Hum , vol.83 , pp. 1-1438
  • 13
    • 0021674404 scopus 로고
    • Sites of recurrence in resected stage I non-small-cell lung cancer: A guide for future studies
    • F eld R, Rubinstein LV, Weisenberger TH. Sites of recurrence in resected stage I non-small-cell lung cancer: a guide for future studies. J Clin Oncol 1984; 2:1352-8.
    • (1984) J Clin Oncol , vol.2 , pp. 1352-1358
    • Feld, R.1    Rubinstein, L.V.2    Weisenberger, T.H.3
  • 14
    • 63049090100 scopus 로고    scopus 로고
    • Metastasis: From dissemination to organ-specific colonization
    • Nguyen DX, Bos PD, Massague J. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 2009; 9:274-84.
    • (2009) Nat Rev Cancer , vol.9 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Massague, J.3
  • 15
    • 28544432790 scopus 로고    scopus 로고
    • The differential effects of mutant p53 alleles on advanced murine lung cancer
    • DOI 10.1158/0008-5472.CAN-05-2193
    • Jackson EL, Olive KP, Tuveson DA, Bronson R, Crowley D, Brown M, et al. The differential effects of mutant p53 alleles on advanced murine lung cancer. Cancer Res 2005; 65:10280-8. (Pubitemid 41743720)
    • (2005) Cancer Research , vol.65 , Issue.22 , pp. 10280-10288
    • Jackson, E.L.1    Olive, K.P.2    Tuveson, D.A.3    Bronson, R.4    Crowley, D.5    Brown, M.6    Jacks, T.7
  • 16
    • 33847323129 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in lung cancer
    • DOI 10.1038/nrc2088, PII NRC2088
    • Sharma SV, Bell DW, Settleman J, Haber DA. Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer 2007; 7:169-81. (Pubitemid 46316032)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.3 , pp. 169-181
    • Sharma, S.V.1    Bell, D.W.2    Settleman, J.3    Haber, D.A.4
  • 19
    • 18744434862 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression correlates with poor prognosis in non-small cell lung cancer patients with p53 overexpression
    • Ohsaki Y, Tanno S, Fujita Y, Toyoshima E, Fujiuchi S, Nishigaki Y, et al. Epidermal growth factor receptor expression correlates with poor prognosis in non-small cell lung cancer patients with p53 overexpression. Oncol Rep 2000; 7:603-7.
    • (2000) Oncol Rep , vol.7 , pp. 603-607
    • Ohsaki, Y.1    Tanno, S.2    Fujita, Y.3    Toyoshima, E.4    Fujiuchi, S.5    Nishigaki, Y.6
  • 20
    • 0026568687 scopus 로고
    • Autocrine growth stimulation by transforming growth factoralpha in human non-small cell lung cancer
    • Putnam EA, Yen N, Gallick GE, Steck PA, Fang K, Akpakip B, et al. Autocrine growth stimulation by transforming growth factoralpha in human non-small cell lung cancer. Surg Oncol 1992; 1:49-60.
    • (1992) Surg Oncol , vol.1 , pp. 49-60
    • Putnam, E.A.1    Yen, N.2    Gallick, G.E.3    Steck, P.A.4    Fang, K.5    Akpakip, B.6
  • 21
    • 0027159063 scopus 로고
    • Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung
    • R usch V, Baselga J, Cordon-Cardo C, Orazem J, Zaman M, Hoda S, et al. Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung. Cancer Res 1993; 53:2379-85.
    • (1993) Cancer Res , vol.53 , pp. 2379-2385
    • Rusch, V.1    Baselga, J.2    Cordon-Cardo, C.3    Orazem, J.4    Zaman, M.5    Hoda, S.6
  • 22
    • 33646888233 scopus 로고    scopus 로고
    • Where next for gefitinib in patients with lung cancer?
    • Blackhall F, Ranson M, Thatcher N. Where next for gefitinib in patients with lung cancer? Lancet Oncol 2006; 7:499-507.
    • (2006) Lancet Oncol , vol.7 , pp. 499-507
    • Blackhall, F.1    Ranson, M.2    Thatcher, N.3
  • 23
    • 24944440830 scopus 로고    scopus 로고
    • TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
    • Herbst RS, Prager D, Hermann R, Fehrenbacher L, Johnson BE, Sandler A, et al. TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 2005; 23:5892-9.
