-
1
-
-
33846457870
-
Cancer statistics, 2007
-
Jemal A, Siegel R, Ward E, Murray T, Xu J, et al. (2007) Cancer statistics, 2007. CA Cancer J Clin 57: 43-66.
-
(2007)
CA Cancer J Clin
, vol.57
, pp. 43-66
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Murray, T.4
Xu, J.5
-
2
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, Stephens P, Edkins, S, et al. (2002) Mutations of the BRAF gene in human cancer. Nature 417: 949-954.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
-
3
-
-
0037454224
-
Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma
-
Singer G, Oldt R 3rd, Cohen Y, Wang BG, Sidransky D, et al. (2003) Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma. J Natl Cancer Inst 95: 484-486.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 484-486
-
-
Singer, G.1
Oldt 3rd, R.2
Cohen, Y.3
Wang, B.G.4
Sidransky, D.5
-
4
-
-
12144287841
-
In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours
-
Sieben NL, Macropoulos P, Roemen GM, Kolkman-Uljee SM, Jan Fleuren G, et al. (2004) In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours. J Pathol 202: 336-340.
-
(2004)
J Pathol
, vol.202
, pp. 336-340
-
-
Sieben, N.L.1
Macropoulos, P.2
Roemen, G.M.3
Kolkman-Uljee, S.M.4
Jan Fleuren, G.5
-
5
-
-
33845200848
-
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set
-
Ikediobi ON, Davies H, Bignell C, Edkins S, Stevens C, et al. (2006) Mutation analysis of 24 known cancer genes in the NCI-60 cell line set. Mol Cancer Ther 5: 2606-2612.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2606-2612
-
-
Ikediobi, O.N.1
Davies, H.2
Bignell, C.3
Edkins, S.4
Stevens, C.5
-
7
-
-
17144382038
-
Frequent mutation of the PIK3CA gene in ovarian and breast cancers
-
Levine DA, Bogomolniy F, Yee CJ, Lash A, Barakat RR, et al. (2005) Frequent mutation of the PIK3CA gene in ovarian and breast cancers. Clin Cancer Res 11: 2875-2878.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2875-2878
-
-
Levine, D.A.1
Bogomolniy, F.2
Yee, C.J.3
Lash, A.4
Barakat, R.R.5
-
8
-
-
24144452026
-
PIK3CA mutations in advanced ovarian carcinomas
-
Wang Y, Helland A, Holm R, Kristensen GB, Borresen-Dale AL (2005) PIK3CA mutations in advanced ovarian carcinomas. Hum Mutat 25: 322.
-
(2005)
Hum Mutat
, vol.25
, pp. 322
-
-
Wang, Y.1
Helland, A.2
Holm, R.3
Kristensen, G.B.4
Borresen-Dale, A.L.5
-
9
-
-
33751190974
-
Sequence mutations and implification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms
-
Nakayama K, Nakayama N, Kurman RJ, Cope L, Pohl G, et al. (2006) Sequence mutations and implification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms. Cancer Biol Ther 5: 779-785.
-
(2006)
Cancer Biol Ther
, vol.5
, pp. 779-785
-
-
Nakayama, K.1
Nakayama, N.2
Kurman, R.J.3
Cope, L.4
Pohl, G.5
-
10
-
-
0034650817
-
Allelic imbalance and mutations of the PTEN gene in ovarian cancer
-
Saito M, Okamoto A, Kohno T, Takakura S, Shinozaki H, et al. (2000) Allelic imbalance and mutations of the PTEN gene in ovarian cancer. Int J Cancer 85: 160-165.
-
(2000)
Int J Cancer
, vol.85
, pp. 160-165
-
-
Saito, M.1
Okamoto, A.2
Kohno, T.3
Takakura, S.4
Shinozaki, H.5
-
12
-
-
0033035921
-
Mutation analysis of BRCA1, TP53, and KRAS2 in ovarian and related pelvic tumors
-
Tworek H, Peng R, Fetzer S, Werness BA, Piver MS, et al. (1999) Mutation analysis of BRCA1, TP53, and KRAS2 in ovarian and related pelvic tumors. Cancer Genet Cytogenet 112: 105-118.
