High Frequency of Mutations of the PIK3CA Gene in Human Cancers

Science

Volumn 304, Issue 5670, 2004, Pages 554-

  Samuels, Yardena ^a   Wang, Zhenghe ^a   Bardelli, Alberto ^a   Silliman, Natalie ^a   Ptak, Janine ^a   Szabo, Steve ^a   Yan, Hai ^b   Gazdar, Adi ^c   Powell, Steven M ^d   Riggins, Gregory J ^a   Willson, James K V ^e   Markowitz, Sanford ^e   Kinzler, Kenneth W ^a   Vogelstein, Bert ^a   Velculescu, Victor E ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^e UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; RAS PROTEIN;

MEDICINE;

ARTICLE; BRAIN CANCER; BREAST CANCER; CANCER; CARCINOGENESIS; CELL ADHESION; CELL MOTILITY; CELL PROLIFERATION; CELL SURVIVAL; COLON CANCER; EARLY DIAGNOSIS; GENE; GLIOBLASTOMA; HUMAN; LUNG CANCER; MISSENSE MUTATION; PIK3CA GENE; PRIORITY JOURNAL; STOMACH CANCER; TUMOR GROWTH;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BREAST NEOPLASMS; CATALYTIC DOMAIN; COLORECTAL NEOPLASMS; GLIOBLASTOMA; HUMANS; LUNG NEOPLASMS; MUTATION; NEOPLASMS; SEQUENCE ANALYSIS, DNA; STOMACH NEOPLASMS;

EID: 11144358645     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1096502     Document Type: Article

References (6)

1. I. Vivanco, C. L. Sawyers, Nature Rev. Cancer 2, 489 (2002).
2. W. A. Phillips, F. St. Clair, A. D. Munday, R. J. Thomas, C. A. Mitchell, Cancer 83, 41 (1998).
3. Materials and methods are available as supporting material on Science Online.
4. T. L. Wang et al., Proc. Natl. Acad. Sci. U.S.A. 99, 3076 (2002).
5. L. Shayesteh et al., Nature Genet. 21, 99 (1999).
6. We thank S. Kern for tumor samples. Supported by the Benjamin Baker Scholarship Fund, the Ludwig Trust, the European Molecular Biology Organization Fellowship Fund, and NIH grant nos. CA 43460, CA S7345, CA 62924, CA 88128, and CA 67900.