    • (2005) J Clin Oncol , vol.23 , pp. 5892-5899
    • Herbst, R.S.1    Prager, D.2    Hermann, R.3    Fehrenbacher, L.4    Johnson, B.E.5    Sandler, A.6
  • 25
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • DOI 10.1016/S0140-6736(05)67625-8, PII S0140673605676258
    • Thatcher N, Chang A, Parikh P, Rodrigues Pereira J, Ciuleanu T, von Pawel J, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 2005; 366:1527-37. (Pubitemid 41540110)
    • (2005) Lancet , vol.366 , Issue.9496 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3    Pereira, J.R.4    Ciuleanu, T.5    Von Pawel, J.6    Thongprasert, S.7    Tan, E.H.8    Pemberton, K.9    Archer, V.10    Carroll, K.11
  • 26
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial)
    • [corrected]
    • F ukuoka M, Yano S, Giaccone G, Tamura T, Nakagawa K, Douillard JY, et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]. J Clin Oncol 2003; 21:2237-46.
    • (2003) J Clin Oncol , vol.21 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3    Tamura, T.4    Nakagawa, K.5    Douillard, J.Y.6
  • 31
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonists in cancer treatment
    • Ciardiello F, Tortora G. EGFR antagonists in cancer treatment. N Engl J Med 2008; 358:1160-74.
    • (2008) N Engl J Med , vol.358 , pp. 1160-1174
    • Ciardiello, F.1    Tortora, G.2
  • 32
    • 56249109644 scopus 로고    scopus 로고
    • Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): A randomised phase III trial
    • Kim ES, Hirsh V, Mok T, Socinski MA, Gervais R, Wu YL, et al. Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial. Lancet 2008; 372:1809-18.
    • (2008) Lancet , vol.372 , pp. 1809-1818
    • Kim, E.S.1    Hirsh, V.2    Mok, T.3    Socinski, M.A.4    Gervais, R.5    Wu, Y.L.6
  • 33
    • 28844501639 scopus 로고    scopus 로고
    • Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers
    • DOI 10.1002/ijc.21496
    • Shigematsu H, Gazdar AF. Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers. Int J Cancer 2006; 118:257-62. (Pubitemid 41779062)
    • (2006) International Journal of Cancer , vol.118 , Issue.2 , pp. 257-262
    • Shigematsu, H.1    Gazdar, A.F.2
  • 34
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005; 2:73.
    • (2005) PLoS Med , vol.2 , pp. 73
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6
  • 35
    • 15744372810 scopus 로고    scopus 로고
    • KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
    • Pao W, Wang TY, Riely GJ, Miller VA, Pan Q, Ladanyi M, et al. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med 2005; 2:17.
    • (2005) PLoS Med , vol.2 , pp. 17
    • Pao, W.1    Wang, T.Y.2    Riely, G.J.3    Miller, V.A.4    Pan, Q.5    Ladanyi, M.6
  • 36
    • 33947498978 scopus 로고    scopus 로고
    • Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer
    • Sequist LV, Bell DW, Lynch TJ, Haber DA. Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer. J Clin Oncol 2007; 25:587-95.
    • (2007) J Clin Oncol , vol.25 , pp. 587-595
    • Sequist, L.V.1    Bell, D.W.2    Lynch, T.J.3    Haber, D.A.4
  • 37
    • 33748074447 scopus 로고    scopus 로고
    • Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer
    • Inukai M, Toyooka S, Ito S, Asano H, Ichihara S, Soh J, et al. Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer. Cancer Res 2006; 66:7854-8.
    • (2006) Cancer Res , vol.66 , pp. 7854-7858
    • Inukai, M.1    Toyooka, S.2    Ito, S.3    Asano, H.4    Ichihara, S.5    Soh, J.6
  • 39
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • Bean J, Brennan C, Shih JY, Riely G, Viale A, Wang L, et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci USA 2007; 104:20932-7.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 20932-20937
    • Bean, J.1    Brennan, C.2    Shih, J.Y.3    Riely, G.4    Viale, A.5    Wang, L.6
  • 40
    • 60549110433 scopus 로고    scopus 로고
    • MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients
    • Cappuzzo F, Janne PA, Skokan M, Finocchiaro G, Rossi E, Ligorio C, et al. MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients. Ann Oncol 2009; 20:298-304.
    • (2009) Ann Oncol , vol.20 , pp. 298-304
    • Cappuzzo, F.1    Janne, P.A.2    Skokan, M.3    Finocchiaro, G.4    Rossi, E.5    Ligorio, C.6
  • 41
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • E ngelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007; 316:1039-43.
