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Volumn 9, Issue 3, 2010, Pages 456-459

Double trouble: When Sonic hedgehog signaling meets TSC inactivation

Author keywords

Cerebellum; Medulloblastoma; mTOR; p27kip1; Sonic hedgehog; TSC

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3; MAMMALIAN TARGET OF RAPAMYCIN; SOMATOMEDIN; SONIC HEDGEHOG PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; TUBERIN; TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN; TUMOR SUPPRESSOR PROTEIN;

EID: 77951898362     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.3.10532     Document Type: Article
Times cited : (18)

References (37)
  • 1
    • 33645211987 scopus 로고    scopus 로고
    • Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes
    • Knoepfler PS, Kenney AM. Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes. Cell Cycle 2006; 5:47-52.
    • (2006) Cell Cycle , vol.5 , pp. 47-52
    • Knoepfler, P.S.1    Kenney, A.M.2
  • 2
    • 0037309324 scopus 로고    scopus 로고
    • Sonic hedgehog in normal and neoplastic proliferation: Insight gained from human tumors and animal models
    • DOI 10.1016/S0959-437X(03)00002-9
    • Wetmore C. Sonic hedgehog in normal and neoplastic proliferation: insight gained from human tumors and animal models. Curr Opin Genet Dev 2003; 13:34-42. (Pubitemid 36143925)
    • (2003) Current Opinion in Genetics and Development , vol.13 , Issue.1 , pp. 34-42
    • Wetmore, C.1
  • 3
    • 48449107168 scopus 로고    scopus 로고
    • Even cancers want commitment: Lineage identity and medulloblastoma formation
    • Eberhart CG. Even cancers want commitment: lineage identity and medulloblastoma formation. Cancer Cell 2008; 14:105-7.
    • (2008) Cancer Cell , vol.14 , pp. 105-107
    • Eberhart, C.G.1
  • 7
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • DOI 10.1038/sj.onc.1207542
    • Fingar DC, Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004; 23:3151-71. (Pubitemid 38638827)
    • (2004) Oncogene , vol.23 , Issue.18 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 8
    • 11244297916 scopus 로고    scopus 로고
    • Dysregulation of the TSC-mTOR pathway in human disease
    • DOI 10.1038/ng1494
    • Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 2005; 37:19-24. (Pubitemid 40070934)
    • (2005) Nature Genetics , vol.37 , Issue.1 , pp. 19-24
    • Inoki, K.1    Corradetti, M.N.2    Guan, K.-L.3
  • 10
    • 0030663735 scopus 로고    scopus 로고
    • Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase
    • DOI 10.1074/jbc.272.46.29301
    • Soucek T, Pusch O, Wienecke R, DeClue JE, Hengstschlager M. Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase. J Biol Chem 1997; 272:29301-8. (Pubitemid 27498223)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.46 , pp. 29301-29308
    • Soucek, T.1    Pusch, O.2    Wienecke, R.3    Declue, J.E.4    Hengstschlager, M.5
  • 11
    • 0035833356 scopus 로고    scopus 로고
    • Tuberous sclerosis causing mutants of the TSC2 gene product affect proliferation and p27 expression
    • DOI 10.1038/sj.onc.1204627
    • Soucek T, Rosner M, Miloloza A, Kubista M, Cheadle JP, Sampson JR, et al. Tuberous sclerosis causing mutants of the TSC2 gene product affect proliferation and p27 expression. Oncogene 2001; 20:4904-9. (Pubitemid 32803162)
    • (2001) Oncogene , vol.20 , Issue.35 , pp. 4904-4909
    • Soucek, T.1    Rosner, M.2    Miloloza, A.3    Kubista, M.4    Cheadle, J.P.5    Sampson, J.R.6    Hengstschlager, M.7
  • 13
    • 10344243550 scopus 로고    scopus 로고
    • Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2
    • DOI 10.1074/jbc.M405528200
    • Rosner M, Hengstschlager M. Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2. J Biol Chem 2004; 279:48707-15. (Pubitemid 39625747)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.47 , pp. 48707-48715
    • Rosner, M.1    Hengstschlager, M.2
  • 14
    • 0034255133 scopus 로고    scopus 로고
    • A role for p27/Kip1 in the control of cerebellar granule cell precursor proliferation