-
(1999)
Cancer Genet Cytogenet
, vol.112
, pp. 105-118
-
-
Tworek, H.1
Peng, R.2
Fetzer, S.3
Werness, B.A.4
Piver, M.S.5
-
13
-
-
12844251290
-
Patterns of p53 mutations separate ovarian serous borderline tumors and low- and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: A mutational analysis with immunohistochemical correlation
-
Singer G, Stohr R, Cope L, Dehari R, Hartmann A, et al. (2005) Patterns of p53 mutations separate ovarian serous borderline tumors and low- and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: a mutational analysis with immunohistochemical correlation. Am J Surg Pathol 29: 218-224.
-
(2005)
Am J Surg Pathol
, vol.29
, pp. 218-224
-
-
Singer, G.1
Stohr, R.2
Cope, L.3
Dehari, R.4
Hartmann, A.5
-
14
-
-
30944447568
-
The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions
-
Yoon S, Seger R (2006) The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors 24: 21-44.
-
(2006)
Growth Factors
, vol.24
, pp. 21-44
-
-
Yoon, S.1
Seger, R.2
-
15
-
-
0033590636
-
Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors
-
Hoshino R, Chatani Y, Yamori T, Tsuruo T, Oka H, et al. (1999) Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors. Oncogene 18: 813-822.
-
(1999)
Oncogene
, vol.18
, pp. 813-822
-
-
Hoshino, R.1
Chatani, Y.2
Yamori, T.3
Tsuruo, T.4
Oka, H.5
-
16
-
-
10344258041
-
Targeting the mitogen-activated protein kinase cascade to treat cancer
-
Sebolt-Leopold JS, Herrera R (2004) Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer 4: 937-947.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 937-947
-
-
Sebolt-Leopold, J.S.1
Herrera, R.2
-
17
-
-
4944250783
-
Mutations of BRAF and KRAS precede the development of ovarian serous borderline tumors
-
Ho CL, Kurman RJ, Dehari R, Wang TL, Shih le M (2004) Mutations of BRAF and KRAS precede the development of ovarian serous borderline tumors. Cancer Res 64: 6915-6918.
-
(2004)
Cancer Res
, vol.64
, pp. 6915-6918
-
-
Ho, C.L.1
Kurman, R.J.2
Dehari, R.3
Wang, T.L.4
Shih le, M.5
-
18
-
-
33644696097
-
Germline mutations in genes within the MAPK pathway cause cardiofacio-cutaneous syndrome
-
Rodriguez-Viciana P, Tetsu O, Tidyman WE, Estep AL, Conger BA, et al. (2006) Germline mutations in genes within the MAPK pathway cause cardiofacio-cutaneous syndrome. Science 311: 1287-1290.
-
(2006)
Science
, vol.311
, pp. 1287-1290
-
-
Rodriguez-Viciana, P.1
Tetsu, O.2
Tidyman, W.E.3
Estep, A.L.4
Conger, B.A.5
-
19
-
-
2642583203
-
A multistep model for ovarian tumorigenesis: The value of mutation analysis in the KRAS and BRAF genes
-
Russell SE, McCluggage WG (2004) A multistep model for ovarian tumorigenesis: the value of mutation analysis in the KRAS and BRAF genes. J Pathol 203: 617-619.
-
(2004)
J Pathol
, vol.203
, pp. 617-619
-
-
Russell, S.E.1
McCluggage, W.G.2
-
20
-
-
0034015746
-
Incidence of P53 and K-ras alterations in ovarian mucinous and serous tumors
-
Morita K, Ono Y, Fukui H, Tomita S, Ueda Y, et al. (2000) Incidence of P53 and K-ras alterations in ovarian mucinous and serous tumors. Pathol Int 50: 219-223.