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3    Song, Y.4    Hyland, C.5    Park, J.O.6
  • 42
    • 34249049000 scopus 로고    scopus 로고
    • Implication of the insulin-like growth factor- IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib
    • Morgillo F, Kim WY, Kim ES, Ciardiello F, Hong WK, Lee HY. Implication of the insulin-like growth factor- IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib. Clin Cancer Res 2007; 13:2795-803.
    • (2007) Clin Cancer Res , vol.13 , pp. 2795-2803
    • Morgillo, F.1    Kim, W.Y.2    Kim, E.S.3    Ciardiello, F.4    Hong, W.K.5    Lee, H.Y.6
  • 44
    • 70349684791 scopus 로고    scopus 로고
    • Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
    • R egales L, Gong Y, Shen R, de Stanchina E, Vivanco I, Goel A, et al. Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. J Clin Invest 2009; 119:3000-10.
    • (2009) J Clin Invest , vol.119 , pp. 3000-3010
    • Regales, L.1    Gong, Y.2    Shen, R.3    De Stanchina, E.4    Vivanco, I.5    Goel, A.6
  • 45
    • 77956296140 scopus 로고    scopus 로고
    • MET kinase inhibitor SGX523 synergizes with EGFR inhibitor erlotinib in an HGF-dependent fashion to suppress carcinoma growth
    • Zhang YW, Staal B, Essenburg C, Su Y, Kang L, West RA, et al. MET kinase inhibitor SGX523 synergizes with EGFR inhibitor erlotinib in an HGF-dependent fashion to suppress carcinoma growth. Cancer Res 2010; 70:6880-90.
    • (2010) Cancer Res , vol.70 , pp. 6880-6890
    • Zhang, Y.W.1    Staal, B.2    Essenburg, C.3    Su, Y.4    Kang, L.5    West, R.A.6
  • 46
    • 33744814638 scopus 로고    scopus 로고
    • Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors
    • DOI 10.1101/gad.1417406
    • Politi K, Zakowski MF, Fan PD, Schonfeld EA, Pao W, Varmus HE. Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to downregulation of the receptors. Genes Dev 2006; 20:1496-510. (Pubitemid 43830656)
    • (2006) Genes and Development , vol.20 , Issue.11 , pp. 1496-1510
    • Politi, K.1    Zakowski, M.F.2    Fan, P.-D.3    Schonfeld, E.A.4    Pao, W.5    Varmus, H.E.6
  • 47
    • 41049089483 scopus 로고    scopus 로고
    • Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors
    • R egales L, Balak MN, Gong Y, Politi K, Sawai A, Le C, et al. Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors. PLoS One 2007; 2:810.
    • (2007) PLoS One , vol.2 , pp. 810
    • Regales, L.1    Balak, M.N.2    Gong, Y.3    Politi, K.4    Sawai, A.5    Le, C.6
  • 48
    • 33947535112 scopus 로고    scopus 로고
    • Lung cancer, smoke exposure and sex
    • G azdar AF, Thun MJ. Lung cancer, smoke exposure and sex. J Clin Oncol 2007; 25:469-71.
    • (2007) J Clin Oncol , vol.25 , pp. 469-471
    • Gazdar, A.F.1    Thun, M.J.2
  • 49
    • 0025322751 scopus 로고
    • Association of point mutation in c-Ki-ras oncogene in lung adenocarcinoma with particular reference to cytologic subtypes
    • DOI 10.1002/1097-0142(19900715)66:2<289::AID-CNCR2820660216>3.0. CO;2-6
    • Kobayashi T, Tsuda H, Noguchi M, Hirohashi S, Shimosato Y, Goya T, et al. Association of point mutation in c-Ki-ras oncogene in lung adenocarcinoma with particular reference to cytologic subtypes. Cancer 1990; 66:289-94. (Pubitemid 20205910)
    • (1990) Cancer , vol.66 , Issue.2 , pp. 289-294
    • Kobayashi, T.1    Tsuda, H.2    Noguchi, M.3    Hirohashi, S.4    Shimosato, Y.5    Goya, T.6    Hayata, Y.7
  • 50
    • 0028958222 scopus 로고
    • Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma
    • Mills NE, Fishman CL, Rom WN, Dubin N, Jacobson DR. Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma. Cancer Res 1995; 55:1444-7.
