Insulin resistance due to nutrient excess: Is it a consequence of AMPK downregulation?

Cell Cycle

Volumn 10, Issue 20, 2011, Pages 3447-3451

  Saha, Asish K ^a   Xu, X Julia ^a   Balon, Thomas W ^c   Brandon, Amanda ^b   Kraegen, Edward W ^b   Ruderman, Neil B ^a  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c NONE

Author keywords

AMP activated protein kinase; Branched chain amino acids; Insulin resistance; mTOR p70s6k; Protein synthesis

Indexed keywords

GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN;

DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; INSULIN RESISTANCE; NONHUMAN; NUTRIENT; OVERNUTRITION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

RATTUS;

EID: 80055115885     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.20.17886     Document Type: Review

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