-
(2000)
Pathol Int
, vol.50
, pp. 219-223
-
-
Morita, K.1
Ono, Y.2
Fukui, H.3
Tomita, S.4
Ueda, Y.5
-
21
-
-
0042624835
-
Role of KRAS and BRAF gene mutations in mucinous ovarian carcinoma
-
Gemignani ML, Schlaerth AC, Bogomolniy F, Barakat RR, Lin O, et al. (2003) Role of KRAS and BRAF gene mutations in mucinous ovarian carcinoma. Gynecol Oncol 90: 378-381.
-
(2003)
Gynecol Oncol
, vol.90
, pp. 378-381
-
-
Gemignani, M.L.1
Schlaerth, A.C.2
Bogomolniy, F.3
Barakat, R.R.4
Lin, O.5
-
22
-
-
0031014476
-
Analysis of loss of heterozygosity and KRAS2 mutations in ovarian neoplasms: Clinicopathological correlations
-
Chenevix-Trench G, Kerr J, Hurst T, Shih YC, Purdie D, et al. (1997) Analysis of loss of heterozygosity and KRAS2 mutations in ovarian neoplasms: clinicopathological correlations. Genes Chromosomes Cancer 18: 75-83.
-
(1997)
Genes Chromosomes Cancer
, vol.18
, pp. 75-83
-
-
Chenevix-Trench, G.1
Kerr, J.2
Hurst, T.3
Shih, Y.C.4
Purdie, D.5
-
23
-
-
33847293670
-
High-throughput oncogene mutation profiling in human cancer
-
Thomas RK, Baker AC, Debiasi RM, Winckler W, Laframboise T, et al. (2007) High-throughput oncogene mutation profiling in human cancer. Nat Genet 39: 347-351.
-
(2007)
Nat Genet
, vol.39
, pp. 347-351
-
-
Thomas, R.K.1
Baker, A.C.2
Debiasi, R.M.3
Winckler, W.4
Laframboise, T.5
-
25
-
-
12144289677
-
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
-
Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, et al. (2004) Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116: 855-867.
-
(2004)
Cell
, vol.116
, pp. 855-867
-
-
Wan, P.T.1
Garnett, M.J.2
Roe, S.M.3
Lee, S.4
Niculescu-Duvaz, D.5
-
26
-
-
33644629727
-
Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome
-
Niihori T, Aoki Y, Narumi Y, Neri G, Cave H, et al. (2006) Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. Nat Genet 38: 294-296.
-
(2006)
Nat Genet
, vol.38
, pp. 294-296
-
-
Niihori, T.1
Aoki, Y.2
Narumi, Y.3
Neri, G.4
Cave, H.5
-
27
-
-
0025949649
-
Multifactorial mechanisms associated with broad cross-resistance of ovarian carcinoma cells selected by cyanomorpholino doxorubicin
-
Lau DH, Lewis AD, Ehsan MN, Sikic BI (1991) Multifactorial mechanisms associated with broad cross-resistance of ovarian carcinoma cells selected by cyanomorpholino doxorubicin. Cancer Res 51: 5181-5187.
-
(1991)
Cancer Res
, vol.51
, pp. 5181-5187
-
-
Lau, D.H.1
Lewis, A.D.2
Ehsan, M.N.3
Sikic, B.I.4
-
28
-
-
0021933379
-
Comparative properties of five human ovarian adenocarcinoma cell lines
-
Buick RN, Pullano R, Trent JM (1985) Comparative properties of five human ovarian adenocarcinoma cell lines. Cancer Res 45: 3668-3676.
-
(1985)
Cancer Res
, vol.45
, pp. 3668-3676
-
-
Buick, R.N.1
Pullano, R.2
Trent, J.M.3
-
29
-
-
37249013316
-
-
J Med Genet ePub
-
Nava C, Hanna N, Michot C, Pereira S, Pouvreau N, et al. (2007) CFC and Noonan syndromes due to mutations in RAS/MAPK signaling pathway: genotype/phenotype relationships and overlap with Costello syndrome. J Med Genet ePub.