    • (1995) Cancer Res , vol.55 , pp. 1444-1447
    • Mills, N.E.1    Fishman, C.L.2    Rom, W.N.3    Dubin, N.4    Jacobson, D.R.5
  • 51
    • 53249145767 scopus 로고    scopus 로고
    • Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma
    • R iely GJ, Kris MG, Rosenbaum D, Marks J, Li A, Chitale DA, et al. Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. Clin Cancer Res 2008; 14:5731-4.
    • (2008) Clin Cancer Res , vol.14 , pp. 5731-5734
    • Riely, G.J.1    Kris, M.G.2    Rosenbaum, D.3    Marks, J.4    Li, A.5    Chitale, D.A.6
  • 52
    • 65349107082 scopus 로고    scopus 로고
    • KRAS mutations in non-small cell lung cancer
    • R iely GJ, Marks J, Pao W. KRAS mutations in non-small cell lung cancer. Proc Am Thorac Soc 2009; 6:201-5.
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 201-205
    • Riely, G.J.1    Marks, J.2    Pao, W.3
  • 53
    • 0023707058 scopus 로고
    • Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung
    • R odenhuis S, Slebos RJ, Boot AJ, Evers SG, Mooi WJ, Wagenaar SS, et al. Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung. Cancer Res 1988; 48:5738-41.
    • (1988) Cancer Res , vol.48 , pp. 5738-5741
    • Rodenhuis, S.1    Slebos, R.J.2    Boot, A.J.3    Evers, S.G.4    Mooi, W.J.5    Wagenaar, S.S.6
  • 54
    • 0024376173 scopus 로고
    • ras oncogenes in human cancer: A review
    • Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989; 49:4682-9.
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 55
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • DOI 10.1038/nrc969
    • Downward J. Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 2003; 3:11-22. (Pubitemid 37328883)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.1 , pp. 11-22
    • Downward, J.1
  • 56
    • 24944497744 scopus 로고    scopus 로고
    • Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
    • E berhard DA, Johnson BE, Amler LC, Goddard AD, Heldens SL, Herbst RS, et al. Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 2005; 23:5900-9.
    • (2005) J Clin Oncol , vol.23 , pp. 5900-5909
    • Eberhard, D.A.1    Johnson, B.E.2    Amler, L.C.3    Goddard, A.D.4    Heldens, S.L.5    Herbst, R.S.6
  • 57
    • 0035953550 scopus 로고    scopus 로고
    • Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
    • DOI 10.1038/35074129
    • Johnson L, Mercer K, Greenbaum D, Bronson RT, Crowley D, Tuveson DA, et al. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 2001; 410:1111-6. (Pubitemid 32391044)
    • (2001) Nature , vol.410 , Issue.6832 , pp. 1111-1116
    • Johnson, L.1    Mercer, K.2    Greenbaum, D.3    Bronson, R.T.4    Crowley, D.5    Tuveson, D.A.6    Jacks, T.7
  • 61
    • 35349020997 scopus 로고    scopus 로고
    • A genetic mouse model for metastatic lung cancer with gender differences in survival
    • DOI 10.1038/sj.onc.1210493, PII 1210493
    • Zheng S, El-Naggar AK, Kim ES, Kurie JM, Lozano G. A genetic mouse model for metastatic lung cancer with gender differences in survival. Oncogene 2007; 26:6896-904. (Pubitemid 47609074)
    • (2007) Oncogene , vol.26 , Issue.48 , pp. 6896-6904
    • Zheng, S.1    El-Naggar, A.K.2    Kim, E.S.3    Kurie, J.M.4    Lozano, G.5
  • 62
    • 25444497278 scopus 로고    scopus 로고
    • The concept of synthetic lethality in the context of anticancer therapy
    • Kaelin WG Jr. The concept of synthetic lethality in the context of anticancer therapy. Nat Rev Cancer 2005; 5:689-98.
    • (2005) Nat Rev Cancer , vol.5 , pp. 689-698
    • Kaelin Jr., W.G.1
  • 63
    • 77954279920 scopus 로고    scopus 로고
    • A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma
    • Puyol M, Martin A, Dubus P, Mulero F, Pizcueta P, Khan G, et al. A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. Cancer Cell 2010; 18:63-73.
    • (2010) Cancer Cell , vol.18 , pp. 63-73
    • Puyol, M.1    Martin, A.2    Dubus, P.3    Mulero, F.4    Pizcueta, P.5    Khan, G.6
  • 64
    • 60749109846 scopus 로고    scopus 로고
    • Cell cycle, CDKs and cancer: A changing paradigm
    • Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 2009; 9:153-66.