    • Miyazawa K, Himi T, Garcia V, Yamagishi H, Sato S, Ishizaki Y. A role for p27/Kip1 in the control of cerebellar granule cell precursor proliferation. J Neurosci 2000; 20:5756-63. (Pubitemid 30636904)
    • (2000) Journal of Neuroscience , vol.20 , Issue.15 , pp. 5756-5763
    • Miyazawa, K.1    Himi, T.2    Garcia, V.3    Yamagishi, H.4    Sato, S.5    Ishizaki, Y.6
  • 16
    • 0033559264 scopus 로고    scopus 로고
    • The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
    • Cheng M, Olivier P, Diehl JA, Fero M, Roussel MF, Roberts JM, et al. The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J 1999; 18:1571-83. (Pubitemid 29127070)
    • (1999) EMBO Journal , vol.18 , Issue.6 , pp. 1571-1583
    • Cheng, M.1    Olivier, P.2    Diehl, J.A.3    Fero, M.4    Roussel, M.F.5    Roberts, J.M.6    Sherr, C.J.7
  • 22
    • 70449710913 scopus 로고    scopus 로고
    • p27 as Jekyll and Hyde: Regulation of cell cycle and cell motility
    • Larrea MD, Wander SA, Slingerland JM. p27 as Jekyll and Hyde: Regulation of cell cycle and cell motility. Cell Cycle 2009; 8:3455-61.
    • (2009) Cell Cycle , vol.8 , pp. 3455-3461
    • Larrea, M.D.1    Wander, S.A.2    Slingerland, J.M.3
  • 23
    • 0242361321 scopus 로고    scopus 로고
    • PDGFRB is overexpressed in metastatic medulloblastoma
    • Gilbertson RJ, Clifford SC. PDGFRB is overexpressed in metastatic medulloblastoma. Nat Genet 2003; 35:197-8.
    • (2003) Nat Genet , vol.35 , pp. 197-198
    • Gilbertson, R.J.1    Clifford, S.C.2
  • 26
    • 1642474000 scopus 로고    scopus 로고
    • Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors
    • Kenney AM, Widlund HR, Rowitch DH. Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Development 2004; 131:217-28.
    • (2004) Development , vol.131 , pp. 217-228
    • Kenney, A.M.1    Widlund, H.R.2    Rowitch, D.H.3
  • 27
    • 57449121927 scopus 로고    scopus 로고
    • Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors
    • Parathath SR, Mainwaring LA, Fernandez LA, Campbell DO, Kenney AM. Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors. Development 2008; 135:3291-300.
    • (2008) Development , vol.135 , pp. 3291-3300
    • Parathath, S.R.1    Mainwaring, L.A.2    Fernandez, L.A.3    Campbell, D.O.4    Kenney, A.M.5
  • 30
    • 33750040886 scopus 로고    scopus 로고
    • S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt
    • Zhang HH, Lipovsky AI, Dibble CC, Sahin M, Manning BD. S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol Cell 2006; 24:185-97.
    • (2006) Mol Cell , vol.24 , pp. 185-197
    • Zhang, H.H.1    Lipovsky, A.I.2    Dibble, C.C.3    Sahin, M.4    Manning, B.D.5
  • 31
    • 0032533225 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization
    • Diehl JA, Cheng M, Roussel MF, Sherr CJ. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 1998; 12:3499-511. (Pubitemid 28553242)
    • (1998) Genes and Development , vol.12 , Issue.22 , pp. 3499-3511
    • Diehl, J.A.1    Cheng, M.2    Roussel, M.F.3    Sherr, C.J.4
  • 32
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse patched mutants
    • DOI 10.1126/science.277.5329.1109
    • Goodrich LV, Milenkovic L, Higgins KM, Scott MP. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 1997; 277:1109-13. (Pubitemid 27371635)
    • (1997) Science , vol.277 , Issue.5329 , pp. 1109-1113
    • Goodrich, L.V.1    Milenkovic, L.2    Higgins, K.M.3    Scott, M.P.4
  • 36
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
    • Engelman JA. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 2009; 9:550-62.
    • (2009) Nat Rev Cancer , vol.9 , pp. 550-562
    • Engelman, J.A.1
  • 37
    • 67650289584 scopus 로고    scopus 로고
    • Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
    • Scales SJ, de Sauvage FJ. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci 2009; 30:303-12.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 303-312
    • Scales, S.J.1    De Sauvage, F.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.