-
(2007)
CFC and Noonan syndromes due to mutations in RAS/MAPK signaling pathway: Genotype/phenotype relationships and overlap with Costello syndrome
-
-
Nava, C.1
Hanna, N.2
Michot, C.3
Pereira, S.4
Pouvreau, N.5
-
30
-
-
0033869716
-
Characterization of four novel epithelial ovarian cancer cell lines
-
Provencher DM, Lounis H, Champoux L, Tetrault M, Manderson EN, et al. (2000) Characterization of four novel epithelial ovarian cancer cell lines. In Vitro Cell Dev Biol Anim 36: 357-361.
-
(2000)
In Vitro Cell Dev Biol Anim
, vol.36
, pp. 357-361
-
-
Provencher, D.M.1
Lounis, H.2
Champoux, L.3
Tetrault, M.4
Manderson, E.N.5
-
31
-
-
0141842689
-
Absence of PRAF and NRAS mutations in uveal melanoma
-
Cruz F 3rd, Rubin BP, Wilson D, Town A, Schroeder A, et al. (2003). Absence of PRAF and NRAS mutations in uveal melanoma. Cancer Res 63: 5761-5766.
-
(2003)
Cancer Res
, vol.63
, pp. 5761-5766
-
-
Cruz 3rd, F.1
Rubin, B.P.2
Wilson, D.3
Town, A.4
Schroeder, A.5
-
32
-
-
21544476746
-
A new BRAF gene mutation detected in a case of a solid variant of papillary thyroid carcinoma
-
Trovisco V, Soares P, Soares R, Magalhaes J, Sa-Couto P, et al. (2005) A new BRAF gene mutation detected in a case of a solid variant of papillary thyroid carcinoma. Hum Pathol 36: 694-697.
-
(2005)
Hum Pathol
, vol.36
, pp. 694-697
-
-
Trovisco, V.1
Soares, P.2
Soares, R.3
Magalhaes, J.4
Sa-Couto, P.5
-
33
-
-
0043122919
-
SIFT: Predicting amino acid changes that affect protein function
-
Ng PC, Henikoff S (2003) SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Res 31: 3812-3814.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 3812-3814
-
-
Ng, P.C.1
Henikoff, S.2
-
34
-
-
33750353461
-
Predicting the effects of amino Acid substitutions on protein function
-
Ng PC, Henikoff S (2006) Predicting the effects of amino Acid substitutions on protein function. Annu Rev Genomics Hum Genet 7: 61-80.
-
(2006)
Annu Rev Genomics Hum Genet
, vol.7
, pp. 61-80
-
-
Ng, P.C.1
Henikoff, S.2
-
35
-
-
30644457228
-
Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults
-
Bignell G, Smith R, Hunter C, Stephens P, Davies H, et al. (2006) Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults. Genes Chromosomes Cancer 45: 42-46.
-
(2006)
Genes Chromosomes Cancer
, vol.45
, pp. 42-46
-
-
Bignell, G.1
Smith, R.2
Hunter, C.3
Stephens, P.4
Davies, H.5
-
36
-
-
24744453982
-
Somatic mutations of the protein kinase gene family in human lung cancer
-
Davies H, Hunter C, Smith R, Stephens P, Greenman C, et al. (2005) Somatic mutations of the protein kinase gene family in human lung cancer. Cancer Res 65: 7591-7595.
-
(2005)
Cancer Res
, vol.65
, pp. 7591-7595
-
-
Davies, H.1
Hunter, C.2
Smith, R.3
Stephens, P.4
Greenman, C.5
-
37
-
-
33646256145
-
A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy
-
Hunter C, Smith R, Cahill DP, Stephens P, Stevens C, et al. (2006) A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy. Cancer Res 66: 3987-3991.
-
(2006)
Cancer Res
, vol.66
, pp. 3987-3991
-
-
Hunter, C.1
Smith, R.2
Cahill, D.P.3
Stephens, P.4
Stevens, C.5
-
38
-
-
20044381123
-
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
-
Stephens P, Edkins S, Davies H, Greenman C, Cox C, et al. (2005) A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nat Genet 37: 590-592.