    • (2009) Nat Rev Cancer , vol.9 , pp. 153-166
    • Malumbres, M.1    Barbacid, M.2
  • 66
    • 9444228344 scopus 로고    scopus 로고
    • Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts
    • F ry DW, Harvey PJ, Keller PR, Elliott WL, Meade M, Trachet E, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther 2004; 3:1427-38.
    • (2004) Mol Cancer Ther , vol.3 , pp. 1427-1438
    • Fry, D.W.1    Harvey, P.J.2    Keller, P.R.3    Elliott, W.L.4    Meade, M.5    Trachet, E.6
  • 67
    • 77953006634 scopus 로고    scopus 로고
    • The mutation spectrum revealed by paired genome sequences from a lung cancer patient
    • Lee W, Jiang Z, Liu J, Haverty PM, Guan Y, Stinson J, et al. The mutation spectrum revealed by paired genome sequences from a lung cancer patient. Nature 2010; 465:473-7.
    • (2010) Nature , vol.465 , pp. 473-477
    • Lee, W.1    Jiang, Z.2    Liu, J.3    Haverty, P.M.4    Guan, Y.5    Stinson, J.6
  • 68
    • 77953238558 scopus 로고    scopus 로고
    • Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors
    • Carretero J, Shimamura T, Rikova K, Jackson AL, Wilkerson MD, Borgman CL, et al. Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. Cancer Cell 2010; 17:547-59.
    • (2010) Cancer Cell , vol.17 , pp. 547-559
    • Carretero, J.1    Shimamura, T.2    Rikova, K.3    Jackson, A.L.4    Wilkerson, M.D.5    Borgman, C.L.6
  • 69
    • 57349194139 scopus 로고    scopus 로고
    • Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
    • E ngelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 2008; 14:1351-6.
    • (2008) Nat Med , vol.14 , pp. 1351-1356
    • Engelman, J.A.1    Chen, L.2    Tan, X.3    Crosby, K.4    Guimaraes, A.R.5    Upadhyay, R.6
  • 70
    • 77957676330 scopus 로고    scopus 로고
    • Primary tumor genotype is an important determinant in identification of lung cancer propagating cells
    • Curtis SJ, Sinkevicius KW, Li D, Lau AN, Roach RR, Zamponi R, et al. Primary tumor genotype is an important determinant in identification of lung cancer propagating cells. Cell Stem Cell 2010; 7:127-33.
    • (2010) Cell Stem Cell , vol.7 , pp. 127-133
    • Curtis, S.J.1    Sinkevicius, K.W.2    Li, D.3    Lau, A.N.4    Roach, R.R.5    Zamponi, R.6
  • 71
    • 77958501985 scopus 로고    scopus 로고
    • Tumor oncogenotypes and lung cancer stem cell identity
    • Sullivan JP, Minna JD. Tumor oncogenotypes and lung cancer stem cell identity. Cell Stem Cell 2010; 7:2-4.
    • (2010) Cell Stem Cell , vol.7 , pp. 2-4
    • Sullivan, J.P.1    Minna, J.D.2
  • 72
    • 69449096005 scopus 로고    scopus 로고
    • Heterogeneity in cancer: Cancer stem cells versus clonal evolution
    • Shackleton M, Quintana E, Fearon ER, Morrison SJ. Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 2009; 138:822-9.
    • (2009) Cell , vol.138 , pp. 822-829
    • Shackleton, M.1    Quintana, E.2    Fearon, E.R.3    Morrison, S.J.4
  • 73
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
    • Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 2008; 8:755-68.
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 74
    • 57149142495 scopus 로고    scopus 로고
    • The impact of O2 availability on human cancer
    • Bertout JA, Patel SA, Simon MC. The impact of O2 availability on human cancer. Nat Rev Cancer 2008; 8:967-75.
    • (2008) Nat Rev Cancer , vol.8 , pp. 967-975
    • Bertout, J.A.1    Patel, S.A.2    Simon, M.C.3
  • 75
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
    • Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 2008; 30:393-402.