-
(2005)
Nat Genet
, vol.37
, pp. 590-592
-
-
Stephens, P.1
Edkins, S.2
Davies, H.3
Greenman, C.4
Cox, C.5
-
39
-
-
34147097054
-
Molecular and clinical characterization of cardio-facio-cutaneous (CFC) syndrome: Overlapping clinical manifestations with Costello syndrome
-
Narumi Y, Aoki Y, Niihori T, Neri G, Cave H, et al. (2007) Molecular and clinical characterization of cardio-facio-cutaneous (CFC) syndrome: Overlapping clinical manifestations with Costello syndrome. Am J Med Genet A 143: 799-807.
-
(2007)
Am J Med Genet A
, vol.143
, pp. 799-807
-
-
Narumi, Y.1
Aoki, Y.2
Niihori, T.3
Neri, G.4
Cave, H.5
-
40
-
-
0036837671
-
Identification of a novel mitogen-activated protein kinase kinase activation domain recognized by the inhibitor PD 184352
-
Delaney AM, Printen JA, Chen H, Fauman EB, Dudley DT (2002) Identification of a novel mitogen-activated protein kinase kinase activation domain recognized by the inhibitor PD 184352. Mol Cell Biol 22: 7593-7602.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7593-7602
-
-
Delaney, A.M.1
Printen, J.A.2
Chen, H.3
Fauman, E.B.4
Dudley, D.T.5
-
41
-
-
0031453047
-
A novel regulatory mechanism in the mitogen-activated protein (MAP) kinase cascade. Role of nuclear export signal of MAP kinase kinase
-
Fukuda M, Gotoh I, Adachi M, Gotoh Y, Nishida E (1997) A novel regulatory mechanism in the mitogen-activated protein (MAP) kinase cascade. Role of nuclear export signal of MAP kinase kinase. J Biol Chem 272: 32642-32648.
-
(1997)
J Biol Chem
, vol.272
, pp. 32642-32648
-
-
Fukuda, M.1
Gotoh, I.2
Adachi, M.3
Gotoh, Y.4
Nishida, E.5
-
42
-
-
0027932676
-
Mitogen-activated protein (NUP) kinase phosphorylation of MAP kinase kinase: Determination of phosphorylation sites by mass spectrometry and site-directed mutagenesis
-
Mansour SJ, Resing KA, Candi JM, Hermann AS, Gloor JW, et al. (1994) Mitogen-activated protein (NUP) kinase phosphorylation of MAP kinase kinase: determination of phosphorylation sites by mass spectrometry and site-directed mutagenesis. J Biochem. (Tokyo) 116: 304-314.
-
(1994)
J Biochem. (Tokyo)
, vol.116
, pp. 304-314
-
-
Mansour, S.J.1
Resing, K.A.2
Candi, J.M.3
Hermann, A.S.4
Gloor, J.W.5
-
43
-
-
0030898976
-
Mutation analysis of the coding sequences of MEK-1 and MEK-2 genes in human lung cancer cell lines
-
Bansal A, Ramirez RD, Minna JD (1997) Mutation analysis of the coding sequences of MEK-1 and MEK-2 genes in human lung cancer cell lines. Oncogene 14: 1231-1234.
-
(1997)
Oncogene
, vol.14
, pp. 1231-1234
-
-
Bansal, A.1
Ramirez, R.D.2
Minna, J.D.3
-
44
-
-
31144453233
-
BRAF mutation predicts sensitivity to MEK inhibition
-
Solit DB, Garraway LA, Pratilas CA, Sawai A, Getz G, et al. (2006) BRAF mutation predicts sensitivity to MEK inhibition. Nature 439: 358-362.
-
(2006)
Nature
, vol.439
, pp. 358-362
-
-
Solit, D.B.1
Garraway, L.A.2
Pratilas, C.A.3
Sawai, A.4
Getz, G.5
|