    • (2008) Mol Cell , vol.30 , pp. 393-402
    • Kaelin Jr., W.G.1    Ratcliffe, P.J.2
  • 76
    • 40949132841 scopus 로고    scopus 로고
    • Turn me on: Regulating HIF transcriptional activity
    • DOI 10.1038/sj.cdd.4402315, PII 4402315, The biology of Hypoxia-inducible factors
    • Lisy K, Peet DJ. Turn me on: regulating HIF transcriptional activity. Cell Death Differ 2008; 15:642-9. (Pubitemid 351405067)
    • (2008) Cell Death and Differentiation , vol.15 , Issue.4 , pp. 642-649
    • Lisy, K.1    Peet, D.J.2
  • 77
    • 70449527373 scopus 로고    scopus 로고
    • Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing
    • Webb JD, Coleman ML, Pugh CW. Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing. Cell Mol Life Sci 2009; 66:3539-54.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 3539-3554
    • Webb, J.D.1    Coleman, M.L.2    Pugh, C.W.3
  • 78
    • 35148828429 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 (HIF-1) pathway
    • Semenza GL. Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE 2007; 2007:8.
    • (2007) Sci STKE , vol.2007 , pp. 8
    • Semenza, G.L.1
  • 79
    • 0035860147 scopus 로고    scopus 로고
    • Relation of hypoxia inducible factor1alpha and 2alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival
    • G iatromanolaki A, Koukourakis MI, Sivridis E, Turley H, Talks K, Pezzella F, et al. Relation of hypoxia inducible factor1alpha and 2alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br J Cancer 2001; 85:881-90.
    • (2001) Br J Cancer , vol.85 , pp. 881-890
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Sivridis, E.3    Turley, H.4    Talks, K.5    Pezzella, F.6
  • 82
    • 0031000736 scopus 로고    scopus 로고
    • A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development
    • Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci USA 1997; 94:4273-8.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4273-4278
    • Ema, M.1    Taya, S.2    Yokotani, N.3    Sogawa, K.4    Matsuda, Y.5    Fujii-Kuriyama, Y.6
  • 88
    • 1642333964 scopus 로고    scopus 로고
    • Down Regulation of High in Normal-1 (HIN-1) is a Frequent Event in Stage I Non-Small Cell Lung Cancer and Correlates with Poor Clinical Outcome
    • DOI 10.1158/1078-0432.CCR-1174-03
    • Marchetti A, Barassi F, Martella C, Chella A, Salvatore S, Castrataro A, et al. Downregulation of high in normal-1 (HIN-1) is a frequent event in stage I non-small cell lung cancer and correlates with poor clinical outcome. Clin Cancer Res 2004; 10:1338-43. (Pubitemid 38365226)
    • (2004) Clinical Cancer Research , vol.10 , Issue.4 , pp. 1338-1343
    • Marchetti, A.1    Barassi, F.2    Martella, C.3    Chella, A.4    Salvatore, S.5    Castrataro, A.6    Mucilli, F.7    Sacco, R.8    Buttitta, F.9
  • 89
    • 0036011265 scopus 로고    scopus 로고
    • Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues
    • DOI 10.1016/S0925-4773(02)00056-4, PII S0925477302000564
    • Porter D, Lahti-Domenici J, Torres-Arzayus M, Chin L, Polyak K. Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues. Mech Dev 2002; 114:201-4. (Pubitemid 34462975)
    • (2002) Mechanisms of Development , vol.114 , Issue.1-2 , pp. 201-204
    • Porter, D.1    Lahti-Domenici, J.2    Torres-Arzayus, M.3    Chin, L.4    Polyak, K.5
  • 92
    • 60549092506 scopus 로고    scopus 로고
    • Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells
    • Lee K, Qian DZ, Rey S, Wei H, Liu JO, Semenza GL. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc Natl Acad Sci USA 2009; 106:2353-8.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 2353-2358
    • Lee, K.1    Qian, D.Z.2    Rey, S.3    Wei, H.4    Liu, J.O.5    Semenza, G.L.6
  • 94
    • 34547660100 scopus 로고    scopus 로고
    • Preclinical evaluation of YC-1, a HIF inhibitor, for the prevention of tumor spreading
    • Shin DH, Kim JH, Jung YJ, Kim KE, Jeong JM, Chun YS, et al. Preclinical evaluation of YC-1, a HIF inhibitor, for the prevention of tumor spreading. Cancer Lett 2007; 255:107-16.
    • (2007) Cancer Lett , vol.255 , pp. 107-116
    • Shin, D.H.1    Kim, J.H.2    Jung, Y.J.3    Kim, K.E.4    Jeong, J.M.5    Chun, Y.S.6
  • 95


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.